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Volumn 19, Issue 25, 2013, Pages 3931-3941

Why interleukin-10 supplementation does not work in Crohn's disease patients

Author keywords

Crohn's disease; Inflammatory bowel disease; Interleukin 10; Recombinant human interleukin 10

Indexed keywords

ALPHA INTERFERON; AZATHIOPRINE; CORTICOSTEROID; CYCLOSPORIN; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INFLIXIMAB; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 6; INTERLEUKIN 8; MESALAZINE; MONOCLONAL ANTIBODY; PREDNISONE; RECOMBINANT GROWTH FACTOR; RECOMBINANT INTERLEUKIN 10; RHUIL 10; STAT3 PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 84880076939     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v19.i25.3931     Document Type: Article
Times cited : (120)

References (131)
  • 1
    • 34547176642 scopus 로고    scopus 로고
    • Unravelling the pathogenesis of inflammatory bowel disease
    • [PMID: 17653185 DOI: 10.1038/nature06005]
    • Xavier RJ, Podolsky DK. Unravelling the pathogenesis of inflammatory bowel disease. Nature 2007; 448: 427-434 [PMID: 17653185 DOI: 10.1038/nature06005]
    • (2007) Nature , vol.448 , pp. 427-434
    • Xavier, R.J.1    Podolsky, D.K.2
  • 2
    • 83155172493 scopus 로고    scopus 로고
    • Inflamed gut mucosa: Downstream of interleukin-10
    • [PMID: 21631466 DOI: 10.1111/j.1365-2362.2011.02552.x]WJ
    • Paul G, Khare V, Gasche C. Inflamed gut mucosa: downstream of interleukin-10. Eur J Clin Invest 2012; 42: 95-109 [PMID: 21631466 DOI: 10.1111/j.1365-2362.2011.02552.x]
    • (2012) Eur J Clin Invest , vol.42 , pp. 95-109
    • Paul, G.1    Khare, V.2    Gasche, C.3
  • 3
    • 70449479014 scopus 로고    scopus 로고
    • The genetic basis of inflammatory bowel disease
    • [PMID: 19897957 DOI: 10.1159/000234909]
    • Cooney R, Jewell D. The genetic basis of inflammatory bowel disease. Dig Dis 2009; 27: 428-442 [PMID: 19897957 DOI: 10.1159/000234909]
    • (2009) Dig Dis , vol.27 , pp. 428-442
    • Cooney, R.1    Jewell, D.2
  • 4
    • 84855318412 scopus 로고    scopus 로고
    • IL-10 and IL-10 receptor defects in humans
    • [PMID: 22236434 DOI: 10.1111/ j.1749-6632.2011.06339.x]
    • Glocker EO, Kotlarz D, Klein C, Shah N, Grimbacher B. IL-10 and IL-10 receptor defects in humans. Ann N Y Acad Sci 2011; 1246: 102-107 [PMID: 22236434 DOI: 10.1111/ j.1749-6632.2011.06339.x]
    • (2011) Ann N Y Acad Sci , vol.1246 , pp. 102-107
    • Glocker, E.O.1    Kotlarz, D.2    Klein, C.3    Shah, N.4    Grimbacher, B.5
  • 5
    • 84868212109 scopus 로고    scopus 로고
    • Crohn's disease
    • [PMID: 22914295 DOI: 10.1016/ S0140-6736(12)60026-9]
    • Baumgart DC, Sandborn WJ. Crohn's disease. Lancet 2012; 380: 1590-1605 [PMID: 22914295 DOI: 10.1016/ S0140-6736(12)60026-9]
    • (2012) Lancet , vol.380 , pp. 1590-1605
    • Baumgart, D.C.1    Sandborn, W.J.2
  • 6
    • 44349124113 scopus 로고    scopus 로고
    • The genetics and immunopathogenesis of inflammatory bowel disease
    • [PMID: 18500230 DOI: 10.1038/nri2340]
    • Cho JH. The genetics and immunopathogenesis of inflammatory bowel disease. Nat Rev Immunol 2008; 8: 458-466 [PMID: 18500230 DOI: 10.1038/nri2340]
    • (2008) Nat Rev Immunol , vol.8 , pp. 458-466
    • Cho, J.H.1
  • 8
    • 71949112397 scopus 로고    scopus 로고
    • Inflammatory bowel disease, gut bacteria and probiotic therapy
    • [PMID: 19800289]
    • Reiff C, Kelly D. Inflammatory bowel disease, gut bacteria and probiotic therapy. Int J Med Microbiol 2010; 300: 25-33 [PMID: 19800289]
    • (2010) Int J Med Microbiol , vol.300 , pp. 25-33
    • Reiff, C.1    Kelly, D.2
  • 9
    • 33847345567 scopus 로고    scopus 로고
    • Inflammatory bowel disease: Current insights into pathogenesis and new therapeutic options; probiotics, prebiotics and synbiotics
    • [PMID: 17137666 DOI: 10.1016/j.ijfoodmicro.2006.10.006]
    • Geier MS, Butler RN, Howarth GS. Inflammatory bowel disease: current insights into pathogenesis and new therapeutic options; probiotics, prebiotics and synbiotics. Int J Food Microbiol 2007; 115: 1-11 [PMID: 17137666 DOI: 10.1016/j.ijfoodmicro.2006.10.006]
    • (2007) Int J Food Microbiol , vol.115 , pp. 1-11
    • Geier, M.S.1    Butler, R.N.2    Howarth, G.S.3
  • 10
    • 0035986101 scopus 로고    scopus 로고
    • Epidemiology of inflammatory bowel disease
    • [PMID: 12122726]
    • Loftus EV, Sandborn WJ. Epidemiology of inflammatory bowel disease. Gastroenterol Clin North Am 2002; 31: 1-20 [PMID: 12122726]
    • (2002) Gastroenterol Clin North Am , vol.31 , pp. 1-20
    • Loftus, E.V.1    Sandborn, W.J.2
  • 11
    • 1942420154 scopus 로고    scopus 로고
    • Probiotics in inflammatory bowel disease-- therapeutic rationale and role
    • [PMID: 15063591 DOI: 10.1016/j.addr.2003.11.003]
    • Shanahan F. Probiotics in inflammatory bowel disease-- therapeutic rationale and role. Adv Drug Deliv Rev 2004; 56: 809-818 [PMID: 15063591 DOI: 10.1016/j.addr.2003.11.003]
    • (2004) Adv Drug Deliv Rev , vol.56 , pp. 809-818
    • Shanahan, F.1
  • 14
    • 80655149205 scopus 로고    scopus 로고
    • New IBD genetics: Common pathways with other diseases
    • [PMID: 21300624 DOI: 10.1136/gut.2009.199679]
    • Lees CW, Barrett JC, Parkes M, Satsangi J. New IBD genetics: common pathways with other diseases. Gut 2011; 60: 1739-1753 [PMID: 21300624 DOI: 10.1136/gut.2009.199679]
    • (2011) Gut , vol.60 , pp. 1739-1753
    • Lees, C.W.1    Barrett, J.C.2    Parkes, M.3    Satsangi, J.4
  • 16
    • 0034945486 scopus 로고    scopus 로고
    • Role of polymorphisms in the interleukin- 10 gene in determining disease susceptibility and phenotype in inflamatory bowel disease
    • [PMID: 11478505]
    • Aithal GP, Craggs A, Day CP, Welfare M, Daly AK, Mansfield JC, Hudson M. Role of polymorphisms in the interleukin- 10 gene in determining disease susceptibility and phenotype in inflamatory bowel disease. Dig Dis Sci 2001; 46: 1520-1525 [PMID: 11478505]
    • (2001) Dig Dis Sci , vol.46 , pp. 1520-1525
    • Aithal, G.P.1    Craggs, A.2    Day, C.P.3    Welfare, M.4    Daly, A.K.5    Mansfield, J.C.6    Hudson, M.7
  • 18
    • 79954605781 scopus 로고    scopus 로고
    • The effect of IL-10 genetic variation and interleukin 10 serum levels on Crohn's disease susceptibility in a New Zealand population
    • [PMID: 21354456 DOI: 10.1016/ j.humimm.2011.02.014]
    • Wang AH, Lam WJ, Han DY, Ding Y, Hu R, Fraser AG, Ferguson LR, Morgan AR. The effect of IL-10 genetic variation and interleukin 10 serum levels on Crohn's disease susceptibility in a New Zealand population. Hum Immunol 2011; 72: 431-435 [PMID: 21354456 DOI: 10.1016/ j.humimm.2011.02.014]
    • (2011) Hum Immunol , vol.72 , pp. 431-435
    • Wang, A.H.1    Lam, W.J.2    Han, D.Y.3    Ding, Y.4    Hu, R.5    Fraser, A.G.6    Ferguson, L.R.7    Morgan, A.R.8
  • 19
    • 0038283161 scopus 로고    scopus 로고
    • Interleukin-10 therapy-- review of a new approach
    • [PMID: 12773629 DOI: 10.1124/pr.55.2.4]
    • Asadullah K, Sterry W, Volk HD. Interleukin-10 therapy-- review of a new approach. Pharmacol Rev 2003; 55: 241-269 [PMID: 12773629 DOI: 10.1124/pr.55.2.4]
    • (2003) Pharmacol Rev , vol.55 , pp. 241-269
    • Asadullah, K.1    Sterry, W.2    Volk, H.D.3
  • 20
    • 0042170179 scopus 로고    scopus 로고
    • Interleukin-10- based therapy for inflammatory bowel disease
    • [PMID: 12880373 DOI: 10.1517/147 12598.3.5.725]
    • Braat H, Peppelenbosch MP, Hommes DW. Interleukin-10- based therapy for inflammatory bowel disease. Expert Opin Biol Ther 2003; 3: 725-731 [PMID: 12880373 DOI: 10.1517/147 12598.3.5.725]
    • (2003) Expert Opin Biol Ther , vol.3 , pp. 725-731
    • Braat, H.1    Peppelenbosch, M.P.2    Hommes, D.W.3
  • 21
    • 44949162009 scopus 로고    scopus 로고
    • Recombinant human interleukin 10 for induction of remission in Crohn's disease
    • [PMID: 21069683 DOI: 10.1002/14651858.CD005109.pub3]
    • Buruiana FE, Solà I, Alonso-Coello P. Recombinant human interleukin 10 for induction of remission in Crohn's disease. Cochrane Database Syst Rev 2010; (11): CD005109 [PMID: 21069683 DOI: 10.1002/14651858.CD005109.pub3]
    • (2010) Cochrane Database Syst Rev , Issue.11
    • Buruiana, F.E.1    Solà, I.2    Alonso-Coello, P.3
  • 23
    • 0034463305 scopus 로고    scopus 로고
    • Recombinant human interleukin 10 in the treatment of patients with mild to moderately active Crohn's disease. The Interleukin 10 Inflammatory Bowel Disease Coopera-tive Study Group
    • [PMID: 11113068]
    • Fedorak RN, Gangl A, Elson CO, Rutgeerts P, Schreiber S, Wild G, Hanauer SB, Kilian A, Cohard M, LeBeaut A, Feagan B. Recombinant human interleukin 10 in the treatment of patients with mild to moderately active Crohn's disease. The Interleukin 10 Inflammatory Bowel Disease Coopera-tive Study Group. Gastroenterology 2000; 119: 1473-1482 [PMID: 11113068]
    • (2000) Gastroenterology , vol.119 , pp. 1473-1482
    • Fedorak, R.N.1    Gangl, A.2    Elson, C.O.3    Rutgeerts, P.4    Schreiber, S.5    Wild, G.6    Hanauer, S.B.7    Kilian, A.8    Cohard, M.9    Lebeaut, A.10    Feagan, B.11
  • 24
    • 0036153673 scopus 로고    scopus 로고
    • IL-10 therapy in Crohn's disease: At the crossroads. Treatment of Crohn's disease with the anti-inflammatory cytokine interleukin 10
    • [PMID: 11788549]
    • Herfarth H, Schölmerich J. IL-10 therapy in Crohn's disease: at the crossroads. Treatment of Crohn's disease with the anti-inflammatory cytokine interleukin 10. Gut 2002; 50: 146-147 [PMID: 11788549]
    • (2002) Gut , vol.50 , pp. 146-147
    • Herfarth, H.1    Schölmerich, J.2
  • 25
    • 0034777212 scopus 로고    scopus 로고
    • Review article: The immunoregulatory cytokine interleukin-10--a therapy for Crohn's disease?
    • [PMID: 11683684]
    • Lindsay JO, Hodgson HJ. Review article: the immunoregulatory cytokine interleukin-10--a therapy for Crohn's disease? Aliment Pharmacol Ther 2001; 15: 1709-1716 [PMID: 11683684]
    • (2001) Aliment Pharmacol Ther , vol.15 , pp. 1709-1716
    • Lindsay, J.O.1    Hodgson, H.J.2
  • 28
    • 0030835754 scopus 로고    scopus 로고
    • Multiple doses of intravenous interleukin 10 in steroid-refractory Crohn's disease. Crohn's Disease Study Group
    • [PMID: 9247454]
    • van Deventer SJ, Elson CO, Fedorak RN. Multiple doses of intravenous interleukin 10 in steroid-refractory Crohn's disease. Crohn's Disease Study Group. Gastroenterology 1997; 113: 383-389 [PMID: 9247454]
    • (1997) Gastroenterology , vol.113 , pp. 383-389
    • van Deventer, S.J.1    Elson, C.O.2    Fedorak, R.N.3
  • 29
    • 0024408824 scopus 로고
    • Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones
    • [PMID: 2531194]
    • Fiorentino DF, Bond MW, Mosmann TR. Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. J Exp Med 1989; 170: 2081-2095 [PMID: 2531194]
    • (1989) J Exp Med , vol.170 , pp. 2081-2095
    • Fiorentino, D.F.1    Bond, M.W.2    Mosmann, T.R.3
  • 30
    • 1642554780 scopus 로고    scopus 로고
    • The multifaceted relationship between IL-10 and adaptive immunity: Putting together the pieces of a puzzle
    • [PMID: 14746814]
    • Mocellin S, Marincola F, Rossi CR, Nitti D, Lise M. The multifaceted relationship between IL-10 and adaptive immunity: putting together the pieces of a puzzle. Cytokine Growth Factor Rev 2004; 15: 61-76 [PMID: 14746814]
    • (2004) Cytokine Growth Factor Rev , vol.15 , pp. 61-76
    • Mocellin, S.1    Marincola, F.2    Rossi, C.R.3    Nitti, D.4    Lise, M.5
  • 31
    • 0029644946 scopus 로고
    • Crystal structure of interleukin-10 reveals the functional dimer with an unexpected topological similarity to interferon gamma
    • [PMID: 8590020]
    • Zdanov A, Schalk-Hihi C, Gustchina A, Tsang M, Weatherbee J, Wlodawer A. Crystal structure of interleukin-10 reveals the functional dimer with an unexpected topological similarity to interferon gamma. Structure 1995; 3: 591-601 [PMID: 8590020]
    • (1995) Structure , vol.3 , pp. 591-601
    • Zdanov, A.1    Schalk-Hihi, C.2    Gustchina, A.3    Tsang, M.4    Weatherbee, J.5    Wlodawer, A.6
  • 33
    • 0028122043 scopus 로고
    • Properties and functions of interleukin-10
    • [PMID: 8073945]
    • Mosmann TR. Properties and functions of interleukin-10. Adv Immunol 1994; 56: 1-26 [PMID: 8073945]
    • (1994) Adv Immunol , vol.56 , pp. 1-26
    • Mosmann, T.R.1
  • 35
    • 0033022837 scopus 로고    scopus 로고
    • A role for transcription factor NF-kappa B in intestinal inflammation
    • [PMID: 10207726]
    • Schottelius AJ, Baldwin AS. A role for transcription factor NF-kappa B in intestinal inflammation. Int J Colorectal Dis 1999; 14: 18-28 [PMID: 10207726]
    • (1999) Int J Colorectal Dis , vol.14 , pp. 18-28
    • Schottelius, A.J.1    Baldwin, A.S.2
  • 36
    • 0035981659 scopus 로고    scopus 로고
    • Blockade of NF-kappaB activation and donation of nitric oxide: New treatment options in inflammatory bowel disease?
    • [PMID: 12408502]
    • Dijkstra G, Moshage H, Jansen PL. Blockade of NF-kappaB activation and donation of nitric oxide: new treatment options in inflammatory bowel disease? Scand J Gastroenterol Suppl 2002; (236): 37-41 [PMID: 12408502]
    • (2002) Scand J Gastroenterol Suppl , Issue.236 , pp. 37-41
    • Dijkstra, G.1    Moshage, H.2    Jansen, P.L.3
  • 37
    • 0033527549 scopus 로고    scopus 로고
    • Interleukin- 10 signaling blocks inhibitor of kappaB kinase activity and nuclear factor kappaB DNA binding
    • [PMID: 10542212]
    • Schottelius AJ, Mayo MW, Sartor RB, Baldwin AS. Interleukin- 10 signaling blocks inhibitor of kappaB kinase activity and nuclear factor kappaB DNA binding. J Biol Chem 1999; 274: 31868-31874 [PMID: 10542212]
    • (1999) J Biol Chem , vol.274 , pp. 31868-31874
    • Schottelius, A.J.1    Mayo, M.W.2    Sartor, R.B.3    Baldwin, A.S.4
  • 38
    • 0028948176 scopus 로고
    • Interleukin (IL)-10 inhibits nuclear factor kappa B (NF kappa B) activation in human monocytes. IL-10 and IL-4 suppress cytokine synthesis by different mechanisms
    • [PMID: 7721885]
    • Wang P, Wu P, Siegel MI, Egan RW, Billah MM. Interleukin (IL)-10 inhibits nuclear factor kappa B (NF kappa B) activation in human monocytes. IL-10 and IL-4 suppress cytokine synthesis by different mechanisms. J Biol Chem 1995; 270: 9558-9563 [PMID: 7721885]
    • (1995) J Biol Chem , vol.270 , pp. 9558-9563
    • Wang, P.1    Wu, P.2    Siegel, M.I.3    Egan, R.W.4    Billah, M.M.5
  • 39
    • 0347949510 scopus 로고    scopus 로고
    • Molecular mechanisms of interleukin-10-mediated inhibition of NF-kappaB activity: A role for p50
    • [PMID: 14678266]
    • Driessler F, Venstrom K, Sabat R, Asadullah K, Schottelius AJ. Molecular mechanisms of interleukin-10-mediated inhibition of NF-kappaB activity: a role for p50. Clin Exp Immunol 2004; 135: 64-73 [PMID: 14678266]
    • (2004) Clin Exp Immunol , vol.135 , pp. 64-73
    • Driessler, F.1    Venstrom, K.2    Sabat, R.3    Asadullah, K.4    Schottelius, A.J.5
  • 40
    • 0031406170 scopus 로고    scopus 로고
    • Interleukin-10 down-regulates MHC class II alphabeta peptide complexes at the plasma membrane of monocytes by affecting arrival and recycling
    • [PMID: 9430231]
    • Koppelman B, Neefjes JJ, de Vries JE, de Waal Malefyt R. Interleukin-10 down-regulates MHC class II alphabeta peptide complexes at the plasma membrane of monocytes by affecting arrival and recycling. Immunity 1997; 7: 861-871 [PMID: 9430231]
    • (1997) Immunity , vol.7 , pp. 861-871
    • Koppelman, B.1    Neefjes, J.J.2    de Vries, J.E.3    de Waal Malefyt, R.4
  • 41
    • 0028299069 scopus 로고
    • Interleukin-10 inhibits B7 and intercellular adhesion molecule-1 expression on human monocytes
    • [PMID: 7512027 DOI: 10.1002/eji.1830240435]
    • Willems F, Marchant A, Delville JP, Gérard C, Delvaux A, Velu T, de Boer M, Goldman M. Interleukin-10 inhibits B7 and intercellular adhesion molecule-1 expression on human monocytes. Eur J Immunol 1994; 24: 1007-1009 [PMID: 7512027 DOI: 10.1002/eji.1830240435]
    • (1994) Eur J Immunol , vol.24 , pp. 1007-1009
    • Willems, F.1    Marchant, A.2    Delville, J.P.3    Gérard, C.4    Delvaux, A.5    Velu, T.6    de Boer, M.7    Goldman, M.8
  • 42
    • 77954336090 scopus 로고    scopus 로고
    • A role for STAT3 and cathepsin S in IL-10 down-regulation of IFN-gammainduced MHC class II molecule on primary human blood macrophages
    • [PMID: 20356901 DOI: 10.1189/jlb.1009659]
    • Chan LL, Cheung BK, Li JC, Lau AS. A role for STAT3 and cathepsin S in IL-10 down-regulation of IFN-gammainduced MHC class II molecule on primary human blood macrophages. J Leukoc Biol 2010; 88: 303-311 [PMID: 20356901 DOI: 10.1189/jlb.1009659]
    • (2010) J Leukoc Biol , vol.88 , pp. 303-311
    • Chan, L.L.1    Cheung, B.K.2    Li, J.C.3    Lau, A.S.4
  • 43
    • 0027239842 scopus 로고
    • IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7 expression
    • [PMID: 7687627]
    • Ding L, Linsley PS, Huang LY, Germain RN, Shevach EM. IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7 expression. J Immunol 1993; 151: 1224-1234 [PMID: 7687627]
    • (1993) J Immunol , vol.151 , pp. 1224-1234
    • Ding, L.1    Linsley, P.S.2    Huang, L.Y.3    Germain, R.N.4    Shevach, E.M.5
  • 44
    • 0029086123 scopus 로고
    • Interleukin-10 differentially regulates B7-1 (CD80) and B7-2 (CD86) expression on human peripheral blood dendritic cells
    • [PMID: 7589143 DOI: 10.1002/eji.1830250940]
    • Buelens C, Willems F, Delvaux A, Piérard G, Delville JP, Velu T, Goldman M. Interleukin-10 differentially regulates B7-1 (CD80) and B7-2 (CD86) expression on human peripheral blood dendritic cells. Eur J Immunol 1995; 25: 2668-2672 [PMID: 7589143 DOI: 10.1002/eji.1830250940]
    • (1995) Eur J Immunol , vol.25 , pp. 2668-2672
    • Buelens, C.1    Willems, F.2    Delvaux, A.3    Piérard, G.4    Delville, J.P.5    Velu, T.6    Goldman, M.7
  • 45
    • 0036387002 scopus 로고    scopus 로고
    • IL-10 alters DC function via modulation of cell surface molecules resulting in impaired T-cell responses
    • [PMID: 12202153]
    • McBride JM, Jung T, de Vries JE, Aversa G. IL-10 alters DC function via modulation of cell surface molecules resulting in impaired T-cell responses. Cell Immunol 2002; 215: 162-172 [PMID: 12202153]
    • (2002) Cell Immunol , vol.215 , pp. 162-172
    • McBride, J.M.1    Jung, T.2    de Vries, J.E.3    Aversa, G.4
  • 46
    • 0026094306 scopus 로고
    • Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: An autoregulatory role of IL-10 produced by monocytes
    • [PMID: 1940799]
    • de Waal Malefyt R, Abrams J, Bennett B, Figdor CG, de Vries JE. Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J Exp Med 1991; 174: 1209-1220 [PMID: 1940799]
    • (1991) J Exp Med , vol.174 , pp. 1209-1220
    • de Waal Malefyt, R.1    Abrams, J.2    Bennett, B.3    Figdor, C.G.4    de Vries, J.E.5
  • 47
    • 0027204621 scopus 로고
    • Human IL-10 is produced by both type 1 helper (Th1) and type 2 helper (Th2) T cell clones and inhibits their antigen-specific proliferation and cytokine production
    • [PMID: 8419468]
    • Del Prete G, De Carli M, Almerigogna F, Giudizi MG, Biagiotti R, Romagnani S. Human IL-10 is produced by both type 1 helper (Th1) and type 2 helper (Th2) T cell clones and inhibits their antigen-specific proliferation and cytokine production. J Immunol 1993; 150: 353-360 [PMID: 8419468]
    • (1993) J Immunol , vol.150 , pp. 353-360
    • Del Prete, G.1    de Carli, M.2    Almerigogna, F.3    Giudizi, M.G.4    Biagiotti, R.5    Romagnani, S.6
  • 48
    • 0025889028 scopus 로고
    • IL-10 inhibits cytokine production by activated macrophages
    • [PMID: 1940369]
    • Fiorentino DF, Zlotnik A, Mosmann TR, Howard M, O'Garra A. IL-10 inhibits cytokine production by activated macrophages. J Immunol 1991; 147: 3815-3822 [PMID: 1940369]
    • (1991) J Immunol , vol.147 , pp. 3815-3822
    • Fiorentino, D.F.1    Zlotnik, A.2    Mosmann, T.R.3    Howard, M.4    O'Garra, A.5
  • 49
    • 84861706091 scopus 로고    scopus 로고
    • MARCH1 down-regulation in IL-10-activated B cells increases MHC class II expression
    • [PMID: 22503116 DOI: 10.1016/j.cyto.2012.03.015]
    • Galbas T, Steimle V, Lapointe R, Ishido S, Thibodeau J. MARCH1 down-regulation in IL-10-activated B cells increases MHC class II expression. Cytokine 2012; 59: 27-30 [PMID: 22503116 DOI: 10.1016/j.cyto.2012.03.015]
    • (2012) Cytokine , vol.59 , pp. 27-30
    • Galbas, T.1    Steimle, V.2    Lapointe, R.3    Ishido, S.4    Thibodeau, J.5
  • 51
    • 77958003426 scopus 로고    scopus 로고
    • Infant colitis--it's in the genes
    • [PMID: 20934598 DOI: 10.1016/ S0140-6736(10)61008-2]
    • Glocker EO, Frede N, Perro M, Sebire N, Elawad M, Shah N, Grimbacher B. Infant colitis--it's in the genes. Lancet 2010; 376: 1272 [PMID: 20934598 DOI: 10.1016/ S0140-6736(10)61008-2]
    • (2010) Lancet , vol.376 , pp. 1272
    • Glocker, E.O.1    Frede, N.2    Perro, M.3    Sebire, N.4    Elawad, M.5    Shah, N.6    Grimbacher, B.7
  • 53
    • 0032779561 scopus 로고    scopus 로고
    • The interleukin- 10 signal transduction pathway and regulation of gene expression in mononuclear phagocytes
    • [PMID: 10433356 DOI: 10.1089/107999099313695]
    • Donnelly RP, Dickensheets H, Finbloom DS. The interleukin- 10 signal transduction pathway and regulation of gene expression in mononuclear phagocytes. J Interferon Cytokine Res 1999; 19: 563-573 [PMID: 10433356 DOI: 10.1089/107999099313695]
    • (1999) J Interferon Cytokine Res , vol.19 , pp. 563-573
    • Donnelly, R.P.1    Dickensheets, H.2    Finbloom, D.S.3
  • 54
    • 0035062021 scopus 로고    scopus 로고
    • Interleukin-10 and the interleukin-10 receptor
    • [PMID: 11244051 DOI: 10.1146/annurev. immunol.19.1.683]
    • Moore KW, de Waal Malefyt R, Coffman RL, O'Garra A. Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol 2001; 19: 683-765 [PMID: 11244051 DOI: 10.1146/annurev. immunol.19.1.683]
    • (2001) Annu Rev Immunol , vol.19 , pp. 683-765
    • Moore, K.W.1    de Waal Malefyt, R.2    Coffman, R.L.3    O'Garra, A.4
  • 55
    • 8144226985 scopus 로고    scopus 로고
    • Interleukin-10 suppression of myeloid cell activation- -a continuing puzzle
    • [PMID: 15500614 DOI: 10.1111/j.1365-2567.2004.01988.x]
    • Williams LM, Ricchetti G, Sarma U, Smallie T, Foxwell BM. Interleukin-10 suppression of myeloid cell activation- -a continuing puzzle. Immunology 2004; 113: 281-292 [PMID: 15500614 DOI: 10.1111/j.1365-2567.2004.01988.x]
    • (2004) Immunology , vol.113 , pp. 281-292
    • Williams, L.M.1    Ricchetti, G.2    Sarma, U.3    Smallie, T.4    Foxwell, B.M.5
  • 56
    • 84861337029 scopus 로고    scopus 로고
    • New insights into the role of STAT3 in IBD
    • [PMID: 21994179 DOI: 10.1002/ ibd.21884]
    • Li Y, de Haar C, Peppelenbosch MP, van der Woude CJ. New insights into the role of STAT3 in IBD. Inflamm Bowel Dis 2012; 18: 1177-1183 [PMID: 21994179 DOI: 10.1002/ ibd.21884]
    • (2012) Inflamm Bowel Dis , vol.18 , pp. 1177-1183
    • Li, Y.1    de Haar, C.2    Peppelenbosch, M.P.3    van der Woude, C.J.4
  • 58
    • 0036644327 scopus 로고    scopus 로고
    • IL-15-dependent activation-induced cell death-resistant Th1 type CD8 alpha beta+NK1.1+ T cells for the development of small intestinal inflammation
    • [PMID: 12077277]
    • Ohta N, Hiroi T, Kweon MN, Kinoshita N, Jang MH, Mashimo T, Miyazaki J, Kiyono H. IL-15-dependent activation-induced cell death-resistant Th1 type CD8 alpha beta+NK1.1+ T cells for the development of small intestinal inflammation. J Immunol 2002; 169: 460-468 [PMID: 12077277]
    • (2002) J Immunol , vol.169 , pp. 460-468
    • Ohta, N.1    Hiroi, T.2    Kweon, M.N.3    Kinoshita, N.4    Jang, M.H.5    Mashimo, T.6    Miyazaki, J.7    Kiyono, H.8
  • 59
    • 0036080142 scopus 로고    scopus 로고
    • Leptin: A pivotal mediator of intestinal inflammation in mice
    • [PMID: 12055606]
    • Siegmund B, Lehr HA, Fantuzzi G. Leptin: a pivotal mediator of intestinal inflammation in mice. Gastroenterology 2002; 122: 2011-2025 [PMID: 12055606]
    • (2002) Gastroenterology , vol.122 , pp. 2011-2025
    • Siegmund, B.1    Lehr, H.A.2    Fantuzzi, G.3
  • 60
    • 84870431806 scopus 로고    scopus 로고
    • Novel Pharmacological Approaches for Inflammatory Bowel Disease: Targeting Key Intracellular Pathways and the IL-23/IL-17 Axis
    • [PMID: 22506136 DOI: 10.1155/2012/389404]
    • Fitzpatrick LR. Novel Pharmacological Approaches for Inflammatory Bowel Disease: Targeting Key Intracellular Pathways and the IL-23/IL-17 Axis. Int J Inflam 2012; 2012: 389404 [PMID: 22506136 DOI: 10.1155/2012/389404]
    • (2012) Int J Inflam , pp. 389404
    • Fitzpatrick, L.R.1
  • 63
    • 0035123651 scopus 로고    scopus 로고
    • Enhanced survival and mucosal repair after dextran sodium sulfate-induced colitis in transgenic mice that overexpress growth hormone
    • [PMID: 11231946]
    • Williams KL, Fuller CR, Dieleman LA, DaCosta CM, Haldeman KM, Sartor RB, Lund PK. Enhanced survival and mucosal repair after dextran sodium sulfate-induced colitis in transgenic mice that overexpress growth hormone. Gastroenterology 2001; 120: 925-937 [PMID: 11231946]
    • (2001) Gastroenterology , vol.120 , pp. 925-937
    • Williams, K.L.1    Fuller, C.R.2    Dieleman, L.A.3    Dacosta, C.M.4    Haldeman, K.M.5    Sartor, R.B.6    Lund, P.K.7
  • 64
    • 0346103717 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 3 is the dominant mediator of the anti-inflammatory effects of IL-10 in human macrophages
    • [PMID: 14688368]
    • Williams L, Bradley L, Smith A, Foxwell B. Signal transducer and activator of transcription 3 is the dominant mediator of the anti-inflammatory effects of IL-10 in human macrophages. J Immunol 2004; 172: 567-576 [PMID: 14688368]
    • (2004) J Immunol , vol.172 , pp. 567-576
    • Williams, L.1    Bradley, L.2    Smith, A.3    Foxwell, B.4
  • 65
    • 58149232723 scopus 로고    scopus 로고
    • Role of STAT3 in inflammatory bowel disease
    • [PMID: 18777586]
    • Sugimoto K. Role of STAT3 in inflammatory bowel disease. World J Gastroenterol 2008; 14: 5110-5114 [PMID: 18777586]
    • (2008) World J Gastroenterol , vol.14 , pp. 5110-5114
    • Sugimoto, K.1
  • 66
    • 77149154668 scopus 로고    scopus 로고
    • STAT3 and its activators in intestinal defense and mucosal homeostasis
    • [PMID: 20040863 DOI: 10.1097/ MOG.0b013e3283365279]
    • Hruz P, Dann SM, Eckmann L. STAT3 and its activators in intestinal defense and mucosal homeostasis. Curr Opin Gastroenterol 2010; 26: 109-115 [PMID: 20040863 DOI: 10.1097/ MOG.0b013e3283365279]
    • (2010) Curr Opin Gastroenterol , vol.26 , pp. 109-115
    • Hruz, P.1    Dann, S.M.2    Eckmann, L.3
  • 68
    • 33745700364 scopus 로고    scopus 로고
    • Understanding and exploiting the endogenous interleukin-10/STAT3-mediated anti-inflammatory response
    • [PMID: 16713356 DOI: 10.1016/j.coph.2006.01.010]
    • Murray PJ. Understanding and exploiting the endogenous interleukin-10/STAT3-mediated anti-inflammatory response. Curr Opin Pharmacol 2006; 6: 379-386 [PMID: 16713356 DOI: 10.1016/j.coph.2006.01.010]
    • (2006) Curr Opin Pharmacol , vol.6 , pp. 379-386
    • Murray, P.J.1
  • 69
    • 0037443661 scopus 로고    scopus 로고
    • Activation of STAT3 by IL-6 and IL-10 in primary human macrophages is differentially modulated by suppressor of cytokine signaling 3
    • [PMID: 12626585]
    • Niemand C, Nimmesgern A, Haan S, Fischer P, Schaper F, Rossaint R, Heinrich PC, Müller-Newen G. Activation of STAT3 by IL-6 and IL-10 in primary human macrophages is differentially modulated by suppressor of cytokine signaling 3. J Immunol 2003; 170: 3263-3272 [PMID: 12626585]
    • (2003) J Immunol , vol.170 , pp. 3263-3272
    • Niemand, C.1    Nimmesgern, A.2    Haan, S.3    Fischer, P.4    Schaper, F.5    Rossaint, R.6    Heinrich, P.C.7    Müller-Newen, G.8
  • 70
    • 0038269009 scopus 로고    scopus 로고
    • Constitutive STAT3 activation in intestinal T cells from patients with Crohn's disease
    • [PMID: 12615922 DOI: 10.1074/jbc.M207999200]
    • Lovato P, Brender C, Agnholt J, Kelsen J, Kaltoft K, Svejgaard A, Eriksen KW, Woetmann A, Ødum N. Constitutive STAT3 activation in intestinal T cells from patients with Crohn's disease. J Biol Chem 2003; 278: 16777-16781 [PMID: 12615922 DOI: 10.1074/jbc.M207999200]
    • (2003) J Biol Chem , vol.278 , pp. 16777-16781
    • Lovato, P.1    Brender, C.2    Agnholt, J.3    Kelsen, J.4    Kaltoft, K.5    Svejgaard, A.6    Eriksen, K.W.7    Woetmann, A.8    ødum, N.9
  • 71
    • 13744249714 scopus 로고    scopus 로고
    • Activation pattern of signal transducers and activators of transcription (STAT) factors in inflammatory bowel diseases
    • [PMID: 15654782 DOI: 10.1111/ j.1572-0241.2005.40615.x]
    • Mudter J, Weigmann B, Bartsch B, Kiesslich R, Strand D, Galle PR, Lehr HA, Schmidt J, Neurath MF. Activation pattern of signal transducers and activators of transcription (STAT) factors in inflammatory bowel diseases. Am J Gastroenterol 2005; 100: 64-72 [PMID: 15654782 DOI: 10.1111/ j.1572-0241.2005.40615.x]
    • (2005) Am J Gastroenterol , vol.100 , pp. 64-72
    • Mudter, J.1    Weigmann, B.2    Bartsch, B.3    Kiesslich, R.4    Strand, D.5    Galle, P.R.6    Lehr, H.A.7    Schmidt, J.8    Neurath, M.F.9
  • 72
  • 73
    • 77952704894 scopus 로고    scopus 로고
    • The polymorphism rs3024505 proximal to IL-10 is associated with risk of ulcerative colitis and Crohns disease in a Danish casecontrol study
    • DOI: 10.1186/1471-2350-11-82
    • Andersen V, Ernst A, Christensen J, Ostergaard M, Jacobsen B, Tjonneland A, Krarup H, Vogel U. The polymorphism rs3024505 proximal to IL-10 is associated with risk of ulcerative colitis and Crohns disease in a Danish casecontrol study. BMC Medical Genetics 2010; 11: 82 [DOI: 10.1186/1471-2350-11-82]
    • (2010) BMC Medical Genetics , vol.11 , pp. 82
    • Andersen, V.1    Ernst, A.2    Christensen, J.3    Ostergaard, M.4    Jacobsen, B.5    Tjonneland, A.6    Krarup, H.7    Vogel, U.8
  • 74
    • 70350453460 scopus 로고    scopus 로고
    • IL-10 and TNFalpha promoter haplotypes are associated with childhood Crohn's disease location
    • [PMID: 19673019]
    • Sanchez R, Levy E, Costea F, Sinnett D. IL-10 and TNFalpha promoter haplotypes are associated with childhood Crohn's disease location. World J Gastroenterol 2009; 15: 3776-3782 [PMID: 19673019]
    • (2009) World J Gastroenterol , vol.15 , pp. 3776-3782
    • Sanchez, R.1    Levy, E.2    Costea, F.3    Sinnett, D.4
  • 77
    • 0027521572 scopus 로고
    • Interleukin- 10-deficient mice develop chronic enterocolitis
    • [PMID: 8402911 DOI: 10.1016/0092-8674(9 3)80068-P]
    • Kühn R, Löhler J, Rennick D, Rajewsky K, Müller W. Interleukin- 10-deficient mice develop chronic enterocolitis. Cell 1993; 75: 263-274 [PMID: 8402911 DOI: 10.1016/0092-8674(9 3)80068-P]
    • (1993) Cell , vol.75 , pp. 263-274
    • Kühn, R.1    Löhler, J.2    Rennick, D.3    Rajewsky, K.4    Müller, W.5
  • 78
    • 65549131489 scopus 로고    scopus 로고
    • Defective IL-10 production in severe phenotypes of Crohn's disease
    • [PMID: 19237638 DOI: 10.1189/jlb.1108698]
    • Correa I, Veny M, Esteller M, Piqué JM, Yagüe J, Panés J, Salas A. Defective IL-10 production in severe phenotypes of Crohn's disease. J Leukoc Biol 2009; 85: 896-903 [PMID: 19237638 DOI: 10.1189/jlb.1108698]
    • (2009) J Leukoc Biol , vol.85 , pp. 896-903
    • Correa, I.1    Veny, M.2    Esteller, M.3    Piqué, J.M.4    Yagüe, J.5    Panés, J.6    Salas, A.7
  • 79
    • 0028907439 scopus 로고
    • Immunoregulatory role of interleukin 10 in patients with inflammatory bowel disease
    • [PMID: 7729636]
    • Schreiber S, Heinig T, Thiele HG, Raedler A. Immunoregulatory role of interleukin 10 in patients with inflammatory bowel disease. Gastroenterology 1995; 108: 1434-1444 [PMID: 7729636]
    • (1995) Gastroenterology , vol.108 , pp. 1434-1444
    • Schreiber, S.1    Heinig, T.2    Thiele, H.G.3    Raedler, A.4
  • 80
    • 0033782650 scopus 로고    scopus 로고
    • IL-10 secretion and sensitivity in normal human intestine and inflammatory bowel disease
    • [PMID: 11051278]
    • Gasche C, Bakos S, Dejaco C, Tillinger W, Zakeri S, Reinisch W. IL-10 secretion and sensitivity in normal human intestine and inflammatory bowel disease. J Clin Immunol 2000; 20: 362-370 [PMID: 11051278]
    • (2000) J Clin Immunol , vol.20 , pp. 362-370
    • Gasche, C.1    Bakos, S.2    Dejaco, C.3    Tillinger, W.4    Zakeri, S.5    Reinisch, W.6
  • 81
    • 0029744262 scopus 로고    scopus 로고
    • Involvement of interleukin-4 and -10 in inflammatory bowel disease
    • [PMID: 8794795]
    • Nielsen OH, Køppen T, Rüdiger N, Horn T, Eriksen J, Kirman I. Involvement of interleukin-4 and -10 in inflammatory bowel disease. Dig Dis Sci 1996; 41: 1786-1793 [PMID: 8794795]
    • (1996) Dig Dis Sci , vol.41 , pp. 1786-1793
    • Nielsen, O.H.1    Køppen, T.2    Rüdiger, N.3    Horn, T.4    Eriksen, J.5    Kirman, I.6
  • 82
    • 0029028515 scopus 로고
    • Circulating antiinflammatory cytokine IL-10 in patients with inflammatory bowel disease (IBD)
    • [PMID: 7774055]
    • Kucharzik T, Stoll R, Lügering N, Domschke W. Circulating antiinflammatory cytokine IL-10 in patients with inflammatory bowel disease (IBD). Clin Exp Immunol 1995; 100: 452-456 [PMID: 7774055]
    • (1995) Clin Exp Immunol , vol.100 , pp. 452-456
    • Kucharzik, T.1    Stoll, R.2    Lügering, N.3    Domschke, W.4
  • 83
    • 0036136867 scopus 로고    scopus 로고
    • Low ileal interleukin 10 concentrations are predictive of endoscopic recurrence in patients with Crohn's disease
    • [PMID: 11772962]
    • Meresse B, Rutgeerts P, Malchow H, Dubucquoi S, Dessaint JP, Cohard M, Colombel JF, Desreumaux P. Low ileal interleukin 10 concentrations are predictive of endoscopic recurrence in patients with Crohn's disease. Gut 2002; 50: 25-28 [PMID: 11772962]
    • (2002) Gut , vol.50 , pp. 25-28
    • Meresse, B.1    Rutgeerts, P.2    Malchow, H.3    Dubucquoi, S.4    Dessaint, J.P.5    Cohard, M.6    Colombel, J.F.7    Desreumaux, P.8
  • 85
    • 34248206040 scopus 로고    scopus 로고
    • Interleukin- 10 in the pathophysiology of inflammatory bowel disease: Increased serum concentrations during the recovery phase
    • [PMID: 17392581 DOI: 10.1155/MI/2006/26875]
    • Mitsuyama K, Tomiyasu N, Takaki K, Masuda J, Yamasaki H, Kuwaki K, Takeda T, Kitazaki S, Tsuruta O, Sata M. Interleukin- 10 in the pathophysiology of inflammatory bowel disease: increased serum concentrations during the recovery phase. Mediators Inflamm 2006; 2006: 26875 [PMID: 17392581 DOI: 10.1155/MI/2006/26875]
    • (2006) Mediators Inflamm , vol.2006 , pp. 26875
    • Mitsuyama, K.1    Tomiyasu, N.2    Takaki, K.3    Masuda, J.4    Yamasaki, H.5    Kuwaki, K.6    Takeda, T.7    Kitazaki, S.8    Tsuruta, O.9    Sata, M.10
  • 86
    • 77954423455 scopus 로고    scopus 로고
    • Circulating cytokines reflect mucosal inflammatory status in patients with Crohn's disease
    • [PMID: 19834804 DOI: 10.1007/s10620-009-1016-9]
    • Ljuca F, Gegic A, Salkic NN, Pavlovic-Calic N. Circulating cytokines reflect mucosal inflammatory status in patients with Crohn's disease. Dig Dis Sci 2010; 55: 2316-2326 [PMID: 19834804 DOI: 10.1007/s10620-009-1016-9]
    • (2010) Dig Dis Sci , vol.55 , pp. 2316-2326
    • Ljuca, F.1    Gegic, A.2    Salkic, N.N.3    Pavlovic-Calic, N.4
  • 88
    • 48249088180 scopus 로고    scopus 로고
    • Serum levels of the pro-inflammatory cytokine interleukin-12 and the anti-inflammatory cytokine interleukin-10 in patients with psoriasis treated by the Goeckerman regimen
    • [PMID: 18717859 DOI: 10.1111/j.1365-4632.2008.03677.x]
    • Borska L, Andrys C, Krejsek J, Hamakova K, Kremlacek J, Ettler K, Fiala Z. Serum levels of the pro-inflammatory cytokine interleukin-12 and the anti-inflammatory cytokine interleukin-10 in patients with psoriasis treated by the Goeckerman regimen. Int J Dermatol 2008; 47: 800-805 [PMID: 18717859 DOI: 10.1111/j.1365-4632.2008.03677.x]
    • (2008) Int J Dermatol , vol.47 , pp. 800-805
    • Borska, L.1    Andrys, C.2    Krejsek, J.3    Hamakova, K.4    Kremlacek, J.5    Ettler, K.6    Fiala, Z.7
  • 89
    • 78651076415 scopus 로고    scopus 로고
    • Association of polymorphisms in the human IL-10 and IL-18 genes with rheumatoid arthritis
    • [PMID: 20424918 DOI: 10.1007/s11033-010-0119-x]
    • Ying B, Shi Y, Pan X, Song X, Huang Z, Niu Q, Cai B, Wang L. Association of polymorphisms in the human IL-10 and IL-18 genes with rheumatoid arthritis. Mol Biol Rep 2011; 38: 379-385 [PMID: 20424918 DOI: 10.1007/s11033-010-0119-x]
    • (2011) Mol Biol Rep , vol.38 , pp. 379-385
    • Ying, B.1    Shi, Y.2    Pan, X.3    Song, X.4    Huang, Z.5    Niu, Q.6    Cai, B.7    Wang, L.8
  • 91
    • 84880074086 scopus 로고    scopus 로고
    • Cytokine Networks in Ulcerative Colitis
    • DOI: 10.1155/2011/391787
    • Roda G, Marocchi M, Sartini A, Roda E. Cytokine Networks in Ulcerative Colitis. Ulcers 2011; 2011: 391787 [DOI: 10.1155/2011/391787]
    • (2011) Ulcers , pp. 2011
    • Roda, G.1    Marocchi, M.2    Sartini, A.3    Roda, E.4
  • 93
    • 79960234773 scopus 로고    scopus 로고
    • Association of cytokine gene polymorphisms with psoriasis in cases from the nile delta of egypt
    • [PMID: 21772586]
    • Settin AA, Hassan HA, El-Baz RA, Hassan TA. Association of cytokine gene polymorphisms with psoriasis in cases from the nile delta of egypt. Indian J Dermatol 2011; 56: 272-277 [PMID: 21772586]
    • (2011) Indian J Dermatol , vol.56 , pp. 272-277
    • Settin, A.A.1    Hassan, H.A.2    El-Baz, R.A.3    Hassan, T.A.4
  • 94
    • 73449119229 scopus 로고    scopus 로고
    • Polymorphism in the IL10 promoter region and early markers of atherosclerosis: The Cardiovascular Risk in Young Finns Study
    • [PMID: 19700159 DOI: 10.1016/j.atherosclerosis.200 9.06.032]
    • Heiskanen M, Kähönen M, Hurme M, Lehtimäki T, Mononen N, Juonala M, Hutri-Kähönen N, Viikari J, Raitakari O, Hulkkonen J. Polymorphism in the IL10 promoter region and early markers of atherosclerosis: the Cardiovascular Risk in Young Finns Study. Atherosclerosis 2010; 208: 190-196 [PMID: 19700159 DOI: 10.1016/j.atherosclerosis.200 9.06.032]
    • (2010) Atherosclerosis , vol.208 , pp. 190-196
    • Heiskanen, M.1    Kähönen, M.2    Hurme, M.3    Lehtimäki, T.4    Mononen, N.5    Juonala, M.6    Hutri-Kähönen, N.7    Viikari, J.8    Raitakari, O.9    Hulkkonen, J.10
  • 96
    • 0141504225 scopus 로고    scopus 로고
    • Association of breast cancer and polymorphisms of interleukin-10 and tumor necrosis factor-alpha genes
    • [PMID: 14500594]
    • Giordani L, Bruzzi P, Lasalandra C, Quaranta M, Schittulli F, Della Ragione F, Iolascon A. Association of breast cancer and polymorphisms of interleukin-10 and tumor necrosis factor-alpha genes. Clin Chem 2003; 49: 1664-1667 [PMID: 14500594]
    • (2003) Clin Chem , vol.49 , pp. 1664-1667
    • Giordani, L.1    Bruzzi, P.2    Lasalandra, C.3    Quaranta, M.4    Schittulli, F.5    della Ragione, F.6    Iolascon, A.7
  • 97
    • 0035892319 scopus 로고    scopus 로고
    • Cancer of the uterine cervix may be significantly associated with a gene polymorphism coding for increased IL-10 production
    • [PMID: 11745479 DOI: 10.1002/ijc.1543]
    • Stanczuk GA, Sibanda EN, Perrey C, Chirara M, Pravica V, Hutchinson IV, Tswana SA. Cancer of the uterine cervix may be significantly associated with a gene polymorphism coding for increased IL-10 production. Int J Cancer 2001; 94: 792-794 [PMID: 11745479 DOI: 10.1002/ijc.1543]
    • (2001) Int J Cancer , vol.94 , pp. 792-794
    • Stanczuk, G.A.1    Sibanda, E.N.2    Perrey, C.3    Chirara, M.4    Pravica, V.5    Hutchinson, I.V.6    Tswana, S.A.7
  • 98
    • 84859743395 scopus 로고    scopus 로고
    • A meta-analysis of interleukin- 10-1082 promoter polymorphism associated with gastric cancer risk
    • [PMID: 22335769 DOI: 10.1089/dna.2011.1440]
    • Ni P, Xu H, Xue H, Lin B, Lu Y. A meta-analysis of interleukin- 10-1082 promoter polymorphism associated with gastric cancer risk. DNA Cell Biol 2012; 31: 582-591 [PMID: 22335769 DOI: 10.1089/dna.2011.1440]
    • (2012) DNA Cell Biol , vol.31 , pp. 582-591
    • Ni, P.1    Xu, H.2    Xue, H.3    Lin, B.4    Lu, Y.5
  • 99
    • 84858607126 scopus 로고    scopus 로고
    • Interleukin-10-819 promoter polymorphism in association with gastric cancer risk
    • [PMID: 22436502 DOI: 10.118 6/1471-2407-12-102]
    • Xue H, Lin B, An J, Zhu Y, Huang G. Interleukin-10-819 promoter polymorphism in association with gastric cancer risk. BMC Cancer 2012; 12: 102 [PMID: 22436502 DOI: 10.118 6/1471-2407-12-102]
    • (2012) BMC Cancer , vol.12 , pp. 102
    • Xue, H.1    Lin, B.2    An, J.3    Zhu, Y.4    Huang, G.5
  • 103
    • 20544469356 scopus 로고    scopus 로고
    • TNFalpha and IL10 SNPs act together to predict disease behaviour in Crohn's disease
    • [PMID: 15937090 DOI: 10.1136/jmg.2004.027425]
    • Fowler EV, Eri R, Hume G, Johnstone S, Pandeya N, Lincoln D, Templeton D, Radford-Smith GL. TNFalpha and IL10 SNPs act together to predict disease behaviour in Crohn's disease. J Med Genet 2005; 42: 523-528 [PMID: 15937090 DOI: 10.1136/jmg.2004.027425]
    • (2005) J Med Genet , vol.42 , pp. 523-528
    • Fowler, E.V.1    Eri, R.2    Hume, G.3    Johnstone, S.4    Pandeya, N.5    Lincoln, D.6    Templeton, D.7    Radford-Smith, G.L.8
  • 105
    • 45749128746 scopus 로고    scopus 로고
    • Interleukin-10 promoter polymorphisms influence susceptibility to ulcerative colitis in a gender-specific manner
    • [PMID: 18569989 DOI: 10.1080/00365520701885507]
    • Tedde A, Laura Putignano A, Bagnoli S, Congregati C, Milla M, Sorbi S, Genuardi M, Papi L. Interleukin-10 promoter polymorphisms influence susceptibility to ulcerative colitis in a gender-specific manner. Scand J Gastroenterol 2008; 43: 712-718 [PMID: 18569989 DOI: 10.1080/00365520701885507]
    • (2008) Scand J Gastroenterol , vol.43 , pp. 712-718
    • Tedde, A.1    Laura Putignano, A.2    Bagnoli, S.3    Congregati, C.4    Milla, M.5    Sorbi, S.6    Genuardi, M.7    Papi, L.8
  • 107
    • 0034139448 scopus 로고    scopus 로고
    • Cytokine (TNF alpha, LT alpha and IL-10) polymorphisms in inflammatory bowel diseases and normal controls: Differential effects on production and allele frequencies
    • [PMID: 11196710 DOI: 10.1038/ sj.gene.6363657]
    • Koss K, Satsangi J, Fanning GC, Welsh KI, Jewell DP. Cytokine (TNF alpha, LT alpha and IL-10) polymorphisms in inflammatory bowel diseases and normal controls: differential effects on production and allele frequencies. Genes Immun 2000; 1: 185-190 [PMID: 11196710 DOI: 10.1038/ sj.gene.6363657]
    • (2000) Genes Immun , vol.1 , pp. 185-190
    • Koss, K.1    Satsangi, J.2    Fanning, G.C.3    Welsh, K.I.4    Jewell, D.P.5
  • 108
    • 0037949473 scopus 로고    scopus 로고
    • Differential regulation of interleukin-10 production by genetic and environmental factors--a twin study
    • [PMID: 12424622]
    • Reuss E, Fimmers R, Kruger A, Becker C, Rittner C, Höhler T. Differential regulation of interleukin-10 production by genetic and environmental factors--a twin study. Genes Immun 2002; 3: 407-413 [PMID: 12424622]
    • (2002) Genes Immun , vol.3 , pp. 407-413
    • Reuss, E.1    Fimmers, R.2    Kruger, A.3    Becker, C.4    Rittner, C.5    Höhler, T.6
  • 109
    • 0033031984 scopus 로고    scopus 로고
    • Polymorphic haplotypes of the interleukin-10 5' flanking region determine variable interleukin-10 transcription and are associated with particular phenotypes of juvenile rheumatoid arthritis
    • [PMID: 10366102 DOI: 10.1002/1529-0131(199906)42]
    • Crawley E, Kay R, Sillibourne J, Patel P, Hutchinson I, Woo P. Polymorphic haplotypes of the interleukin-10 5' flanking region determine variable interleukin-10 transcription and are associated with particular phenotypes of juvenile rheumatoid arthritis. Arthritis Rheum 1999; 42: 1101-1108 [PMID: 10366102 DOI: 10.1002/1529-0131(199906)42]
    • (1999) Arthritis Rheum , vol.42 , pp. 1101-1108
    • Crawley, E.1    Kay, R.2    Sillibourne, J.3    Patel, P.4    Hutchinson, I.5    Woo, P.6
  • 110
    • 66149121918 scopus 로고    scopus 로고
    • Dieleman LA. Prebiotics in chronic intestinal inflammation
    • [PMID: 18831524 DOI: 10.1002/ibd.20737]
    • Looijer-van Langen MA, Dieleman LA. Prebiotics in chronic intestinal inflammation. Inflamm Bowel Dis 2009; 15: 454-462 [PMID: 18831524 DOI: 10.1002/ibd.20737]
    • (2009) Inflamm Bowel Dis , vol.15 , pp. 454-462
    • Looijer-Van langen, M.A.1
  • 111
    • 80051480268 scopus 로고    scopus 로고
    • Treatment of inflammatory bowel disease (IBD)
    • [PMID: 21857074]
    • Pithadia AB, Jain S. Treatment of inflammatory bowel disease (IBD). Pharmacol Rep 2011; 63: 629-642 [PMID: 21857074]
    • (2011) Pharmacol Rep , vol.63 , pp. 629-642
    • Pithadia, A.B.1    Jain, S.2
  • 112
    • 38549103697 scopus 로고    scopus 로고
    • Nutrigenomics in the whole-genome scanning era: Crohn's disease as example
    • [PMID: 17922230 DOI: 10.1007/s00018-007-7303-8]
    • Ferguson LR, Philpott M, Dryland P. Nutrigenomics in the whole-genome scanning era: Crohn's disease as example. Cell Mol Life Sci 2007; 64: 3105-3118 [PMID: 17922230 DOI: 10.1007/s00018-007-7303-8]
    • (2007) Cell Mol Life Sci , vol.64 , pp. 3105-3118
    • Ferguson, L.R.1    Philpott, M.2    Dryland, P.3
  • 113
    • 34547700318 scopus 로고    scopus 로고
    • Genes, diet and inflammatory bowel disease
    • [PMID: 17628615 DOI: 10.1016/ j.mrfmmm.2007.05.011]
    • Ferguson LR, Shelling AN, Browning BL, Huebner C, Petermann I. Genes, diet and inflammatory bowel disease. Mutat Res 2007; 622: 70-83 [PMID: 17628615 DOI: 10.1016/ j.mrfmmm.2007.05.011]
    • (2007) Mutat Res , vol.622 , pp. 70-83
    • Ferguson, L.R.1    Shelling, A.N.2    Browning, B.L.3    Huebner, C.4    Petermann I5
  • 114
    • 77955269066 scopus 로고    scopus 로고
    • Dietary factors in chronic inflammation: Food tolerances and intolerances of a New Zealand Caucasian Crohn's disease population
    • [PMID: 20144628 DOI: 10.1016/ j.mrfmmm.2010.01.020]
    • Triggs CM, Munday K, Hu R, Fraser AG, Gearry RB, Barclay ML, Ferguson LR. Dietary factors in chronic inflammation: food tolerances and intolerances of a New Zealand Caucasian Crohn's disease population. Mutat Res 2010; 690: 123-138 [PMID: 20144628 DOI: 10.1016/ j.mrfmmm.2010.01.020]
    • (2010) Mutat Res , vol.690 , pp. 123-138
    • Triggs, C.M.1    Munday, K.2    Hu, R.3    Fraser, A.G.4    Gearry, R.B.5    Barclay, M.L.6    Ferguson, L.R.7
  • 115
    • 0034231537 scopus 로고    scopus 로고
    • Responses of people with inflammatory bowel disease to foods consumed
    • [PMID: 11310083]
    • Joachim G. Responses of people with inflammatory bowel disease to foods consumed. Gastroenterol Nurs 2000; 23: 160-167 [PMID: 11310083]
    • (2000) Gastroenterol Nurs , vol.23 , pp. 160-167
    • Joachim, G.1
  • 116
    • 4644295599 scopus 로고    scopus 로고
    • Influence of dietary factors on the clinical course of ulcerative colitis: A prospective cohort study
    • [PMID: 15361498 DOI: 10.1136/ gut.2003.024828]
    • Jowett SL, Seal CJ, Pearce MS, Phillips E, Gregory W, Barton JR, Welfare MR. Influence of dietary factors on the clinical course of ulcerative colitis: a prospective cohort study. Gut 2004; 53: 1479-1484 [PMID: 15361498 DOI: 10.1136/ gut.2003.024828]
    • (2004) Gut , vol.53 , pp. 1479-1484
    • Jowett, S.L.1    Seal, C.J.2    Pearce, M.S.3    Phillips, E.4    Gregory, W.5    Barton, J.R.6    Welfare, M.R.7
  • 117
    • 1642486750 scopus 로고    scopus 로고
    • Dietary beliefs of people with ulcerative colitis and their effect on relapse and nutrient intake
    • [PMID: 15030955 DOI: 10.1016/ S0261-5614(03)00132-8]
    • Jowett SL, Seal CJ, Phillips E, Gregory W, Barton JR, Welfare MR. Dietary beliefs of people with ulcerative colitis and their effect on relapse and nutrient intake. Clin Nutr 2004; 23: 161-170 [PMID: 15030955 DOI: 10.1016/ S0261-5614(03)00132-8]
    • (2004) Clin Nutr , vol.23 , pp. 161-170
    • Jowett, S.L.1    Seal, C.J.2    Phillips, E.3    Gregory, W.4    Barton, J.R.5    Welfare, M.R.6
  • 118
    • 79953773560 scopus 로고    scopus 로고
    • Dietary intake and risk of developing inflammatory bowel disease: A systematic review of the literature
    • [PMID: 21468064 DOI: 10.1038/ajg.2011.44]
    • Hou JK, Abraham B, El-Serag H. Dietary intake and risk of developing inflammatory bowel disease: a systematic review of the literature. Am J Gastroenterol 2011; 106: 563-573 [PMID: 21468064 DOI: 10.1038/ajg.2011.44]
    • (2011) Am J Gastroenterol , vol.106 , pp. 563-573
    • Hou, J.K.1    Abraham, B.2    El-Serag, H.3
  • 120
    • 0036182819 scopus 로고    scopus 로고
    • Preclinical safety evaluation of recombinant human interleukin-10
    • [PMID: 11846636 DOI: 10.1006/rtph.2001.1504]
    • Rosenblum IY, Johnson RC, Schmahai TJ. Preclinical safety evaluation of recombinant human interleukin-10. Regul Toxicol Pharmacol 2002; 35: 56-71 [PMID: 11846636 DOI: 10.1006/rtph.2001.1504]
    • (2002) Regul Toxicol Pharmacol , vol.35 , pp. 56-71
    • Rosenblum, I.Y.1    Johnson, R.C.2    Schmahai, T.J.3
  • 121
    • 0034122396 scopus 로고    scopus 로고
    • Interleukin 10 gene transfer prevents experimental colitis in rats
    • [PMID: 10673295]
    • Barbara G, Xing Z, Hogaboam CM, Gauldie J, Collins SM. Interleukin 10 gene transfer prevents experimental colitis in rats. Gut 2000; 46: 344-349 [PMID: 10673295]
    • (2000) Gut , vol.46 , pp. 344-349
    • Barbara, G.1    Xing, Z.2    Hogaboam, C.M.3    Gauldie, J.4    Collins, S.M.5
  • 122
    • 0029993786 scopus 로고    scopus 로고
    • Tolerance towards resident intestinal flora in mice is abrogated in experimental colitis and restored by treatment with interleukin-10 or antibodies to interleukin-12
    • [PMID: 8625991 DOI: 10.1002/eji.1830260432]
    • Duchmann R, Schmitt E, Knolle P, Meyer zum Büschenfelde KH, Neurath M. Tolerance towards resident intestinal flora in mice is abrogated in experimental colitis and restored by treatment with interleukin-10 or antibodies to interleukin-12. Eur J Immunol 1996; 26: 934-938 [PMID: 8625991 DOI: 10.1002/eji.1830260432]
    • (1996) Eur J Immunol , vol.26 , pp. 934-938
    • Duchmann, R.1    Schmitt, E.2    Knolle, P.3    Meyer zum Büschenfelde, K.H.4    Neurath, M.5
  • 124
    • 0030951387 scopus 로고    scopus 로고
    • Anti-inflammatory properties of interleukin-10 administration in hapten-induced colitis
    • [PMID: 9128846]
    • Ribbons KA, Thompson JH, Liu X, Pennline K, Clark DA, Miller MJ. Anti-inflammatory properties of interleukin-10 administration in hapten-induced colitis. Eur J Pharmacol 1997; 323: 245-254 [PMID: 9128846]
    • (1997) Eur J Pharmacol , vol.323 , pp. 245-254
    • Ribbons, K.A.1    Thompson, J.H.2    Liu, X.3    Pennline, K.4    Clark, D.A.5    Miller, M.J.6
  • 125
    • 28444443002 scopus 로고    scopus 로고
    • Alexander JS. Reversal of experimental colitis disease activity in mice following administration of an adenoviral IL-10 vector
    • [PMID: 16259632 DOI: 10.1186/1476-9255-2-13]
    • Sasaki M, Mathis JM, Jennings MH, Jordan P, Wang Y, Ando T, Joh T, Alexander JS. Reversal of experimental colitis disease activity in mice following administration of an adenoviral IL-10 vector. J Inflamm (Lond) 2005; 2: 13 [PMID: 16259632 DOI: 10.1186/1476-9255-2-13]
    • (2005) J Inflamm (Lond) , vol.2 , pp. 13
    • Sasaki, M.1    Mathis, J.M.2    Jennings, M.H.3    Jordan, P.4    Wang, Y.5    Ando, T.6    Joh, T.7
  • 126
    • 0031900372 scopus 로고    scopus 로고
    • Role of interleukin-10 in a murine model of dextran sulfate sodium-induced colitis
    • [PMID: 9605267]
    • Tomoyose M, Mitsuyama K, Ishida H, Toyonaga A, Tanikawa K. Role of interleukin-10 in a murine model of dextran sulfate sodium-induced colitis. Scand J Gastroenterol 1998; 33: 435-440 [PMID: 9605267]
    • (1998) Scand J Gastroenterol , vol.33 , pp. 435-440
    • Tomoyose, M.1    Mitsuyama, K.2    Ishida, H.3    Toyonaga, A.4    Tanikawa, K.5
  • 129
    • 0037369649 scopus 로고    scopus 로고
    • Local delivery of adenoviral vectors encoding murine interleukin 10 induces colonic interleukin 10 production and is therapeutic for murine colitis
    • [PMID: 12584217]
    • Lindsay JO, Ciesielski CJ, Scheinin T, Brennan FM, Hodgson HJ. Local delivery of adenoviral vectors encoding murine interleukin 10 induces colonic interleukin 10 production and is therapeutic for murine colitis. Gut 2003; 52: 363-369 [PMID: 12584217]
    • (2003) Gut , vol.52 , pp. 363-369
    • Lindsay, J.O.1    Ciesielski, C.J.2    Scheinin, T.3    Brennan, F.M.4    Hodgson, H.J.5
  • 131
    • 0031707727 scopus 로고    scopus 로고
    • Subtherapeutic corticosteroids potentiate the ability of interleukin 10 to prevent chronic inflammation in rats
    • [PMID: 9753488]
    • Herfarth HH, Böcker U, Janardhanam R, Sartor RB. Subtherapeutic corticosteroids potentiate the ability of interleukin 10 to prevent chronic inflammation in rats. Gastroenterology 1998; 115: 856-865 [PMID: 9753488]
    • (1998) Gastroenterology , vol.115 , pp. 856-865
    • Herfarth, H.H.1    Böcker, U.2    Janardhanam, R.3    Sartor, R.B.4


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