Lineage Tracing in Humans Enabled by Mitochondrial Mutations and Single-Cell Genomics

Cell

Volumn 176, Issue 6, 2019, Pages 1325-1339.e22

  Ludwig, Leif S ^a,b   Lareau, Caleb A ^a,b,c   Ulirsch, Jacob C ^a,b   Christian, Elena ^a   Muus, Christoph ^a,d   Li, Lauren H ^a,b   Pelka, Karin ^a,b   Ge, Will ^a   Oren, Yaara ^a,b   Brack, Alison ^a   Law, Travis ^a   Rodman, Christopher ^a   Chen, Jonathan H ^a,b   Boland, Genevieve M ^b   Hacohen, Nir ^a,b   Rozenblatt Rosen, Orit ^a   Aryee, Martin J ^a,c,e   Buenrostro, Jason D ^a,f   Regev, Aviv ^a,g   Sankaran, Vijay G ^a,b,h  

^a BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d HARVARD UNIVERSITY   (United States)

^e HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^f HARVARD UNIVERSITY   (United States)

^g MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^h HARVARD STEM CELL INSTITUTE   (United States)

Author keywords

chronic myeloid leukemia; colon cancer; hematopoiesis; lineage tracing; mitochondrial DNA; mtDNA; sequencing; single cell genomics; somatic mutations

Indexed keywords

MITOCHONDRIAL DNA; TRANSPOSASE;

ARTICLE; CHIMERA; CHROMATIN; CHRONIC MYELOID LEUKEMIA; COLORECTAL CANCER; CONTROLLED STUDY; DNA BARCODING; GENE EXPRESSION; GENETIC VARIATION; GENOMICS; HEMATOPOIETIC CELL; HETEROPLASMY; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; NUCLEAR GENOME SEQUENCING; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SINGLE CELL ASSAY FOR TRANSPOSASE ACCESSIBLE CHROMATIN SEQUENCING; SINGLE CELL GENOMICS; SINGLE CELL RNA SEQUENCING; SOLID MALIGNANT NEOPLASM; SOMATIC MUTATION; T LYMPHOCYTE; CELL LINEAGE; COLORECTAL TUMOR; GENETICS; HEK293 CELL LINE; HEMATOPOIETIC STEM CELL; HIGH THROUGHPUT SEQUENCING; MITOCHONDRION; MUTATION; NUCLEOTIDE SEQUENCE; PATHOLOGY; PHYSIOLOGY; PROCEDURES; SINGLE CELL ANALYSIS;

BASE SEQUENCE; CELL LINEAGE; CHROMATIN; COLORECTAL NEOPLASMS; DNA, MITOCHONDRIAL; GENOMICS; HEK293 CELLS; HEMATOPOIETIC STEM CELLS; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; MITOCHONDRIA; MUTATION; SINGLE-CELL ANALYSIS; TRANSPOSASES;

EID: 85062426134     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2019.01.022     Document Type: Article

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