Cellular Cholesterol Directly Activates Smoothened in Hedgehog Signaling

Cell

Volumn 166, Issue 5, 2016, Pages 1176-1187.e14

  Huang, Pengxiang ^a   Nedelcu, Daniel ^a   Watanabe, Miyako ^a   Jao, Cindy ^a   Kim, Youngchang ^b   Liu, Jing ^a   Salic, Adrian ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b ARGONNE NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; MUTANT PROTEIN; OXYSTEROL; SMOOTHENED PROTEIN; SONIC HEDGEHOG PROTEIN; PROTEIN BINDING;

ARTICLE; BINDING SITE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; INTRACELLULAR SIGNALING; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; REGULATORY MECHANISM; VERTEBRATE; AGONISTS; ANIMAL; CHEMISTRY; METABOLISM; MOUSE; NIH 3T3 CELL LINE; PROTEIN CONFORMATION; SIGNAL TRANSDUCTION; X RAY CRYSTALLOGRAPHY; XENOPUS LAEVIS;

ANIMALS; CHOLESTEROL; CRYSTALLOGRAPHY, X-RAY; HEDGEHOG PROTEINS; MICE; NIH 3T3 CELLS; OXYSTEROLS; PROTEIN BINDING; PROTEIN CONFORMATION; SIGNAL TRANSDUCTION; SMOOTHENED RECEPTOR; XENOPUS LAEVIS;

EID: 84983804225     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2016.08.003     Document Type: Article

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