Association between genetic traits for immune-mediated diseases and Alzheimer disease

JAMA Neurology

Volumn 73, Issue 6, 2016, Pages 691-697

  Yokoyama, Jennifer S ^a   Wang, Yunpeng ^b,c   Schork, Andrew J ^d   Thompson, Wesley K ^e   Karch, Celeste M ^b   Cruchaga, Carlos ^b   McEvoy, Linda K ^f   Witoelar, Aree ^g,h   Chen, Chi Hua ^f   Holland, Dominic ^c   Brewer, James B ^c,f   Franke, Andre ⁱ   Dillon, William P ^a   Wilson, David M ^a   Mukherjee, Pratik ^a   Hess, Christopher P ^a   Miller, Zachary ^a   Bonham, Luke W ^a   Shen, Jeffrey ^a   Rabinovici, Gil D ^a   Rosen, Howard J ^a   Miller, Bruce L ^a   Hyman, Bradley T ^j   Schellenberg, Gerard D ^k   Karlsen, Tom H ^l,m   Andreassen, Ole A ^g,h   Dale, Anders M ^c,d,e,f   Desikan, Rahul S ^a   more..

^a UNIVERSITY OF CALIFORNIA   (United States)

^b WASHINGTON UNIVERSITY   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g UNIVERSITY OF OSLO   (Norway)

^h OSLO UNIVERSITY HOSPITAL   (Norway)

ⁱ UNIVERSITY OF KIEL   (Germany)

^j MASSACHUSETTS GENERAL HOSPITAL   (United States)

^k UNIVERSITY OF PENNSYLVANIA   (United States)

^l OSLO UNIVERSITY HOSPITAL   (Norway)

^m UNIVERSITY OF BERGEN   (Norway)

more..

Author keywords

[No Author keywords available]

Indexed keywords

HLA DRB5 ANTIGEN; INOSITOL POLYPHOSPHATE MULTIKINASE; PHOSPHOTRANSFERASE;

AGED; ALZHEIMER DISEASE; ARTICLE; CELIAC DISEASE; COHORT ANALYSIS; CONTROLLED STUDY; CROHN DISEASE; DISEASE COURSE; FEMALE; FOLLOW UP; GENE; GENE EXPRESSION; GENETIC ASSOCIATION; GENOME-WIDE ASSOCIATION STUDY; HLA DRB5 GENE; HUMAN; IMMUNOPATHOLOGY; INFLAMMATION; INSULIN DEPENDENT DIABETES MELLITUS; IPMK GENE; MAJOR CLINICAL STUDY; MALE; NEUROFIBRILLARY TANGLE; PATHOGENESIS; PLEIOTROPY; PRIORITY JOURNAL; PSORIASIS; RHEUMATOID ARTHRITIS; SINGLE NUCLEOTIDE POLYMORPHISM; ULCERATIVE COLITIS; COGNITION DISORDERS; COMPLICATION; GENETICS; IMMUNOLOGY;

ALZHEIMER DISEASE; COGNITION DISORDERS; FEMALE; GENOME-WIDE ASSOCIATION STUDY; HLA-DRB5 CHAINS; HUMANS; INFLAMMATION; MALE; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84974528083     PISSN: 21686149     EISSN: None     Source Type: Journal    
DOI: 10.1001/jamaneurol.2016.0150     Document Type: Article

References (31)

1. Brookmeyer R, Johnson E, Ziegler-Graham K, Arrighi HM. Forecasting the global burden of Alzheimer's disease. Alzheimers Dement. 2007;3 (3):186-191.
2. Eikelenboom P, Hoozemans JJ, Veerhuis R, van Exel E, Rozemuller AJ, van GoolWA. Whether, when and how chronic inflammation increases the risk of developing late-onset Alzheimer's disease. Alzheimers Res Ther. 2012;4(3):15.
3. Schmidt R, Schmidt H, Curb JD, Masaki K, White LR, Launer LJ. Early inflammation and dementia: a 25-year follow-up of the Honolulu-Asia Aging Study. Ann Neurol. 2002;52(2):168-174.
4. Koyama A, O'Brien J,Weuve J, Blacker D, Metti AL, Yaffe K. The role of peripheral inflammatory markers in dementia and Alzheimer's disease: ameta-analysis. J Gerontol A Biol Sci Med Sci. 2013; 68(4):433-440.
5. Jonsson T, Stefansson H, Steinberg S, et al. Variant of TREM2 associated with the risk of Alzheimer's disease. N Engl J Med. 2013;368(2): 107-116.
6. Guerreiro R,Wojtas A, Bras J, et al; Alzheimer Genetic Analysis Group. TREM2 variants in Alzheimer's disease.NEnglJMed. 2013;368(2):117-127.
7. Bradshaw EM, Chibnik LB, Keenan BT, et al; Alzheimer Disease Neuroimaging Initiative. CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology. Nat Neurosci. 2013;16 (7):848-850.
8. Desikan RS, Schork AJ,Wang Y, et al; InflammationWorking Group and International Genomics of Alzheimer's Disease Project (IGAP) and DemGene Investigators. Polygenic overlap between C-reactive protein, plasma lipids, and Alzheimer disease. Circulation. 2015;131(23):2061-2069.
9. Karch CM, Cruchaga C, Goate AM. Alzheimer's disease genetics: from the bench to the clinic. Neuron. 2014;83(1):11-26.
10. Andreassen OA, Djurovic S, Thompson WK, et al; International Consortium for Blood Pressure GWAS; Diabetes Genetics Replication and Meta-analysis Consortium; Psychiatric Genomics Consortium SchizophreniaWorking Group. Improved detection of common variants associated with schizophrenia by leveraging pleiotropy with cardiovascular-disease risk factors. Am J Hum Genet. 2013;92(2):197-209.
11. Andreassen OA, Thompson WK, Schork AJ, et al; Psychiatric Genomics Consortium; Bipolar Disorder and SchizophreniaWorking Groups. Improved detection of common variants associated with schizophrenia and bipolar disorder using pleiotropy-informed conditional false discovery rate. PLoS Genet. 2013;9(4):e1003455.
12. Lambert JC, Ibrahim-Verbaas CA, Harold D, et al; European Alzheimer's Disease Initiative; Genetic and Environmental Risk in Alzheimer's Disease; Alzheimer's Disease Genetic Consortium; Cohorts for Heart and Aging Research in Genomic Epidemiology. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. Nat Genet. 2013;45(12):1452-1458.
13. Franke A,McGovern DPB, Barrett JC, et al. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet. 2010;42(12):1118-1125.
14. Stahl EA, Raychaudhuri S, Remmers EF, et al; BIRAC Consortium; YEAR Consortium. Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. Nat Genet. 2010;42(6):508-514.
15. Barrett JC, Clayton DG, Concannon P, et al; Type 1 Diabetes Genetics Consortium. Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nat Genet. 2009;41(6):703-707.
16. Dubois PCA, Trynka G, Franke L, et al. Multiple common variants for celiac disease influencing immune gene expression. Nat Genet. 2010;42(4): 295-302.
17. Ellinghaus D, Ellinghaus E, Nair RP, et al. Combined analysis of genome-wide association studies for Crohn disease and psoriasis identifies seven shared susceptibility loci. Am J Hum Genet. 2012;90(4):636-647.
18. Anderson CA, Boucher G, Lees CW, et al. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nat Genet. 2011;43(3):246-252.
19. Zhang B, Gaiteri C, Bodea L-G, et al. Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease. Cell. 2013;153(3):707-720.
20. Beecham GW, Hamilton K, Naj AC, et al; Alzheimer's Disease Genetics Consortium. Genome-wide associationmeta-analysis of neuropathologic features of Alzheimer's disease and related dementias. PLoS Genet. 2014;10(9): e1004606.
21. Andreassen OA, Zuber V, Thompson WK, et al; PRACTICAL Consortium; CRUK GWAS. Shared common variants in prostate cancer and blood lipids. Int J Epidemiol. 2014;43(4):1205-1214.
22. Andreassen OA, McEvoy LK, Thompson WK, et al; International Consortium for Blood Pressure Genome-Wide Association Studies, Genetic Factors for Osteoporosis Consortium. Identifying common genetic variants in blood pressure due to polygenic pleiotropywith associated phenotypes. Hypertension. 2014;63(4):819-826.
23. Andreassen OA, Desikan RS,Wang Y, et al. Abundant genetic overlap between blood lipids and immune-mediated diseases indicates shared molecular genetic mechanisms. PLoS One. 2015;10 (4):e0123057.
24. Nichols T, Brett M, Andersson J,Wager T, Poline JB. Valid conjunction inference with theminimum statistic. Neuroimage. 2005;25(3):653-660.
25. Kim S, Kim SF, Maag D, et al. Amino acid signaling tomTOR mediated by inositol polyphosphate multikinase. Cell Metab. 2011;13(2): 215-221.
26. Xu R, Paul BD, Smith DR, et al. Inositol polyphosphate multikinase is a transcriptional coactivator required for immediate early gene induction. Proc Natl Acad Sci U S A. 2013;110(40): 16181-16186.
27. Xu R, Sen N, Paul BD, et al. Inositol polyphosphate multikinase is a coactivator of p53-mediated transcription and cell death. Sci Signal. 2013;6(269):ra22.
28. Wickramasinghe VO, Savill JM, Chavali S, et al. Human inositol polyphosphate multikinase regulates transcript-selective nuclearmRNAexport to preserve genome integrity. Mol Cell. 2013;51(6):737-750.
29. Ahmed I, Sbodio JI, Harraz MM, et al. Huntington's disease: neural dysfunction linked to inositol polyphosphate multikinase. Proc Natl Acad Sci U S A. 2015;112(31):9751-9756.
30. Jolles J, Bothmer J, MarkerinkM, Ravid R. Phosphatidylinositol kinase is reduced in Alzheimer's disease. J Neurochem. 1992;58(6): 2326-2329.
31. Heppner FL, Ransohoff RM, Becher B. Immune attack: the role of inflammation in Alzheimer disease. Nat Rev Neurosci. 2015;16(6):358-372.