Recruitment of SLP-76 to the membrane and glycolipid-enriched membrane microdomains replaces the requirement for linker for activation of T cells in T cell receptor signaling

Journal of Experimental Medicine

Volumn 192, Issue 7, 2000, Pages 1047-1058

  Boerth, Nancy J ^a   Sadler, Jeffrey J ^a   Bauer, Daniel E ^b   Clements, James L ^a   Gheith, Shereen M ^a   Koretzky, Gary A ^a,b  

^a Department of Pathology and Laboratory Medicine   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Adapter proteins; Lipid rafts; Protein tyrosine kinase; Signal transduction; T cell activation

Indexed keywords

AMINO ACID; MEMBRANE LIPID; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOLIPASE; PHOSPHOPROTEIN; PROTEIN SLP 76; PROTEIN TYROSINE KINASE; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; CELL COMPARTMENTALIZATION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; BINDING SITES; CARRIER PROTEINS; CELL MEMBRANE; GLYCOLIPIDS; HUMANS; JURKAT CELLS; MEMBRANE PROTEINS; PHOSPHOPROTEINS; PHOSPHORYLATION; RECEPTORS, ANTIGEN, T-CELL; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAINS; T-LYMPHOCYTES; TYROSINE;

EID: 0034596827     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.192.7.1047     Document Type: Article

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