Single-cell transcriptomics uncovers distinct molecular signatures of stem cells in chronic myeloid leukemia

Nature Medicine

Volumn 23, Issue 6, 2017, Pages 692-702

  Giustacchini, Alice ^a   Thongjuea, Supat ^a   Barkas, Nikolaos ^a   Woll, Petter S ^a   Povinelli, Benjamin J ^a   Booth, Christopher A G ^a   Sopp, Paul ^a   Norfo, Ruggiero ^a   Rodriguez Meira, Alba ^a   Ashley, Neil ^a   Jamieson, Lauren ^a   Vyas, Paresh ^a   Anderson, Kristina ^b   Segerstolpe, Åsa ^c   Qian, Hong ^c   Olsson Strömberg, Ulla ^d   Mustjoki, Satu ^e   Sandberg, Rickard ^c,f   Jacobsen, Sten Eirik W ^a,c,g   Mead, Adam J ^a,h  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b OSLO UNIVERSITY HOSPITAL   (Norway)

^c KAROLINSKA INSTITUTE   (Sweden)

^d UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^e UNIVERSITY OF HELSINKI   (Finland)

^f LUDWIG INSTITUTE FOR CANCER RESEARCH   (Sweden)

^g KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^h CHURCHILL HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTOME; RUNX1 PROTEIN, HUMAN; TRANSCRIPTION FACTOR RUNX1;

ARTICLE; BLAST CELL CRISIS; CANCER STEM CELL; CELL SUBPOPULATION; CHRONIC MYELOID LEUKEMIA; CLINICAL OUTCOME; CONTROLLED STUDY; DISEASE COURSE; FLUORESCENCE ACTIVATED CELL SORTING; HEMATOPOIESIS; HUMAN; HUMAN CELL; LEUKEMIA REMISSION; PRIORITY JOURNAL; RNA SEQUENCE; SINGLE CELL ANALYSIS; SOMATIC MUTATION; TRANSCRIPTOMICS; ADULT; AGED; CHROMATIN IMMUNOPRECIPITATION; DNA SEQUENCE; FEMALE; FLOW CYTOMETRY; FLUORESCENCE IN SITU HYBRIDIZATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE LIBRARY; GENETICS; MALE; METABOLISM; MIDDLE AGED; ONCOGENE; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; YOUNG ADULT;

ADULT; AGED; BLAST CRISIS; CHROMATIN IMMUNOPRECIPITATION; CORE BINDING FACTOR ALPHA 2 SUBUNIT; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE LIBRARY; GENES, ABL; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; MALE; MIDDLE AGED; NEOPLASTIC STEM CELLS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS, DNA; SEQUENCE ANALYSIS, RNA; SINGLE-CELL ANALYSIS; TRANSCRIPTOME; YOUNG ADULT;

EID: 85020241989     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.4336     Document Type: Article

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