Dynamic changes of NuMA during the cell cycle and possible appearance of a truncated form of NuMA during apoptosis

Journal of Cell Science

Volumn 109, Issue 2, 1996, Pages 277-288

  Hsu, Hsin Ling ^a   Yeh, Ning Hsing ^a  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

Apoptosis; Cell cycle; Mitosis; NuMA

Indexed keywords

5,6 DICHLOROBENZIMIDAZOLE RIBOSIDE; CALCIMYCIN; CAMPTOTHECIN; CELL PROTEIN; CYCLIN DEPENDENT KINASE; CYCLOHEXIMIDE; DNA FRAGMENT; STAUROSPORINE;

APOPTOSIS; ARTICLE; CELL CYCLE; CELL STRAIN HL 60; CHROMATIN CONDENSATION; CONTROLLED STUDY; DNA CLEAVAGE; HELA CELL; HUMAN; HUMAN CELL; INTERPHASE; MICRONUCLEUS; MITOSIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN INDUCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN TRANSPORT;

ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; APOPTOSIS; CDC2 PROTEIN KINASE; CELL CYCLE; CELL NUCLEUS; DNA DAMAGE; EPITOPE MAPPING; HELA CELLS; HL-60 CELLS; HUMANS; INTERPHASE; MITOSIS; MITOTIC SPINDLE APPARATUS; PHOSPHORYLATION;

EID: 0030058584     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (55)

1. Bertrand, R., Solary, E., O'Connor, P., Kohn, K. W. and Pommier, Y. (1994). Induction of a common pathway of apoptosis by staurosporine. Exp. Cell Res. 211, 314-321.
2. Caelles, C., Helmberg, A. and Karin, M. (1994). p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes. Nature 370, 220-223.
3. Chen, C.-M., Chiang, S.-Y. and Yeh, N.-H. (1991). Increased stability of nucleolin in proliferating cells by inhibition of its self-cleaving activity. J. Biol. Chem. 266, 7754-7758.
4. Cleveland, D. W. (1995). NuMA a protein involved in nuclear structure, spindle assembly and nuclear re-formation. Trends Cell Biol. 5, 60-64.
5. Compton, D. A., Yen, T. J. and Cleveland, D. W. (1991). Identification of novel centromere/kinetochure-associaled proteins using monoclonal antibodies generated against human mitotic chromosome scaffolds. J. Cell Biol. 112, 1083-1097.
6. Compton, D. A., Szilak, I. and Cleveland, D. W. (1992). Primary structure of NuMA, an intranuclear protein that defines a novel pathway for segregation of proteins at mitosis J. Cell Biol. 116, 1395-1408.
7. Compton, D. A. and Cleveland, D. W. (1993) NuMA is required for the proper completion of mitosis. J. Cell Biol. 120, 947-957.
8. cdc2 phosphorylation sites in NuMA impair the assembly of the mitotic spindle and block mitosis. J Cell Sci. 108, 621-633.
9. Dasso, M. (1993). RCCl in the cell cycle: the regulator of chromosome condensation takes on new roles. Trends Biochem. Sci. 18, 96-101.
10. Fang, S.-H. and Yeh, N.-H. (1993). The self-cleaving activity of nucleolin determines its molecular dynamics in relation to cell proliferation. Exp. Cell Res. 208, 48-53.
11. Fernandes-Alnemri, T., Litwack, G. and Alnemri, E. S. (1994). CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1β-converting enzyme J. Biol Chem. 269, 30761-30764.
12. Glotzer, M., Murray, A. W. and Kirshner, M. W. (1991). Cyclin is degraded by the ubiquitin pathway. Nature 349, 132-138.
13. Gong, J., Li, X. and Darzynkiewicz, Z. (1993). Different patterns of apoptosis of HL-60 cells induced by cycloheximide and camptothecin. J. Cell. Physiol. 157, 263-270.
14. Heins, S. and Aebi, U. (1994). Making heads and tails of intermediate filament assembly, dynamics and networks. Curr. Opin. Cell Biol. 6, 25-33.
15. Heusel, J. W., Wesselschmidt, R. L., Shresta, S., Russell, J. H. and Ley, T. J. (1994). Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells. Cell 76, 977-987.
16. Holloway, S. L., Glotzer, M., King, R. W. and Murray, A. W. (1993). Anaphase is initiated by proteolysis rather than by the inactivation of maturation-promoting factor. Cell 73, 1393-1402.
17. cdc2 and p42 during meiotic maturation of Xenopus oocyte: Antagonistic action of okadaic acid and 6-DMAP. Development 111, 813-820.
18. Johnson, G. D. and Nogueira Araujo, G. M. de C. (1981). A simple method of reducing the fading of immunofluorescence during microscopy. J. Immunol Meth 43, 349-350.
19. Kallajoki, M., Weber, K. and Osborn, M. (1991). A 210 kDa nuclear matrix protein is a functional part of the mitotic spindle; a microinjection study using SPN monoclonal antibodies. EMBO J. 10, 3351-3362.
20. 2 cells goes with the SPN antigen and not with the centrosome. J. Cell Sci. 102, 91-102.
21. Kallajoki, M., Harborth, J., Weber, K. and Osborn, M. (1993). Microinjection of a monoclonal antibody against SPN antigen, now identified by peptide sequences as the NuMA protein, induces micronuclei in PtK2 cells. J. Cell Sci. 104, 139-150.
22. Kaufmann, S. H., Desnoyers, S., Ottaviano, Y., Davidson, N. E. and Poirier, G. G. (1993). Specific proteolytic cleavage of poly(ADP-ribose) polymerase: An early marker of chemotherapy-induced apoptosis. Cancer Res. 53, 3976-3985.
23. King, R. W., Jackson, P. K. and Kirschner, M. W. (1994) Mitosis in transition Cell 79, 563-571.
24. Lazebnik, Y. A., Kaufmann, S. H., Desnoyers, S., Poirier, G. G. and Earnshaw, W. C. (1994). Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. Nature 371, 346-347.
25. Ludérus, M. E. E., den Blaauwen, J. L., de Smit, O. J. B., Compton, D. A. and van Driel, R. (1994). Binding of matrix attachment regions to lamin polymers involves single-stranded regions and the minor groove. Mol. Cell. Biol. 14, 6297-6305.
26. Lydersen, B. K. and Pettijohn, D. E. (1980). Human-specific nuclear protein that associates with the polar region of the mitotic apparatus: Distribution in a human/hamster hybrid cell. Cell 22, 489-499
27. Maekawa, T., Leslie, R. and Kuriyama, R. (1991). Identification of a minus end-specific microtubule-associated protein located at the mitotic poles in cultured mammalian cells. Eur. J Cell Biol. 54, 255-267.
28. Maekawa, T. and Kuriyama, R. (1993). Primary structure and microtubule-interacting domain of the SP-H antigen: a mitotic MAP located at the spindle pole and characterized as a homologous protein to NuMA J. Cell Sci. 105, 589-600
29. Matsubara, K., Kubota, M., Adachi, S., Kuwakado, K., Hirota, H., Wakazono, Y., Akiyama, Y. and Mikawa, H. (1994) Different mode of cell death induced by calcium ionophore in human leukemia cell lines: possible role of constitutive endonuclease. Exp. Cell Res. 210, 19-25.
30. Miura, M., Zhu, H., Rotello, R., Hartwieg, E. A. and Yuan, J. (1993) Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3. Cell 75, 653-660.
31. relIII, members of the ICE/CED-3 family of cysteine proteases J. Biol. Chem. 270, 15870-15876.
32. Nicholson, D. W., Ali, A., Thornberry, N. A., Vaillancourt, J. P., Ding, C. K., Gallant, M., Gareau, Y., Griffin, P. R., Labelle, M., Lazebnik, Y. A., Munday, N. A., Raju, S. M., Smulson, M. E., Yamin, T.-T., Yu, V. L. and Miller, D. K. (1995). Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature 376, 37-43.
33. Pai, C.-Y., Chen, H.-K. Sheu, H.-L. and Yeh, N.-H. (1995). Cell cycle-dependent alterations of a highly phosphorylated nucleolar protein p130 are associated with nucleologenesis. J. Cell Sci. 108, 1911-1920.
34. Peterson, C. L. (1994). The SMC family Novel motor proteins for chromosome condensation? Cell 79, 389-392.
35. Pinna L. A. (1990). Casein kinase 2: an 'eminence grise' in cellular regulation? Biochim Biophys. Acta 1054, 267-284.
36. Ray, C. A., Black, R. A., Kronheim, S. R., Greenstreet, T. A., Sleath, P. R., Salvesen, G. S. and Pickup, D. J. (1992). Viral inhibition of inflammation: Cowpox virus encodes an inhibitor of the interleukin-1β converting enzyme. Cell 69, 597-604.
37. Squier, M. K. T., Miller, A. C. K., Malkinson, A. M. and Cohen, J. J. (1994). Calpain activation in apoptosis. J. Cell. Physiol. 159, 229-237.
38. Stewart, M. (1990). Intermediate filaments: structure, assembly and molecular interactions. Curr. Opin. Cell Biol. 2, 91-100.
39. Swedlow, J. R., Sedat, J. W. and Agard, D. A. (1993). Multiple chromosomal populations of topoisomerase II detected in vivo by time-lapse, three-dimensional wide-field microscopy. Cell 73, 97-108.
40. Tang, T. K., Tang, C. C., Chen Y.-L. and Wu C.-W. (1993) Nuclear proteins of the bovine esophageal epithelium. II. The NuMA gene gives rise to multiple mRNAs and gene products reactive with monoclonal antibody W1. J. Cell Sci. 104, 249-260.
41. Tang, T. K., Tang, C. C., Chao, Y.-J. and Wu, C.-W. (1994). Nuclear mitotic apparatus protein (NuMA): spindle association, nuclear targeting and differential subcellular localizaiton of various NuMA isoforms. J. Cell Sci. 107, 1389-1402.
42. Tewari, M. and Dixit, V. M. (1995). Fas- and tumor necrosis factor-induced apoptosis is inhibited by the poxvirus crmA gene product. J. Biol. Chem. 270, 3255-3260.
43. Tewari, M., Quan, L. T., O'Rourke, K., Desnoyers, S., Zeng, Z., Beidler, D. R., Poirier, G. G., Salvesen, G. S. and Dixit, V. M. (1995). Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase. Cell 81, 801-809.
44. Thiry, M. (1992). Ultrastructural detection of DNA within the nucleolus by sensitive molecular immunocytochemistry. Exp. Cell Res. 200, 135-144.
45. Tousson, A., Zeng, C., Brinkley, B. R. and Valdivia, M. M. (1991). Centrophilin: A novel mitotic spindle protein involved in microtubule nucleation. J. Cell Biol. 112, 427-440.
46. Wang, L., Miura, M., Bergeron, L., Zhu, H. and Yuan, J. (1994). Ich-I, an Ice/ced-2-related gene, encodes both positive and negative regulators of programmed cell death. Cell 78, 739-750.
47. Wang, Z.-Q., Auer, B., Stingl, L., Berghammer, H., Haidacher, D., Schweiger, M. and Wagner, E. F. (1995). Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease. Genes Dev. 9, 509-520.
48. Weaver, V. M., Lach, B., Walker, P. R. and Sikorska, M. (1993). Role of proteolysis in apoptosis: involvement of senne proteases in internucleosomal DNA fragmentation in immature thymocytes. Biochem. Cell Biol. 71, 488-500.
49. Yamashita, K., Yasuda, H., Pines, J., Yasumoto, K., Nishitani, H., Ohtsubo, M., Hunter, T., Sugimura, T. and Nishimoto, T. (1990). Okadaic acid, a potent inhibitor of type 1 and type 2A protein phosphatases, activates cdc2/H1 kinase and transiently induces a premature mitosis-like state in BHK21 cells. EMBO J. 9, 4331-4338.
50. Yang, C. H., Lambie, E. J. and Snyder, M. (1992). NuMA: an unusually long coiled-coil related protein in the mammalian nucleus. J. Cell Biol. 116, 1303-1317.
51. Yang, C. H. and Snyder, M. (1992). The nuclear-mitotic apparatus protein is important in the establishment and maintenance of the bipolar mitotic spindle apparatus. Mol. Biol. Cell 3, 1259-1267.
52. Yuan, J., Shaham, S., Ledoux, S., Ellis, H. M. and Horvitz, H. R. (1993). The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1-β-converting enzyme. Cell 75, 641-652.
53. Zandomeni, R. and Weinmann, R. (1984) Inhibitory effect of 5,6-dichloro-1-β-D-ribofuranosylbenzimidazole on a protein kinase. J. Biol. Chem. 259, 14804-14811.
54. Zeng, C., He, D., Berget, S. M. and Brinkley, B. R. (1994). Nuclear-mitotic apparatus protein: A structural protein interface between the nucleoskeleton and RNA splicing. Proc. Nat Acad. Sci. USA 91, 1505-1509.
55. Zhivotovsky, B., Wade, D., Gahm, A., Orrenius, S. and Nicotera, P. (1994) Formation of 50 kbp chromatin fragments in isolated liver nuclei is mediated by protease and endonuclease activation. FEBS Lett 351, 150-154.