Somatic mutations reveal asymmetric cellular dynamics in the early human embryo

Nature

Volumn 543, Issue 7647, 2017, Pages 714-718

  Ju, Young Seok ^a,b   Martincorena, Inigo ^a   Gerstung, Moritz ^a,c   Petljak, Mia ^a   Alexandrov, Ludmil B ^a,d   Rahbari, Raheleh ^a   Wedge, David C ^a,e   Davies, Helen R ^a   Ramakrishna, Manasa ^a   Fullam, Anthony ^a   Martin, Sancha ^a   Alder, Christopher ^a   Patel, Nikita ^a   Gamble, Steve ^a   O'Meara, Sarah ^a   Giri, DIlip D ^f   Sauer, Torril ^g   Pinder, Sarah E ^h   Purdie, Colin A ⁱ   Borg, Åke ^j,k,l   Stunnenberg, Henk ⁿ   Van De Vijver, Marc ^o   Tan, Benita K T ^p   Caldas, Carlos ^q,r   Tutt, Andrew ^s   Ueno, Naoto T ^t   Van 'T Veer, Laura J ^u   Martens, John W M ^v   Sotiriou, Christos ^w,x   Knappskog, Stian ^m   Span, Paul N ^y,z,aa   Lakhani, Sunil R ^m   Eyfjörd, Jórunn Erla ^ab   Børresen Dale, Anne Lise ^ac,ad   Richardson, Andrea ^ae   Thompson, Alastair M ^s   Viari, Alain ^af   Hurles, Matthew E ^a   Nik Zainal, Serena ^a   Campbell, Peter J ^a   Stratton, Michael R ^a   more..

^a WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^b Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^c EUROPEAN BIOINFORMATICS INSTITUTE   (United Kingdom)

^d LOS ALAMOS NATIONAL LABORATORY   (United States)

^e UNIVERSITY OF OXFORD   (United Kingdom)

^f MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^g AKERSHUS UNIVERSITY HOSPITAL   (Norway)

^h GUY S HOSPITAL   (United Kingdom)

ⁱ UNIVERSITY OF DUNDEE   (United Kingdom)

^j BioCare Strategic Cancer Research Program   (Sweden)

^k CREATE Health   (Sweden)

^l LUND UNIVERSITY   (Sweden)

^m RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

ⁿ ACADEMIC MEDICAL CENTER   (Netherlands)

^o SINGAPORE GENERAL HOSPITAL   (Singapore)

^p UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^q KING'S COLLEGE LONDON   (United Kingdom)

^r INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^s UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^t UNIVERSITY OF CALIFORNIA   (United States)

^u ERASMUS MC CANCER INSTITUTE   (Netherlands)

^v JULES BORDET INSTITUTE   (Belgium)

^w UNIVERSITY OF BERGEN   (Norway)

^x HAUKELAND UNIVERSITY HOSPITAL   (Norway)

^y UNIVERSITY OF QUEENSLAND   (Australia)

^z ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

^aa UNIVERSITY OF QUEENSLAND   (Australia)

^ab UNIVERSITY OF ICELAND   (Iceland)

^ac OSLO UNIVERSITY HOSPITAL   (Norway)

^ad UNIVERSITY OF OSLO   (Norway)

^ae JOHNS HOPKINS UNIVERSITY   (United States)

^af CENTRE LÉON BÉRARD   (France)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; BLOOD; CANCER; CHROMOSOME; EMBRYO; EMBRYONIC DEVELOPMENT; GENOME; MUTATION;

ARTICLE; EMBRYO; EMBRYO CELL; EMBRYO DEVELOPMENT; HUMAN; PRIORITY JOURNAL; SOMATIC CELL; SOMATIC MUTATION; WHOLE GENOME SEQUENCING; ADULT; BLOOD CELL; CELL LINEAGE; CYTOLOGY; GENETICS; GERMLINE MUTATION; HUMAN GENOME; MAMMALIAN EMBRYO; METABOLISM; MOSAICISM; MUTAGENESIS; MUTATION; MUTATION RATE;

ADULT; BLOOD CELLS; CELL LINEAGE; EMBRYO, MAMMALIAN; EMBRYONIC DEVELOPMENT; GENOME, HUMAN; GERM-LINE MUTATION; HUMANS; MOSAICISM; MUTAGENESIS; MUTATION; MUTATION RATE;

EID: 85018869720     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature21703     Document Type: Article

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