Anti-PD-1 and anti-CTLA-4 therapies in cancer: Mechanisms of action, efficacy, and limitations

Frontiers in Oncology

Volumn 8, Issue MAR, 2018, Pages

  Seidel, Judith A ^a   Otsuka, Atsushi ^a   Kabashima, Kenji ^a,b  

^a KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b AGENCY FOR SCIENCE   (Singapore)

Author keywords

Biomarkers; Cancer; Immune checkpoint inhibitors; Immunotherapy; Melanoma; Mode of action; Side effects

Indexed keywords

ALANINE AMINOTRANSFERASE; ANTINEOPLASTIC MONOCLONAL ANTIBODY; BIOLOGICAL MARKER; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4 ANTIBODY; IPILIMUMAB; PROGRAMMED DEATH 1 LIGAND 1 ANTIBODY; PROGRAMMED DEATH 1 RECEPTOR; PROGRAMMED DEATH 1 RECEPTOR ANTIBODY; UNCLASSIFIED DRUG;

CANCER IMMUNOTHERAPY; CANCER RECURRENCE; CLINICAL TRIAL; COLITIS; DECREASED APPETITE; DRUG EFFICACY; DRUG MECHANISM; FATIGUE; HUMAN; IMMUNOPATHOLOGY; INSULIN DEPENDENT DIABETES MELLITUS; INTERSTITIAL NEPHRITIS; MALIGNANT NEOPLASM; MELANOMA; NAUSEA; NONHUMAN; PNEUMONIA; PRURITUS; PSORIASIS; RASH; REVIEW; SIDE EFFECT; VITILIGO;

EID: 85044932853     PISSN: None     EISSN: 2234943X     Source Type: Journal    
DOI: 10.3389/fonc.2018.00086     Document Type: Review

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