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Volumn 5, Issue , 2014, Pages

Sequential transcriptional changes dictate safe and effective antigen-specific immunotherapy

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; IMMUNOGLOBULIN E; INTERLEUKIN 10; INTERLEUKIN 2; MBP AC1 9[4Y]; MYELIN BASIC PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR C MAF; TRANSCRIPTION FACTOR NFIL3; UNCLASSIFIED DRUG; AUTOANTIGEN; BASIC LEUCINE ZIPPER TRANSCRIPTION FACTOR; CD223 ANTIGEN; DRUG MIXTURE; FREUND ADJUVANT; HAVCR2 PROTEIN, MOUSE; IL10 PROTEIN, MOUSE; IMMUNOGLOBULIN RECEPTOR; LEUKOCYTE ANTIGEN; MAF PROTEIN, MOUSE; NFIL3 PROTEIN, MOUSE; PDCD1 PROTEIN, MOUSE; PEPTIDE; PROGRAMMED DEATH 1 RECEPTOR; T CELL IG AND ITIM DOMAIN PROTEIN, MOUSE; TRANSCRIPTOME; VIRUS RECEPTOR;

EID: 84907371316     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms5741     Document Type: Article
Times cited : (144)

References (58)
  • 1
    • 78049232715 scopus 로고    scopus 로고
    • Antigen-specific immunotherapy of autoimmune and allergic diseases
    • Sabatos-Peyton, C. A., Verhagen, J. & Wraith, D. C. Antigen-specific immunotherapy of autoimmune and allergic diseases. Curr. Opin. Immunol. 22, 609-615 (2010).
    • (2010) Curr. Opin. Immunol. , vol.22 , pp. 609-615
    • Sabatos-Peyton, C.A.1    Verhagen, J.2    Wraith, D.C.3
  • 2
    • 34548204279 scopus 로고    scopus 로고
    • Antigen-specific tolerance strategies for the prevention and treatment of autoimmune disease
    • Miller, S. D., Turley, D. M. & Podojil, J. R. Antigen-specific tolerance strategies for the prevention and treatment of autoimmune disease. Nat. Rev. Immunol. 7, 665-677 (2007).
    • (2007) Nat. Rev. Immunol. , vol.7 , pp. 665-677
    • Miller, S.D.1    Turley, D.M.2    Podojil, J.R.3
  • 3
    • 14844346513 scopus 로고    scopus 로고
    • Very low-dose tolerance with nucleosomal peptides controls lupus and induces potent regulatory T cell subsets
    • Kang, H. K., Michaels, M. A., Berner, B. R. & Datta, S. K. Very low-dose tolerance with nucleosomal peptides controls lupus and induces potent regulatory T cell subsets. J. Immunol. 174, 3247-3255 (2005).
    • (2005) J. Immunol. , vol.174 , pp. 3247-3255
    • Kang, H.K.1    Michaels, M.A.2    Berner, B.R.3    Datta, S.K.4
  • 4
    • 58249118715 scopus 로고    scopus 로고
    • Tolerization with Hsp65 induces protection against adjuvant-induced arthritis by modulating the antigen-directed interferon-gamma, interleukin-17, and antibody responses
    • Satpute, S. R., Rajaiah, R., Polumuri, S. K. & Moudgil, K. D. Tolerization with Hsp65 induces protection against adjuvant-induced arthritis by modulating the antigen-directed interferon-gamma, interleukin-17, and antibody responses. Arthritis Rheum. 60, 103-113 (2009).
    • (2009) Arthritis Rheum. , vol.60 , pp. 103-113
    • Satpute, S.R.1    Rajaiah, R.2    Polumuri, S.K.3    Moudgil, K.D.4
  • 5
    • 77149140452 scopus 로고    scopus 로고
    • Antigen-specific tolerance inhibits autoimmune uveitis in pre-sensitized animals by deletion and CD4+CD25+ T-regulatory cells
    • Matta, B., Jha, P., Bora, P. S. & Bora, N. S. Antigen-specific tolerance inhibits autoimmune uveitis in pre-sensitized animals by deletion and CD4+CD25+ T-regulatory cells. Immunol. Cell Biol. 88, 187-196 (2010).
    • (2010) Immunol. Cell Biol. , vol.88 , pp. 187-196
    • Matta, B.1    Jha, P.2    Bora, P.S.3    Bora, N.S.4
  • 6
    • 33746446276 scopus 로고    scopus 로고
    • Intravenous synthetic peptide MBP8298 delayed disease progression in an HLA Class II-defined cohort of patients with progressive multiple sclerosis: Results of a 24-month double-blind placebo-controlled clinical trial and 5 years of follow-up treatment
    • Warren, K. G., Catz, I., Ferenczi, L. Z. & Krantz, M. J. Intravenous synthetic peptide MBP8298 delayed disease progression in an HLA Class II-defined cohort of patients with progressive multiple sclerosis: results of a 24-month double-blind placebo-controlled clinical trial and 5 years of follow-up treatment. Eur. J. Neurol. 13, 887-895 (2006).
    • (2006) Eur. J. Neurol. , vol.13 , pp. 887-895
    • Warren, K.G.1    Catz, I.2    Ferenczi, L.Z.3    Krantz, M.J.4
  • 7
    • 70350521825 scopus 로고    scopus 로고
    • Epitope-specific immunotherapy of rheumatoid arthritis: Clinical responsiveness occurs with immune deviation and relies on the expression of a cluster of molecules associated with T cell tolerance in a double-blind, placebo-controlled, pilot phase II trial
    • Koffeman, E. C. et al. Epitope-specific immunotherapy of rheumatoid arthritis: clinical responsiveness occurs with immune deviation and relies on the expression of a cluster of molecules associated with T cell tolerance in a double-blind, placebo-controlled, pilot phase II trial. Arthritis Rheum. 60, 3207-3216 (2009).
    • (2009) Arthritis Rheum. , vol.60 , pp. 3207-3216
    • Koffeman, E.C.1
  • 8
    • 58149302798 scopus 로고    scopus 로고
    • Proinsulin peptide immunotherapy in type 1 diabetes: Report of a first-in-man Phase I safety study
    • Thrower, S. L. et al. Proinsulin peptide immunotherapy in type 1 diabetes: report of a first-in-man Phase I safety study. Clin. Exp. Immunol. 155, 156-165 (2009).
    • (2009) Clin. Exp. Immunol. , vol.155 , pp. 156-165
    • Thrower, S.L.1
  • 9
    • 79952302102 scopus 로고    scopus 로고
    • A randomized controlled study of peanut oral immunotherapy: Clinical desensitization and modulation of the allergic response
    • Varshney, P. et al. A randomized controlled study of peanut oral immunotherapy: clinical desensitization and modulation of the allergic response. J. Allergy Clin. Immunol. 127, 654-660 (2011).
    • (2011) J. Allergy Clin. Immunol. , vol.127 , pp. 654-660
    • Varshney, P.1
  • 10
    • 84864005869 scopus 로고    scopus 로고
    • Oral immunotherapy for treatment of egg allergy in children
    • Burks, A. W. et al. Oral immunotherapy for treatment of egg allergy in children. New Engl. J. Med. 367, 233-243 (2012).
    • (2012) New Engl. J. Med. , vol.367 , pp. 233-243
    • Burks, A.W.1
  • 11
    • 84869111251 scopus 로고    scopus 로고
    • Birch pollen immunotherapy results in long-term loss of Bet v 1-specific TH2 responses, transient TR1 activation, and synthesis of IgE-blocking antibodies
    • Mobs, C. et al. Birch pollen immunotherapy results in long-term loss of Bet v 1-specific TH2 responses, transient TR1 activation, and synthesis of IgE-blocking antibodies. J. Allergy Clin. Immunol. 130, 1108-1116.e6 (2012).
    • (2012) J. Allergy Clin. Immunol. , vol.130
    • Mobs, C.1
  • 12
    • 67650492400 scopus 로고    scopus 로고
    • Peptide immunotherapy in allergic asthma generates IL-10-dependent immunological tolerance associated with linked epitope suppression
    • Campbell, J. D. et al. Peptide immunotherapy in allergic asthma generates IL-10-dependent immunological tolerance associated with linked epitope suppression. J. Exp. Med. 206, 1535-1547 (2009).
    • (2009) J. Exp. Med. , vol.206 , pp. 1535-1547
    • Campbell, J.D.1
  • 13
    • 77955549725 scopus 로고    scopus 로고
    • Subcutaneous insulin B:9-23/IFA immunisation induces Tregs that control late-stage prediabetes in NOD mice through IL-10 and IFNgamma
    • Fousteri, G. et al. Subcutaneous insulin B:9-23/IFA immunisation induces Tregs that control late-stage prediabetes in NOD mice through IL-10 and IFNgamma. Diabetologia 53, 1958-1970 (2010).
    • (2010) Diabetologia , vol.53 , pp. 1958-1970
    • Fousteri, G.1
  • 14
    • 33645301858 scopus 로고    scopus 로고
    • Induction of interleukin-10 and suppressor of cytokine signalling-3 gene expression following peptide immunotherapy
    • Tarzi, M. et al. Induction of interleukin-10 and suppressor of cytokine signalling-3 gene expression following peptide immunotherapy. Clin. Exp. Allergy 36, 465-474 (2006).
    • (2006) Clin. Exp. Allergy , vol.36 , pp. 465-474
    • Tarzi, M.1
  • 15
    • 0028824098 scopus 로고
    • Low avidity recognition of self-antigen by T cells permits escape from central tolerance
    • Liu, G. Y. et al. Low avidity recognition of self-antigen by T cells permits escape from central tolerance. Immunity 3, 407-415 (1995).
    • (1995) Immunity , vol.3 , pp. 407-415
    • Liu, G.Y.1
  • 16
    • 0032821774 scopus 로고    scopus 로고
    • Peptideinduced T cell regulation of experimental autoimmune encephalomyelitis: A role for IL-10
    • Burkhart, C., Liu, G. Y., Anderton, S. M., Metzler, B. & Wraith, D. C. Peptideinduced T cell regulation of experimental autoimmune encephalomyelitis: a role for IL-10. Int. Immunol. 11, 1625-1634 (1999).
    • (1999) Int. Immunol. , vol.11 , pp. 1625-1634
    • Burkhart, C.1    Liu, G.Y.2    Anderton, S.M.3    Metzler, B.4    Wraith, D.C.5
  • 17
    • 77951720536 scopus 로고    scopus 로고
    • Antigenic strength controls the generation of antigen-specific IL-10-secreting T regulatory cells
    • Gabrysova, L. & Wraith, D. C. Antigenic strength controls the generation of antigen-specific IL-10-secreting T regulatory cells. Eur. J. Immunol. 40, 1386-1395 (2010).
    • (2010) Eur. J. Immunol. , vol.40 , pp. 1386-1395
    • Gabrysova, L.1    Wraith, D.C.2
  • 18
    • 0037310355 scopus 로고    scopus 로고
    • Role for IL-10 in suppression mediated by Peptide-induced regulatory T cells in vivo
    • Sundstedt, A., O'Neill, E. J., Nicolson, K. S. & Wraith, D. C. Role for IL-10 in suppression mediated by Peptide-induced regulatory T cells in vivo. J. Immunol. 170, 1240-1248 (2003).
    • (2003) J. Immunol. , vol.170 , pp. 1240-1248
    • Sundstedt, A.1    O'Neill, E.J.2    Nicolson, K.S.3    Wraith, D.C.4
  • 19
    • 33646015692 scopus 로고    scopus 로고
    • Antigen-induced IL-10+ regulatory T cells are independent of CD25+ regulatory cells for their growth, differentiation, and function
    • Nicolson, K. S. et al. Antigen-induced IL-10+ regulatory T cells are independent of CD25+ regulatory cells for their growth, differentiation, and function. J. Immunol. 176, 5329-5337 (2006).
    • (2006) J. Immunol. , vol.176 , pp. 5329-5337
    • Nicolson, K.S.1
  • 20
    • 33745335278 scopus 로고    scopus 로고
    • Persistent antigenic stimulation alters the transcription program in T cells, resulting in antigen-specific tolerance
    • Anderson, P. O. et al. Persistent antigenic stimulation alters the transcription program in T cells, resulting in antigen-specific tolerance. Eur. J. Immunol. 36, 1374-1385 (2006).
    • (2006) Eur. J. Immunol. , vol.36 , pp. 1374-1385
    • Anderson, P.O.1
  • 21
    • 68149100383 scopus 로고    scopus 로고
    • Negative feedback control of the autoimmune response through antigen-induced differentiation of IL-10-secreting Th1 cells
    • Gabrysova, L. et al. Negative feedback control of the autoimmune response through antigen-induced differentiation of IL-10-secreting Th1 cells. J. Exp. Med. 206, 1755-1767 (2009).
    • (2009) J. Exp. Med. , vol.206 , pp. 1755-1767
    • Gabrysova, L.1
  • 22
    • 84876903600 scopus 로고    scopus 로고
    • Update on allergy immunotherapy: American Academy of Allergy, Asthma & Immunology/European Academy of Allergy and Clinical Immunology/PRACTALL consensus report
    • Burks, A. W. et al. Update on allergy immunotherapy: American Academy of Allergy, Asthma & Immunology/European Academy of Allergy and Clinical Immunology/PRACTALL consensus report. J. Allergy Clin. Immunol. 131, 1288-1296.e3 (2013).
    • (2013) J. Allergy Clin. Immunol. , vol.131
    • Burks, A.W.1
  • 23
    • 17644401678 scopus 로고    scopus 로고
    • Peptide-based therapeutic vaccines for allergic and autoimmune diseases
    • Larche, M. & Wraith, D. C. Peptide-based therapeutic vaccines for allergic and autoimmune diseases. Nat. Med. 11, S69-S76 (2005).
    • (2005) Nat. Med. , vol.11
    • Larche, M.1    Wraith, D.C.2
  • 24
    • 0029151763 scopus 로고
    • Affinity for class II MHC determines the extent to which soluble peptides tolerize autoreactive T cells in naive and primed adult mice - implications for autoimmunity
    • Liu, G. Y. & Wraith, D. C. Affinity for class II MHC determines the extent to which soluble peptides tolerize autoreactive T cells in naive and primed adult mice - implications for autoimmunity. Int. Immunol. 7, 1255-1263 (1995).
    • (1995) Int. Immunol. , vol.7 , pp. 1255-1263
    • Liu, G.Y.1    Wraith, D.C.2
  • 25
    • 0035286208 scopus 로고    scopus 로고
    • An unexpected version of horror autotoxicus: Anaphylactic shock to a self-peptide
    • Pedotti, R. et al. An unexpected version of horror autotoxicus: anaphylactic shock to a self-peptide. Nat. Immunol. 2, 216-222 (2001).
    • (2001) Nat. Immunol. , vol.2 , pp. 216-222
    • Pedotti, R.1
  • 26
    • 22144479728 scopus 로고    scopus 로고
    • Differential induction of IgE-mediated anaphylaxis after soluble vs. Cell-bound tolerogenic peptide therapy of autoimmune encephalomyelitis
    • Smith, C. E., Eagar, T. N., Strominger, J. L. & Miller, S. D. Differential induction of IgE-mediated anaphylaxis after soluble vs. cell-bound tolerogenic peptide therapy of autoimmune encephalomyelitis. Proc. Natl Acad. Sci. USA 102, 9595-9600 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 9595-9600
    • Smith, C.E.1    Eagar, T.N.2    Strominger, J.L.3    Miller, S.D.4
  • 27
    • 68649116551 scopus 로고    scopus 로고
    • Interleukin-10 production by Th1 cells requires interleukin-12-induced STAT4 transcription factor and ERK MAP kinase activation by high antigen dose
    • Saraiva, M. et al. Interleukin-10 production by Th1 cells requires interleukin-12-induced STAT4 transcription factor and ERK MAP kinase activation by high antigen dose. Immunity 31, 209-219 (2009).
    • (2009) Immunity , vol.31 , pp. 209-219
    • Saraiva, M.1
  • 28
    • 84856567798 scopus 로고    scopus 로고
    • IL-27 promotes IL-10 production by effector Th1 CD4+ T cells: A critical mechanism for protection from severe immunopathology during malaria infection
    • Freitas do Rosario, A. P. et al. IL-27 promotes IL-10 production by effector Th1 CD4+ T cells: a critical mechanism for protection from severe immunopathology during malaria infection. J. Immunol. 188, 1178-1190 (2012).
    • (2012) J. Immunol. , vol.188 , pp. 1178-1190
    • Freitas Do Rosario, A.P.1
  • 30
    • 58149306013 scopus 로고    scopus 로고
    • In vivo switch to IL-10-secreting T regulatory cells in high dose allergen exposure
    • Meiler, F. et al. In vivo switch to IL-10-secreting T regulatory cells in high dose allergen exposure. J. Exp. Med. 205, 2887-2898 (2008).
    • (2008) J. Exp. Med. , vol.205 , pp. 2887-2898
    • Meiler, F.1
  • 31
    • 77954911545 scopus 로고    scopus 로고
    • Transcriptome analysis of early organogenesis in human embryos
    • Fang, H. et al. Transcriptome analysis of early organogenesis in human embryos. Dev. Cell 19, 174-184 (2010).
    • (2010) Dev. Cell , vol.19 , pp. 174-184
    • Fang, H.1
  • 32
    • 0037434889 scopus 로고    scopus 로고
    • Component plane presentation integrated self-organizing map for microarray data analysis
    • Xiao, L., Wang, K., Teng, Y. & Zhang, J. Component plane presentation integrated self-organizing map for microarray data analysis. FEBS Lett. 538, 117-124 (2003).
    • (2003) FEBS Lett. , vol.538 , pp. 117-124
    • Xiao, L.1    Wang, K.2    Teng, Y.3    Zhang, J.4
  • 33
    • 0034069495 scopus 로고    scopus 로고
    • Gene ontology: Tool for the unification of biology. The Gene Ontology Consortium
    • Ashburner, M. et al. Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat. Genet. 25, 25-29 (2000).
    • (2000) Nat. Genet. , vol.25 , pp. 25-29
    • Ashburner, M.1
  • 34
    • 84859727275 scopus 로고    scopus 로고
    • The Mouse Genome Database (MGD): Comprehensive resource for genetics and genomics of the laboratory mouse
    • Eppig, J. T., Blake, J. A., Bult, C. J., Kadin, J. A. & Richardson, J. E. The Mouse Genome Database (MGD): comprehensive resource for genetics and genomics of the laboratory mouse. Nucleic Acids Res. 40, D881-D886 (2012).
    • (2012) Nucleic Acids Res. , vol.40
    • Eppig, J.T.1    Blake, J.A.2    Bult, C.J.3    Kadin, J.A.4    Richardson, J.E.5
  • 35
    • 58149177166 scopus 로고    scopus 로고
    • Reactome knowledgebase of human biological pathways and processes
    • Matthews, L. et al. Reactome knowledgebase of human biological pathways and processes. Nucleic Acids Res. 37, D619-D622 (2009).
    • (2009) Nucleic Acids Res. , vol.37
    • Matthews, L.1
  • 36
    • 84859699832 scopus 로고    scopus 로고
    • Disease ontology: A backbone for disease semantic integration
    • Schriml, L. M. et al. Disease ontology: a backbone for disease semantic integration. Nucleic Acids Res. 40, D940-D946 (2012).
    • (2012) Nucleic Acids Res. , vol.40
    • Schriml, L.M.1
  • 37
    • 0033590502 scopus 로고    scopus 로고
    • ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28
    • Hutloff, A. et al. ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28. Nature 397, 263-266 (1999).
    • (1999) Nature , vol.397 , pp. 263-266
    • Hutloff, A.1
  • 38
    • 69249083836 scopus 로고    scopus 로고
    • Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells
    • Pot, C. et al. Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells. J. Immunol. 183, 797-801 (2009).
    • (2009) J. Immunol. , vol.183 , pp. 797-801
    • Pot, C.1
  • 39
    • 79954992071 scopus 로고    scopus 로고
    • The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells
    • Motomura, Y. et al. The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells. Nat. Immunol. 12, 450-459 (2011).
    • (2011) Nat. Immunol. , vol.12 , pp. 450-459
    • Motomura, Y.1
  • 40
    • 77955903212 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27
    • Apetoh, L. et al. The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27. Nat. Immunol. 11, 854-861 (2010).
    • (2010) Nat. Immunol. , vol.11 , pp. 854-861
    • Apetoh, L.1
  • 41
    • 33847001284 scopus 로고    scopus 로고
    • The kinases aurora B and mTOR regulate the G1-S cell cycle progression of T lymphocytes
    • Song, J., Salek-Ardakani, S., So, T. & Croft, M. The kinases aurora B and mTOR regulate the G1-S cell cycle progression of T lymphocytes. Nat. Immunol. 8, 64-73 (2007).
    • (2007) Nat. Immunol. , vol.8 , pp. 64-73
    • Song, J.1    Salek-Ardakani, S.2    So, T.3    Croft, M.4
  • 42
    • 0035863821 scopus 로고    scopus 로고
    • Induction of anergy in Th1 cells associated with increased levels of cyclin-dependent kinase inhibitors p21Cip1 and p27Kip1
    • Jackson, S. K., DeLoose, A. & Gilbert, K. M. Induction of anergy in Th1 cells associated with increased levels of cyclin-dependent kinase inhibitors p21Cip1 and p27Kip1. J. Immunol. 166, 952-958 (2001).
    • (2001) J. Immunol. , vol.166 , pp. 952-958
    • Jackson, S.K.1    DeLoose, A.2    Gilbert, K.M.3
  • 43
    • 33845453812 scopus 로고    scopus 로고
    • Expression of interleukin-10 in intestinal lymphocytes detected by an interleukin-10 reporter knockin tiger mouse
    • Kamanaka, M. et al. Expression of interleukin-10 in intestinal lymphocytes detected by an interleukin-10 reporter knockin tiger mouse. Immunity 25, 941-952 (2006).
    • (2006) Immunity , vol.25 , pp. 941-952
    • Kamanaka, M.1
  • 44
    • 84880275285 scopus 로고    scopus 로고
    • Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells
    • Gagliani, N. et al. Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells. Nat. Med. 19, 739-746 (2013).
    • (2013) Nat. Med. , vol.19 , pp. 739-746
    • Gagliani, N.1
  • 45
    • 0033738813 scopus 로고    scopus 로고
    • Antigen-specific therapy for autoimmune disease
    • Harrison, L. C. & Hafler, D. A. Antigen-specific therapy for autoimmune disease. Curr. Opin. Immunol. 12, 704-711 (2000).
    • (2000) Curr. Opin. Immunol. , vol.12 , pp. 704-711
    • Harrison, L.C.1    Hafler, D.A.2
  • 46
    • 0025228924 scopus 로고
    • In vivo cell activation following OKT3 administration. Systemic cytokine release and modulation by corticosteroids
    • Chatenoud, L. et al. In vivo cell activation following OKT3 administration. Systemic cytokine release and modulation by corticosteroids. Transplantation 49, 697-702 (1990).
    • (1990) Transplantation , vol.49 , pp. 697-702
    • Chatenoud, L.1
  • 47
    • 33748416499 scopus 로고    scopus 로고
    • Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412
    • Suntharalingam, G. et al. Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412. New Engl. J. Med. 355, 1018-1028 (2006).
    • (2006) New Engl. J. Med. , vol.355 , pp. 1018-1028
    • Suntharalingam, G.1
  • 48
    • 84897378786 scopus 로고    scopus 로고
    • Immunology: A tolerant approach
    • Garber, K. Immunology: a tolerant approach. Nature 507, 418-420 (2014).
    • (2014) Nature , vol.507 , pp. 418-420
    • Garber, K.1
  • 49
    • 50249230114 scopus 로고
    • Prophylactic innoculation against hay fever
    • Noon, L. Prophylactic innoculation against hay fever. Lancet 1572-1573 (1911).
    • (1911) Lancet , pp. 1572-1573
    • Noon, L.1
  • 51
    • 84883697510 scopus 로고    scopus 로고
    • Regulation of adaptive immunity; the role of interleukin-10
    • Ng, T. H. et al. Regulation of adaptive immunity; the role of interleukin-10. Front Immunol. 4, 129 (2013).
    • (2013) Front Immunol. , vol.4 , pp. 129
    • Ng, T.H.1
  • 52
    • 0030068998 scopus 로고    scopus 로고
    • Regulation of house dust mite responses by intranasally administered peptide: Transient activation of CD4+ T cells precedes the development of tolerance in vivo
    • Hoyne, G. F., Askonas, B. A., Hetzel, C., Thomas, W. R. & Lamb, J. R. Regulation of house dust mite responses by intranasally administered peptide: transient activation of CD4+ T cells precedes the development of tolerance in vivo. Int. Immunol. 8, 335-342 (1996).
    • (1996) Int. Immunol. , vol.8 , pp. 335-342
    • Hoyne, G.F.1    Askonas, B.A.2    Hetzel, C.3    Thomas, W.R.4    Lamb, J.R.5
  • 53
    • 79956077563 scopus 로고    scopus 로고
    • T cell exhaustion
    • Wherry, E. J. T cell exhaustion. Nat. Immunol. 12, 492-499 (2011).
    • (2011) Nat. Immunol. , vol.12 , pp. 492-499
    • Wherry, E.J.1
  • 54
    • 69549124480 scopus 로고    scopus 로고
    • CD4+CD25-LAG3+ regulatory T cells controlled by the transcription factor Egr-2
    • Okamura, T. et al. CD4+CD25-LAG3+ regulatory T cells controlled by the transcription factor Egr-2. Proc. Natl Acad. Sci. USA 106, 13974-13979 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 13974-13979
    • Okamura, T.1
  • 55
    • 33847165817 scopus 로고    scopus 로고
    • Interleukin-10 production by effector T cells: Th1 cells show self control
    • Trinchieri, G. Interleukin-10 production by effector T cells: Th1 cells show self control. J. Exp. Med. 204, 239-243 (2007).
    • (2007) J. Exp. Med. , vol.204 , pp. 239-243
    • Trinchieri, G.1
  • 56
    • 34249678457 scopus 로고    scopus 로고
    • 1 cells control themselves by producing interleukin-10
    • O'Garra, A. & Vieira, P. T(H)1 cells control themselves by producing interleukin-10. Nat. Rev. Immunol. 7, 425-428 (2007).
    • (2007) Nat. Rev. Immunol. , vol.7 , pp. 425-428
    • O'Garra, A.1    Vieira, P.T.2
  • 57
    • 84876001604 scopus 로고    scopus 로고
    • Modification of the FoxP3 transcription factor principally affects inducible T regulatory cells in a model of experimental autoimmune encephalomyelitis
    • Verhagen, J. et al. Modification of the FoxP3 transcription factor principally affects inducible T regulatory cells in a model of experimental autoimmune encephalomyelitis. PLoS ONE 8, e61334 (2013).
    • (2013) PLoS ONE , vol.8
    • Verhagen, J.1
  • 58
    • 0037314097 scopus 로고    scopus 로고
    • Matrix2png: A utility for visualizing matrix data
    • Pavlidis, P. & Noble, W. S. Matrix2png: a utility for visualizing matrix data. Bioinformatics 19, 295-296 (2003).
    • (2003) Bioinformatics , vol.19 , pp. 295-296
    • Pavlidis, P.1    Noble, W.S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.