Structural basis of Smoothened regulation by its extracellular domains

Nature

Volumn 535, Issue 7613, 2016, Pages 517-522

  Byrne, Eamon F X ^a   Sircar, Ria ^b   Miller, Paul S ^a   Hedger, George ^c   Luchetti, Giovanni ^b   Nachtergaele, Sigrid ^b   Tully, Mark D ^d   Mydock Mcgrane, Laurel ^e   Covey, Douglas F ^e   Rambo, Robert P ^d   Sansom, Mark S P ^c   Newstead, Simon ^c   Rohatgi, Rajat ^b   Siebold, Christian ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d DIAMOND LIGHT SOURCE LTD   (United Kingdom)

^e WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; G PROTEIN COUPLED RECEPTOR; SMOOTHENED PROTEIN; SONIC HEDGEHOG PROTEIN; VISMODEGIB; WNT PROTEIN; ANILIDE; ANTINEOPLASTIC AGENT; CYSTEINE; LIGAND; PROTEIN BINDING; PYRIDINE DERIVATIVE; SMO PROTEIN, HUMAN;

BIOCHEMICAL COMPOSITION; CELLS AND CELL COMPONENTS; CHEMICAL BINDING; CRYSTAL STRUCTURE; LIGAND; PROTEIN; SENSORY SYSTEM;

ARTICLE; BINDING SITE; CELL MEMBRANE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; FIBROBLAST; GENE MUTATION; HUMAN; HYDROGEN BOND; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN STRUCTURE; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG EFFECTS; EXTRACELLULAR SPACE; GENETICS; METABOLISM; MOLECULAR MODEL; PROTEIN STABILITY; PROTEIN TERTIARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

ERINACEIDAE;

ANILIDES; ANTINEOPLASTIC AGENTS; BINDING SITES; CHOLESTEROL; CRYSTALLOGRAPHY, X-RAY; CYSTEINE; EXTRACELLULAR SPACE; HEDGEHOG PROTEINS; HUMANS; LIGANDS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN STABILITY; PROTEIN STRUCTURE, TERTIARY; PYRIDINES; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; SMOOTHENED RECEPTOR;

EID: 84982728617     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature18934     Document Type: Article

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