A common intronic variant of PARP1 confers melanoma risk and mediates melanocyte growth via regulation of MITF

Nature Genetics

Volumn 49, Issue 9, 2017, Pages 1326-1335

  Choi, Jiyeon ^a   Xu, Mai ^a   Makowski, Matthew M ^b   Zhang, Tongwu ^a   Law, Matthew H ^c   Kovacs, Michael A ^a   Granzhan, Anton ^d   Kim, Wendy J ^a   Parikh, Hemang ^a,e   Gartside, Michael ^c   Trent, Jeffrey M ^f   Teulade Fichou, Marie Paule ^d   Iles, Mark M ^g   Newton Bishop, Julia A ^g   Bishop, D Timothy ^g   Macgregor, Stuart ^c   Hayward, Nicholas K ^c   Vermeulen, Michiel ^b   Brown, Kevin M ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^c QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^d INSERM   (France)

^e UNIVERSITY OF SOUTH FLORIDA   (United States)

^f TRANSLATIONAL GENOMICS RESEARCH INSTITUTE   (United States)

^g UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

MICROPHTHALMIA ASSOCIATED TRANSCRIPTION FACTOR; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; B RAF KINASE; BRAF PROTEIN, HUMAN; MITF PROTEIN, HUMAN; PARP1 PROTEIN, HUMAN; TELOMERASE; TERT PROTEIN, HUMAN;

ALLELE; ALLELIC IMBALANCE; ALTERNATIVE RNA SPLICING; ARTICLE; CANCER GROWTH; CANCER RISK; CELL PROLIFERATION; CONTROLLED STUDY; ECTOPIC EXPRESSION; GENE EXPRESSION; GENOTYPE; HUMAN; HUMAN CELL; INTRON; MELANOCYTE; MELANOMA; PHENOTYPE; PRIORITY JOURNAL; PROTEOMICS; QUANTITATIVE TRAIT LOCUS; TRANSCRIPTION INITIATION; CELL AGING; CELL CULTURE; CELL TRANSFORMATION; CONFOCAL MICROSCOPY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; IMMUNOBLOTTING; INDEL MUTATION; METABOLISM; NUCLEOTIDE SEQUENCE; PATHOLOGY; PROCEDURES; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; TUMOR CELL LINE;

BASE SEQUENCE; CELL AGING; CELL LINE, TUMOR; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOBLOTTING; INDEL MUTATION; INTRONS; MELANOCYTES; MELANOMA; MICROPHTHALMIA-ASSOCIATED TRANSCRIPTION FACTOR; MICROSCOPY, CONFOCAL; POLY (ADP-RIBOSE) POLYMERASE-1; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTO-ONCOGENE PROTEINS B-RAF; RISK FACTORS; TELOMERASE;

EID: 85028719052     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng.3927     Document Type: Article

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