Proteases and cell-mediated cytotoxicity

Critical Reviews in Immunology

Volumn 18, Issue 3, 1997, Pages 255-273

  Darmon, Alison J ^a   Bleackley, R Chris ^b  

^a LUDWIG INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

^b UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Apoptosis; Caspases; Death receptors; Granzymes; ICE Ced 3 proteases

Indexed keywords

CYSTEINE PROTEINASE; CYTOPLASM PROTEIN; GRANZYME A;

APOPTOSIS; CELL DEATH; CELL GRANULE; CELL MEDIATED CYTOTOXICITY; CYTOLYSIS; CYTOTOXIC T LYMPHOCYTE; EXOCYTOSIS; HOST RESISTANCE; HUMAN; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; CYSTEINE ENDOPEPTIDASES; CYTOTOXICITY TESTS, IMMUNOLOGIC; ENDOPEPTIDASES; HUMANS; IMMUNITY, CELLULAR; SUBSTRATE SPECIFICITY; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0031393753     PISSN: 10408401     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (181)

1. Atkinson, E. A. and Bleackley, R. C., Mechanisms of lysis by cytotoxic T cells, Crit. Rev. Immunol., 15, 359-384 1995.
2. Lenardo, M. J., Fas and the art of lymphocyte maintenance, J. Exp. Med., 183, 721-724, 1996.
3. Duvall, E. and A. H. Wyllie, Death and the cell, Immunol. Today, 7, 115-119, 1986.
4. Savill, J., Fadok, V., Henson, P., and Haslett, C., Phagocyte recognition of cells undergoing apoptosis, Immunol. Today, 14, 131-136, 1993.
5. Hale, A. J., C. A. Smith, L. C. Sutherland, V. E. Stoneman, V. L. Longthorne, A. C. Culhane, and G. T. Williams., Apoptosis: molecular regulation of cell death, Eur. J. Biochem., 236, 1-26, 1996.
6. Salvesen, G. S., and V. M. Dixit., Caspases: intracellular signaling by proteolysis, Cell, 91, 443-446, 1997.
7. Yuan, J., Shaham, S., Ledoux, S., Ellis, H. M., and Horvitz, H. R., The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin1β-converting enzyme, Cell, 75, 641-652, 1993.
8. Miura, M., Zhu, H., Rotello, R., Hartwieg, E. A., and Yuan, J., Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3, Cell, 75, 653-660, 1993.
9. Alnemri, E. S., Livingston, D. J., Nicholson, D. W., Salvesen, G. S., Thornberry, N. A., Wong, W. W., and Yuan, J., Human ICE/CED-3 protease nomenclature, Cell, 87, 171, 1996.
10. Thornberry, N. A., Bull, H. G., Calaycay, J. R., Chapman, K. T., Howard, A. D., Kostura, M. J., Miller, D. K., Molineaux, S. M., Weidner, J. R., Aunins, J., Elliston, K. O., Ayala, J. M., Casano, F. J., Chin, J., Ding, G. J.-F., Egger, L. A., Gaffney, E. P., Limjuco, G., Palyha, O. C., Raju, S. M., Rolando, A. M., Salley, J. P., Yamin, T.-T., Lee, T. D., Shively, J. E., MacCross, M., Mumford, R. A., Schmidt, J. A., and Tocci, M. J., A novel heterodimeric cysteine protease is required for interleukin-1β processing in monocytes, Nature, 356, 768-774, 1992.
11. Thornberry, N. A. and Molineaux, S. M., Interleukin-1β converting enzyme: a novel cysteine protease required for IL-1βproduction and implicated in programmed cell death, Protein Sci., 4, 3-12, 1995.
12. Cerretti, D. P., Kozlosky, C. J., Mosley, B., Nelson, N., Van Ness, K., Greenstreet, T. A., March, C. J., Kronheim, S. R., Druck, T., Cannizzaro, L. A., Huebner, K., and Black, R. A., Molecular cloning of the interleukin-1β converting enzyme, Science, 256, 97-100, 1992.
13. Ghayur, T., Banerjee, S., Hugunin, M., Butler, D., Herzog, L., Carter, A., Quintal, L., Sekut, L., Talanian, R., Paskind, M., Wong, W., Kamen, R., Tracey, D., and Allen, H., Caspase-1 processes IFNγ-inducing factor and regulates LPS-induced IFN-γ production, Nature, 386, 619-623, 1997.
14. Akita, K., Ohtsuki, T., Nukada, Y., Tanimoto, T., Namba, M., Okura, T., Takakura-Yamamoto, R., Torigoe, K., Gu, Y., Su, M. S. S., Fujii, M., Satoh-Itoh, M., Yamamoto, K., Kohno, K., Ikeda, M., and Kurimoto, M., Involvement of caspase-1 and caspase-3 in the production and processing of mature human interleukin 18 in monocytic THP.1 cells, J. Biol. Chem., 272, 26595-26603, 1997.
15. Li, P., Allen, H., Banerjee, S., Franklin, S., Herzog, L., Johnston, C., McPowell, J., Paskind, M., Rodman, L., Salfeld, J., Towne, E., Tracey, D., Wardwell, S., Wei, F.-Y., Wong, W., Kamen, R., and Seshadri, T., Mice deficient in IL-1β-converting enzyme are defective in production of mature IL-1βand resistant to endotoxic shock, Cell, 80, 401-411, 1995.
16. Darmon, A. J. and Bleackley, R. C., An Interleukin1β Converting Enzyme-like protease is a key component of Fas-mediated apoptosis, J. Biol. Chem., 271, 21699-21702, 1996.
17. Schlegel, J., Peters, I., Orrenius, S., Miller, D. K., Thornberry, N. A., Yamin, T. T., and Nicholson, D. W., CPP32/apopain is a key interleukin 1β converting enzyme-like protease involved in Fas-mediated apoptosis, J. Biol. Chem., 271, 1841-1844, 1996.
18. Margolin, N., Raybuck, S. A., Wilson, K. P., Chen, W. Y., Fox, T., Gu, Y., and Livingston, D. J., Substrate and inhibitor specificity of interleukin-1β-converting enzyme and related caspases, J. Biol. Chem., 272, 7223-7228, 1997.
19. Kamada, S., Funahashi, Y., and Tsujimoto, Y., Caspase-4 and caspase-5, members of the ICE/CED-3 family of cysteine proteases, are CrmA-inhibitable proteases, Cell Death Differ., 4, 473-478, 1997.
20. Kamada, S., Washida, M., Hasegawa, J., Kusano, H., Funahashi, Y., and Tsujimoto, Y., Involvement of caspase-4(-like) protease in Fas-mediated apoptotic pathway, Oncogene, 15, 285-290, 1997.
21. Casciola-Rosen, L., Nicholson, D. W., Chong, T., Rowan, K. R., Thornberry, N. A., Miller, D. K., and Rosen, A., Apopain/CPP32 cleaves proteins that are essential for cellular repair: A fundamental principle of apoptotic death, J. Exp. Med., 183, 1957-1964, 1996.
22. Teraoka, H., Yumoto, Y., Watanabe, F., Tsukada, K., Suwa, A., Enari, M., and Nagata, S., CPP32/Yama/Apopain cleaves the catalytic component of DNA-dependent protein-kinase in the holoenzyme, FEBS Lett., 393, 1-6, 1996.
23. Song, Q., Lees-Miller, S. P., Kumar, S., Zhang, N., Chan, D. W., Smith, G. C. M., Jackson, S. P., Alnemri, E. S., Litwack, G., Khanna, K. K., and Lavin, M. F., DNA-dependent protein kinase catalytic subunit: A target for an ICE-like protease, EMBO J., 15, 3238-3246, 1996.
24. Han, Z. Y., Malik, N., Carter, T., Reeves, W. H., Wyche, J. H., and Hendrickson, E. A., DNA-dependent protein-kinase is a target for a CPP32-like apoptotic protease, J. Biol. Chem., 271, 25035-25040, 1996.
25. Orth, K., Chinnaiyan, A. M., Garg, M., Froelich, C. J., and Dixit, V. M., The CED-3/ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin A, J. Biol. Chem., 271, 16443-16446, 1996.
26. Takahashi, A., Alnemri, E. S., Lazebnik, Y. A., Fernandes-Alnemri, T., Litwack, G., Moir, R. D., Goldman, R. D., Poirier, G. G., Kaufmann, S. H., and Earnshaw, W. C., Cleavage of lamin A by Mch2α but not CPP32: Multiple interleukin-1β-converting enzyme-related proteases with distinct substrate recognition are active In apoptosis, Proc. Natl. Acad. Sci. U.S.A., 93, 8395-8400, 1996.
27. Thornberry, N. A., Rano, T. A., Peterson, E. P., Rasper, D. M., Timkey, T., Garcia-Calvo, M., Houtzager, V. M., Nordstrom, P. A., Roy, S., Vaillancourt, J. P., Chapman, K. T., and Nicholson, D. W., A combinatorial approach defines specificities of members of the caspase family and granzyme B: Functional relationships established for key mediators of apoptosis, J. Biol. Chem., 272, 17907-17911, 1997.
28. Kuida, K., Zheng, T. S., Na, S. Q., Kuan, C. Y., Yang, D., Karasuyama, H., Rakic, P., and Flavell, R. A., Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice, Nature, 384, 368-372, 1996.
29. Masson, D. and Tschopp, J., Isolation of a lytic, pore-forming protein (perforin) from cytolytic T-lymphocytes, J. Biol. Chem., 260, 9069-9072, 1985.
30. Liu, C. C., Perussia, B., Cohn, Z. A., and Young, J. D., Identification and characterization of a pore-forming protein of human peripheral blood natural killer cells, J. Exp. Med., 164, 2061-2076, 1986.
31. Podack, E. R., Young, J. D., and Cohn, Z. A., Isolation and biochemical and functional characterization of perforin 1 from cytolytic T-cell granules, Proc. Natl. Acad. Sci. U.S.A., 82, 8629-8633, 1985.
32. Zalman, L. S., Martin, D. E., Jung, G., and Muller-Eberhard, H. J., The cytolytic protein of human lymphocytes related to the ninth component (C9) of human complement: Isolation from anti-CD3-activated peripheral blood mononuclear cells, Proc. Natl. Acad. Sci. U.S.A., 84, 2426-2429, 1987.
33. Dourmashkin, R. R., Deteix P., Simone, C. B., and Henkart, P., Electron microscopic demonstration of lesions in target cell membranes associated with antibody-dependent cellular cytotoxicity, Clin. Exp. Immunol., 42, 554-560, 1980.
34. Duke, R. C., Persechini, P. M., Chang, S., Liu, C. C., Cohen, J. J., and Young, J. D., Purified perforin induces target cell lysis but not DNA fragmentation, J. Exp. Med., 170, 1451-1456, 1989.
35. Duke, R. C., Chervenak, R., and Cohen, J. J., Endogenous endonuclease-induced DNA fragmentation: an early event in cell-mediated cytolysis, Proc. Natl. Acad. Sci. U.S.A., 80, 6361-6365, 1983.
36. Cohen, J. J., Duke, R. C., Chervenak, R., Sellins, K. S., and Olson, L. K., DNA fragmentation in targets of CTL: an example of programmed cell death in the immune system, Adv. Exp. Med. Biol., 184, 493-508, 1985.
37. Jans, D. A., Jans, P., Briggs, L. J., Sutton, V., and Trapani, J. A., Nuclear transport of granzyme B (fragmentin-2): dependence on perforin in vivo and cytosolic factors in vitro, J. Biol. Chem., 271, 30781-30789, 1996.
38. Froelich, C. J., Orth, K., Turbov, J., Seth, P., Gottlieb, R., Babior, B., Shah, G. M., Bleackley, R. C., Dixit, V. M., and Hanna, W., New paradigm for lymphocyte granule-mediated cytotoxicity: target cells bind and internalize granzyme B, but an endosomolytic agent is necessary for cytosolic delivery and subsequent apoptosis, J. Biol. Chem., 271, 29073-29079, 1996.
39. Shi, L., Mai, S., Israels, S.,Browne,K.,Trapani, J. A., and Greenberg, A. H., Granzyme B (GraB) autonomously crosses the cell membrane and perforin initiates apoptosis and GraB nuclear localization, J. Exp. Med., 185, 855-866, 1997.
40. Lowin, B., Hahne, M., Mattmann, C., and Tschopp, J., Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways, Nature, 370, 650-652, 1994.
41. Kagi, D., Vignaux, F., Ledermann, B., Burki, K., Depraetere, V., Nagata, S., Hengartner, H., and Golstein, P., Fas and perform pathways as major mechanisms of T cell-mediated cytotoxicity, Science, 265, 528-530, 1994.
42. Kagi, D., Ledermann, B., Burki, K., Seiler, P., Odermatt, B., Olsen, K. J., Podack, E. R., Zinkernagel, R. M., and Hengartner, H., Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice, Nature, 369, 31-37, 1994.
43. Kojima, H., Shinohara, N., Hanaoka, S., Someya-Shirota, Y., Takagaki, Y., Ohno, H., Saito, T., Katayama, T., Yagita, H., Okumura, K., Shinkai, Y., Alt, F. W., Matsuzawa, A., Yonehara, S., and Takayama, H., Two distinct pathways of specific killing revealed by perforin mutant cytotoxic T lymphocytes, immunity, 1, 357-364, 1994.
44. Smyth, M. J., O'Connor, M. D., and Trapani, J. A., Granzymes: a variety of serine-protease specificities encoded by genetically distinct subfamilies, J. Leuk. Biol., 60, 555-562, 1996.
45. Hayes, M. P., Berrebi, G. A., and Henkart, P. A., Induction of target cell DNA release by the cytotoxic T lymphocyte granule protease granzyme A, J. Exp. Med., 170, 933-946, 1986.
46. Shi, L., Kam, C. M., Powers, J. C., Aebersold, R., and Greenberg, A. H., Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions, J. Exp. Med., 176, 1521-1529, 1992.
47. Shi, L., R. Kraut, P., Aebersold, R., and Greenberg, A. H., A natural killer cell granule protein that induces DNA fragmentation and apoptosis, J. Exp. Med., 175, 553-566, 1992.
48. Heusel, J. W., Wesselschmidt R. L., Shresta, S., Russell, J. H., and Ley, T. J., Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells, Cell, 76, 977-987, 1994.
49. Shresta, S., MacIvor, D. M., Heusel, J. W., Russell, J. H., and Ley, T. J., Natural killer and lymphokine-activated killer cells require granzyme B for the-rapid induction of apoptosis in susceptible target cells, Proc. Natl. Acad. Sci. U.S.A., 92, 5679-5683, 1995.
50. Ebnet, K., Hausmann, M., Lehmann-Grube, F., Mullbacher, A., Kopf, M., Lamers, M., and Simon, M. M., Granzyme A-deficient mice retain potent cell-mediated cytotoxicity, EMBO J., 14, 4230-4239, 1995.
51. Smyth, M. J., Browne, K. A., Thia, K. Y., Apostolidis, V. A., Kershaw, M. H., and Trapani, J. A., Hypothesis: cytotoxic lymphocyte granule serine proteases activate target cell endonucleases to trigger apoptosis, Clin. Exp. Pharmacol. Physiol., 21, 67-70, 1994.
52. Murphy, M. E., Moult, J., Bleackley, R. C., Gershenfeld, H., Weissman, I. L., and James, M. N. G., Comparative molecular model building of two serine proteinases from cytotoxic T lymphocytes, Proteins, 4, 190-204, 1988.
53. Odake, S., Kam, C. M., Narasimhan, L., Poe, M., Blake, J. T., Krahenbuhl, O., Tschopp, J., and Powers, J. C., Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins, Biochemistry, 30, 2217-2227, 1991.
54. Caputo, A., James, M. N. G., Powers, J. C., Hudig, D., and Bleackley, R. C., Conversion of the substrate specificity of mouse proteinase granzyme B, Nat. Struct. Biol., 1, 364-367, 1994.
55. Vaux, D. L., Haecker, G., and Strasser, A., An evolutionary perspective on apoptosis, Cell, 76, 777-779, 1994.
56. Darmon, A. J., Ehrman, N., Caputo, A., Fujinaga, J., and Bleackley, R. C., The cytotoxic T cell proteinase granzyme B does not activate interleukin1β-converting enzyme, J. Biol. Chem., 269, 32043-32046, 1994.
57. Nicholson, D. W., Ali, A., Thornberry, N. A., Vaillancourt, J. P., Ding, C. K., Gallant, M., Gareau, Y., Griffin, P. R., Labelle, M., Lazebnik, Y. A., Munday, N. A., Raju, S. M., Smulson, M. E., Yamon, T.-T., Yu, V. L., and Miller, D. K., Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis, Nature, 376, 37-43, 1995.
58. Tewari, M., Quan, L. T., O'Rourke, K., Desnoyers, S., Zeng, Z., Beidler, D. R., Poirier, G. G., Salvesen, G. S., and Dixit, V. M., Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase, Cell, 81, 801-809, 1995.
59. 2+-dependent endonuclease of bull seminal plasma induced-by ADP-ribosylation, J. Biol. Chem., 259, 6579-6585, 1984.
60. 2+-dependent endonuclease activity by nicotinamide adenine dinucleotide and poly (adenosine diphosphate ribose) synthetase, Biochem. Biophys. Res. Commun., 59, 658-665, 1974.
61. 2+-dependent endonuclease in thymocytes of irradiated rats, Int. J. Radiat. Biol., 53, 749-765, 1988.
62. Darmon, A. J., Nicholson, D. W., and Bleackley, R. C., Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B, Nature, 377, 446-448, 1995.
63. Darmon, A. J., Ley, T. J., Nicholson, D. W., and Bleackley, R. C., Cleavage of CPP32 by granzyme B represents a critical role for granzyme B in the induction of target cell DNA fragmentation, J. Biol. Chem., 271, 21709-21712, 1996.
64. Liu, X. S., Zou, H., Slaughter, C., and Wang, X. D., DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis, Cell, 89, 175-184, 1997.
65. Martin, S. J., Amarante-Mendes, G. P., Shi, L., Chuang, T. H., Casiano, C. A., O'Brien, G. A., Fitzgerald, P., Tan, E. M., Bokoch, G. M., Greenberg, A. H., and Green, D. R., The cytotoxic cell protease granzyme B initiates apoptosis in a cell-free system by proteolytic processing and activation of the ICE/CED-3 family protease, CPP32, via a novel two-step mechanism, EMBO J., 15, 2407-2416, 1996.
66. Quan, L. T., Tewari, M., O'Rourke, K., Dixit, V., Snipas, S. J., Poirier, G. G., Ray, C., Pickup, D. J., and Salvesen, G. S., Proteolytic activation of the cell death protease Yama/CPP32 by granzyme B, Proc. Natl. Acad. Sci. U.S.A., 93, 1972-1976, 1996.
67. Harvey, N. L., Trapani, J. A., Fernandes-Alnemri, T., Litwack, G., Alnemri, E. S., and Kumar, S., Processing of the Nedd2 precursor by ICE-like proteases and granzyme B, Genes Cells, 1, 673-685, 1996.
68. Van de Craen, M., Van den Brande, I., Declerq, W., Irmler, M., Beyaert, R., Tschopp, J., Fiers, W., and Vandenabeele, P., Cleavage of caspase family members by granzyme B: a comparative study in vitro, Eur. J. Immunol, 27, 1296-1299, 1997.
69. Talanian, R. V., Yang, X. H., Turbov, J., Seth, P., Ghayur, T., Casiano, C. A., Orth, K., and Froelich, C. J., Granule-mediated killing: Pathways for granzyme B-initiated apoptosis, J. Exp. Med., 16, 1323-1331, 1997.
70. Zhou, Q. and Salvesen, G. S., Activation of procaspase-7 by serine proteases includes a noncanonical specificity, Biochem. 7., 324, 361-364, 1997.
71. Anel, A., Gamen, S., Alava, M. A., Schmitt-Verhulst, A. M., Pineiro, A., and Naval, J., Inhibition of CPP32-like proteases prevents granzyme B-and Fas-, but not granzyme A-based cytotoxicity exerted by CTL clones, J. Immunol., 158, 1999-2006, 1997.
72. Vignaux, F., Vivier, E., Malissen, B., Depraetere, V., Nagata, S., and Golstein, P., TCR/CD3 coupling to Fas-based cytotoxicity, J. Exp. Med., 181, 781-786, 1995.
73. Eischen, C. M., Schilling, J. D., Lynch, D. H., Krammer, P. H., and Leibson, P. J., Fc receptor induced expression of Fas ligand on activated NK cells facilitates cell-mediated cytotoxicity and subsequent autocrine NK cell apoptosis, J. Immunol., 156, 2693-2699, 1996.
74. Montel, A. H., Bochan, M. R., Hobbs, J. A., Lynch, D. H., and Brahmi, Z., Fas involvement in cytotoxicity mediated by human NK cells, Cell. Immunol., 166, 236-246, 1995.
75. Kischkel, F. C., Hellbardt, S., Behrmann, I., Germer, M., Pawlita, M., Krammer, P. H., and Peter, M. E., Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor, EMBO J., 14, 5579-5588, 1995.
76. Zheng, L., Fisher, G., Miller, R. E., Peschon, J., Lynch, D. H., and Lenardo, M. J., Induction of apoptosis in mature T cells by tumor necrosis factor, Nature, 377, 348-351, 1995.
77. Lee, R. K., Spielman, J., Zhao, D. Y., Olsen, K. J., and Podack, E. R., Perforin, Fas ligand and tumor necrosis factor are the major cytotoxic molecules used by lymphokine-activated killer cells, J. Immunol., 157, 1919-1925, 1996.
78. Chinnaiyan, A. M., O'Rourke, K., Yu, G.-L., Lyons, R. H., Garg, M., Duan, D. R., Xing, L., Gentz, R., Ni, J., and Dixit, V. M., Signal transduction by DR3, a death domain-containing receptor related to TNFRI and CD95, Science, 274, 990-992, 1996.
79. Kitson, J., Raven, T., Jiang, Y. P., Goeddel, D. V., Giles, K. M., Pun, K.-T., Grinham, C. J., Brown, R., and Farrow, S. N., A death-domain-containing receptor that mediates apoptosis, Nature, 384, 372-375, 1996.
80. Marsters, S. A., Sheridan, J. P., Donahue, C. J., Pitti, R. M., Gray, C. L., Goddard, A. D., Bauer, K. D., and Ashkenazi, A., APO-3, a new member of the tumor-necrosis-factor receptor family, contains a death domain and activates apoptosis and NF-kB, Curr. Biol., 6, 1669-1676, 1996.
81. Bodmer, J. L., Burns, K., Schneider, P., Hofmann, K., Steiner, V., Thome, M., Bornand, T., Hahne, M., Schroter, M., Becker, K., Wilson, A., French, L. E., Browning, J. L., MacDonald, H. R., and Tschopp, J., TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor I and Fas(Apo-1/CD95), Immunity, 6, 79-88, 1997.
82. Screaton, G. R., Xu, X. N., Olsen, A. L., Cowper, A. E., Tan, R., McMichael, A. J., and Bell, J. I., LARD: A new lymphoid-specific death domain containing receptor regulated by alternative pre-mRNA splicing, Proc. Natl. Acad. Sci. U.S.A., 94, 4615-4619, 1997.
83. Pan, G., O'Rourke, K., Chinnaiyan, A. M., Gentz, R., Ebner, R., Ni, J., and Dixit, V. M., The receptor for the cytotoxic ligand TRAIL, Science, 276, 111-113 1997.
84. Pan, G., Ni, J., Wei, Y.-F., Yu, G.-L., Gentz, R., and V. Dixit, M., An antagonist decoy receptor and a death domain-containing receptor for TRAIL, Science, 271, 815-818, 1997.
85. Walczak, H., Degli-Esposti, M. A., Johnson, R. S., Smolak, P. J., Waugh, J. Y., Boiani, N., Timour, M. S., Gerhart, M. J., Schooley, K. A., Smith, C. A., Goodwin, R. G., and Rauch, C. T., TRAIL-R2: A novel apoptosis-mediating receptor for TRAIL, EMBO J., 16, 5386-5397, 1997.
86. Wiley, S. R., Schooley, K., Smolak, P. J., Din, W. S., Huang, C. P., Nicholl, J. K., Sutherland, G. R., Smith, T. D., Rauch, C., Smith, C. A., and Goodwin, R. G., Identification and characterization of a new member of the TNF family, Immunity, 3, 673-682, 1995.
87. Pitti, R. M., Marsters, S. A., Ruppert, S., Donahue, C. J., Moore, A., and Ashkenazi, A., Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family, J. Biol. Chem., 271, 12687-12690, 1996.
88. Ray, C. A., Black, R. A., Kronheim, S. R., Greenstreet, T. A., Sleath, P. R., Salvesen, G. S., and Pickup, D. J., Viral inhibition of inflammation: Cowpox virus encodes an inhibitor of interleukin-1β converting enzyme, Cell, 69, 597-604, 1992.
89. Tewari, M. and Dixit, V. M., Fas- and tumor necrosis factor-induced apoptosis is inhibited by the poxvirus crmA gene product, J. Biol. Chem., 270, 3255-3260, 1995.
90. Miura, M., Friedlander, R. M., and Yuan, J., Tumor necrosis factor-induced apoptosis is mediated by a CrmA-sensitive cell death pathway, Proc. Natl. Acad. Sci. U.S.A., 92, 8318-8322, 1995.
91. Smith, K. G. C., Strasser, A., and Vaux, D. L., CrmA expression in T lymphocytes of transgenic mice inhibits CD95 (Fas/Apo-1)-transduced apoptosis, but does not cause lymphadenopathy or autoimmune disease, EMBO J., 15, 5167-5176, 1996.
92. Tewari, M., Telford, W. G., Miller, R. A., and Dixit, V. M., CrmA, a poxvirus-encoded serpin, inhibits cytotoxic T-lymphocyte-mediated apoptosis, J. Biol. Chem., 270, 22705-22708, 1995.
93. Macen, J. L., Garner, R. S., Musy, P.-Y., Brooks, M. A., Turner, P. C., Mover, R. W., McFadden, G., and Bleackley, R. C., Differential inhibition of the Fas-mediated and granule-mediated cytolysis pathways by the orthopoxvirus cytokine response modifier A/SPI-2 and SPI-1 protein, Proc. Natl. Acad. Sci. U.S.A., 93, 9108-9113, 1996.
94. Quan, L. T., Caputo, A., Bleackley, R. C., Pickup, D. J., and Salvesen, G. S., Granzyme B is inhibited by the cowpox virus serpin cytokine response modifier-A, J. Biol. Chem., 270, 10377-10379, 1995.
95. Enari, M., Hug, H., and Nagata, S., Involvement of an ICE-like protease in Fas-mediated apoptosis, Nature, 375, 78-81, 1995.
96. Los, M., Van de Craen, M., Penning, L. C., Schenk, H., Westendorp, M., Baeuerle, P. A., Droge, W., Krammer, P. H., Fields, W., and Schulze Osthoff, K., Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis, Nature, 375, 81-83, 1995.
97. Smith, D. J., McGuire, M. J., Tocci, M. J., and Thiele, D. L., IL-1β convertase (ICE) does not play a requisite role in apoptosis induced in T lymphoblasts by Fas-dependent or Fas-independent CTL effector mechanisms, J. Immunol., 158, 163-170, 1997.
98. Hasegawa, J., Kamada, S., Kamiike, W., Shimizu, S., Imazu, T., Matsuda, H., and Tsujimoto, Y., Involvement of CPP32/Yama(-like) proteases in Fas-mediated apoptosis, Cancer Res., 56, 1713-1718, 1996.
99. Dubrez, L., Savoy, I., Hamman, A., and Solary, E., Pivotal role of a DEVD-sensitive step in etoposide-induced and Fas-mediated apoptotic pathways, EMBO J., 15, 5504-5512, 1996.
100. Enari, M., Talanian, R. V., Wong, W. W., and Nagata, S., Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis, Nature, 380, 723-726, 1996.
101. Hsu, H., Xiong, J., and Goeddel, D. V., The TNF receptor 1-associated protein TRADD signals cell death and NF-kB activation, Cell, 81, 495-504, 1995.
102. Chinnaiyan, A. M., O'Rourke, K., Tewari, M., and Dixit, V. M., FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis, Cell, 81, 505-512, 1995.
103. Boldin, M. P., Varfolomeev, E. E., Pancer, Z., Mett, I. L., Camonis, J. H., and Wallach, D., A novel protein that interacts with the death domain of Fas/Apo-1 contains a sequence motif related to the death domain, J. Biol. Chem., 270, 7795-7798, 1995.
104. Chinnaiyan, A. M., Tepper, C. G., Seldin, M. F., O'Rourke, K., Kischkel, F. C., Hellbardt, S., Krammer, P. H., Peter, M. E., and Dixit, V. M., FADD/MORT1 is a common mediator of CD95 (Fas/APO-1) and tumor necrosis factor receptor-induced apoptosis, J. Biol. Chem., 271, 4961-4965, 1996.
105. Stanger, B. Z., Leder, P., Lee, T.-H., Kim, E., and Seed, B., RIP: A novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death, Cell, 81, 513-523, 1995.
106. Hsu, H. L., Huang. J., Shu, H.-B., Baichwal, V., and D. Goeddel, V., TNF-dependent recruitment of the protein-kinase RIP to the TNF receptor-1 signaling complex, Immunity, 4, 387-396, 1996.
107. Muzio, M., Chinnaiyan, A. M., Kischkel, F. C., O'Rourke, K., Shevchenko, A., Ni, J., Scaffidi, C., Bretz, J. D., Zhang, M., Gentz, R., Mann, M., Krammer, P. H., Peter, M. E., and Dixit, V. M., FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex, Cell, 85, 817-827, 1996.
108. Vincenz, C. and Dixit, V. M., Fas-associated death domain protein interleukin-1β converting enzyme 2 (FLICE2), an ICE/Ced-3 homologue, is proximally involved in CD95- and p55-mediated death signaling, J. Biol. Chem., 272, 6578-6583, 1997.
109. Srinivasula, S. M., Ahmad, M., Fernandes-Alnemri, T., Litwack, G., and Alnemri, E. S., Molecular or dering of the Fas-apoptotic pathway: the Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases, Proc. Natl. Acad. Sci. U.S.A., 93, 14486-14491, 1996.
110. Muzio, M., Salvesen, G. S., and Dixit, V. M., FLICE induced apoptosis in a cell-free system: cleavage of caspase zymogens, J. Biol. Chem., 272, 2952-2956, 1997.
111. Takahashi, A., Hirata, H., Yonehara, S., Imai, Y., Lee, K. K., Moyer, R. W., Turner, P. C., Mesner, P. W., Okazaki, T., Sawai, H., Kishi, S., Yamamoto, K., Okuma, and Sasada, M., Affinity labeling displays the stepwise activation of ICE-related proteases by Fas, staurosporine, and CrmA-sensitive caspase-8, Oncogene, 14, 2741-2752, 1997.
112. Zhou, Q., Snipas, S., Orth, K., Muzio, M., Dixit, V. M., and Salvesen, G. S., Target protease specificity of the viral serpin CrmA: analysis of five caspases, J. Biol. Chem., 212, 7797-7800, 1997.
113. Duan, H. and Dixit, V. M., RAIDD is a new "death" adaptor molecule, Nature, 385, 86-89, 1997.
114. Ahmad, M., Srinivasula, S. M., Wang, L. J., Talanian, R. V., Litwack, G., Fernandes-Alnemri, T., and Alnemri, E. S., CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL tumor necrosis factor receptor-interacting protein RIP, Cancer Res., 57, 615-619, 1997.
115. Li, H., Bergeron, L., Cryns, V., Pasternack, M. S., Zhu, H., Shi, L., Greenberg, A. H., and Yuan, J., Activation of caspase-2 in apoptosis, J. Biol. Chem., 272, 21010-21017, 1997.
116. Harvey, N. L., Butt, A. J., and Kumar, S., Functional activation of Nedd2/ICH-1 (Caspase-2) is an early process in apoptosis, J. Biol. Chem., 272, 13134-13139, 1997.
117. Grimm, S., Stanger, B. Z., and Leder, P., RIP and FADD: 2 death domain-containing proteins can induce apoptosis by convergent, but dissociable, pathways, Proc. Natl. Acad. Sci. U.S.A., 93, 10923-10927, 1996.
118. Schulze-Osthoff, K., Krammer, P. H., and Droge, W., Divergent signalling via APO-1/Fas and the TNF receptor, two homologous molecules involved in physiological cell death, EMBO J., 13, 4587-4596, 1994.
119. 2 is not involved in Fas-mediated apoptosis, Eur. J. Biochem., 236, 533-538, 1996.
120. Ting, A. T., Pimentel-Muinos, F. X., and Seed, B., RIP mediates tumor necrosis factor receptor 1 activation of NF-kB but not Fas/APO-1-initiated apoptosis, EMBO J., 15, 6189-6196, 1996.
121. Fernandes-Alnemri, T., Litwack, G., and Alnemri, E. S., CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1β-converting enzyme, J. Biol. Chem., 269, 30761-30764, 1994.
122. Fernandes-Alnemri, T., Litwack, G., and Alnemri, E. S., Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family, Cancer Res., 55, 2737-2742, 1995.
123. Waterhouse, N., Kumar, S., Song, Q., Strike, P., Sparrow, L., Dreyfuss, G., Alnemri, E. S., Litwack, G., Lavin, M., and Watters, D., Heteronuclear ribonucleoproteins C1 and C2, components of the spliceosome, are specific targets of interleukin 1βconverting enzyme-like proteases in apoptosis, J. Biol. Chem., 271, 29335-29341, 1996.
124. Bing, A. and Dou, Q. P., Cleavage of retinoblastoma protein during apoptosis: An interleukin 1β-converting enzyme-like protease as candidate, Cancer Res., 56, 438-442, 1996.
125. Janicke, R. U., Walker, P. A., Lin, X. Y., and Porter, A. G., Specific cleavage of the retinoblastoma protein by an ICE-like protease in apoptosis, EMBO J., 15, 6969-6978, 1996.
126. Fattman, C. L., An, B., and Dou, Q. P., Characterization of interior cleavage of retinoblastoma protein in apoptosis, J. Cell Biochem., 67, 399-408, 1997.
127. Tan, X., Martin, S. J., Green, D. R., and Wang, J. Y. J., Degradation of retinoblastoma protein in tumor necrosis factor- and CD95-induced cell death, J. Biol. Chem., 272, 9613-9616, 1997.
128. Lahti, J. M., Xiang, J., Heath, L. S., Campana, D., and Kidd, V. J., PITSLRE protein kinase activity is associated with apoptosis, Mol. Cell. Biol., 15, 1-11, 1995.
129. Chen, L. H., Marechal, V., Moreau, J., Levine, A. J., and Chen, J. D., Proteolytic cleavage of the mdm2 oncoprotein during apoptosis, J. Biol. Chem., 272, 22966-22973, 1997.
130. Stack, J. H. and Newport, J. W., Developmentally regulated activation of apoptosis early in Xenopus gastrulation results in cyclin A degradation during interphase of the cell cycle, Development, 124, 3185-3195, 1997.
131. Ubeda, M. and Habener, J. F., The large subunit of the DNA replication complex C (DSEB/RF-C140) cleaved and inactivated by caspase-3 (CPP32/YAMA) during Fas-induced apoptosis, J. Biol. Chem., 272, 19562-19568, 1997.
132. Rheaume, E., Cohen, L. Y., Uhlmann, F., Lazure, C., Alam, A., Hurwitz, J., Sekaly, P. P., and Denis, F., The large subunit of replication factor C is a substrate for caspase-3 in vitro and is cleaved by a caspase3-like protease during Fas-mediated apoptosis, EMBO J., 16, 6346-6354, 1997.
133. Emoto, Y., Manome, Y., Meinhardt, G., Kisaki, H., Kharbanda, S., Robertson, M., Ghayur, T., Wong, W. W., Kamen, R., Weichselbaum, R., and Kufe, D., Proteolytic activation of protein kinase C δ by an ICE-like protease in apoptotic cells, EMBO J., 14, 6148-6156, 1995.
134. Ghayur, T., Hugunin, M., Talanian, R. V., Ratnofsky, S., Quinlan, C., Emoto, Y., Pandey, P., Datta, R., Huang, Y. Y., Kharbanda, S., Allen, H., Kamen, R., Wong, W., and Kufe, D., Proteolytic activation of protein kinase C K by an ICE/CED 3-like protease induces characteristics of apoptosis, J. Exp. Med., 184, 2399-2404, 1996.
135. Mizuno, K., Noda, K., Araki, T., Imaoka, T., Kobayashi, Y., Akita, Y., Shimonaka, M., Kishi, S., and Ohno, S., Proteolytic cleavage of protein kinase C isotypes, which generates kinase and regulatory fragments, correlates with Fas-mediated and 12-O-tetradecanoyl-phorbol-13-acetate-induced apoptosis, Eur. J. Biochem., 250, 7-18, 1997.
136. Datta, R., Kojima, H., Yoshida, K., and Kufe, D., Caspase-3-mediated cleavage of protein kinase C θ in induction of apoptosis, J. Biol. Chem., 272, 20317-20320, 1997.
137. Cryns, V. L., Byun, Y., Rana, A., Mellor, H., Lustig, K. D., Ghanem, L., Parker, P. J., Kirschner, M. W., and Yuan, J. Y., Specific proteolysis of the kinase protein kinase C-related kinase 2 by caspase-3 during apoptosis: identification by a novel, small pool expression cloning strategy, J. Biol. Chem., 272, 29449-29453, 1997.
138. 2 in tumor necrosis factor-induced apoptosis, Proc. Natl. Acad. Sci. U.S.A., 94, 5073-5077, 1997.
139. Juo, P., Kuo, C. J., Reynolds, S. E., Konz, R. F., Raingeaud, J., Davis, R. J., Biemann, H.-P., and Blenis, J., Fas activation of the p38 mitogen-activated protein kinase signalling pathway requires ICE/CED-3 family proteases, Mol. Cell. Biol. 17, 24-35, 1997.
140. Cardone, M. H., Salvesen, G. S., Widmann, C., Johnson, G., and Frisch, S. M., The regulation of anoikis: MEKK-1 activation requires cleavage by caspases, Cell, 90, 315-323, 1997.
141. Wang, X., Pai, J. T., Wiedenfeld, E. A., Medina, J. C., Slaughter, C. A., Goldstein, J. L., and Brown, M. S., Purification of an interleukin-1β converting enzyme-related cysteine protease that cleaves sterol regulatory element-binding proteins between the leucine zipper and transmembrane domains, J. Biol. Chem., 270, 18044-18050, 1995.
142. Wang, X., Zelenski, N. G., Yang, J., Sakai, J., Brown, and M. S., Goldstein, J. L., Cleavage of sterol regulatory element binding proteins (SREBPs) by CPP32 during apoptosis, EMBO J., 15, 1012-1020, 1996.
143. Pai, J. T., Brown, M. S., and Goldstein, J. L., Purification and cDNA cloning of a second apoptosis-related cysteine protease that cleaves and activates sterol regulatory element binding proteins, Proc. Natl. Acad. Sci. U.S.A., 93, 5437-5442, 1996.
144. Cosulich, S. C., Horiuchi, H., Zerial, M., Clarke, P. R., and Woodman, P. G., Cleavage of Rabaptin-5 blocks endosome fusion during apoptosis, EMBO J., 16, 6182-6191, 1997.
145. Martin, S. J., Finucane, D. M., Amarante-Mendes, G. P., O'Brien, G. A., and Green, D. R., Phosphatidylserine externalization during CD95-induced apoptosis of cells and cytoplasts requires ICE/CED-3 protease activity, J. Biol. Chem., 271, 28753-28756, 1996.
146. Vanags, D. M., Porn-Ares, M. I., Coppola, S., Burgess, D. H., and Orrenius, S., Protease involvement in fodrin cleavage and phosphatidyl serine exposure in apoptosis, J. Biol. Chem., 271, 31075-31085, 1996.
147. Weaver, V. M., Carson, Walker, P. R., Chaly, N., Lach, B., Raymond, Y., Brown, D. L., and Sikorsak, M., Degradation of nuclear matrix and DNA cleavage in apoptotic thymocytes, J. Cell Sci., 109, 45-56, 1996.
148. Hsu, H.-L. and Yeh, N.-H., Dynamic changes in NuMA during the cell cycle and possible appearance of a truncated form of NuMA during apoptosis, J. Cell Sci., 109, 277-288, 1996.
149. Lazebnik, Y. A., Takahashi, A., Moir, R. D., Goldman, R. D., Poirier, G. G., Kaufmann, S. H., and Earnshaw, W. C., Studies of the lamin proteinase reveal multiple parallel biochemical pathways during apoptotic execution, Proc. Natl. Acad. Sci. U.S.A., 92, 9042-9046, 1995.
150. Takahashi, A., Musy, P.-Y., Martins, L. M., Poirier, G. G., Moyer, R. W., and Earnshaw, W. C., CrmA/SPI-2 inhibition of an endogenous ICE-related protease responsible for lamin A cleavage and apoptotic nuclear fragmentation, J. Biol. Chem., 271, 32487-32490, 1996.
151. Martin, S. J., O'Brien, G. A., Nishioka, W. K., McGahon, A. J., Mahboubi, A., Saido, T. C., and Green, D. R., Proteolysis of fodrin (non-erythroid spectrin) during apoptosis, J. Biol. Chem., 270, 6425-6428, 1995.
152. Cryns, V. L., Bergeron, L., Zhu, H., Li, H., and Yuan, J., Specific cleavage of α-fodrin during Fasand tumor necrosis factor-induced apoptosis is mediated by an interleukin-1β-converting enzyme/Ced-3 protease distinct from the poly(ADP-ribose) polymerase protease, J. Biol. Chem., 271, 31277-31282, 1996.
153. Maravei, D. V., Trbovich, A. M., Perez, G. I., Tilly, K. I., Banach, D., Talanian, R. V., Wong, W. W., and Tilly, J. L., Cleavage of cytoskeletal proteins by caspases during ovarian cell death: Evidence that cell-free systems do not always mimic apoptotic events in intact cells, Cell Death Differ., 4, 707-712, 1997.
154. Mashima, T., Naito, M., Fujita, N., Noguchi, K., and Tsuruo, T., Identification of actin as a substrate of ICE and an ICE-like protease and involvement of an ICE-like protease but not ICE in VP-16-induced U937 apoptosis, Biochem. Biophys. Res. Commun., 217, 1185-1192, 1995.
155. Kayalar, C., Ord, T., Testa, M. P., Zhong, L.-t., and Bredesen, D. E., Cleavage of actin by interleukin 1β-converting enzyme to reverse DNase I inhibition, Proc. Natl. Acad. Sci. U.S.A., 93, 2234-2238, 1996.
156. Brancolini, C., Benedetti, M., and Schneider, C., Microfilament reorganization during apoptosis: the role of Gas2, a possible substrate for ICE-like proteases, EMBO J., 14, 5179-5190, 1995.
157. Na, S., Chuang, T. H., Cunningham, A., Turi, T. G., Hanke, J. H., Bokoch, G. M., and Danley, D. E., D4-GDI, a substrate of CPP32, is proteolyzed during Fas-induced apoptosis, J. Biol. Chem., 271, 11209-11213, 1996.
158. Rudel, T. and Bokoch, G. M., Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2, Science, 216, 1571-1574, 1997.
159. Caulin, C., Salvesen, G. S., and Oshima, R. G., Caspase cleavage of keratin 18 and reorganization of intermediate filaments during epithelial cell apoptosis, J. Cell Biol., 138, 1379-1394, 1997.
160. Brancolini, C., Lazarevic, D., Rodriguez, J., and Schneider, C., Dismantling cell-cell contacts during apoptosis is coupled to a caspase-dependent proteolytic cleavage of β-catenin, J. Cell Biol., 139, 759-771, 1997.
161. Wen, L. P., Fahrni, J. A., Troie, S., Guan, J. L., Orth, K., and Rosen, G. D., Cleavage of focal adhesion kinase by caspases during apoptosis, J. Biol. Chem., 272, 26056-26061, 1997.
162. Kothakota, S., Azuma, T., Reinhard, C., Klippel, A., Tang, J., Chu, K., McGarry, T. J., Kirschner, M. W., Koths, K., Kwiatkowski, D. J., and Williams, L. T., Caspase-3-generated fragment of gelsolin: effector of morphological change in apoptosis, Science, 278, 294-298, 1997.
163. relIII, members of the ICE/CED-3 family of cysteine proteases, J. Biol. Chem., 270, 15870-15876, 1995.
164. Faucheu, C., Diu, A., Chan, A. W., Blanchet, A. M., Miossec, C., Herve, F., Collard Dutilleul, V., Gu, Y., Aldape, R. A., Lippke, J. A., Rocher, C., Su, M. S.-S., Livingston, D. J., Hercend, T., and Lalanne, J.-L., A novel human protease similar to the interleukin-1β converting enzyme induces apoptosis in transfected cells, EMBO J., 14, 1914-1922, 1995.
165. Kamens, J., Paskind, M., Hugunin, M., Talan-ian, R. V., Alien, H., Banach, D., Bump, N., Hackett, M., Johnston, C. G., Li, P., Mankovich, J. A., Terranova, M., and Ghayur, T., Identification and characterization of ICH-2, a novel member of the interleukin-1βconverting enzyme family of cysteine proteases, J. Biol. Chem., 270, 15250-15256, 1995.
166. Faucheu, C., Blanchet, A. M., Collard-Dutilleul, V., Lalanne, J.-L., and Diu-Hercend, A., Identification of a cysteine protease closely related to Interleukin- 1β-converting enzyme, Eur. J. Biochem., 236, 207-213, 1996.
167. Fernandes-Alnemri, T., Takahashi, A., Armstrong, R., Krebs, J., Fritz, L., Tomaselli, K. J., Wang, L., Yu, Z., Croce, C. M., Salveson, G., Earnshaw, W. C., Litwack, G., and Alnemri, E. S., Mch3, a novel human apoptotic cysteine protease highly related to CPP32, Cancer Res., 55, 6045-6052, 1995.
168. Lippke, J. A., Gu, Y., Sarnecki, C., Caron, P. R., and Su, M. S.-S., Identification and characterization of CPP32/Mch2 homolog 1, a novel cysteine protease similar to CPP32, J. Biol. chem., 271, 1825-1828, 1996.
169. Duan, H., Chinnaiyan, A. M., Hudson, P. L., Wing, J. P., He, W. W., and Dixit, V. M., ICE-LAP3, a novel mammalian homologue of the Caenorhabditis elegans cell death protein Ced-3 is activated during Fas- and tumor necrosis factor-induced apoptosis, J. Biol Chem., 271, 1621-1625, 1996.
170. Juan, T. S., McNiece, I. K., Argento, J. M., Jenkins, N. A., Gilbert, D. J., Copeland, N. G., and Fletcher, F. A., Identification and mapping of Casp7, a cysteine protease resembling CPP32β, IL1β converting enzyme and CED-3, Genomics, 40, 86-93, 1997.
171. Fernandes-Alnemri, T., Armstrong, R. C., Krebs, J., Srinivasula, S. M., Wang, L., Bullrich, F., Fritz, L. C., Trapani, J. A., Tomaselli, K. J., Litwack, G., and Alnemri, E. S., In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains, Proc. Natl. Acad. Sci. U.S.A., 93, 7464-7469, 1996.
172. Boldin, M. P., Goncharov, T. M., Goltsev, Y. V., and Wallach, D., Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1and TNF receptor-induced cell death, Cell, 85, 803-815, 1996.
173. Duan, H., Orth, K., Chinnaiyan, A. M., Poirier, G. G., Froelich, C. J., He, W. W., and Dixit, V. M., ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B, J. Biol. Chem., 271, 16720-16724, 1996.
174. Wang, L., Miura, M., Bergeron, L., Zhu, H., and Yuan, J., Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death, Cell, 78, 739-750, 1994.
175. Kumar, S., Kinoshita, M., Noda, M., Copeland, N. G., and Jenkins, N. A., Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1β-converting enzyme, Genes Dev., 8, 1613-1626, 1994.
176. Kroemer, G., Zamzami, N., and Susin, S. A., Mitochondrial control of apoptosis, Immunol. Today, 18, 44-51, 1997.
177. Reed, J. C., Cytochrome c: can't live with it - can't live without it, Cell, 91, 559-562, 1997.
178. Marchetti, P., Castedo, M., Susin, S. A., Zamzami, N., Hirsch, T., Macho, A., Haeffner, A., Hirsch, F., Geuskens, M., and Kroemer, G., Mitochondrial permeability transition is a central coordinating event of apoptosis, J. Exp. Med., 184, 1155-1160, 1996.
179. Susin, S. A., Zamzami, N., Castedo, M., Daugas, E., Wang, H-G., Geley, S., Fassy, F., Reed, F. C., and Kroemer, G., The central executioner of apoptosis: Multiple connections between protease activation and mitochondria in Fas/APO-1/CD95 and ceramide-induced apoptosis, J. Exp. Med., 186, 25-37, 1997.
180. Kluck, R. M., Bossy-Wetzel, E., Green, D. R., and Newmeyer, D. D., The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis, Science, 275, 1132-1136, 1997.
181. Li, P., Nijhawan, D., Budihardjo, I., Srinivasula, S. M., Ahmad, M., Alnemri, E. S., and Wang, X., Cytochrome c and dATP-dependent formation of Apaf-1/Caspase-9 complex initiates an apoptotic protease cascade, Cell, 91, 479-489, 1997.