-
1
-
-
77954140531
-
Common SNPs explain a large proportion of the heritability for human height
-
Yang, J., et al. Common SNPs explain a large proportion of the heritability for human height. Nat. Genet. 42, 565-569 (2010).
-
(2010)
Nat. Genet.
, vol.42
, pp. 565-569
-
-
Yang, J.1
-
2
-
-
84860333083
-
Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis
-
Stahl, E.A., et al. Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis. Nat. Genet. 44, 483-489 (2012).
-
(2012)
Nat. Genet.
, vol.44
, pp. 483-489
-
-
Stahl, E.A.1
-
3
-
-
84865790047
-
An integrated encyclopedia of DNA elements in the human genome
-
ENCODE Project Consortium.
-
ENCODE Project Consortium. An integrated encyclopedia of DNA elements in the human genome. Nature 489, 57-74 (2012).
-
(2012)
Nature
, vol.489
, pp. 57-74
-
-
-
4
-
-
84923362619
-
Integrative analysis of 111 reference human epigenomes
-
Roadmap Epigenomics Consortium.
-
Roadmap Epigenomics Consortium. Integrative analysis of 111 reference human epigenomes. Nature 518, 317-330 (2015).
-
(2015)
Nature
, vol.518
, pp. 317-330
-
-
-
5
-
-
84873086126
-
Chromatin marks identify critical cell types for fine mapping complex trait variants
-
Trynka, G., et al. Chromatin marks identify critical cell types for fine mapping complex trait variants. Nat. Genet. 45, 124-130 (2013).
-
(2013)
Nat. Genet.
, vol.45
, pp. 124-130
-
-
Trynka, G.1
-
6
-
-
84937424402
-
Disentangling effects of colocalizing genomic annotations to functionally prioritize non-coding variants within complex trait loci
-
Trynka, G., et al. Disentangling effects of colocalizing genomic annotations to functionally prioritize non-coding variants within complex trait loci. Am. J. Hum. Genet. 97, 139-152 (2015).
-
(2015)
Am. J. Hum. Genet.
, vol.97
, pp. 139-152
-
-
Trynka, G.1
-
7
-
-
84923326765
-
Genetic and epigenetic fine mapping of causal autoimmune disease variants
-
Farh, K.K.-H., et al. Genetic and epigenetic fine mapping of causal autoimmune disease variants. Nature 518, 337-343 (2015).
-
(2015)
Nature
, vol.518
, pp. 337-343
-
-
Farh, K.K.-H.1
-
8
-
-
84908324508
-
Integrating functional data to prioritize causal variants in statistical fine-mapping studies
-
Kichaev, G., et al. Integrating functional data to prioritize causal variants in statistical fine-mapping studies. PLoS Genet. 10, e1004722 (2014).
-
(2014)
PLoS Genet.
, vol.10
, pp. e1004722
-
-
Kichaev, G.1
-
9
-
-
84898723939
-
Joint analysis of functional genomic data and genome-wide association studies of 18 human traits
-
Pickrell, J.K. Joint analysis of functional genomic data and genome-wide association studies of 18 human traits. Am. J. Hum. Genet. 94, 559-573 (2014).
-
(2014)
Am. J. Hum. Genet.
, vol.94
, pp. 559-573
-
-
Pickrell, J.K.1
-
10
-
-
84865822182
-
Systematic localization of common disease-Associated variation in regulatory DNA
-
Maurano, M.T., et al. Systematic localization of common disease-Associated variation in regulatory DNA. Science 337, 1190-1195 (2012).
-
(2012)
Science
, vol.337
, pp. 1190-1195
-
-
Maurano, M.T.1
-
11
-
-
78650856517
-
GCTA: A tool for genome-wide complex trait analysis
-
Yang, J., Lee, S.H., Goddard, M.E., & Visscher, P.M. GCTA: a tool for genome-wide complex trait analysis. Am. J. Hum. Genet. 88, 76-82 (2011).
-
(2011)
Am. J. Hum. Genet.
, vol.88
, pp. 76-82
-
-
Yang, J.1
Lee, S.H.2
Goddard, M.E.3
Visscher, P.M.4
-
12
-
-
84862777863
-
Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs
-
Lee, S.H., et al. Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs. Nat. Genet. 44, 247-250 (2012).
-
(2012)
Nat. Genet.
, vol.44
, pp. 247-250
-
-
Lee, S.H.1
-
13
-
-
84887265151
-
Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture
-
Davis, L.K., et al. Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture. PLoS Genet. 9, e1003864 (2013).
-
(2013)
PLoS Genet.
, vol.9
, pp. e1003864
-
-
Davis, L.K.1
-
14
-
-
84922273141
-
Partitioning heritability of regulatory and cell-Dype-specific variants across 11 common diseases
-
Gusev, A., et al. Partitioning heritability of regulatory and cell-Dype-specific variants across 11 common diseases. Am. J. Hum. Genet. 95, 535-552 (2014).
-
(2014)
Am. J. Hum. Genet.
, vol.95
, pp. 535-552
-
-
Gusev, A.1
-
15
-
-
79959241413
-
Genomic inflation factors under polygenic inheritance
-
Yang, J., et al. Genomic inflation factors under polygenic inheritance. Eur. J. Hum. Genet. 19, 807-812 (2011).
-
(2011)
Eur. J. Hum. Genet.
, vol.19
, pp. 807-812
-
-
Yang, J.1
-
16
-
-
84923946495
-
LD Score regression distinguishes confounding from polygenicity in genome-wide association studies
-
Bulik-Sullivan, B.K., et al. LD Score regression distinguishes confounding from polygenicity in genome-wide association studies. Nat. Genet. 47, 291-295 (2015).
-
(2015)
Nat. Genet.
, vol.47
, pp. 291-295
-
-
Bulik-Sullivan, B.K.1
-
17
-
-
0036079158
-
The human genome browser at UCSC
-
Kent, W.J., et al. The human genome browser at UCSC. Genome Res. 12, 996-1006 (2002).
-
(2002)
Genome Res.
, vol.12
, pp. 996-1006
-
-
Kent, W.J.1
-
18
-
-
84904804929
-
Biological insights from 108 schizophrenia-Associated genetic loci
-
Schizophrenia Working Group of the Psychiatric Genomics Consortium.
-
Schizophrenia Working Group of the Psychiatric Genomics Consortium. Biological insights from 108 schizophrenia-Associated genetic loci. Nature 511, 421-427 (2014).
-
(2014)
Nature
, vol.511
, pp. 421-427
-
-
-
19
-
-
84888015137
-
Super-enhancers in the control of cell identity and disease
-
Hnisz, D., et al. Super-enhancers in the control of cell identity and disease. Cell 155, 934-947 (2013).
-
(2013)
Cell
, vol.155
, pp. 934-947
-
-
Hnisz, D.1
-
20
-
-
84875448918
-
Integrative annotation of chromatin elements from ENCODE data
-
Hoffman, M.M., et al. Integrative annotation of chromatin elements from ENCODE data. Nucleic Acids Res. 41, 827-841 (2013).
-
(2013)
Nucleic Acids Res.
, vol.41
, pp. 827-841
-
-
Hoffman, M.M.1
-
21
-
-
80054973803
-
A high-resolution map of human evolutionary constraint using 29 mammals
-
Lindblad-Doh, K., et al. A high-resolution map of human evolutionary constraint using 29 mammals. Nature 478, 476-482 (2011).
-
(2011)
Nature
, vol.478
, pp. 476-482
-
-
Lindblad-Doh, K.1
-
22
-
-
84866775366
-
Evidence of abundant purifying selection in humans for recently-Acquired regulatory functions
-
Ward, L.D., & Kellis, M. Evidence of abundant purifying selection in humans for recently-Acquired regulatory functions. Science 337, 1675-1678 (2012).
-
(2012)
Science
, vol.337
, pp. 1675-1678
-
-
Ward, L.D.1
Kellis, M.2
-
23
-
-
84897459814
-
An atlas of active enhancers across human cell types and tissues
-
Andersson, R., et al. An atlas of active enhancers across human cell types and tissues. Nature 507, 455-461 (2014).
-
(2014)
Nature
, vol.507
, pp. 455-461
-
-
Andersson, R.1
-
24
-
-
77957947562
-
Hundreds of variants clustered in genomic loci and biological pathways affect human height
-
Lango Allen, H., et al. Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature 467, 832-838 (2010).
-
(2010)
Nature
, vol.467
, pp. 832-838
-
-
Lango Allen, H.1
-
25
-
-
78049337953
-
Association analyses of 249, 796 individuals reveal 18 new loci associated with body mass index
-
Speliotes, E.K., et al. Association analyses of 249, 796 individuals reveal 18 new loci associated with body mass index. Nat. Genet. 42, 937-948 (2010).
-
(2010)
Nat. Genet.
, vol.42
, pp. 937-948
-
-
Speliotes, E.K.1
-
26
-
-
84908024873
-
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche
-
Perry, J.R., et al. Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. Nature 514, 92-97 (2014).
-
(2014)
Nature
, vol.514
, pp. 92-97
-
-
Perry, J.R.1
-
27
-
-
77955505564
-
Biological, clinical and population relevance of 95 loci for blood lipids
-
Teslovich, T.M., et al. Biological, clinical and population relevance of 95 loci for blood lipids. Nature 466, 707-713 (2010).
-
(2010)
Nature
, vol.466
, pp. 707-713
-
-
Teslovich, T.M.1
-
28
-
-
79953204259
-
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
-
Schunkert, H., et al. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat. Genet. 43, 333-338 (2011).
-
(2011)
Nat. Genet.
, vol.43
, pp. 333-338
-
-
Schunkert, H.1
-
29
-
-
84868337361
-
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
-
Morris, A.P., et al. Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat. Genet. 44, 981-990 (2012).
-
(2012)
Nat. Genet.
, vol.44
, pp. 981-990
-
-
Morris, A.P.1
-
30
-
-
84861614905
-
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance
-
Manning, A.K., et al. A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat. Genet. 44, 659-669 (2012).
-
(2012)
Nat. Genet.
, vol.44
, pp. 659-669
-
-
Manning, A.K.1
-
31
-
-
80053385384
-
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4
-
Psychiatric GWAS Consortium Bipolar Disorder Working Group.
-
Psychiatric GWAS Consortium Bipolar Disorder Working Group. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. Nat. Genet. 43, 977-983 (2011).
-
(2011)
Nat. Genet.
, vol.43
, pp. 977-983
-
-
-
32
-
-
84905856652
-
A genome-wide association study of anorexia nervosa
-
Boraska, V., et al. A genome-wide association study of anorexia nervosa. Mol. Psychiatry 19, 1085-1094 (2014).
-
(2014)
Mol. Psychiatry
, vol.19
, pp. 1085-1094
-
-
Boraska, V.1
-
33
-
-
84879271608
-
GWAS of 126, 559 individuals identifies genetic variants associated with educational attainment
-
Rietveld, C.A., et al. GWAS of 126, 559 individuals identifies genetic variants associated with educational attainment. Science 340, 1467-1471 (2013).
-
(2013)
Science
, vol.340
, pp. 1467-1471
-
-
Rietveld, C.A.1
-
34
-
-
77951711343
-
Genome-wide meta-Analyses identify multiple loci associated with smoking behavior
-
Tobacco and Genetics Consortium.
-
Tobacco and Genetics Consortium. Genome-wide meta-Analyses identify multiple loci associated with smoking behavior. Nat. Genet. 42, 441-447 (2010).
-
(2010)
Nat. Genet.
, vol.42
, pp. 441-447
-
-
-
35
-
-
84894288992
-
Genetics of rheumatoid arthritis contributes to biology and drug discovery
-
Okada, Y., et al. Genetics of rheumatoid arthritis contributes to biology and drug discovery. Nature 506, 376-381 (2014).
-
(2014)
Nature
, vol.506
, pp. 376-381
-
-
Okada, Y.1
-
36
-
-
84868336049
-
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease
-
Jostins, L., et al. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature 491, 119-124 (2012).
-
(2012)
Nature
, vol.491
, pp. 119-124
-
-
Jostins, L.1
-
37
-
-
84865859048
-
What does our genome encode?
-
Stamatoyannopoulos, J.A. What does our genome encode? Genome Res. 22, 1602-1611 (2012).
-
(2012)
Genome Res
, vol.22
, pp. 1602-1611
-
-
Stamatoyannopoulos, J.A.1
-
38
-
-
84925283769
-
What are super-enhancers?
-
Pott, S., & Lieb, J.D. What are super-enhancers? Nat. Genet. 47, 8-12 (2015).
-
(2015)
Nat Genet.
, vol.47
, pp. 8-12
-
-
Pott, S.1
Lieb, J.D.2
-
41
-
-
84887072795
-
Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants
-
Parker, S.C.J., et al. Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants. Proc. Natl. Acad. Sci. USA 110, 17921-17926 (2013).
-
(2013)
Proc. Natl. Acad. Sci. USA
, vol.110
, pp. 17921-17926
-
-
Parker, S.C.J.1
-
42
-
-
84895806401
-
Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-Associated variants
-
Pasquali, L., et al. Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-Associated variants. Nat. Genet. 46, 136-143 (2014).
-
(2014)
Nat. Genet.
, vol.46
, pp. 136-143
-
-
Pasquali, L.1
-
43
-
-
84862644604
-
The Th17/Treg imbalance and cytokine environment in peripheral blood of patients with rheumatoid arthritis
-
Wang, W., et al. The Th17/Treg imbalance and cytokine environment in peripheral blood of patients with rheumatoid arthritis. Rheumatol. Int. 32, 887-893 (2012).
-
(2012)
Rheumatol. Int.
, vol.32
, pp. 887-893
-
-
Wang, W.1
-
44
-
-
84902212919
-
Defining the neural basis of appetite and obesity: From genes to behaviour
-
Farooqi, I.S. Defining the neural basis of appetite and obesity: from genes to behaviour. Clin. Med. 14, 286-289 (2014).
-
(2014)
Clin. Med.
, vol.14
, pp. 286-289
-
-
Farooqi, I.S.1
-
45
-
-
85000692305
-
An atlas of genetic correlations across human diseases and traits
-
doi:10.1038/ng.3406 (28 September
-
Bulik-Sullivan B., et al. An atlas of genetic correlations across human diseases and traits. Nat. Genet. doi:10.1038/ng.3406 28 September 2015).
-
(2015)
Nat. Genet.
-
-
Bulik-Sullivan, B.1
-
46
-
-
77956331627
-
Integrating common and rare genetic variation in diverse human populations
-
International HapMap 3 Consortium.
-
International HapMap 3 Consortium. Integrating common and rare genetic variation in diverse human populations. Nature 467, 52-58 (2010).
-
(2010)
Nature
, vol.467
, pp. 52-58
-
-
-
47
-
-
84975795680
-
An integrated map of genetic variation from 1, 092 human genomes
-
1000 Genomes Project Consortium.
-
A1000 Genomes Project Consortium. An integrated map of genetic variation from 1, 092 human genomes. Nature 491, 56-65 (2012).
-
(2012)
Nature
, vol.491
, pp. 56-65
-
-
-
48
-
-
84969213492
-
Genome-wide association study of 14, 000 cases of seven common diseases and 3, 000 shared controls
-
Wellcome Trust Case Control Consortium.
-
Wellcome Trust Case Control Consortium. Genome-wide association study of 14, 000 cases of seven common diseases and 3, 000 shared controls. Nature 446, 661-663 (2007).
-
(2007)
Nature
, vol.446
, pp. 661-663
-
-
-
49
-
-
84895808047
-
Meta-Analysis of gene-level tests for rare variant association
-
Liu, D.J., et al. Meta-Analysis of gene-level tests for rare variant association. Nat. Genet. 46, 200-204 (2014).
-
(2014)
Nat. Genet.
, vol.46
, pp. 200-204
-
-
Liu, D.J.1
|