Regulation of T-cell receptor signaling by membrane microdomains

Immunology

Volumn 113, Issue 4, 2004, Pages 413-426

  Razzaq, Tahir M ^a   Ozegbe, Patricia ^a   Jury, Elizabeth C ^b   Sembi, Phupinder ^a   Blackwell, Nathan M ^a   Kabouridis, Panagiotis S ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

Author keywords

Adapter; Lck; Lipid rafts; Microdomains; Signal transduction; T cell receptor

Indexed keywords

MEMBRANE PROTEIN; T LYMPHOCYTE RECEPTOR;

AMINO ACID SEQUENCE; CELL COMPARTMENTALIZATION; HUMAN; LIPID MEMBRANE; LYMPHOCYTE MEMBRANE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEOMICS; REVIEW; SIGNAL TRANSDUCTION;

HUMANS; LYMPHOCYTE SPECIFIC PROTEIN TYROSINE KINASE P56(LCK); MEMBRANE MICRODOMAINS; MODELS, IMMUNOLOGICAL; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION;

EID: 9944248585     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2567.2004.01998.x     Document Type: Review

References (176)

1. Garboczi DN, Ghosh P, Utz U, Fan QR, Biddison WE, Wiley DC. Structure of the complex between human T-cell receptor, viral peptide and HLA-A2. Nature 1996; 384:134-41.
2. Davis MM, Boniface JJ, Reich Z, Lyons D, Hampl J, Arden B, Chien Y. Ligand recognition by alpha beta T cell receptors. Annu Rev Immunol 1998; 16:523-44.
3. Wange RL, Samelson LE. Complex complexes: signaling at the TCR. Immunity 1996; 5:197-205.
4. Qian D, Weiss A. T cell antigen receptor signal transduction. Curr Opin Cell Biol 1997; 9:205-12.
5. Werlen G, Palmer E. The T-cell receptor signalosome: a dynamic structure with expanding complexity. Curr Opin Immunol 2002; 14:299-305.
6. Reth M. Antigen receptor tail clue. Nature 1989; 338:383-4.
7. Irving BA, Weiss A. The cytoplasmic domain of the T cell receptor ζ chain is sufficient to couple to receptor-associated signal transduction pathways. Cell 1991; 64:891-901.
8. Irving BA, Chan AC, Weiss A. Functional characterization of a signal transducing motif present in the T cell antigen receptor zeta chain. J Exp Med 1993; 177:1093-103.
9. Cambier JC. Antigen and Fc receptor signaling. The awesome power of the immunoreceptor tyrosine-based activation motif (ITAM). J Immunol 1995; 155:3281-5.
10. Ardouin L, Boyer C, Gillet A et al. Crippling of CD3-zeta ITAMs does not impair T cell receptor signaling. Immunity 1999; 10:409-20.
11. Love PE, Shores EW. ITAM multiplicity and thymocyte selection: how low can you go? Immunity 2000; 12:591-7.
12. Germain RN, Stefanova I. The dynamics of T cell receptor signaling: complex orchestration and the key roles of tempo and cooperation. Annu Rev Immunol 1999; 17:467-522.
13. Cantrell D. T cell antigen receptor signal transduction pathways. Annu Rev Immunol 1996; 14:259-74.
14. Weiss A, Littman DR. Signal transduction by lymphocyte antigen receptors. Cell 1994; 76:263-74.
15. van Leeuwen JEM, Samelson LE. T cell antigen-receptor signal transduction. Curr Opin Immunol 1999; 11:242-8.
16. Latour S, Veillette A. Proximal protein tyrosine kinases in immunoreceptor signaling. Curr Opin Immunol 2001; 13:299-306.
17. Straus DB, Weiss A. Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor. Cell 1992; 70:585-93.
18. Karnitz L, Sutor SL, Toshihiko T, Reed JC, Bell MP, McKean DJ, Leibson PJ, Abraham RT. Effects of p56lck deficiency on the growth and cytolytic effector function of an interleukin-2 dependent cytotoxic T cell line. Mol Cell Biol 1992; 12:4521-30.
19. Molina TJ, Kishihara K, Siderovski DP et al. Profound block in thymocyte development in mice lacking p56lck. Nature 1992; 357:161-4.
20. Seddon B, Legname G, Tomlinson P, Zamoyska R. Long-term survival but impaired homeostatic proliferation of naive T cells in the absence of p56lck. Science 2000; 290:127-31.
21. Rudd CE, Trevillyan JM, Dasgupta JD, Wong LL, Schlossman SF. The CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes. Proc Natl Acad Sci USA 1988; 85:5190-4.
22. Veillette A, Bookman MA, Horak EM, Bolen JB. The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck. Cell 1988; 55:301-8.
23. Barber EK, Dasgupta JD, Schlossman SF, Trevillyan JM, Rudd CE. The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex. Proc Natl Acad Sci USA 1989; 86:3277-81.
24. Stein PL, Lee H-M, Rich S, Soriano P. pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells. Cell 1992; 70:741-50.
25. Groves T, Smiley P, Cooke MP, Forbush K, Perlmutter RM, Guidos CJ. Fyn can partially substitute for Lck in T lymphocyte development. Immunity 1996; 5:417-28.
26. da Silva AJ, Li Z, de Vera C, Canto E, Findell P, Rudd CE. Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production. Proc Natl Acad Sci USA 1997; 94:7493-8.
27. Musci MA, Hendricks-Taylor LR, Motto DG, Paskind M, Kamens J, Turck CW, Koretzky GA. Molecular cloning of SLAP-130, an SLP-76-associated substrate of the T cell antigen receptor-stimulated protein tyrosine kinases. J Biol Chem 1997; 272:11674-7.
28. Marie-Cardine A, Bruyns E, Eckerskorn C, Kirchgessner H, Meuer SC, Schraven B. Molecular cloning of SKAP55, a novel protein that associates with the protein tyrosine kinase p59fyn in human T-lymphocytes. J Biol Chem 1997; 272:16077-80.
29. Griffiths EK, Krawczyk C, Kong YY et al. Positive regulation of T cell activation and integrin adhesion by the adapter Fyb/Slap. Science 2001; 293:2260-3.
30. Peterson EJ, Woods ML, Dmowski SA et al. Coupling of the TCR to integrin activation by Slap-130/Fyb. Science 2001; 293:2263-5.
31. Wang H, Moon EY, Azouz A, Wu X, Smith A, Schneider H, Hogg N, Rudd CE. SKAP-55 regulates integrin adhesion and formation of T cell-APC conjugates. Nat Immunol 2003; 4:366-74.
32. Wu LYuZ, Shen SH. SKAP55 recruits to lipid rafts and positively mediates the MAPK pathway upon T cell receptor activation. J Biol Chem 2002; 277:40420-7.
33. Chan AC, Iwashima M, Turck CW, Weiss A. ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain. Cell 1992; 71:649-62.
34. Chan AC, Dalton M, Johnson R, Kong GH, Wang T, Thoma R, Kurosaki T. Activation of ZAP-70 kinase activity by phosphorylation of tyrosine 493 is required for lymphocyte antigen receptor function. EMBO J 1995; 14:2499-508.
35. Wange RL, Guitian R, Isakov N, Watts JD, Aebersold R, Samelson LE. Activating and inhibitory mutations in adjacent tyrosines in the kinase domain of ZAP-70. J Biol Chem 1995; 270:18730-3.
36. Chan AC, Shaw AS. Regulation of antigen receptor signal transduction by protein tyrosine kinases. Curr Opin Immunol 1996; 8:394-401.
37. + thymic selection in humans lacking zap-70 kinase. Cell 1994; 76:947-58.
38. Elder ME, Lin D, Clever J, Chan AC, Hope TJ, Weiss A, Parslow TG. Human severe combined immunodeficiency due to a defect in ZAP-70, a T cell tyrosine kinase. Science 1994; 264:1596-9.
39. Chan AC, Kadlecek TA, Elder ME, Filipovich AH, Kuo WL, Iwashima M, Parslow TG, Weiss A. ZAP-70 deficiency in an autosomal recessive form of severe combined immunodeficiency. Science 1994; 264:1599-601.
40. Negishi I, Motoyama N, Nakayama K et al. Essential role for ZAP-70 in both positive and negative selection of thymocytes. Nature 1995; 376:435-8.
41. Zhang W, Sloan-Lancaster J, Kitchen J, Trible RP, Samelson LELAT. The ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. Cell 1998; 92:83-92.
42. Wange RL. LAT, the linker for activation of T cells. A bridge between T cell-specific and general signaling pathways. Science's STKE 2000; www.stke.org/cgi/content/full/OC_sigtrans; 2000/63/re:1-13 (web only).
43. Harder T, Kuhn M. Selective accumulation of raft-associated membrane protein LAT in T cell receptor signaling assemblies. J Cell Biol 2000; 151:199-208.
44. Samelson LA. Signal transduction mediated by the T cell antigen receptor: the role of adapter proteins. Annu Rev Immunol 2002; 20:371-94.
45. Finco TS, Kadlecek T, Zhang W, Samelson LE, Weiss A. LAT is required for TCR-mediated activation of PLCg1- and the Ras pathway. Immunity 1998; 9:617-26.
46. Zhang W, Sommers CL, Burshtyn DN et al. Essential role of LAT in T cell development. Immunity 1999; 10:323-32.
47. Liu SK, Fang N, Koretzky GA, McGlade CJ. The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors. Curr Biol 1999; 9:67-75.
48. Sommers CL, Rabin RL, Grinberg A, Tsay HC, Farber J, Love PE. A role for the Tec family tyrosine kinase Txk in T cell activation and thymocyte selection. J Exp Med 1999; 190:1427-38.
49. Ching KA, Grasis JA, Tailor P, Kawakami Y, Kawakami T, Tsoukas CD. TCR/CD3-induced activation and binding of Emt/Itk to linker of activated T cell complexes: requirement for the Src homology 2 domain. J Immunol 2000; 165:256-62.
50. Yablonski D, Kuhne MR, Kadlecek T, Weiss A. Uncoupling of nonreceptor tyrosine kinases from PLC-gamma1 in an SLP-76-deficient T cell. Science 1998; 281:413-6.
51. Cantrell DA. GTPases and T cell activation. Immunol Rev 2003; 192:122-30.
52. Acuto O, Cantrell D. T cell activation and the cytoskeleton. Annu Rev Immunol 2000; 18:165-84.
53. Thomas SM, Brugge JS. Cellular functions regulated by Src family kinases. Annu Rev Cell Dev Biol 1997; 13:513-609.
54. Sicheri F, Kuriyan J. Structures of Src-family tyrosine kinases. Curr Opin Struct Biol 1997; 7:777-85.
55. Resh MD. Myristylation and palmitylation of Src family members: the fats of the matter. Cell 1994; 76:411-3.
56. Jackson CS, Zlatkine P, Bano C et al. Dynamic protein acylation and the regulation of localization and function of signal-transducing proteins. Biochem Soc Trans 1995; 23:568-71.
57. Milligan G, Parenti M, Magee AI. The dynamic role of palmitoylation in signal transduction. Trends Biochem Sci 1995; 20:181-7.
58. Shenoy-Scaria AM, Gauen LKT, Kwong J, Shaw AS, Lublin DM. Palmitylation of an amino-terminal cysteine motif of protein tyrosine kinases p56lck and p59fyn mediates interaction with glycosyl-phosphatidylinositol-anchored proteins. Mol Cell Biol 1993; 13:6385-92.
59. Shenoy-Scaria AM, Dietzen DJ, Kwong J, Link DC, Lublin DM. Cysteine3 of Src family protein tyrosine kinases determines palmitoylation and localization in caveolae. J Cell Biol 1994; 126:353-63.
60. Rodgers W, Crise B, Rose JK. Signals determining protein tyrosine kinase and glycosyl-phosphatidylinositol-anchored protein targeting to a glycolipid-enriched membrane fraction. Mol Cell Biol 1994; 14:5384-91.
61. Koegl M, Zlatkine P, Ley SC, Courtneidge SA, Magee AI. Palmitoylation of multiple Src-family kinases at a homologous N-terminal motif. Biochem J 1994; 303:749-53.
62. Timson Gauen LK, Linder ME, Shaw AS. Multiple features of the p59fyn src homology 4 domain define a motif for immune-receptor tyrosine-based activation motif (ITAM) binding and for plasma membrane localization. J Cell Biol 1996; 133:1007-15.
63. Kabouridis PS, Magee AI, Ley SC. S-acylation of LCK protein tyrosine kinase is essential for its signalling function in T lymphocytes. EMBO J 1997; 16:4983-98.
64. Bijlmakers MJ, Isobe-Nakamura M, Ruddock LJ, Marsh M. Intrinsic signals in the unique domain target p56 (lck) to the plasma membrane independently of CD4. J Cell Biol 1997; 137:1029-40.
65. van't Hof W, Resh MD. Rapid plasma membrane anchoring of newly synthesized p59fyn: selective requirement for NH2-terminal myristoylation and palmitoylation at cysteine-3. J Cell Biol 1997; 136:1023-35.
66. Kwong J, Lublin DM. Amino-terminal palmitate or polybasic domain can provide required second signal to myristate for membrane binding of p56lck. Biochem Biophys Res Commun 1995; 207:868-76.
67. Zlatkine P, Mehul B, Magee AI. Retargeting of cytosolic proteins to the plasma membrane by the Lck protein tyrosine kinase dual acylation motif. J Cell Sci 1997; 110:673-9.
68. Watts JD, Sanghera JS, Pelech SL, Aebersold R. Phosphorylation of serine 59 of p56lck in activated T cells. J Biol Chem 1993; 268:23275-82.
69. Winkler DG, Park I, Kim T, Payne NS, Walsh CT, Strominger JL, Shin J. Phosphorylation of Ser-42 and Ser-59 in the N-terminal region of the tyrosine kinase p56lck. Proc Natl Acad Sci USA 1993; 90:5176-80.
70. Gervais FG, Veillette A. The unique amino-terminal domain of p56lck regulates interactions with tyrosine protein phosphatases in T lymphocytes. Mol Cell Biol 1995; 15: 2393-401.
71. Joung I, Kim T, Stolz LA, Payne G, Winkler DG, Walsh CT, Strominger JL, Shin J. Modification of Ser59 in the unique N-terminal region of tyrosine kinase p56lck regulates specificity of its Src homology 2 domain. Proc Natl Acad Sci USA 1995; 92:5778-82.
72. Park I, Chung J, Walsh CT, Yun Y, Strominger JL, Shin J. Phosphotyrosine-independent binding of a 62-kDa protein to the src homology 2 (SH2) domain of p56lck and its regulation by phosphorylation of Ser-59 in the lck unique N-terminal region. Proc Natl Acad Sci USA 1995; 92:12338-42.
73. Kesavan KP, Isaacson CC, Ashendel CL, Geahlen RL, Harrison ML. Characterization of the in vivo sites of serine phosphorylation on Lck identifying serine 59 as a site of mitotic phosphorylation. J Biol Chem 2002; 277:14666-73.
74. Pawson T, Nash P. Assembly of cell regulatory systems through protein interaction domains. Science 2003; 300:445-52.
75. Reynolds AB, Vila J, Lansing TJ, Potts WM, Weber MJ, Parsons JT. Activation of the oncogenic potential of the avian cellular src protein by specific structural alteration of the carboxy terminus. EMBO J 1987; 6:2359-64.
76. MacAuley A, Cooper JA. Structural defferences between repressed and derepressed forms of p60c-src. Mol Cell Biol 1989; 9:2648-56.
77. Reynolds PJ, Hurley TR, Sefton BM. Functional analysis of the SH2 and SH3 domains of the lck tyrosine protein kinase. Oncogene 1992; 7:1949-55.
78. Moarefi I, LaFevre-Bernt M, Sicheri F, Huse M, Lee CH, Kuriyan J, Miller WT. Activation of the Src-family tyrosine kinase Hck by SH3 domain displacement. Nature 1997; 385:650-3.
79. Xu W, Harrison SC, Eck MJ. Three-dimensional structure of the tyrosine kinase c-Src. Nature 1997; 385:595-602.
80. Xu W, Doshi A, Lei M, Eck MJ, Harrison SC. Crystal structures of c-Src reveal features of its autoinhibitory mechanism. Molec Cell 1999; 3:629-38.
81. Yamaguchi H, Hendrickson WA. Structural basis for activation of human lymphocyte kinase Lck upon tyrosine phosphorylation. Nature 1996; 384:484-9.
82. Okada M, Nakagawa H. A protein tyrosine kinase involved in regulation of pp60c-src function. J Biol Chem 1989; 264:20886-93.
83. Nada S, Okada M, MacAuley A, Cooper JA, Nakagawa H. Cloning of a complementary DNA for a protein-tyrosine kinase that specifically phosphorylates a negative regulatory site of p60c-src. Nature 1991; 351:69-72.
84. Okada M, Nada S, Yamanashi Y, Yamamoto T, Nakagawa HCSK. a protein-tyrosine kinase involved in regulation of src family kinases. J Biol Chem 1991; 266:24249-52.
85. Bergman M, Mustelin T, Oetken C et al. The human p50csk tyrosine kinase phosphorylates p56lck at Tyr-505 and down regulates its catalytic activity. EMBO J 1992; 11:2919-24.
86. Chow LM, Fournel M, Davidson D, Veillette A. Negative regulation of T-cell receptor signalling by tyrosine protein kinase p50csk. Nature 1993; 365:156-60.
87. Mustelin T, Altman A. Dephosphorylation and activation of the T cell tyrosine kinase pp56lck by the leukocyte common antigen (CD45). Oncogene 1990; 5:809-13.
88. Sieh M, Bolen JB, Weiss A. CD45 specifically modulates binding of Lck to a phosphopeptide encompassing the negative regulatory tyrosine of Lck. EMBO J 1993; 12:315-21.
89. Burns CM, Sakaguchi K, Appella E, Ashwell JD. CD45 regulation of tyrosine phosphorylation and enzyme activity of src family kinases. J Biol Chem 1994; 269:13594-600.
90. Penninger JM, Irie-Sasaki J, Sasaki T, Oliveira-dos-Santos AJ. CD45: new jobs for an old acquaintance. Nat Immunol 2001; 2:389-96.
91. D'Oro U, Ashwell JD. Cutting edge, the CD45 tyrosine phosphatase is an inhibitor of Lck activity in thymocytes. J Immunol 1999; 162:1879-83.
92. Thomas ML, Brown EJ. Positive and negative regulation of Src-family membrane kinases by CD45. Immunol Today 1999; 20:406-11.
93. Simons K, Ikonen E. Functional rafts in cell membranes. Nature 1997; 387:569-72.
94. Harder T, Simons K. Caveolae, DIGs, and the dynamics of sphingolipid-cholesterol microdomains. Curr Opin Cell Biol 1997; 9:534-42.
95. Edidin M. Lipid microdomains in cell surface membranes. Curr Opin Struct Biol 1997; 7:528-32.
96. Brown DA, London E. Functions of lipid rafts in biological membranes. Annu Rev Cell Dev Biol 1998; 14:111-36.
97. Simons K, Toomre D. Lipid rafts and signal transduction. Nat Rev Mol Cell Biol 2000; 1:31.
98. Schuck S, Honsho M, Ekroos K, Shevchenko A, Simons K. Resistance of cell membranes to different detergents. Proc Natl Acad Sci USA 2003; 100:5795-800.
99. Brown RE. Sphingolipid organization in biomembranes: what physical studies of model membranes reveal. J Cell Sci 1998; 111:1-9.
100. Furuchi T, Anderson RGW. Cholesterol depletion of caveolae causes hyperactivation of extracellular signal-related kinase (ERK). J Biol Chem 1998; 273:21099-104.
101. Visconti PE, Ning X, Fornes MW, Alvarez JG, Stein P, Connors SA, Kopf GS. Cholesterol efflux-mediated signal transduction in mammalian sperm: cholesterol release signals an increase in protein tyrosine phosphorylation during mouse sperm capacitation. Dev Biol 1999; 214:429-43.
102. Kabouridis PS, Janzen J, Magee AL, Ley SC. Cholesterol depletion disrupts lipid rafts and modulates the activity of multiple signaling pathways in T lymphocytes. Eur J Immunol 2000; 30:954-63.
103. Zacharias DA, Violin JD, Newton AC, Tsien RY. Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cells. Science 2002; 296:913-6.
104. Shvartsman DE, Kotler M, Tall RD, Roth MG, Henis YI. Differently anchored influenza hemagglutinin mutants display distinct interaction dynamics with mutual rafts. J Cell Biol 2003; 163:879-88.
105. Pralle A, Keller P, Florin EL, Simons K, Horber JK. Sphingolipid- cholesterol rafts diffuse as small entities in the plasma membrane of mammalian cells. J Cell Biol 2000; 148:997-1008.
106. Subczynski WK, Kusumi A. Dynamics of raft molecules in the cell and artificial membranes, approaches by pulse EPR spin labeling and single molecule optical microscopy. Biochim Biophys Acta 2003; 1610:231-43.
107. Friedrichson T, Kurzchalia TV. Microdomains of GPI-anchored proteins in living cells revealed by crosslinking. Nature 1998; 394:356-60.
108. Varma R, Mayor S. GPI-anchored proteins are organized in submicron domains at the cell surface. Nature 1998; 394:798-801.
109. Brown DA, London E. Structure and origin of ordered lipid domains in biological membranes. J Membr Biol 1998; 164:103-14.
110. Rozelle AL, Machesky LM, Yamamoto M et al. Phosphatidylinositol 4,5-bisphosphate induces actin-based movement of raft-enriched vesicles through WASP-Arp2/3. Curr Biol 2000; 10:311-20.
111. Jordan S, Rodgers W. T cell glycolipid-enriched membrane domains are constitutively assembled as membrane patches that translocate to immune synapses. J Immunol 2003; 171:78-87.
112. Zhang W, Trible RP, Samelson LE. LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation. Immunity 1998; 9:239-46.
113. Brdicka T, Pavlistova D, Leo A et al. Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation. J Exp Med 2000; 191:1591-604.
114. Kawabuchi M, Satomi Y, Takao T, Shimonishi Y, Nada S, Nagai K, Tarakhovsky A, Okada M. Transmembrane phosphoprotein Cbp regulates the activities of Src-family tyrosine kinases. Nature 2000; 404:999-1003.
115. Brdicka T, Imrich M, Angelisova P et al. Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling. J Exp Med 2002; 196:1617-26.
116. Janssen E, Zhang W. Adaptor proteins in lymphocyte activation. Curr Opin Immunol 2003; 15:269-76.
117. Brdickova N, Brdicka T, Angelisova P et al. LIME. A new membrane raft-associated adaptor protein involved in CD4 and CD8 coreceptor signaling. J Exp Med 2003; 198:1453-62.
118. Hur EM, Son M, Lee OH, Choi YB, Park C, Lee H, Yun Y. LIME, a novel transmembrane adaptor protein, associates with p56lck and mediates T cell activation. J Exp Med 2003; 198:1463-73.
119. Lin J, Weiss A, Finco TS. Localization of LAT in glycolipid-enriched microdomains is required for T cell activation. J Biol Chem 1999; 274:28861-4.
120. Foster LJ, De Hoog CL, Mann M. Unbiased quantitative proteomics of lipid rafts reveals high specificity for signaling factors. Proc Natl Acad Sci USA 2003; 100:5813-8.
121. Nebl T, Pestonjamasp KN, Leszyk JD, Crowley JL, Oh SW, Luna EJ. Proteomic analysis of a detergent-resistant membrane skeleton from neutrophil plasma membranes. J Biol Chem 2002; 277:43399-409.
122. Bini L, Pacini S, Liberatori S, Valensin S, Pellegrini M, Raggiaschi R, Pallini V, Baldari CT. Extensive temporally regulated reorganization of the lipid raft proteome following T-cell antigen receptor triggering. Biochem J 2003; 369:301-9.
123. von Haller PD, Donohoe S, Goodlett DR, Aebersold R, Watts JD. Mass spectrometric characterization of proteins extracted from Jurkat T cell detergent-resistant membrane domains. Proteomics 2001; 1:1010-21.
124. Brdicka T, Cerny J, Horejsi V. T cell receptor signalling results in rapid tyrosine phosphorylation of the linker protein LAT present in detergent-resistant membrane microdomains. Biochem Biophys Res Commun 1998; 248:356-60.
125. Ike H, Kosugi A, Kato A, lino R, Hirano H, Fujiwara T, Ritchie K, Kusumi A. Mechanism of Lck recruitment to the T-cell receptor cluster as studied by single-molecule-fluorescence video imaging. Chemphyschem 2003; 4:620-6.
126. Tanimura N, Nagafuku M, Minaki Y et al. Dynamic changes in the mobility of LAT in aggregated lipid rafts upon T cell activation. J Cell Biol 2003; 160:125-35.
127. Xavier R, Seed B. Membrane compartmentation and the response to antigen. Curr Opin Immunol 1999; 11:265-9.
128. Montixi C, Langlet C, Bernard AM et al. Engagement of T cell receptor triggers its recruitment to low-density detergent-insoluble membrane domains. EMBO J 1998; 17:5334-48.
129. Moran M, Miceli MC. Engagement of GPI-linked CD48 contributes to TCR signals and cytoskeletal reorganization: a role for lipid rafts in T cell activation. Immunity 1998; 9:787-96.
130. Janes PW, Ley SC, Magee AI, Kabouridis PS. The role of lipid rafts in T cell antigen receptor (TCR) signalling. Semin Immunol 2000; 12:23-34.
131. Langlet C, Bernard AM, Drevot P, He HT. Membrane rafts and signaling by the multichain immune recognition receptors. Curr Opin Immunol 2000; 12:250.
132. Viola A. The amplification of TCR signaling by dynamic membrane microdomains. Trends Immunol 2001; 22:322-7.
133. Leitenberg D, Balamuth F, Bottomly K. Changes in the T cell receptor macromolecular signaling complex and membrane microdomains during T cell development and activation. Semin Immunol 2001; 13:129-38.
134. Johmura S, Oh-hora M, Inabe K et al. Regulation of Vav localization in membrane rafts by adaptor molecules Grb2 and BLNK. Immunity 2003; 18:777-87.
135. Foti M, Phelouzat MA, Holm A, Rasmusson BJ, Carpentier JL. p56Lck anchors CD4 to distinct microdomains on microvilli. Proc Natl Acad Sci USA 2002; 99:2008-13.
136. Fragoso R, Ren D, Zhang X, Su MW, Burakoff SJ, Jin YJ. Lipid raft distribution of CD4 depends on its palmitoylation and association with Lck, and evidence for CD4-induced lipid raft aggregation as an additional mechanism to enhance CD3 signaling. J Immunol 2003; 170:913-21.
137. Balamuth F, Brogdon JL, Bottomly K. CD4 raft association and signaling regulate molecular clustering at the immunological synapse site. J Immunol 2004; 172:5887-92.
138. Xavier R, Brennan T, Li Q, McCormack C, Seed B. Membrane compartmentation is required for efficient T cell activation. Immunity 1998; 8:356-60.
139. Pizzo P, Giurisato E, Bigsten A, Tassi M, Tavano R, Shaw A, Viola A. Physiological T cell activation starts and propagates in lipid rafts. Immunol Lett 2004; 91:3-9.
140. Janes PW, Ley SC, Magee AI. Aggregation of lipid rafts accompanies signaling via the T cell antigen receptor. J Cell Biol 1999; 147:447-61.
141. Glebov OO, Nichols BJ. Lipid raft proteins have a random distribution during localized activation of the T-cell receptor. Nat Cell Biol 2004; 6:238-43.
142. + T cells do not require the polarization of lipid rafts for activation and proliferation. Proc Natl Acad Sci USA 2002; 99:15006-11.
143. Drevot P, Langlet C, Guo XJ, Bernard AM, Colard O, Chauvin JP, Lasserre R, He HT. TCR signal initiation machinery is pre-assembled and activated in a subset of membrane rafts. EMBO J 2002; 21:1899-908.
144. Harder T, Simons K. Clusters of glycolipid and glycosylphosphatidylinositol-anchored proteins in lymphoid cells: accumulation of actin regulated by local tyrosine phosphorylation. Eur J Immunol 1999; 29:556-62.
145. Pizzo P, Giurisato E, Tassi M, Benedetti A, Pozzan T, Viola A. Lipid rafts and T cell receptor signaling: a critical re-evaluation. Eur J Immunol 2002; 32:3082-91.
146. Pizzo P, Viola A. Lymphocyte lipid rafts: structure and function. Curr Opin Immunol 2003; 15:255-60.
147. Veri MC, DeBell KE, Seminario MC et al. Membrane raft-dependent regulation of phospholipase Cgamma-1 activation in T lymphocytes. Mol Cell Biol 2001; 21:6939-50.
148. Hope HR, Pike LJ. Phosphoinositides and phosphoinositide-utilizing enzymes in detergent-insoluble lipid domains. Mol Biol Cell 1996; 7:843-51.
149. Liu Y, Casey L, Pike LJ. Compartmentalization of phosphatidylinositol 4,5-bisphosphate in low-density membrane domains in the absence of caveolin. Biochem Biophys Res Commun 1998; 245:684-90.
150. Boerth NJ, Sadler JJ, Bauer DE, Clements JL, Gheith SM, Koretzky GA. Recruitment of SLP-76 to the membrane and glycolipid-enriched membrane microdomains replaces the requirement for linker for activation of T cells in T cell receptor signaling. J Exp Med 2000; 192:1047-58.
151. Jordan MS, Singer AL, Koretzky GA. Adaptors as central mediators of signal transduction in immune cells. Nat Immunol 2003; 4:110-6.
152. Khoshnan A, Bae D, Tindell CA, Nel AE. The physical association of protein kinase C theta with a lipid raft-associated inhibitor of kappa B factor kinase (IKK) complex plays a role in the activation of the NF-kappa B cascade by TCR and CD28. J Immunol 2000; 165:6933-40.
153. Bi K, Tanaka Y, Coudronniere N, Sugie K, Hong S, van Stipdonk MJ, Altman A. Antigen-induced translocation of PKC-theta to membrane rafts is required for T cell activation. Nat Immunol 2001; 2:556-63.
154. Viola A, Schroeder S, Sakakibara Y, Lanzavecchia A. T lymphocyte costimulation mediated by reorganization of membrane microdomains. Science 1999; 283:680-2.
155. Martin M, Schneider H, Azouz A, Rudd CE. Cytotoxic T lymphocyte antigen 4 and CD28 modulate cell surface raft expression in their regulation of T-cell function. J Exp Med 2001; 194:1675-81.
156. Chikuma S, Imboden JB, Bluestone JA. Negative regulation of T cell receptor-lipid raft interaction by cytotoxic T lymphocyte-associated antigen 4. J Exp Med 2003; 197:129-35.
157. Darlington PJ, Baroja ML, Chau TA, Siu E, Ling V, Carreno BM, Madrenas J. Surface cytotoxic T lymphocyte-associated antigen 4 partitions within lipid rafts and relocates to the immunological synapse under conditions of inhibition of T cell activation. J Exp Med 2002; 195:1337-47.
158. Kabouridis PS. Selective interaction of LAT (linker of activated T cells) with the open-active form of Lck in lipid rafts reveals a new mechanism for the regulation of Lck in T cells. Biochem J 2003; 371:907-15.
159. van der Merwe PA, The TCR. Triggering puzzle. Immunity 2001; 14:665-8.
160. Irles C, Symons A, Michel F, Bakker TR, van der Merwe PA, Acuto O. CD45 ectodomain controls interaction with GEMs and Lck activity for optimal TCR signaling. Nat Immunol 2003; 4:189-97.
161. Edmonds SD, Ostergaard HL. Dynamic association of CD45 with detergent-insoluble microdomains in T lymphocytes. J Immunol 2002; 169:5036-42.
162. Jury EC, Kabouridis PS, Flores-Borja F, Mageed RA, Isenberg DA. Altered lipid raft-associated signaling and ganglioside expression in T lymphocytes from patients with systemic lupus erythematosus. J Clin Invest 2004; 113: 1176-87.
163. Krishnan S, Nambiar MP, Warke VG, Fisher CU, Mitchell J, Delaney N, Tsokos GC. Alterations in lipid raft composition and dynamics contribute to abnormal T cell responses in systemic lupus erythematosus. J Immunol 2004; 172:7821-31.
164. Jury EC, Kabouridis PS. T lymphocyte signalling in systemic lupus erythematosus: a lipid raft perspective. Lupus 2004; 13:413-22.
165. He X, Woodford-Thomas TA, Johnson KG, Shah DD, Thomas ML. Targeting of CD45 protein tyrosine phosphatase activity to lipid microdomains on the T cell surface inhibits TCR signaling. Eur J Immunol 2002; 32:2578-87.
166. Rodgers W, Rose JK. Exclusion of CD45 inhibits activity of p56lck associated with glycolipid-enriched membrane domains. J Cell Biol 1996; 135:1515-23.
167. Kosugi A, Sakakura J, Yasuda K, Ogata M, Hamaoka T. Involvement of SHP-1 tyrosine phosphatase in TCR-mediated signaling pathways in lipid rafts. Immunity 2001; 14:669-80.
168. Yasuda K, Nagafuku M, Shima T et al. Fyn is essential for tyrosine phosphorylation of Csk-binding protein/phosphoprotein associated with glycolipid-enriched microdomains in lipid rafts in resting T cells. J Immunol 2002; 169:2813-7.
169. Torgersen KM, Vang T, Abrahamsen H et al. Release from tonic inhibition of T cell activation through transient displacement of C-terminal Src kinase (Csk) from lipid rafts. J Biol Chem 2001; 276:29313-8.
170. Mustelin T, Tasken K. Positive and negative regulation of T-cell activation through kinases and phosphatases. Biochem J 2003; 371:15-27.
171. Filipp D, Zhang J, Leung BL, Shaw A, Levin SD, Veillette A, Julius M. Regulation of Fyn through translocation of activated Lck into lipid rafts. J Exp Med 2003; 197:1221-7.
172. Filipp D, Leung BL, Zhang J, Veillette A, Julius M. Enrichment of lck in lipid rafts regulates colocalized fyn activation and the initiation of proximal signals through TCR alpha beta. J Immunol 2004; 172:4266-74.
173. Gomez-Mouton C, Abad JL, Mira E et al. Segregation of leading-edge and uropod components into specific lipid rafts during T cell polarization. Proc Natl Acad Sci USA 2001; 98:9642-7.
174. Seveau S, Eddy RJ, Maxfield FR, Pierini LM. Cytoskeleton-dependent membrane domain segregation during neutrophil polarization. Mol Biol Cell 2001; 12:3550-62.
175. Pierini LM, Eddy RJ, Fuortes M, Seveau S, Casulo C, Maxfield FR. Membrane lipid organization is critical for human neutrophil polarization. J Biol Chem 2003; 278:10831-41.
176. Manes S, Ana Lacalle R, Gomez-Mouton C, Martinez AC. From rafts to crafts: membrane asymmetry in moving cells. Trends Immunol 2003; 24:320-6.