-
1
-
-
84896905991
-
Metabolic regulation of immune responses
-
Ganeshan, K. & Chawla, A. Metabolic regulation of immune responses. Annu. Rev. Immunol. 32, 609-634 (2014).
-
(2014)
Annu. Rev. Immunol.
, vol.32
, pp. 609-634
-
-
Ganeshan, K.1
Chawla, A.2
-
2
-
-
84875494365
-
Metabolic regulation of T lymphocytes
-
MacIver, N.J., Michalek, R.D. & Rathmell, J.C. Metabolic regulation of T lymphocytes. Annu. Rev. Immunol. 31, 259-283 (2013).
-
(2013)
Annu. Rev. Immunol.
, vol.31
, pp. 259-283
-
-
Maciver, N.J.1
Michalek, R.D.2
Rathmell, J.C.3
-
3
-
-
84885670616
-
Fueling immunity: Insights into metabolism and lymphocyte function
-
Pearce, E.L., Poffenberger, M.C., Chang, C.H. & Jones, R.G. Fueling immunity: insights into metabolism and lymphocyte function. Science 342, 1242454 (2013).
-
(2013)
Science
, vol.342
, pp. 1242454
-
-
Pearce, E.L.1
Poffenberger, M.C.2
Chang, C.H.3
Jones, R.G.4
-
4
-
-
84903277871
-
Integrating canonical and metabolic signalling programmes in the regulation of T cell responses
-
Pollizzi, K.N. & Powell, J.D. Integrating canonical and metabolic signalling programmes in the regulation of T cell responses. Nat. Rev. Immunol. 14, 435-446 (2014).
-
(2014)
Nat. Rev. Immunol.
, vol.14
, pp. 435-446
-
-
Pollizzi, K.N.1
Powell, J.D.2
-
5
-
-
84859388578
-
Regulation of immune responses by mTOR
-
Powell, J.D., Pollizzi, K.N., Heikamp, E.B. & Horton, M.R. Regulation of immune responses by mTOR. Annu. Rev. Immunol. 30, 39-68 (2012).
-
(2012)
Annu. Rev. Immunol.
, vol.30
, pp. 39-68
-
-
Powell, J.D.1
Pollizzi, K.N.2
Heikamp, E.B.3
Horton, M.R.4
-
6
-
-
80052277906
-
Control of TH17/Treg balance by hypoxia-inducible factor 1
-
Dang, E.V. et al. Control of TH17/Treg balance by hypoxia-inducible factor 1. Cell 146, 772-784 (2011).
-
(2011)
Cell
, vol.146
, pp. 772-784
-
-
Dang, E.V.1
-
7
-
-
84886672916
-
Hypoxia-inducible factors enhance the effector responses of CD8+ T cells to persistent antigen
-
Doedens, A.L. et al. Hypoxia-inducible factors enhance the effector responses of CD8+ T cells to persistent antigen. Nat. Immunol. 14, 1173-1182 (2013).
-
(2013)
Nat. Immunol.
, vol.14
, pp. 1173-1182
-
-
Doedens, A.L.1
-
8
-
-
84878238075
-
Natural and inducible TH17 cells are regulated differently by Akt and mTOR pathways
-
Kim, J.S. et al. Natural and inducible TH17 cells are regulated differently by Akt and mTOR pathways. Nat. Immunol. 14, 611-618 (2013).
-
(2013)
Nat. Immunol.
, vol.14
, pp. 611-618
-
-
Kim, J.S.1
-
9
-
-
79953172571
-
Cutting edge: Distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets
-
Michalek, R.D. et al. Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets. J. Immunol. 186, 3299-3303 (2011).
-
(2011)
J. Immunol.
, vol.186
, pp. 3299-3303
-
-
Michalek, R.D.1
-
10
-
-
79952192382
-
Immune cell regulation by autocrine purinergic signalling
-
Junger, W.G. Immune cell regulation by autocrine purinergic signalling. Nat. Rev. Immunol. 11, 201-212 (2011).
-
(2011)
Nat. Rev. Immunol.
, vol.11
, pp. 201-212
-
-
Junger, W.G.1
-
11
-
-
84888169376
-
Aryl hydrocarbon receptor control of adaptive immunity
-
Quintana, F.J. & Sherr, D.H. Aryl hydrocarbon receptor control of adaptive immunity. Pharmacol. Rev. 65, 1148-1161 (2013).
-
(2013)
Pharmacol. Rev.
, vol.65
, pp. 1148-1161
-
-
Quintana, F.J.1
Sherr, D.H.2
-
12
-
-
82755160805
-
Induction of regulatory Tr1 cells and inhibition of TH17 cells by IL-27
-
Pot, C., Apetoh, L., Awasthi, A. & Kuchroo, V.K. Induction of regulatory Tr1 cells and inhibition of TH17 cells by IL-27. Semin. Immunol. 23, 438-445 (2011).
-
(2011)
Semin. Immunol.
, vol.23
, pp. 438-445
-
-
Pot, C.1
Apetoh, L.2
Awasthi, A.3
Kuchroo, V.K.4
-
13
-
-
33746338535
-
Interleukin-10-secreting type 1 regulatory T cells in rodents and humans
-
Roncarolo, M.G. et al. Interleukin-10-secreting type 1 regulatory T cells in rodents and humans. Immunol. Rev. 212, 28-50 (2006).
-
(2006)
Immunol. Rev.
, vol.212
, pp. 28-50
-
-
Roncarolo, M.G.1
-
14
-
-
84958548312
-
Tr1 cells and the counter-regulation of immunity: Natural mechanisms and therapeutic applications
-
Roncarolo, M.G., Gregori, S., Bacchetta, R. & Battaglia, M. Tr1 cells and the counter-regulation of immunity: natural mechanisms and therapeutic applications. Curr. Top. Microbiol. Immunol. 380, 39-68 (2014).
-
(2014)
Curr. Top. Microbiol. Immunol.
, vol.380
, pp. 39-68
-
-
Roncarolo, M.G.1
Gregori, S.2
Bacchetta, R.3
Battaglia, M.4
-
15
-
-
36248970701
-
A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells
-
Awasthi, A. et al. A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells. Nat. Immunol. 8, 1380-1389 (2007).
-
(2007)
Nat. Immunol.
, vol.8
, pp. 1380-1389
-
-
Awasthi, A.1
-
16
-
-
36248951161
-
Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10
-
Stumhofer, J.S. et al. Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10. Nat. Immunol. 8, 1363-1371 (2007).
-
(2007)
Nat. Immunol.
, vol.8
, pp. 1363-1371
-
-
Stumhofer, J.S.1
-
17
-
-
36248970702
-
Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells
-
Fitzgerald, D.C. et al. Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells. Nat. Immunol. 8, 1372-1379 (2007).
-
(2007)
Nat. Immunol.
, vol.8
, pp. 1372-1379
-
-
Fitzgerald, D.C.1
-
18
-
-
69249083836
-
Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells
-
Pot, C. et al. Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells. J. Immunol. 183, 797-801 (2009).
-
(2009)
J. Immunol.
, vol.183
, pp. 797-801
-
-
Pot, C.1
-
19
-
-
64849083153
-
IL-21 mediates suppressive effects via its induction of IL-10
-
Spolski, R., Kim, H.P., Zhu, W., Levy, D.E. & Leonard, W.J. IL-21 mediates suppressive effects via its induction of IL-10. J. Immunol. 182, 2859-2867 (2009).
-
(2009)
J. Immunol
, vol.182
, pp. 2859-2867
-
-
Spolski, R.1
Kim, H.P.2
Zhu, W.3
Levy, D.E.4
Leonard, W.J.5
-
20
-
-
77955903212
-
The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27
-
Apetoh, L. et al. The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27. Nat. Immunol. 11, 854-861 (2010).
-
(2010)
Nat. Immunol.
, vol.11
, pp. 854-861
-
-
Apetoh, L.1
-
21
-
-
77955859470
-
3+ regulatory T cells
-
3+ regulatory T cells. Nat. Immunol. 11, 846-853 (2010).
-
(2010)
Nat. Immunol.
, vol.11
, pp. 846-853
-
-
Gandhi, R.1
-
22
-
-
84871048026
-
Purinergic signaling during inflammation
-
Eltzschig, H.K., Sitkovsky, M.V. & Robson, S.C. Purinergic signaling during inflammation. N. Engl. J. Med. 367, 2322-2333 (2012).
-
(2012)
N. Engl. J. Med.
, vol.367
, pp. 2322-2333
-
-
Eltzschig, H.K.1
Sitkovsky, M.V.2
Robson, S.C.3
-
23
-
-
77956134431
-
3+ regulatory T cells promotes hepatic metastatic tumor growth in mice
-
3+ regulatory T cells promotes hepatic metastatic tumor growth in mice. Gastroenterology 139, 1030-1040 (2010).
-
(2010)
Gastroenterology
, vol.139
, pp. 1030-1040
-
-
Sun, X.1
-
24
-
-
70149105112
-
IL-27 is a key regulator of IL-10 and IL-17 production by human CD4+ T cells
-
Murugaiyan, G. et al. IL-27 is a key regulator of IL-10 and IL-17 production by human CD4+ T cells. J. Immunol. 183, 2435-2443 (2009).
-
(2009)
J. Immunol
, vol.183
, pp. 2435-2443
-
-
Murugaiyan, G.1
-
25
-
-
42649095378
-
Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor
-
Quintana, F.J. et al. Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor. Nature 453, 65-71 (2008).
-
(2008)
Nature
, vol.453
, pp. 65-71
-
-
Quintana, F.J.1
-
26
-
-
84876798411
-
Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1
-
Wu, C. et al. Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1. Nature 496, 513-517 (2013).
-
(2013)
Nature
, vol.496
, pp. 513-517
-
-
Wu, C.1
-
27
-
-
34250351459
-
Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression
-
Deaglio, S. et al. Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression. J. Exp. Med. 204, 1257-1265 (2007).
-
(2007)
J. Exp. Med.
, vol.204
, pp. 1257-1265
-
-
Deaglio, S.1
-
28
-
-
48249097173
-
CD73 is required for efficient entry of lymphocytes into the central nervous system during experimental autoimmune encephalomyelitis
-
Mills, J.H. et al. CD73 is required for efficient entry of lymphocytes into the central nervous system during experimental autoimmune encephalomyelitis. Proc. Natl. Acad. Sci. USA 105, 9325-9330 (2008).
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 9325-9330
-
-
Mills, J.H.1
-
29
-
-
84864146433
-
Aiolos promotes TH17 differentiation by directly silencing Il2 expression
-
Quintana, F.J. et al. Aiolos promotes TH17 differentiation by directly silencing Il2 expression. Nat. Immunol. 13, 770-777 (2012).
-
(2012)
Nat. Immunol.
, vol.13
, pp. 770-777
-
-
Quintana, F.J.1
-
30
-
-
84880275285
-
Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells
-
Gagliani, N. et al. Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells. Nat. Med. 19, 739-746 (2013).
-
(2013)
Nat. Med.
, vol.19
, pp. 739-746
-
-
Gagliani, N.1
-
31
-
-
33845453812
-
Expression of interleukin-10 in intestinal lymphocytes detected by an interleukin-10 reporter knock-in tiger mouse
-
Kamanaka, M. et al. Expression of interleukin-10 in intestinal lymphocytes detected by an interleukin-10 reporter knock-in tiger mouse. Immunity 25, 941-952 (2006).
-
(2006)
Immunity
, vol.25
, pp. 941-952
-
-
Kamanaka, M.1
-
32
-
-
53649100675
-
ATP drives lamina propria TH17 cell differentiation
-
Atarashi, K. et al. ATP drives lamina propria TH17 cell differentiation. Nature 455, 808-812 (2008).
-
(2008)
Nature
, vol.455
, pp. 808-812
-
-
Atarashi, K.1
-
33
-
-
84900530332
-
Nucleotide signalling during inflammation
-
Idzko, M., Ferrari, D. & Eltzschig, H.K. Nucleotide signalling during inflammation. Nature 509, 310-317 (2014).
-
(2014)
Nature
, vol.509
, pp. 310-317
-
-
Idzko, M.1
Ferrari, D.2
Eltzschig, H.K.3
-
34
-
-
84886728752
-
IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39
-
Mascanfroni, I.D. et al. IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39. Nat. Immunol. 14, 1054-1063 (2013).
-
(2013)
Nat. Immunol.
, vol.14
, pp. 1054-1063
-
-
Mascanfroni, I.D.1
-
35
-
-
84903317982
-
Adenosine triphosphate acts as a paracrine signaling molecule to reduce the motility of T cells
-
Wang, C.M., Ploia, C., Anselmi, F., Sarukhan, A. & Viola, A. Adenosine triphosphate acts as a paracrine signaling molecule to reduce the motility of T cells. EMBO J. 33, 1354-1364 (2014).
-
(2014)
EMBO J.
, vol.33
, pp. 1354-1364
-
-
Wang, C.M.1
Ploia, C.2
Anselmi, F.3
Sarukhan, A.4
Viola, A.5
-
36
-
-
84865792756
-
The P2X7 receptor is a key modulator of aerobic glycolysis
-
Amoroso, F., Falzoni, S., Adinolfi, E., Ferrari, D. & Di Virgilio, F. The P2X7 receptor is a key modulator of aerobic glycolysis. Cell Death Dis. 3, e370 (2012).
-
(2012)
Cell Death Dis.
, vol.3
, pp. e370
-
-
Amoroso, F.1
Falzoni, S.2
Adinolfi, E.3
Ferrari, D.4
Di Virgilio, F.5
-
37
-
-
84872132330
-
Disordered purinergic signaling and abnormal cellular metabolism are associated with development of liver cancer in Cd39/ENTPD1 null mice
-
Sun, X. et al. Disordered purinergic signaling and abnormal cellular metabolism are associated with development of liver cancer in Cd39/ENTPD1 null mice. Hepatology 57, 205-216 (2013).
-
(2013)
Hepatology
, vol.57
, pp. 205-216
-
-
Sun, X.1
-
38
-
-
84856739946
-
Hypoxia-inducible factors in physiology and medicine
-
Semenza, G.L. Hypoxia-inducible factors in physiology and medicine. Cell 148, 399-408 (2012).
-
(2012)
Cell
, vol.148
, pp. 399-408
-
-
Semenza, G.L.1
-
39
-
-
84897019542
-
Oxygen sensing, hypoxia-inducible factors, and disease pathophysiology
-
Semenza, G.L. Oxygen sensing, hypoxia-inducible factors, and disease pathophysiology. Annu. Rev. Pathol. 9, 47-71 (2014).
-
(2014)
Annu. Rev. Pathol.
, vol.9
, pp. 47-71
-
-
Semenza, G.L.1
-
40
-
-
79960369458
-
HIF1a-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells
-
Shi, L.Z. et al. HIF1a-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells. J. Exp. Med. 208, 1367-1376 (2011).
-
(2011)
J. Exp. Med.
, vol.208
, pp. 1367-1376
-
-
Shi, L.Z.1
-
41
-
-
84255199079
-
The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation
-
Wang, R. et al. The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation. Immunity 35, 871-882 (2011).
-
(2011)
Immunity
, vol.35
, pp. 871-882
-
-
Wang, R.1
-
42
-
-
81055126129
-
Estrogen-related receptor - A is a metabolic regulator of effector T-cell activation and differentiation
-
Michalek, R.D. et al. Estrogen-related receptor - a is a metabolic regulator of effector T-cell activation and differentiation. Proc. Natl. Acad. Sci. USA 108, 18348-18353 (2011).
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 18348-18353
-
-
Michalek, R.D.1
-
44
-
-
68649116551
-
Interleukin-10 production by TH1 cells requires interleukin-12-induced STAT4 transcription factor and ERK MAP kinase activation by high antigen dose
-
Saraiva, M. et al. Interleukin-10 production by TH1 cells requires interleukin-12-induced STAT4 transcription factor and ERK MAP kinase activation by high antigen dose. Immunity 31, 209-219 (2009).
-
(2009)
Immunity
, vol.31
, pp. 209-219
-
-
Saraiva, M.1
-
45
-
-
84878831880
-
Posttranscriptional control of T cell effector function by aerobic glycolysis
-
Chang, C.H. et al. Posttranscriptional control of T cell effector function by aerobic glycolysis. Cell 153, 1239-1251 (2013).
-
(2013)
Cell
, vol.153
, pp. 1239-1251
-
-
Chang, C.H.1
-
46
-
-
84867581744
-
A validated regulatory network for TH17 cell specification
-
Ciofani, M. et al. A validated regulatory network for TH17 cell specification. Cell 151, 289-303 (2012).
-
(2012)
Cell
, vol.151
, pp. 289-303
-
-
Ciofani, M.1
-
47
-
-
84876806691
-
Dynamic regulatory network controlling TH17 cell differentiation
-
Yosef, N. et al. Dynamic regulatory network controlling TH17 cell differentiation. Nature 496, 461-468 (2013).
-
(2013)
Nature
, vol.496
, pp. 461-468
-
-
Yosef, N.1
-
48
-
-
0345540629
-
Targeted disruption of cd39/ATP diphosphohydrolase results in disordered hemostasis and thromboregulation
-
Enjyoji, K. et al. Targeted disruption of cd39/ATP diphosphohydrolase results in disordered hemostasis and thromboregulation. Nat. Med. 5, 1010-1017 (1999).
-
(1999)
Nat. Med.
, vol.5
, pp. 1010-1017
-
-
Enjyoji, K.1
-
49
-
-
84900005238
-
IL-21 induces IL-22 production in CD4+ T cells
-
Yeste, A. et al. IL-21 induces IL-22 production in CD4+ T cells. Nat. Commun. 5, 3753 (2014).
-
(2014)
Nat. Commun.
, vol.5
, pp. 3753
-
-
Yeste, A.1
-
50
-
-
84864146433
-
Aiolos promotes TH17 differentiation by directly silencing Il2 expression
-
Quintana, F.J. et al. Aiolos promotes TH17 differentiation by directly silencing Il2 expression. Nat. Immunol. 13, 770-777 (2012).
-
(2012)
Nat. Immunol.
, vol.13
, pp. 770-777
-
-
Quintana, F.J.1
-
51
-
-
41349093966
-
IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival
-
Wofford, J.A., Wieman, H.L., Jacobs, S.R., Zhao, Y. & Rathmell, J.C. IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival. Blood 111, 2101-2111 (2008).
-
(2008)
Blood
, vol.111
, pp. 2101-2111
-
-
Wofford, J.A.1
Wieman, H.L.2
Jacobs, S.R.3
Zhao, Y.4
Rathmell, J.C.5
-
52
-
-
79952414321
-
Vascular CD39/ENTPD1 directly promotes tumor cell growth by scavenging extracellular adenosine triphosphate
-
Feng, L. et al. Vascular CD39/ENTPD1 directly promotes tumor cell growth by scavenging extracellular adenosine triphosphate. Neoplasia 13, 206-216 (2011).
-
(2011)
Neoplasia
, vol.13
, pp. 206-216
-
-
Feng, L.1
|