메뉴 건너뛰기




Volumn 21, Issue 6, 2015, Pages 638-646

Metabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-α

Author keywords

[No Author keywords available]

Indexed keywords

5' NUCLEOTIDASE; ADENOSINE TRIPHOSPHATE; AROMATIC HYDROCARBON RECEPTOR; CD39 ANTIGEN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INTERLEUKIN 10; INTERLEUKIN 27; STAT3 PROTEIN; TRANSCRIPTION FACTOR FOXP3; APYRASE; HIF1A PROTEIN, HUMAN; LEUKOCYTE ANTIGEN;

EID: 84930576092     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.3868     Document Type: Article
Times cited : (368)

References (52)
  • 1
    • 84896905991 scopus 로고    scopus 로고
    • Metabolic regulation of immune responses
    • Ganeshan, K. & Chawla, A. Metabolic regulation of immune responses. Annu. Rev. Immunol. 32, 609-634 (2014).
    • (2014) Annu. Rev. Immunol. , vol.32 , pp. 609-634
    • Ganeshan, K.1    Chawla, A.2
  • 3
    • 84885670616 scopus 로고    scopus 로고
    • Fueling immunity: Insights into metabolism and lymphocyte function
    • Pearce, E.L., Poffenberger, M.C., Chang, C.H. & Jones, R.G. Fueling immunity: insights into metabolism and lymphocyte function. Science 342, 1242454 (2013).
    • (2013) Science , vol.342 , pp. 1242454
    • Pearce, E.L.1    Poffenberger, M.C.2    Chang, C.H.3    Jones, R.G.4
  • 4
    • 84903277871 scopus 로고    scopus 로고
    • Integrating canonical and metabolic signalling programmes in the regulation of T cell responses
    • Pollizzi, K.N. & Powell, J.D. Integrating canonical and metabolic signalling programmes in the regulation of T cell responses. Nat. Rev. Immunol. 14, 435-446 (2014).
    • (2014) Nat. Rev. Immunol. , vol.14 , pp. 435-446
    • Pollizzi, K.N.1    Powell, J.D.2
  • 6
    • 80052277906 scopus 로고    scopus 로고
    • Control of TH17/Treg balance by hypoxia-inducible factor 1
    • Dang, E.V. et al. Control of TH17/Treg balance by hypoxia-inducible factor 1. Cell 146, 772-784 (2011).
    • (2011) Cell , vol.146 , pp. 772-784
    • Dang, E.V.1
  • 7
    • 84886672916 scopus 로고    scopus 로고
    • Hypoxia-inducible factors enhance the effector responses of CD8+ T cells to persistent antigen
    • Doedens, A.L. et al. Hypoxia-inducible factors enhance the effector responses of CD8+ T cells to persistent antigen. Nat. Immunol. 14, 1173-1182 (2013).
    • (2013) Nat. Immunol. , vol.14 , pp. 1173-1182
    • Doedens, A.L.1
  • 8
    • 84878238075 scopus 로고    scopus 로고
    • Natural and inducible TH17 cells are regulated differently by Akt and mTOR pathways
    • Kim, J.S. et al. Natural and inducible TH17 cells are regulated differently by Akt and mTOR pathways. Nat. Immunol. 14, 611-618 (2013).
    • (2013) Nat. Immunol. , vol.14 , pp. 611-618
    • Kim, J.S.1
  • 9
    • 79953172571 scopus 로고    scopus 로고
    • Cutting edge: Distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets
    • Michalek, R.D. et al. Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets. J. Immunol. 186, 3299-3303 (2011).
    • (2011) J. Immunol. , vol.186 , pp. 3299-3303
    • Michalek, R.D.1
  • 10
    • 79952192382 scopus 로고    scopus 로고
    • Immune cell regulation by autocrine purinergic signalling
    • Junger, W.G. Immune cell regulation by autocrine purinergic signalling. Nat. Rev. Immunol. 11, 201-212 (2011).
    • (2011) Nat. Rev. Immunol. , vol.11 , pp. 201-212
    • Junger, W.G.1
  • 11
    • 84888169376 scopus 로고    scopus 로고
    • Aryl hydrocarbon receptor control of adaptive immunity
    • Quintana, F.J. & Sherr, D.H. Aryl hydrocarbon receptor control of adaptive immunity. Pharmacol. Rev. 65, 1148-1161 (2013).
    • (2013) Pharmacol. Rev. , vol.65 , pp. 1148-1161
    • Quintana, F.J.1    Sherr, D.H.2
  • 12
    • 82755160805 scopus 로고    scopus 로고
    • Induction of regulatory Tr1 cells and inhibition of TH17 cells by IL-27
    • Pot, C., Apetoh, L., Awasthi, A. & Kuchroo, V.K. Induction of regulatory Tr1 cells and inhibition of TH17 cells by IL-27. Semin. Immunol. 23, 438-445 (2011).
    • (2011) Semin. Immunol. , vol.23 , pp. 438-445
    • Pot, C.1    Apetoh, L.2    Awasthi, A.3    Kuchroo, V.K.4
  • 13
    • 33746338535 scopus 로고    scopus 로고
    • Interleukin-10-secreting type 1 regulatory T cells in rodents and humans
    • Roncarolo, M.G. et al. Interleukin-10-secreting type 1 regulatory T cells in rodents and humans. Immunol. Rev. 212, 28-50 (2006).
    • (2006) Immunol. Rev. , vol.212 , pp. 28-50
    • Roncarolo, M.G.1
  • 14
    • 84958548312 scopus 로고    scopus 로고
    • Tr1 cells and the counter-regulation of immunity: Natural mechanisms and therapeutic applications
    • Roncarolo, M.G., Gregori, S., Bacchetta, R. & Battaglia, M. Tr1 cells and the counter-regulation of immunity: natural mechanisms and therapeutic applications. Curr. Top. Microbiol. Immunol. 380, 39-68 (2014).
    • (2014) Curr. Top. Microbiol. Immunol. , vol.380 , pp. 39-68
    • Roncarolo, M.G.1    Gregori, S.2    Bacchetta, R.3    Battaglia, M.4
  • 15
    • 36248970701 scopus 로고    scopus 로고
    • A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells
    • Awasthi, A. et al. A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells. Nat. Immunol. 8, 1380-1389 (2007).
    • (2007) Nat. Immunol. , vol.8 , pp. 1380-1389
    • Awasthi, A.1
  • 16
    • 36248951161 scopus 로고    scopus 로고
    • Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10
    • Stumhofer, J.S. et al. Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10. Nat. Immunol. 8, 1363-1371 (2007).
    • (2007) Nat. Immunol. , vol.8 , pp. 1363-1371
    • Stumhofer, J.S.1
  • 17
    • 36248970702 scopus 로고    scopus 로고
    • Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells
    • Fitzgerald, D.C. et al. Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells. Nat. Immunol. 8, 1372-1379 (2007).
    • (2007) Nat. Immunol. , vol.8 , pp. 1372-1379
    • Fitzgerald, D.C.1
  • 18
    • 69249083836 scopus 로고    scopus 로고
    • Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells
    • Pot, C. et al. Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells. J. Immunol. 183, 797-801 (2009).
    • (2009) J. Immunol. , vol.183 , pp. 797-801
    • Pot, C.1
  • 19
    • 64849083153 scopus 로고    scopus 로고
    • IL-21 mediates suppressive effects via its induction of IL-10
    • Spolski, R., Kim, H.P., Zhu, W., Levy, D.E. & Leonard, W.J. IL-21 mediates suppressive effects via its induction of IL-10. J. Immunol. 182, 2859-2867 (2009).
    • (2009) J. Immunol , vol.182 , pp. 2859-2867
    • Spolski, R.1    Kim, H.P.2    Zhu, W.3    Levy, D.E.4    Leonard, W.J.5
  • 20
    • 77955903212 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27
    • Apetoh, L. et al. The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27. Nat. Immunol. 11, 854-861 (2010).
    • (2010) Nat. Immunol. , vol.11 , pp. 854-861
    • Apetoh, L.1
  • 21
    • 77955859470 scopus 로고    scopus 로고
    • 3+ regulatory T cells
    • 3+ regulatory T cells. Nat. Immunol. 11, 846-853 (2010).
    • (2010) Nat. Immunol. , vol.11 , pp. 846-853
    • Gandhi, R.1
  • 23
    • 77956134431 scopus 로고    scopus 로고
    • 3+ regulatory T cells promotes hepatic metastatic tumor growth in mice
    • 3+ regulatory T cells promotes hepatic metastatic tumor growth in mice. Gastroenterology 139, 1030-1040 (2010).
    • (2010) Gastroenterology , vol.139 , pp. 1030-1040
    • Sun, X.1
  • 24
    • 70149105112 scopus 로고    scopus 로고
    • IL-27 is a key regulator of IL-10 and IL-17 production by human CD4+ T cells
    • Murugaiyan, G. et al. IL-27 is a key regulator of IL-10 and IL-17 production by human CD4+ T cells. J. Immunol. 183, 2435-2443 (2009).
    • (2009) J. Immunol , vol.183 , pp. 2435-2443
    • Murugaiyan, G.1
  • 25
    • 42649095378 scopus 로고    scopus 로고
    • Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor
    • Quintana, F.J. et al. Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor. Nature 453, 65-71 (2008).
    • (2008) Nature , vol.453 , pp. 65-71
    • Quintana, F.J.1
  • 26
    • 84876798411 scopus 로고    scopus 로고
    • Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1
    • Wu, C. et al. Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1. Nature 496, 513-517 (2013).
    • (2013) Nature , vol.496 , pp. 513-517
    • Wu, C.1
  • 27
    • 34250351459 scopus 로고    scopus 로고
    • Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression
    • Deaglio, S. et al. Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression. J. Exp. Med. 204, 1257-1265 (2007).
    • (2007) J. Exp. Med. , vol.204 , pp. 1257-1265
    • Deaglio, S.1
  • 28
    • 48249097173 scopus 로고    scopus 로고
    • CD73 is required for efficient entry of lymphocytes into the central nervous system during experimental autoimmune encephalomyelitis
    • Mills, J.H. et al. CD73 is required for efficient entry of lymphocytes into the central nervous system during experimental autoimmune encephalomyelitis. Proc. Natl. Acad. Sci. USA 105, 9325-9330 (2008).
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 9325-9330
    • Mills, J.H.1
  • 29
    • 84864146433 scopus 로고    scopus 로고
    • Aiolos promotes TH17 differentiation by directly silencing Il2 expression
    • Quintana, F.J. et al. Aiolos promotes TH17 differentiation by directly silencing Il2 expression. Nat. Immunol. 13, 770-777 (2012).
    • (2012) Nat. Immunol. , vol.13 , pp. 770-777
    • Quintana, F.J.1
  • 30
    • 84880275285 scopus 로고    scopus 로고
    • Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells
    • Gagliani, N. et al. Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells. Nat. Med. 19, 739-746 (2013).
    • (2013) Nat. Med. , vol.19 , pp. 739-746
    • Gagliani, N.1
  • 31
    • 33845453812 scopus 로고    scopus 로고
    • Expression of interleukin-10 in intestinal lymphocytes detected by an interleukin-10 reporter knock-in tiger mouse
    • Kamanaka, M. et al. Expression of interleukin-10 in intestinal lymphocytes detected by an interleukin-10 reporter knock-in tiger mouse. Immunity 25, 941-952 (2006).
    • (2006) Immunity , vol.25 , pp. 941-952
    • Kamanaka, M.1
  • 32
    • 53649100675 scopus 로고    scopus 로고
    • ATP drives lamina propria TH17 cell differentiation
    • Atarashi, K. et al. ATP drives lamina propria TH17 cell differentiation. Nature 455, 808-812 (2008).
    • (2008) Nature , vol.455 , pp. 808-812
    • Atarashi, K.1
  • 33
    • 84900530332 scopus 로고    scopus 로고
    • Nucleotide signalling during inflammation
    • Idzko, M., Ferrari, D. & Eltzschig, H.K. Nucleotide signalling during inflammation. Nature 509, 310-317 (2014).
    • (2014) Nature , vol.509 , pp. 310-317
    • Idzko, M.1    Ferrari, D.2    Eltzschig, H.K.3
  • 34
    • 84886728752 scopus 로고    scopus 로고
    • IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39
    • Mascanfroni, I.D. et al. IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39. Nat. Immunol. 14, 1054-1063 (2013).
    • (2013) Nat. Immunol. , vol.14 , pp. 1054-1063
    • Mascanfroni, I.D.1
  • 35
    • 84903317982 scopus 로고    scopus 로고
    • Adenosine triphosphate acts as a paracrine signaling molecule to reduce the motility of T cells
    • Wang, C.M., Ploia, C., Anselmi, F., Sarukhan, A. & Viola, A. Adenosine triphosphate acts as a paracrine signaling molecule to reduce the motility of T cells. EMBO J. 33, 1354-1364 (2014).
    • (2014) EMBO J. , vol.33 , pp. 1354-1364
    • Wang, C.M.1    Ploia, C.2    Anselmi, F.3    Sarukhan, A.4    Viola, A.5
  • 37
    • 84872132330 scopus 로고    scopus 로고
    • Disordered purinergic signaling and abnormal cellular metabolism are associated with development of liver cancer in Cd39/ENTPD1 null mice
    • Sun, X. et al. Disordered purinergic signaling and abnormal cellular metabolism are associated with development of liver cancer in Cd39/ENTPD1 null mice. Hepatology 57, 205-216 (2013).
    • (2013) Hepatology , vol.57 , pp. 205-216
    • Sun, X.1
  • 38
    • 84856739946 scopus 로고    scopus 로고
    • Hypoxia-inducible factors in physiology and medicine
    • Semenza, G.L. Hypoxia-inducible factors in physiology and medicine. Cell 148, 399-408 (2012).
    • (2012) Cell , vol.148 , pp. 399-408
    • Semenza, G.L.1
  • 39
    • 84897019542 scopus 로고    scopus 로고
    • Oxygen sensing, hypoxia-inducible factors, and disease pathophysiology
    • Semenza, G.L. Oxygen sensing, hypoxia-inducible factors, and disease pathophysiology. Annu. Rev. Pathol. 9, 47-71 (2014).
    • (2014) Annu. Rev. Pathol. , vol.9 , pp. 47-71
    • Semenza, G.L.1
  • 40
    • 79960369458 scopus 로고    scopus 로고
    • HIF1a-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells
    • Shi, L.Z. et al. HIF1a-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells. J. Exp. Med. 208, 1367-1376 (2011).
    • (2011) J. Exp. Med. , vol.208 , pp. 1367-1376
    • Shi, L.Z.1
  • 41
    • 84255199079 scopus 로고    scopus 로고
    • The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation
    • Wang, R. et al. The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation. Immunity 35, 871-882 (2011).
    • (2011) Immunity , vol.35 , pp. 871-882
    • Wang, R.1
  • 42
    • 81055126129 scopus 로고    scopus 로고
    • Estrogen-related receptor - A is a metabolic regulator of effector T-cell activation and differentiation
    • Michalek, R.D. et al. Estrogen-related receptor - a is a metabolic regulator of effector T-cell activation and differentiation. Proc. Natl. Acad. Sci. USA 108, 18348-18353 (2011).
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 18348-18353
    • Michalek, R.D.1
  • 44
    • 68649116551 scopus 로고    scopus 로고
    • Interleukin-10 production by TH1 cells requires interleukin-12-induced STAT4 transcription factor and ERK MAP kinase activation by high antigen dose
    • Saraiva, M. et al. Interleukin-10 production by TH1 cells requires interleukin-12-induced STAT4 transcription factor and ERK MAP kinase activation by high antigen dose. Immunity 31, 209-219 (2009).
    • (2009) Immunity , vol.31 , pp. 209-219
    • Saraiva, M.1
  • 45
    • 84878831880 scopus 로고    scopus 로고
    • Posttranscriptional control of T cell effector function by aerobic glycolysis
    • Chang, C.H. et al. Posttranscriptional control of T cell effector function by aerobic glycolysis. Cell 153, 1239-1251 (2013).
    • (2013) Cell , vol.153 , pp. 1239-1251
    • Chang, C.H.1
  • 46
    • 84867581744 scopus 로고    scopus 로고
    • A validated regulatory network for TH17 cell specification
    • Ciofani, M. et al. A validated regulatory network for TH17 cell specification. Cell 151, 289-303 (2012).
    • (2012) Cell , vol.151 , pp. 289-303
    • Ciofani, M.1
  • 47
    • 84876806691 scopus 로고    scopus 로고
    • Dynamic regulatory network controlling TH17 cell differentiation
    • Yosef, N. et al. Dynamic regulatory network controlling TH17 cell differentiation. Nature 496, 461-468 (2013).
    • (2013) Nature , vol.496 , pp. 461-468
    • Yosef, N.1
  • 48
    • 0345540629 scopus 로고    scopus 로고
    • Targeted disruption of cd39/ATP diphosphohydrolase results in disordered hemostasis and thromboregulation
    • Enjyoji, K. et al. Targeted disruption of cd39/ATP diphosphohydrolase results in disordered hemostasis and thromboregulation. Nat. Med. 5, 1010-1017 (1999).
    • (1999) Nat. Med. , vol.5 , pp. 1010-1017
    • Enjyoji, K.1
  • 49
    • 84900005238 scopus 로고    scopus 로고
    • IL-21 induces IL-22 production in CD4+ T cells
    • Yeste, A. et al. IL-21 induces IL-22 production in CD4+ T cells. Nat. Commun. 5, 3753 (2014).
    • (2014) Nat. Commun. , vol.5 , pp. 3753
    • Yeste, A.1
  • 50
    • 84864146433 scopus 로고    scopus 로고
    • Aiolos promotes TH17 differentiation by directly silencing Il2 expression
    • Quintana, F.J. et al. Aiolos promotes TH17 differentiation by directly silencing Il2 expression. Nat. Immunol. 13, 770-777 (2012).
    • (2012) Nat. Immunol. , vol.13 , pp. 770-777
    • Quintana, F.J.1
  • 51
    • 41349093966 scopus 로고    scopus 로고
    • IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival
    • Wofford, J.A., Wieman, H.L., Jacobs, S.R., Zhao, Y. & Rathmell, J.C. IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival. Blood 111, 2101-2111 (2008).
    • (2008) Blood , vol.111 , pp. 2101-2111
    • Wofford, J.A.1    Wieman, H.L.2    Jacobs, S.R.3    Zhao, Y.4    Rathmell, J.C.5
  • 52
    • 79952414321 scopus 로고    scopus 로고
    • Vascular CD39/ENTPD1 directly promotes tumor cell growth by scavenging extracellular adenosine triphosphate
    • Feng, L. et al. Vascular CD39/ENTPD1 directly promotes tumor cell growth by scavenging extracellular adenosine triphosphate. Neoplasia 13, 206-216 (2011).
    • (2011) Neoplasia , vol.13 , pp. 206-216
    • Feng, L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.