-
1
-
-
76449098262
-
PHENIX: a comprehensive Python-based system for macromolecular structure solution
-
Adams, P.D., Afonine, P.V., Bunkoczi, G., Chen, V.B., Davis, I.W., Echols, N., Headd, J.J., Hung, L.W., Kapral, G.J., Grosse-Kunstleve, R.W., et al. PHENIX: a comprehensive Python-based system for macromolecular structure solution. Acta. Crystallogr. D. Biol. Crystallogr 66 (2010), 213–221.
-
(2010)
Acta. Crystallogr. D. Biol. Crystallogr
, vol.66
, pp. 213-221
-
-
Adams, P.D.1
Afonine, P.V.2
Bunkoczi, G.3
Chen, V.B.4
Davis, I.W.5
Echols, N.6
Headd, J.J.7
Hung, L.W.8
Kapral, G.J.9
Grosse-Kunstleve, R.W.10
-
2
-
-
0030602796
-
The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal
-
Alcedo, J., Ayzenzon, M., Von Ohlen, T., Noll, M., Hooper, J.E., The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal. Cell 86 (1996), 221–232.
-
(1996)
Cell
, vol.86
, pp. 221-232
-
-
Alcedo, J.1
Ayzenzon, M.2
Von Ohlen, T.3
Noll, M.4
Hooper, J.E.5
-
3
-
-
84982728617
-
Structural basis of Smoothened regulation by its extracellular domains
-
Byrne, E.F.X., Sircar, R., Miller, P.S., Hedger, G., Luchetti, G., Nachtergaele, S., Tully, M.D., Mydock-McGrane, L., Covey, D.F., Rambo, R.P., et al. Structural basis of Smoothened regulation by its extracellular domains. Nature 535 (2016), 517–522.
-
(2016)
Nature
, vol.535
, pp. 517-522
-
-
Byrne, E.F.X.1
Sircar, R.2
Miller, P.S.3
Hedger, G.4
Luchetti, G.5
Nachtergaele, S.6
Tully, M.D.7
Mydock-McGrane, L.8
Covey, D.F.9
Rambo, R.P.10
-
4
-
-
67649392795
-
Crystallizing membrane proteins using lipidic mesophases
-
Caffrey, M., Cherezov, V., Crystallizing membrane proteins using lipidic mesophases. Nat. Protoc. 4 (2009), 706–731.
-
(2009)
Nat. Protoc.
, vol.4
, pp. 706-731
-
-
Caffrey, M.1
Cherezov, V.2
-
5
-
-
0036829397
-
Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened
-
Chen, J.K., Taipale, J., Cooper, M.K., Beachy, P.A., Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened. Genes Dev. 16 (2002), 2743–2748.
-
(2002)
Genes Dev.
, vol.16
, pp. 2743-2748
-
-
Chen, J.K.1
Taipale, J.2
Cooper, M.K.3
Beachy, P.A.4
-
6
-
-
0037195074
-
Small molecule modulation of Smoothened activity
-
Chen, J.K., Taipale, J., Young, K.E., Maiti, T., Beachy, P.A., Small molecule modulation of Smoothened activity. Proc. Natl. Acad. Sci. USA 99 (2002), 14071–14076.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 14071-14076
-
-
Chen, J.K.1
Taipale, J.2
Young, K.E.3
Maiti, T.4
Beachy, P.A.5
-
7
-
-
36448995359
-
High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor
-
Cherezov, V., Rosenbaum, D.M., Hanson, M.A., Rasmussen, S.G., Thian, F.S., Kobilka, T.S., Choi, H.J., Kuhn, P., Weis, W.I., Kobilka, B.K., Stevens, R.C., High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor. Science 318 (2007), 1258–1265.
-
(2007)
Science
, vol.318
, pp. 1258-1265
-
-
Cherezov, V.1
Rosenbaum, D.M.2
Hanson, M.A.3
Rasmussen, S.G.4
Thian, F.S.5
Kobilka, T.S.6
Choi, H.J.7
Kuhn, P.8
Weis, W.I.9
Kobilka, B.K.10
Stevens, R.C.11
-
8
-
-
79953234218
-
Crystal structure of metarhodopsin II
-
Choe, H.W., Kim, Y.J., Park, J.H., Morizumi, T., Pai, E.F., Krauss, N., Hofmann, K.P., Scheerer, P., Ernst, O.P., Crystal structure of metarhodopsin II. Nature 471 (2011), 651–655.
-
(2011)
Nature
, vol.471
, pp. 651-655
-
-
Choe, H.W.1
Kim, Y.J.2
Park, J.H.3
Morizumi, T.4
Pai, E.F.5
Krauss, N.6
Hofmann, K.P.7
Scheerer, P.8
Ernst, O.P.9
-
9
-
-
26644460824
-
Vertebrate Smoothened functions at the primary cilium
-
Corbit, K.C., Aanstad, P., Singla, V., Norman, A.R., Stainier, D.Y., Reiter, J.F., Vertebrate Smoothened functions at the primary cilium. Nature 437 (2005), 1018–1021.
-
(2005)
Nature
, vol.437
, pp. 1018-1021
-
-
Corbit, K.C.1
Aanstad, P.2
Singla, V.3
Norman, A.R.4
Stainier, D.Y.5
Reiter, J.F.6
-
10
-
-
33744788672
-
Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells
-
Corcoran, R.B., Scott, M.P., Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells. Proc. Natl. Acad. Sci. USA 103 (2006), 8408–8413.
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 8408-8413
-
-
Corcoran, R.B.1
Scott, M.P.2
-
11
-
-
85033581529
-
Extending the structural view of class B GPCRs
-
de Graaf, C., Song, G., Cao, C., Zhao, Q., Wang, M.W., Wu, B., Stevens, R.C., Extending the structural view of class B GPCRs. Trends Biochem. Sci. 42 (2017), 946–960.
-
(2017)
Trends Biochem. Sci.
, vol.42
, pp. 946-960
-
-
de Graaf, C.1
Song, G.2
Cao, C.3
Zhao, Q.4
Wang, M.W.5
Wu, B.6
Stevens, R.C.7
-
12
-
-
34247844371
-
Oxysterols are novel activators of the hedgehog signaling pathway in pluripotent mesenchymal cells
-
Dwyer, J.R., Sever, N., Carlson, M., Nelson, S.F., Beachy, P.A., Parhami, F., Oxysterols are novel activators of the hedgehog signaling pathway in pluripotent mesenchymal cells. J. Biol. Chem. 282 (2007), 8959–8968.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 8959-8968
-
-
Dwyer, J.R.1
Sever, N.2
Carlson, M.3
Nelson, S.F.4
Beachy, P.A.5
Parhami, F.6
-
14
-
-
18644368453
-
Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists
-
Frank-Kamenetsky, M., Zhang, X.M., Bottega, S., Guicherit, O., Wichterle, H., Dudek, H., Bumcrot, D., Wang, F.Y., Jones, S., Shulok, J., et al. Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists. J. Biol., 1, 2002, 10.
-
(2002)
J. Biol.
, vol.1
, pp. 10
-
-
Frank-Kamenetsky, M.1
Zhang, X.M.2
Bottega, S.3
Guicherit, O.4
Wichterle, H.5
Dudek, H.6
Bumcrot, D.7
Wang, F.Y.8
Jones, S.9
Shulok, J.10
-
16
-
-
0032869218
-
1998 Warkany lecture: signaling pathways in development
-
Gerhart, J., 1998 Warkany lecture: signaling pathways in development. Teratology 60 (1999), 226–239.
-
(1999)
Teratology
, vol.60
, pp. 226-239
-
-
Gerhart, J.1
-
17
-
-
84862777405
-
Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist
-
Haga, K., Kruse, A.C., Asada, H., Yurugi-Kobayashi, T., Shiroishi, M., Zhang, C., Weis, W.I., Okada, T., Kobilka, B.K., Haga, T., Kobayashi, T., Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist. Nature 482 (2012), 547–551.
-
(2012)
Nature
, vol.482
, pp. 547-551
-
-
Haga, K.1
Kruse, A.C.2
Asada, H.3
Yurugi-Kobayashi, T.4
Shiroishi, M.5
Zhang, C.6
Weis, W.I.7
Okada, T.8
Kobilka, B.K.9
Haga, T.10
Kobayashi, T.11
-
18
-
-
77951901129
-
Structural overview of the nuclear receptor superfamily: insights into physiology and therapeutics
-
Huang, P., Chandra, V., Rastinejad, F., Structural overview of the nuclear receptor superfamily: insights into physiology and therapeutics. Annu. Rev. Physiol. 72 (2010), 247–272.
-
(2010)
Annu. Rev. Physiol.
, vol.72
, pp. 247-272
-
-
Huang, P.1
Chandra, V.2
Rastinejad, F.3
-
19
-
-
84983804225
-
Cellular cholesterol directly activates Smoothened in hedgehog signaling
-
Huang, P., Nedelcu, D., Watanabe, M., Jao, C., Kim, Y., Liu, J., Salic, A., Cellular cholesterol directly activates Smoothened in hedgehog signaling. Cell 166 (2016), 1176–1187.e14.
-
(2016)
Cell
, vol.166
, pp. 1176-1187.e14
-
-
Huang, P.1
Nedelcu, D.2
Watanabe, M.3
Jao, C.4
Kim, Y.5
Liu, J.6
Salic, A.7
-
20
-
-
0035577854
-
Hedgehog signaling in animal development: paradigms and principles
-
Ingham, P.W., McMahon, A.P., Hedgehog signaling in animal development: paradigms and principles. Genes Dev. 15 (2001), 3059–3087.
-
(2001)
Genes Dev.
, vol.15
, pp. 3059-3087
-
-
Ingham, P.W.1
McMahon, A.P.2
-
21
-
-
84863543371
-
Structural basis of Wnt recognition by Frizzled
-
Janda, C.Y., Waghray, D., Levin, A.M., Thomas, C., Garcia, K.C., Structural basis of Wnt recognition by Frizzled. Science 337 (2012), 59–64.
-
(2012)
Science
, vol.337
, pp. 59-64
-
-
Janda, C.Y.1
Waghray, D.2
Levin, A.M.3
Thomas, C.4
Garcia, K.C.5
-
22
-
-
84968796800
-
Extra-helical binding site of a glucagon receptor antagonist
-
Jazayeri, A., Doré A.S., Lamb, D., Krishnamurthy, H., Southall, S.M., Baig, A.H., Bortolato, A., Koglin, M., Robertson, N.J., Errey, J.C., et al. Extra-helical binding site of a glucagon receptor antagonist. Nature 533 (2016), 274–277.
-
(2016)
Nature
, vol.533
, pp. 274-277
-
-
Jazayeri, A.1
Doré, A.S.2
Lamb, D.3
Krishnamurthy, H.4
Southall, S.M.5
Baig, A.H.6
Bortolato, A.7
Koglin, M.8
Robertson, N.J.9
Errey, J.C.10
-
23
-
-
84889564886
-
Activation and allosteric modulation of a muscarinic acetylcholine receptor
-
Kruse, A.C., Ring, A.M., Manglik, A., Hu, J., Hu, K., Eitel, K., Hübner, H., Pardon, E., Valant, C., Sexton, P.M., et al. Activation and allosteric modulation of a muscarinic acetylcholine receptor. Nature 504 (2013), 101–106.
-
(2013)
Nature
, vol.504
, pp. 101-106
-
-
Kruse, A.C.1
Ring, A.M.2
Manglik, A.3
Hu, J.4
Hu, K.5
Eitel, K.6
Hübner, H.7
Pardon, E.8
Valant, C.9
Sexton, P.M.10
-
24
-
-
85012027093
-
Polder maps: improving OMIT maps by excluding bulk solvent
-
Liebschner, D., Afonine, P.V., Moriarty, N.W., Poon, B.K., Sobolev, O.V., Terwilliger, T.C., Adams, P.D., Polder maps: improving OMIT maps by excluding bulk solvent. Acta Crystallogr. D Struct. Biol. 73 (2017), 148–157.
-
(2017)
Acta Crystallogr. D Struct. Biol.
, vol.73
, pp. 148-157
-
-
Liebschner, D.1
Afonine, P.V.2
Moriarty, N.W.3
Poon, B.K.4
Sobolev, O.V.5
Terwilliger, T.C.6
Adams, P.D.7
-
25
-
-
85001130088
-
Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling
-
Luchetti, G., Sircar, R., Kong, J.H., Nachtergaele, S., Sagner, A., Byrne, E.F., Covey, D.F., Siebold, C., Rohatgi, R., Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling. eLife, 5, 2016, e20304.
-
(2016)
eLife
, vol.5
, pp. e20304
-
-
Luchetti, G.1
Sircar, R.2
Kong, J.H.3
Nachtergaele, S.4
Sagner, A.5
Byrne, E.F.6
Covey, D.F.7
Siebold, C.8
Rohatgi, R.9
-
26
-
-
2942738996
-
The Hedgehog response network: sensors, switches, and routers
-
Lum, L., Beachy, P.A., The Hedgehog response network: sensors, switches, and routers. Science 304 (2004), 1755–1759.
-
(2004)
Science
, vol.304
, pp. 1755-1759
-
-
Lum, L.1
Beachy, P.A.2
-
27
-
-
85032034089
-
Structural basis for G protein-coupled receptor activation
-
Manglik, A., Kruse, A.C., Structural basis for G protein-coupled receptor activation. Biochemistry 56 (2017), 5628–5634.
-
(2017)
Biochemistry
, vol.56
, pp. 5628-5634
-
-
Manglik, A.1
Kruse, A.C.2
-
28
-
-
34447508216
-
Phaser crystallographic software
-
McCoy, A.J., Grosse-Kunstleve, R.W., Adams, P.D., Winn, M.D., Storoni, L.C., Read, R.J., Phaser crystallographic software. J. Appl. Cryst. 40 (2007), 658–674.
-
(2007)
J. Appl. Cryst.
, vol.40
, pp. 658-674
-
-
McCoy, A.J.1
Grosse-Kunstleve, R.W.2
Adams, P.D.3
Winn, M.D.4
Storoni, L.C.5
Read, R.J.6
-
29
-
-
84940732236
-
Functional Divergence in the Role of N-Linked Glycosylation in Smoothened Signaling
-
Marada, S., Navarro, G., Truong, A., Stewart, D.P., Arensdorf, A.M., Nachtergaele, S., Angelats, E., Opferman, J.T., Rohatgi, R., McCormick, P.J., Ogden, S.K., Functional Divergence in the Role of N-Linked Glycosylation in Smoothened Signaling. PLoS Genet., 11, 2015, e1005473.
-
(2015)
PLoS Genet.
, vol.11
, pp. e1005473
-
-
Marada, S.1
Navarro, G.2
Truong, A.3
Stewart, D.P.4
Arensdorf, A.M.5
Nachtergaele, S.6
Angelats, E.7
Opferman, J.T.8
Rohatgi, R.9
McCormick, P.J.10
Ogden, S.K.11
-
30
-
-
33745933955
-
HKL-3000: the integration of data reduction and structure solution–from diffraction images to an initial model in minutes
-
Minor, W., Cymborowski, M., Otwinowski, Z., Chruszcz, M., HKL-3000: the integration of data reduction and structure solution–from diffraction images to an initial model in minutes. Acta. Crystallogr. D. Biol. Crystallogr 62 (2006), 859–866.
-
(2006)
Acta. Crystallogr. D. Biol. Crystallogr
, vol.62
, pp. 859-866
-
-
Minor, W.1
Cymborowski, M.2
Otwinowski, Z.3
Chruszcz, M.4
-
31
-
-
84883051342
-
Hedgehog pathway modulation by multiple lipid binding sites on the smoothened effector of signal response
-
Myers, B.R., Sever, N., Chong, Y.C., Kim, J., Belani, J.D., Rychnovsky, S., Bazan, J.F., Beachy, P.A., Hedgehog pathway modulation by multiple lipid binding sites on the smoothened effector of signal response. Dev. Cell 26 (2013), 346–357.
-
(2013)
Dev. Cell
, vol.26
, pp. 346-357
-
-
Myers, B.R.1
Sever, N.2
Chong, Y.C.3
Kim, J.4
Belani, J.D.5
Rychnovsky, S.6
Bazan, J.F.7
Beachy, P.A.8
-
32
-
-
84856098531
-
Oxysterols are allosteric activators of the oncoprotein Smoothened
-
Nachtergaele, S., Mydock, L.K., Krishnan, K., Rammohan, J., Schlesinger, P.H., Covey, D.F., Rohatgi, R., Oxysterols are allosteric activators of the oncoprotein Smoothened. Nat. Chem. Biol. 8 (2012), 211–220.
-
(2012)
Nat. Chem. Biol.
, vol.8
, pp. 211-220
-
-
Nachtergaele, S.1
Mydock, L.K.2
Krishnan, K.3
Rammohan, J.4
Schlesinger, P.H.5
Covey, D.F.6
Rohatgi, R.7
-
33
-
-
84887326705
-
Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling
-
Nachtergaele, S., Whalen, D.M., Mydock, L.K., Zhao, Z., Malinauskas, T., Krishnan, K., Ingham, P.W., Covey, D.F., Siebold, C., Rohatgi, R., Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling. eLife, 2, 2013, e01340.
-
(2013)
eLife
, vol.2
, pp. e01340
-
-
Nachtergaele, S.1
Whalen, D.M.2
Mydock, L.K.3
Zhao, Z.4
Malinauskas, T.5
Krishnan, K.6
Ingham, P.W.7
Covey, D.F.8
Siebold, C.9
Rohatgi, R.10
-
34
-
-
0024440611
-
A protein with several possible membrane-spanning domains encoded by the Drosophila segment polarity gene patched
-
Nakano, Y., Guerrero, I., Hidalgo, A., Taylor, A., Whittle, J.R., Ingham, P.W., A protein with several possible membrane-spanning domains encoded by the Drosophila segment polarity gene patched. Nature 341 (1989), 508–513.
-
(1989)
Nature
, vol.341
, pp. 508-513
-
-
Nakano, Y.1
Guerrero, I.2
Hidalgo, A.3
Taylor, A.4
Whittle, J.R.5
Ingham, P.W.6
-
35
-
-
84883185477
-
Oxysterol binding to the extracellular domain of Smoothened in Hedgehog signaling
-
Nedelcu, D., Liu, J., Xu, Y., Jao, C., Salic, A., Oxysterol binding to the extracellular domain of Smoothened in Hedgehog signaling. Nat. Chem. Biol. 9 (2013), 557–564.
-
(2013)
Nat. Chem. Biol.
, vol.9
, pp. 557-564
-
-
Nedelcu, D.1
Liu, J.2
Xu, Y.3
Jao, C.4
Salic, A.5
-
36
-
-
4344581120
-
The retinal conformation and its environment in rhodopsin in light of a new 2.2 A crystal structure
-
Okada, T., Sugihara, M., Bondar, A.N., Elstner, M., Entel, P., Buss, V., The retinal conformation and its environment in rhodopsin in light of a new 2.2 A crystal structure. J. Mol. Biol. 342 (2004), 571–583.
-
(2004)
J. Mol. Biol.
, vol.342
, pp. 571-583
-
-
Okada, T.1
Sugihara, M.2
Bondar, A.N.3
Elstner, M.4
Entel, P.5
Buss, V.6
-
37
-
-
80051658642
-
Crystal structure of the β2 adrenergic receptor-Gs protein complex
-
Rasmussen, S.G., DeVree, B.T., Zou, Y., Kruse, A.C., Chung, K.Y., Kobilka, T.S., Thian, F.S., Chae, P.S., Pardon, E., Calinski, D., et al. Crystal structure of the β2 adrenergic receptor-Gs protein complex. Nature 477 (2011), 549–555.
-
(2011)
Nature
, vol.477
, pp. 549-555
-
-
Rasmussen, S.G.1
DeVree, B.T.2
Zou, Y.3
Kruse, A.C.4
Chung, K.Y.5
Kobilka, T.S.6
Thian, F.S.7
Chae, P.S.8
Pardon, E.9
Calinski, D.10
-
38
-
-
69949084378
-
GDC-0449-a potent inhibitor of the hedgehog pathway
-
Robarge, K.D., Brunton, S.A., Castanedo, G.M., Cui, Y., Dina, M.S., Goldsmith, R., Gould, S.E., Guichert, O., Gunzner, J.L., Halladay, J., et al. GDC-0449-a potent inhibitor of the hedgehog pathway. Bioorg. Med. Chem. Lett. 19 (2009), 5576–5581.
-
(2009)
Bioorg. Med. Chem. Lett.
, vol.19
, pp. 5576-5581
-
-
Robarge, K.D.1
Brunton, S.A.2
Castanedo, G.M.3
Cui, Y.4
Dina, M.S.5
Goldsmith, R.6
Gould, S.E.7
Guichert, O.8
Gunzner, J.L.9
Halladay, J.10
-
39
-
-
62549159642
-
Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process
-
Rohatgi, R., Milenkovic, L., Corcoran, R.B., Scott, M.P., Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process. Proc. Natl. Acad. Sci. USA 106 (2009), 3196–3201.
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 3196-3201
-
-
Rohatgi, R.1
Milenkovic, L.2
Corcoran, R.B.3
Scott, M.P.4
-
40
-
-
33645211374
-
Purmorphamine activates the Hedgehog pathway by targeting Smoothened
-
Sinha, S., Chen, J.K., Purmorphamine activates the Hedgehog pathway by targeting Smoothened. Nat. Chem. Biol. 2 (2006), 29–30.
-
(2006)
Nat. Chem. Biol.
, vol.2
, pp. 29-30
-
-
Sinha, S.1
Chen, J.K.2
-
41
-
-
0034738979
-
Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine
-
Taipale, J., Chen, J.K., Cooper, M.K., Wang, B., Mann, R.K., Milenkovic, L., Scott, M.P., Beachy, P.A., Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine. Nature 406 (2000), 1005–1009.
-
(2000)
Nature
, vol.406
, pp. 1005-1009
-
-
Taipale, J.1
Chen, J.K.2
Cooper, M.K.3
Wang, B.4
Mann, R.K.5
Milenkovic, L.6
Scott, M.P.7
Beachy, P.A.8
-
42
-
-
0037158748
-
Patched acts catalytically to suppress the activity of Smoothened
-
Taipale, J., Cooper, M.K., Maiti, T., Beachy, P.A., Patched acts catalytically to suppress the activity of Smoothened. Nature 418 (2002), 892–897.
-
(2002)
Nature
, vol.418
, pp. 892-897
-
-
Taipale, J.1
Cooper, M.K.2
Maiti, T.3
Beachy, P.A.4
-
43
-
-
77958508124
-
A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu-Gli protein complexes
-
Tukachinsky, H., Lopez, L.V., Salic, A., A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu-Gli protein complexes. J. Cell Biol. 191 (2010), 415–428.
-
(2010)
J. Cell Biol.
, vol.191
, pp. 415-428
-
-
Tukachinsky, H.1
Lopez, L.V.2
Salic, A.3
-
44
-
-
84865783630
-
Dispatched and scube mediate the efficient secretion of the cholesterol-modified hedgehog ligand
-
Tukachinsky, H., Kuzmickas, R.P., Jao, C.Y., Liu, J., Salic, A., Dispatched and scube mediate the efficient secretion of the cholesterol-modified hedgehog ligand. Cell Rep. 2 (2012), 308–320.
-
(2012)
Cell Rep.
, vol.2
, pp. 308-320
-
-
Tukachinsky, H.1
Kuzmickas, R.P.2
Jao, C.Y.3
Liu, J.4
Salic, A.5
-
45
-
-
0029784223
-
smoothened encodes a receptor-like serpentine protein required for hedgehog signalling
-
van den Heuvel, M., Ingham, P.W., smoothened encodes a receptor-like serpentine protein required for hedgehog signalling. Nature 382 (1996), 547–551.
-
(1996)
Nature
, vol.382
, pp. 547-551
-
-
van den Heuvel, M.1
Ingham, P.W.2
-
46
-
-
62449174504
-
Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation
-
Wang, Y., Zhou, Z., Walsh, C.T., McMahon, A.P., Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation. Proc. Natl. Acad. Sci. USA 106 (2009), 2623–2628.
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 2623-2628
-
-
Wang, Y.1
Zhou, Z.2
Walsh, C.T.3
McMahon, A.P.4
-
47
-
-
84878112106
-
Structure of the human smoothened receptor bound to an antitumour agent
-
Wang, C., Wu, H., Katritch, V., Han, G.W., Huang, X.P., Liu, W., Siu, F.Y., Roth, B.L., Cherezov, V., Stevens, R.C., Structure of the human smoothened receptor bound to an antitumour agent. Nature 497 (2013), 338–343.
-
(2013)
Nature
, vol.497
, pp. 338-343
-
-
Wang, C.1
Wu, H.2
Katritch, V.3
Han, G.W.4
Huang, X.P.5
Liu, W.6
Siu, F.Y.7
Roth, B.L.8
Cherezov, V.9
Stevens, R.C.10
-
48
-
-
84904325982
-
Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs
-
Wang, C., Wu, H., Evron, T., Vardy, E., Han, G.W., Huang, X.P., Hufeisen, S.J., Mangano, T.J., Urban, D.J., Katritch, V., et al. Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs. Nat. Commun., 5, 2014, 4355.
-
(2014)
Nat. Commun.
, vol.5
, pp. 4355
-
-
Wang, C.1
Wu, H.2
Evron, T.3
Vardy, E.4
Han, G.W.5
Huang, X.P.6
Hufeisen, S.J.7
Mangano, T.J.8
Urban, D.J.9
Katritch, V.10
-
49
-
-
84894037590
-
Lipidic cubic phase injector facilitates membrane protein serial femtosecond crystallography
-
Weierstall, U., James, D., Wang, C., White, T.A., Wang, D., Liu, W., Spence, J.C., Bruce Doak, R., Nelson, G., Fromme, P., et al. Lipidic cubic phase injector facilitates membrane protein serial femtosecond crystallography. Nat. Commun., 5, 2014, 3309.
-
(2014)
Nat. Commun.
, vol.5
, pp. 3309
-
-
Weierstall, U.1
James, D.2
Wang, C.3
White, T.A.4
Wang, D.5
Liu, W.6
Spence, J.C.7
Bruce Doak, R.8
Nelson, G.9
Fromme, P.10
-
50
-
-
65249123996
-
Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium
-
Wilson, C.W., Chen, M.H., Chuang, P.T., Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium. PLoS ONE, 4, 2009, e5182.
-
(2009)
PLoS ONE
, vol.4
, pp. e5182
-
-
Wilson, C.W.1
Chen, M.H.2
Chuang, P.T.3
-
51
-
-
0031913524
-
Activating Smoothened mutations in sporadic basal-cell carcinoma
-
Xie, J., Murone, M., Luoh, S.M., Ryan, A., Gu, Q., Zhang, C., Bonifas, J.M., Lam, C.W., Hynes, M., Goddard, A., et al. Activating Smoothened mutations in sporadic basal-cell carcinoma. Nature 391 (1998), 90–92.
-
(1998)
Nature
, vol.391
, pp. 90-92
-
-
Xie, J.1
Murone, M.2
Luoh, S.M.3
Ryan, A.4
Gu, Q.5
Zhang, C.6
Bonifas, J.M.7
Lam, C.W.8
Hynes, M.9
Goddard, A.10
-
52
-
-
85019947839
-
Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand
-
Zhang, X., Zhao, F., Wu, Y., Yang, J., Han, G.W., Zhao, S., Ishchenko, A., Ye, L., Lin, X., Ding, K., et al. Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand. Nat. Commun., 8, 2017, 15383.
-
(2017)
Nat. Commun.
, vol.8
, pp. 15383
-
-
Zhang, X.1
Zhao, F.2
Wu, Y.3
Yang, J.4
Han, G.W.5
Zhao, S.6
Ishchenko, A.7
Ye, L.8
Lin, X.9
Ding, K.10
-
53
-
-
85020380548
-
Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein
-
Zhang, Y., Sun, B., Feng, D., Hu, H., Chu, M., Qu, Q., Tarrasch, J.T., Li, S., Sun Kobilka, T., Kobilka, B.K., Skiniotis, G., Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein. Nature 546 (2017), 248–253.
-
(2017)
Nature
, vol.546
, pp. 248-253
-
-
Zhang, Y.1
Sun, B.2
Feng, D.3
Hu, H.4
Chu, M.5
Qu, Q.6
Tarrasch, J.T.7
Li, S.8
Sun Kobilka, T.9
Kobilka, B.K.10
Skiniotis, G.11
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