Extra-helical binding site of a glucagon receptor antagonist

Nature

Volumn 533, Issue , 2016, Pages 274-277

  Jazayeri, Ali ^a   Doré, Andrew S ^a   Lamb, Daniel ^a   Krishnamurthy, Harini ^a   Southall, Stacey M ^a   Baig, Asma H ^a   Bortolato, Andrea ^a   Koglin, Markus ^a   Robertson, Nathan J ^a   Errey, James C ^a   Andrews, Stephen P ^a   Teobald, Iryna ^a   Brown, Alastair J H ^a   Cooke, Robert M ^a   Weir, Malcolm ^a   Marshall, Fiona H ^a  

^a Heptares Therapeutics Ltd   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOTROPIN RELEASING FACTOR RECEPTOR 1; G PROTEIN COUPLED RECEPTOR; GLUCAGON; GLUCAGON RECEPTOR ANTAGONIST; GLUCOSE; GUANINE NUCLEOTIDE BINDING PROTEIN; MK 0893; UNCLASSIFIED DRUG; BETA ALANINE; CORTICOTROPIN RELEASING FACTOR RECEPTOR; GLUCAGON RECEPTOR; LIGAND; LIPID BILAYER; N-((4-(1-(3-(3,5-DICHLOROPHENYL)-5-(6-METHOXYNAPHTHALEN-2-YL)-1H-PYRAZOL-1-YL)ETHYL)PHENYL)CARBONYL)-BETA-ALANINE; PYRAZOLE DERIVATIVE;

ANATOMY; CELLS AND CELL COMPONENTS; DIABETES; DRUG; GLUCOSE; HOMEOSTASIS; HORMONE; LIGAND; LIPID; PEPTIDE; PROTEIN;

ALLOSTERISM; ARTICLE; CRYSTAL STRUCTURE; DIABETIC PATIENT; DRUG BINDING SITE; DRUG RECEPTOR BINDING; GLUCOSE HOMEOSTASIS; LIGAND BINDING; LIPID BILAYER; MUTAGENESIS; NON INSULIN DEPENDENT DIABETES MELLITUS; POSTPRANDIAL STATE; PRIORITY JOURNAL; RECEPTOR UPREGULATION; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; CLASSIFICATION; DRUG EFFECTS; HUMAN; METABOLISM; PROTEIN CONFORMATION; X RAY CRYSTALLOGRAPHY;

ALLOSTERIC SITE; BETA-ALANINE; CRYSTALLOGRAPHY, X-RAY; GLUCAGON; HUMANS; LIGANDS; LIPID BILAYERS; MODELS, MOLECULAR; PROTEIN CONFORMATION; PYRAZOLES; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; RECEPTORS, GLUCAGON;

EID: 84968796800     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature17414     Document Type: Article

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