Integrative annotation of variants from 1092 humans: Application to cancer genomics

Science

Volumn 342, Issue 6154, 2013, Pages

  Khurana, E ^a   Fu, Y ^a   Colonna, V ^a   Mu, X J ^a   Kang, H M ^a   Lappalainen, T ^a   Sboner, A ^a   Lochovsky, L ^a   Chen, J ^a   Harmanci, A ^a   Das, J ^a   Abyzov, A ^a   Balasubramanian, S ^a   Beal, K ^a   Chakravarty, D ^a   Challis, D ^a   Chen, Y ^a   Clarke, D ^a   Clarke, L ^a   Cunningham, F ^a   Evani, U S ^a   Flicek, P ^a   Fragoza, R ^a   Garrison, E ^a   Gibbs, R A ^a   Gumus Z H ^a   Herrero, J ^a   Kitabayashi, N ^a   Kong, Y ^a   Lage, K ^a   Liluashvili, V ^a   Lipkin, S M ^a   MacArthur, D G ^a   Marth, G ^a   Muzny, D ^a   Pers, T H ^a   Ritchie, GRS ^a   Rosenfeld, J A ^a   Sisu, C ^a   Wei, X ^a   Wilson, M ^a   Xue, Y ^a   Yu, F ^a   Dermitzakis, E T ^a   Yu, H ^a   Rubin, M A ^a   Tyler Smith, C ^a   Gerstein, M ^a   Altshuler, D M ^a   Durbin, R M ^a   Abecasis, G R ^a   Bentley, D R ^a   Chakravarti, A ^a   Clark, A G ^a   Donnelly, P ^a   Eichler, E E ^a   Gabriel, S B ^a   Green, E D ^a   Hurles, M E ^a   Knoppers, B M ^a   Korbel, J O ^a   Lander, E S ^a   Lee, C ^a   Lehrach, H ^a   Mardis, E R ^a   McVean, G A ^a   Nickerson, D A ^a   Schmidt, J P ^a   Sherry, S T ^a   Wang, J ^a   Wilson, R K ^a   Dinh, H ^a   Kovar, C ^a   Lee, S ^a   Lewis, L ^a   Reid, J ^a   Wang, M ^a   Fang, X ^a   Guo, X ^a   Jian, M ^a   Jiang, H ^a   Jin, X ^a   Li, G ^a   Li, J ^a   Li, Y ^a   Li, Z ^a   Liu, X ^a   Lu, Y ^a   Ma, X ^a   Su, Z ^a   Tai, S ^a   Tang, M ^a   Wang, B ^a   Wang, G ^a   Wu, H ^a   Wu, R ^a   Yin, Y ^a   Zhang, W ^a   Zhao, J ^a   Zhao, M ^a   Zheng, X ^a   Zhou, Y ^a   Gupta, N ^a   Leinonen, R ^a   Smith, R E ^a   Zheng Bradley, X ^a   Grocock, R ^a   Humphray, S ^a   James, T ^a   Kingsbury, Z ^a   Sudbrak, R ^a   Albrecht, M W ^a   Amstislavskiy, V S ^a   Borodina, T A ^a   Lienhard, M ^a   Mertes, F ^a   Sultan, M ^a   Timmermann, B ^a   Yaspo, M L ^a   Fulton, L ^a   Fulton, R ^a   Weinstock, G M ^a   Balasubramaniam, S ^a   Burton, J ^a   Danecek, P ^a   Keane, T M ^a   Kolb Kokocinski, A ^a   McCarthy, S ^a   Stalker, J ^a   Quail, M ^a   Davies, C J ^a   Gollub, J ^a   Webster, T ^a   Wong, B ^a   Zhan, Y ^a   Auton, A ^a   Bainbridge, M ^a   Lu, J ^a   Nagaswamy, U ^a   Sabo, A ^a   Wang, Y ^a   Yu, J ^a   Coin, L J ^a   Fang, L ^a   Li, Q ^a   Lin, H ^a   Liu, B ^a   Luo, R ^a   Qin, N ^a   Shao, H ^a   Xie, Y ^a   Ye, C ^a   Yu, C ^a   Zhang, F ^a   Zheng, H ^a   Zhu, H ^a   Garrison, E P ^a   Kural, D ^a   Lee, W P ^a   Leong, W F ^a   Ward, A N ^a   Wu, J ^a   Zhang, M ^a   Griffin, L ^a   Hsieh, C H ^a   Mills, R E ^a   Shi, X ^a   von Grotthuss, M ^a   Zhang, C ^a   Daly, M J ^a   DePristo, M A ^a   Banks, E ^a   Bhatia, G ^a   Carneiro, M O ^a   del Angel, G ^a   Genovese, G ^a   Handsaker, R E ^a   Hartl, C ^a   McCarroll, S A ^a   Nemesh, J C ^a   Poplin, R E ^a   Schaffner, S F ^a   Shakir, K ^a   Yoon, S C ^a   Lihm, J ^a   Makarov, V ^a   Jin, H ^a   Kim, W ^a   Kim, K C ^a   Rausch, T ^a   McLaren, W M ^a   Ritchie, G R ^a   Gottipati, S ^a   Keinan, A ^a   Rodriguez Flores, J L ^a   Sabeti, P C ^a   Grossman, S R ^a   Tabrizi, S ^a   Tariyal, R ^a   Cooper, D N ^a   Ball, E V ^a   Stenson, P D ^a   Barnes, B ^a   Bauer, M ^a   Cheetham, R ^a   Cox, T ^a   Eberle, M ^a   Kahn, S ^a   Murray, L ^a   Peden, J ^a   Shaw, R ^a   Ye, K ^a   Batzer, M A ^a   Konkel, M K ^a   Walker, J A ^a   Lek, M ^a   Herwig, R ^a   Shriver, M D ^a   Bustamante, C D ^a   Byrnes, J K ^a   De La Vega, M ^a   Gravel, S ^a   Kenny, E E ^a   Kidd, J M ^a   Lacroute, P ^a   Maples, B K ^a   Moreno Estrada, A ^a   Zakharia, F ^a   Halperin, E ^a   Baran, Y ^a   Craig, D W ^a   Christoforides, A ^a   Homer, N ^a   Izatt, T ^a   Kurdoglu, A A ^a   Sinari, S A ^a   Squire, K ^a   Xiao, C ^a   Sebat, J ^a   Bafna, V ^a   Burchard, E G ^a   Hernandez, R D ^a   Gignoux, C R ^a   Haussler, D ^a   Katzman, S J ^a   Kent, W ^a   Howie, B ^a   Ruiz Linares, A ^a   Devine, S E ^a   Maroo, A ^a   Tallon, L J ^a   Michelson, L P ^a   Anderson, P ^a   Angius, A ^a   Bigham, A ^a   Blackwell, T ^a   Busonero, F ^a   Cucca, F ^a   Fuchsberger, C ^a   Jones, C ^a   Jun, G ^a   Lyons, R ^a   Maschio, A ^a   Porcu, E ^a   Reinier, F ^a   Sanna, S ^a   Schlessinger, D ^a   Sidore, C ^a   Tan, A ^a   Trost, M K ^a   Awadalla, P ^a   Hodgkinson, A ^a   Lunter, G ^a   Marchini, J L ^a   Myers, S ^a   Churchhouse, C ^a   Delaneau, O ^a   Gupta Hinch, A ^a   Iqbal, Z ^a   Mathieson, I ^a   Rimmer, A ^a   Xifara, D K ^a   Oleksyk, T K ^a   Xiong, M ^a   Jorde, L ^a   Witherspoon, D ^a   Xing, J ^a   Browning, B L ^a   Alkan, C ^a   Hajirasouliha, I ^a   Hormozdiari, F ^a   Ko, A ^a   Sudmant, P H ^a   Chen, K ^a   Chinwalla, A ^a   Ding, L ^a   Dooling, D ^a   Koboldt, D C ^a   McLellan, M D ^a   Wallis, J W ^a   Wendl, M C ^a   Zhang, Q ^a   Albers, C A ^a   Ayub, Q ^a   Coffey, A J ^a   Huang, N ^a   Jostins, L ^a   Li, H ^a   Scally, A ^a   Walter, K ^a   Zhang, Y ^a   Gerstein, M B ^a   Habegger, L ^a   Harmanci, A O ^a   Jin, M ^a   Degenhardt, J ^a   Stutz A M ^a   Church, D ^a   Michaelson, J J ^a   Blackburne, B ^a   Lindsay, S J ^a   Ning, Z ^a   De La Vega, F M ^a   Frankish, A ^a   Harrow, J ^a   Kalra, D ^a   Hale, W ^a   Fowler, G ^a   Barker, J ^a   Kelman, G ^a   Kulesha, E ^a   Radhakrishnan, R ^a   Roa, A ^a   Smirnov, D ^a   Streeter, I ^a   Toneva, I ^a   Vaughan, B ^a   Ananiev, V ^a   Belaia, Z ^a   Beloslyudtsev, D ^a   Bouk, N ^a   Chen, C ^a   Cohen, R ^a   Cook, C ^a   Garner, J ^a   Hefferon, T ^a   Kimelman, M ^a   Liu, C ^a   Lopez, J ^a   Meric, P ^a   O'Sullivan, C ^a   Ostapchuk, Y ^a   Phan, L ^a   Ponomarov, S ^a   Schneider, V ^a   Shekhtman, E ^a   Sirotkin, K ^a   Slotta, D ^a   Zhang, H ^a   Barnes, K C ^a   Beiswanger, C ^a   Burchard, E ^a   Cai, H ^a   Cao, H ^a   Gharani, N ^a   Henn, B ^a   Jones, D ^a   Kaye, J S ^a   Kent, A ^a   Kerasidou, A ^a   Mathias, R ^a   Ossorio, P N ^a   Parker, M ^a   Reich, D ^a   Rotimi, C N ^a   Royal, C D ^a   Sandoval, K ^a   Su, Y ^a   Tian, Z ^a   Tishkoff, S ^a   Toji, L H ^a   Via, M ^a   Yang, H ^a   Yang, L ^a   Zhu, J ^a   Bodmer, W ^a   Bedoya, G ^a   Ming, C Z ^a   Yang, G ^a   You, C J ^a   Peltonen, L ^a   Garcia Montero, A ^a   Orfao, A ^a   Dutil, J ^a   Martinez Cruzado, J C ^a   Brooks, L D ^a   Felsenfeld, A L ^a   McEwen, J E ^a   Clemm, N C ^a   Duncanson, A ^a   Dunn, M ^a   Guyer, M S ^a   Peterson, J L ^a   more..

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYRIBONUCLEASE I; FORKHEAD TRANSCRIPTION FACTOR; HUMAN MENOPAUSAL GONADOTROPIN; MADS DOMAIN PROTEIN; PROTEIN C JUN; TRANSCRIPTION FACTOR GATA 1; UNTRANSLATED RNA; WISKOTT ALDRICH SYNDROME PROTEIN; KRUPPEL LIKE FACTOR; ZNF274 PROTEIN, HUMAN;

CANCER; COMPUTER SIMULATION; GENOME; GENOMICS; MUTATION; POLYMORPHISM;

ALLELE; ARTICLE; BINDING SITE; BREAST CANCER; CANCER GENETICS; CHROMATIN IMMUNOPRECIPITATION; DNA BINDING; ENHANCER REGION; GENE DELETION; GENE EXPRESSION; GENE FREQUENCY; GENE INTERACTION; GENETIC ASSOCIATION; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; GENOMICS; HOMOLOGOUS RECOMBINATION; HUMAN; INDEL MUTATION; LOCAL ADAPTATION; LOSS OF FUNCTION MUTATION; MEDULLOBLASTOMA; MULTIPLE CANCER; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN PROTEIN INTERACTION; PURIFYING SELECTION; QUANTITATIVE TRAIT LOCUS; SINGLE NUCLEOTIDE POLYMORPHISM; SOMATIC MUTATION; UNTRANSLATED REGION; GENETIC SELECTION; GENETICS; HUMAN GENOME; METABOLISM; METHODOLOGY; MOLECULAR GENETICS; MUTATION; NEOPLASM; POPULATION;

BINDING SITES; GENETIC VARIATION; GENOME, HUMAN; GENOMICS; HUMANS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MOLECULAR SEQUENCE ANNOTATION; MUTATION; NEOPLASMS; POLYMORPHISM, SINGLE NUCLEOTIDE; POPULATION; RNA, UNTRANSLATED; SELECTION, GENETIC;

EID: 84885639776     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1235587     Document Type: Article

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