FUN-LDA: A Latent Dirichlet Allocation Model for Predicting Tissue-Specific Functional Effects of Noncoding Variation: Methods and Applications

American Journal of Human Genetics

Volumn 102, Issue 5, 2018, Pages 920-942

  Backenroth, Daniel ^a   He, Zihuai ^a   Kiryluk, Krzysztof ^a   Boeva, Valentina ^b,c   Pethukova, Lynn ^a   Khurana, Ekta ^d   Christiano, Angela ^a   Buxbaum, Joseph D ^e   Ionita Laza, Iuliana ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b INSERM U900   (France)

^c INSTITUT CURIE   (France)

^d WEILL CORNELL MEDICAL COLLEGE   (United States)

^e MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

functional genomics; noncoding variation; prediction of functional effect

Indexed keywords

ARTICLE; CELLS BY BODY ANATOMY; CONTROLLED STUDY; EMBRYO; EXPRESSION QUANTITATIVE TRAIT LOCUS; FEMALE; FETUS; GENE FUNCTION; GENETIC VARIABILITY; GENOME-WIDE ASSOCIATION STUDY; HERITABILITY; HUMAN; HUMAN CELL; HUMAN TISSUE; LATENT DIRICHLET ALLOCATION MODEL; MALE; MEASUREMENT ACCURACY; MOUSE; NONHUMAN; PREDICTION; PRIORITY JOURNAL; STATISTICAL MODEL; TISSUE SPECIFICITY; VALIDATION STUDY; ALGORITHM; ANTIBODY SPECIFICITY; BIOLOGICAL MODEL; GENE LINKAGE DISEQUILIBRIUM; GENETIC VARIATION; GENETICS; MOLECULAR GENETICS; PROBABILITY; QUANTITATIVE TRAIT LOCUS; REPRODUCIBILITY; SINGLE NUCLEOTIDE POLYMORPHISM; TWINS;

SPACER DNA;

ALGORITHMS; DNA, INTERGENIC; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; HUMANS; LINKAGE DISEQUILIBRIUM; MODELS, GENETIC; MOLECULAR SEQUENCE ANNOTATION; ORGAN SPECIFICITY; POLYMORPHISM, SINGLE NUCLEOTIDE; PROBABILITY; QUANTITATIVE TRAIT LOCI; REPRODUCIBILITY OF RESULTS; TWINS;

EID: 85046171165     PISSN: 00029297     EISSN: 15376605     Source Type: Journal    
DOI: 10.1016/j.ajhg.2018.03.026     Document Type: Article

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