Parkinson-associated risk variant in distal enhancer of α-synuclein modulates target gene expression

Nature

Volumn 533, Issue 7601, 2016, Pages 95-99

  Soldner, Frank ^a   Stelzer, Yonatan ^a   Shivalila, Chikdu S ^a,b   Abraham, Brian J ^a   Latourelle, Jeanne C ^c   Barrasa, M Inmaculada ^a   Goldmann, Johanna ^a   Myers, Richard H ^c   Young, Richard A ^a,b   Jaenisch, Rudolf ^a,b  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; MESSENGER RNA; EMPTY SPIRACLES HOMEOBOX PROTEINS; HOMEODOMAIN PROTEIN; NKX6-1 PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

BRAIN; CELLS AND CELL COMPONENTS; DISEASE INCIDENCE; GENE EXPRESSION; GENETIC ANALYSIS; GENETIC MARKER; GENETIC VARIATION; GENOME; PHENOTYPE; PROTEIN; RISK FACTOR;

ARTICLE; CELL DIFFERENTIATION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; CRISPR CAS SYSTEM; ENHANCER REGION; EPIGENETICS; FRONTAL CORTEX; GENE CONTROL; GENE EXPRESSION; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; INTRON; NERVE CELL CULTURE; PARKINSON DISEASE; PATHOGENESIS; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SOUTHERN BLOTTING; ALLELE; BIOLOGICAL MODEL; BRAIN; GENE EXPRESSION REGULATION; GENETIC ENGINEERING; GENETIC EPIGENESIS; GENETIC PREDISPOSITION; GENETICS; HUMAN GENOME; METABOLISM; PLURIPOTENT STEM CELL; RISK;

ALLELES; ALPHA-SYNUCLEIN; BRAIN; CRISPR-CAS SYSTEMS; ENHANCER ELEMENTS, GENETIC; EPIGENESIS, GENETIC; GENE EXPRESSION REGULATION; GENETIC ENGINEERING; GENETIC PREDISPOSITION TO DISEASE; GENOME, HUMAN; HOMEODOMAIN PROTEINS; HUMANS; MODELS, GENETIC; PARKINSON DISEASE; PLURIPOTENT STEM CELLS; RISK; TRANSCRIPTION FACTORS;

EID: 84971238775     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature17939     Document Type: Article

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