Cutting edge: The CD45 tyrosine phosphatase is an inhibitor of Lck activity in thymocytes

Journal of Immunology

Volumn 162, Issue 4, 1999, Pages 1879-1883

  D'Oro, Ugo ^a   Ashwell, Jonathan D ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD45 ANTIGEN; PROTEIN KINASE LCK; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE PHOSPHATASE; TYROSINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL TRANSFORMATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; ENZYME REGULATION; FLOW CYTOMETRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; THYMOCYTE;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, CD45; ENZYME ACTIVATION; ENZYME INHIBITORS; FLOW CYTOMETRY; LYMPHOCYTE SPECIFIC PROTEIN TYROSINE KINASE P56(LCK); MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-FYN; T-LYMPHOCYTES; THYMUS GLAND; TYROSINE;

EID: 0033558102     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. June, C. H., M. C. Fletcher, J. A. Ledbetter, and L. E. Samelson. 1990. Increases in tyrosine phosphorylation are detectable before phospholipase C activation after T cell receptor stimulation. J. Immunol. 144:1591.
2. June, C. H., M. C. Fletcher, J. A. Ledbetter, G. L. Schieven, J. N. Siegel, A. F. Phillips, and L. E. Samelson. 1990. Inhibition of tyrosine phosphorylation prevents T-cell receptor-mediated signal transduction. Proc. Natl. Acad. Sci. USA 87:7722.
3. Hanke, J. H., J. P. Gardner, R. L. Dow, P. S. Changelian, W. H. Brissette, E. J. Weringer, B. A. Pollok, and P. A. Connelly. 1996. Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor: study of Lck- and FynT-dependent T cell activation. J. Biol. Chem. 271:695.
4. lck). Mol. Cell. Biol. 8:540.
5. c-fyn catalytic activity, transforming potential, and ability to associate with polyomavirus middle-T antigen. J. Virol. 65:170.
6. lck is positively regulated through its site of autophosphorylation. Oncogene 5:1455.
7. Pingel, J. T., and M. L. Thomas. 1989. Evidence that the leukocyte-common antigen is required for antigen-induced T lymphocyte proliferation. Cell 58:1055.
8. Koretzky, G. A., J. Picus, M. L. Thomas, and A. Weiss. 1990. Tyrosine phosphatase CD45 is essential for coupling T-cell antigen receptor to the phosphatidyl inositol pathway. Nature 346:66.
9. 2+ oscillations. J. Exp. Med. 176:835.
10. Volarevic, S., B. B. Niklinska, C. M. Burns, C. H. June, A. M. Weissman, and J. D. Ashwell. 1993. Regulation of TCR signaling by CD45 lacking transmembrane and extracellular domains. Science 260:541.
11. Hovis, R. R., J. A. Donovan, M. A. Musci, D. G. Motto, F. D. Goldman, S. E. Ross, and G. A. Koretzky. 1993. Rescue of signaling by a chimeric protein containing the cytoplasmic domain of CD45. Science 260:544.
12. lck by the CD45 phosphotyrosine phosphatase. Proc. Natl. Acad. Sci. USA 86:6302.
13. fyn protein tyrosine kinase by the CD45 phosphotyrosine phosphatase. Eur. J. Immunol. 22:1173.
14. Cahir McFarland, E. D., T. R. Hurley, J. T. Pingel, B. M. Sefton, A. Shaw, and M. L. Thomas. 1993. Correlation between Src family member regulation by the protein-tyrosine-phosphatase CD45 and transmembrane signaling through the T-cell receptor. Proc. Natl. Acad. Sci. USA 90:1402.
15. Sieh, M., J. B. Bolen, and A. Weiss. 1993. CD45 specifically modulates binding of Lck to a phosphopeptide encompassing the negative regulatory tyrosine of Lck. EMBO J. 12:315.
16. Ostergaard, H. L., D. A. Shackelford, T. R. Hurley, P. Johnson, R. Hyman, B. M. Sefton, and I. S. Trowbridge. 1989. Expression of CD45 alters phosphorylation of the lck-encoded tyrosine protein kinase in murine lymphoma T-cell lines. Proc. Natl. Acad. Sci. USA 86:8959.
17. Hurley, T. R., R. Hyman, and B. M. Sefton. 1993. Differential effects of expression of the CD45 tyrosine protein phosphatase on the tyrosine phosphorylation of the lck, fyn, and c-src tyrosine protein kinases. Mol. Cell. Biol. 13:1651.
18. Burns, C. M., K. Sakaguchi, E. Appella, and J. D. Ashwell. 1994. CD45 regulation of tyrosine phosphorylation and enzyme activity of src family kinases. J. Biol. Chem. 269:13594.
19. D'Oro, U., K. Sakaguchi, E. Appella, and J. D. Ashwell. 1996. Mutational analysis of Lck in CD45-negative T cells: dominant role of tyrosine 394 phosphorylation in kinase activity. Mol. Cell. Biol. 16:4996.
20. Chan, A. C., D. M. Desai, and A. Weiss. 1994. The role of protein tyrosine kinases and protein tyrosine phosphatases in T cell antigen receptor signal transduction. Annu. Rev. Immunol. 12:555.
21. + thymocytes, and B cell maturation. J. Exp. Med. 183:1707.
22. cdc2 is a specific and efficient substrate of src-family tyrosine kinases. J. Biol. Chem. 267:9248.
23. lck by the leukocyte common antigen (CD45). Oncogene 5:809.
24. c-src transforming ability by mutation of its primary sites of tyrosine phosphorylation. Cell 49:65.
25. Weiss, A. 1998. T lymphocyte activation. In Fundamental Immunology, 4th Ed. Paul, W. E., ed. Lippincott-Raven, Philadelphia, p. 411.
26. Siegel, J. N., and C. H. June. 1996. Signal transduction and T lymphocyte activation. In Clinical Immunology: Principles and Practice. Rich, R. R., T. A. Fleisher, B. D. Schwartz, W. T. Shearer, and W. Strober, eds. Mosby-Year Book, St. Louis, MO, p. 192.
27. lck tyrosine in human T-cells. EMBO J. 13:1920.
28. Deans, J. P., S. B. Kanner, R. M. Torres, and J. A. Ledbetter. 1992. Interaction of CD4:lck with the T cell receptor/CD3 complex induces early signaling events in the absence of CD45 tyrosine phosphatase. Eur. J. Immunol. 22:661.
29. lck. J. Exp. Med. 172: 347.
30. Imbert, V., J. F. Peyron, D. Farahi Far, B. Mari, P. Auberger, and B. Rossi. 1994. Induction of tyrosine phosphorylation and T-cell activation by vanadate peroxide, an inhibitor of protein tyrosine phosphatases. Biochem. J. 297:163.
31. Imbert, V., D. Farahifar, P. Auberger, D. Mary, B. Rossi, and J. F. Peyron. 1996. Stimulation of the T-cell antigen receptor-CD3 complex signaling pathway by the tyrosine phosphatase inhibitor pervanadate is mediated by inhibition of CD45: evidence for two interconnected Lck/Fyn- or zap-70-dependent signaling pathways. J. Inflamm. 46:65.
32. Roach, T., S. Slater, M. Koval, L. White, E. C. McFarland, M. Okumura, M. Thomas, and E. Brown. 1997. CD45 regulates Src family member kinase activity associated with macrophage integrin-mediated adhesion. Curr. Biol. 7:408.
33. Stone, J. D., L. A. Conroy, K. F. Byth, R. A. Hederer, S. Howlett, Y. Takemoto, N. Holmes, and D. R. Alexander. 1997. Aberrant TCR-mediated signaling in CD45-null thymocytes involves dysfunctional regulation of Lck, Fyn, TCR-ζ. and ZAP-70. J. Immunol. 158:5773.