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Volumn 78, Issue 2, 2015, Pages 95-100

Hedgehog signaling in basal cell carcinoma

Author keywords

Acquired immune responses; Basal cell carcinoma; Hedgehog

Indexed keywords

ANTINEOPLASTIC AGENT; ARSENIC TRIOXIDE; CYCLOPAMINE; GAMMA INTERFERON; GLASDEGIB; ITRACONAZOLE; JANUS KINASE; LEQ 506; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PATIDEGIB; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; RAPAMYCIN; S6 KINASE; S6 KINASE 1; SONIDEGIB; STAT1 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 1; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG; VISMODEGIB; ANILIDE; CELL SURFACE RECEPTOR; G PROTEIN COUPLED RECEPTOR; PATCHED RECEPTORS; PYRIDINE DERIVATIVE; SMO PROTEIN, HUMAN; SONIC HEDGEHOG PROTEIN;

EID: 84927087950     PISSN: 09231811     EISSN: 1873569X     Source Type: Journal    
DOI: 10.1016/j.jdermsci.2015.02.007     Document Type: Review
Times cited : (52)

References (45)
  • 1
    • 84860322847 scopus 로고    scopus 로고
    • A systematic review of worldwide incidence of nonmelanoma skin cancer
    • Lomas A., Leonardi-Bee J., Bath-Hextall F. A systematic review of worldwide incidence of nonmelanoma skin cancer. Br J Dermatol 2012, 166:1069-1080.
    • (2012) Br J Dermatol , vol.166 , pp. 1069-1080
    • Lomas, A.1    Leonardi-Bee, J.2    Bath-Hextall, F.3
  • 5
    • 84878346748 scopus 로고    scopus 로고
    • Photodynamic therapy versus topical imiquimod versus topical fluorouracil for treatment of superficial basal-cell carcinoma: a single blind, non-inferiority, randomised controlled trial
    • Arits A.H., Mosterd K., Essers B.A., Spoorenberg E., Sommer A., De Rooij M.J., et al. Photodynamic therapy versus topical imiquimod versus topical fluorouracil for treatment of superficial basal-cell carcinoma: a single blind, non-inferiority, randomised controlled trial. Lancet Oncol 2013, 14:647-654.
    • (2013) Lancet Oncol , vol.14 , pp. 647-654
    • Arits, A.H.1    Mosterd, K.2    Essers, B.A.3    Spoorenberg, E.4    Sommer, A.5    De Rooij, M.J.6
  • 6
    • 84890124815 scopus 로고    scopus 로고
    • Mitochondrial D310 D-Loop instability and histological subtypes in radiation-induced cutaneous basal cell carcinomas
    • Boaventura P., Pereira D., Mendes A., Batista R., da Silva A.F., Guimaraes I., et al. Mitochondrial D310 D-Loop instability and histological subtypes in radiation-induced cutaneous basal cell carcinomas. J Dermatol Sci 2014, 73:31-39.
    • (2014) J Dermatol Sci , vol.73 , pp. 31-39
    • Boaventura, P.1    Pereira, D.2    Mendes, A.3    Batista, R.4    da Silva, A.F.5    Guimaraes, I.6
  • 8
    • 51949085076 scopus 로고    scopus 로고
    • Hedgehog: functions and mechanisms
    • Varjosalo M., Taipale J. Hedgehog: functions and mechanisms. Genes Dev 2008, 22:2454-2472.
    • (2008) Genes Dev , vol.22 , pp. 2454-2472
    • Varjosalo, M.1    Taipale, J.2
  • 9
    • 15844381336 scopus 로고    scopus 로고
    • Human homolog of patched, a candidate gene for the basal cell nevus syndrome
    • Johnson R.L., Rothman A.L., Xie J., Goodrich L.V., Bare J.W., Bonifas J.M., et al. Human homolog of patched, a candidate gene for the basal cell nevus syndrome. Science 1996, 272:1668-1671.
    • (1996) Science , vol.272 , pp. 1668-1671
    • Johnson, R.L.1    Rothman, A.L.2    Xie, J.3    Goodrich, L.V.4    Bare, J.W.5    Bonifas, J.M.6
  • 10
    • 58149333235 scopus 로고    scopus 로고
    • The primary cilium at the crossroads of mammalian hedgehog signaling
    • Wong S.Y., Reiter J.F. The primary cilium at the crossroads of mammalian hedgehog signaling. Curr Top Dev Biol 2008, 85:225-260.
    • (2008) Curr Top Dev Biol , vol.85 , pp. 225-260
    • Wong, S.Y.1    Reiter, J.F.2
  • 11
    • 84887512714 scopus 로고    scopus 로고
    • Unraveling the therapeutic potential of the Hedgehog pathway in cancer
    • Amakye D., Jagani Z., Dorsch M. Unraveling the therapeutic potential of the Hedgehog pathway in cancer. Nat Med 2013, 19:1410-1422.
    • (2013) Nat Med , vol.19 , pp. 1410-1422
    • Amakye, D.1    Jagani, Z.2    Dorsch, M.3
  • 12
    • 15844386165 scopus 로고    scopus 로고
    • Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome
    • Hahn H., Wicking C., Zaphiropoulous P.G., Gailani M.R., Shanley S., Chidambaram A., et al. Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome. Cell 1996, 85:841-851.
    • (1996) Cell , vol.85 , pp. 841-851
    • Hahn, H.1    Wicking, C.2    Zaphiropoulous, P.G.3    Gailani, M.R.4    Shanley, S.5    Chidambaram, A.6
  • 13
    • 0028878117 scopus 로고
    • Nevoid basal cell carcinoma syndrome
    • Gorlin R.J. Nevoid basal cell carcinoma syndrome. Dermatol Clin 1995, 13:113-125.
    • (1995) Dermatol Clin , vol.13 , pp. 113-125
    • Gorlin, R.J.1
  • 15
    • 0031913524 scopus 로고    scopus 로고
    • Activating smoothened mutations in sporadic basal-cell carcinoma
    • Xie J., Murone M., Luoh S.M., Ryan A., Gu Q., Zhang C., et al. Activating smoothened mutations in sporadic basal-cell carcinoma. Nature 1998, 391:90-92.
    • (1998) Nature , vol.391 , pp. 90-92
    • Xie, J.1    Murone, M.2    Luoh, S.M.3    Ryan, A.4    Gu, Q.5    Zhang, C.6
  • 19
    • 0035503886 scopus 로고    scopus 로고
    • A spontaneous mouse mutation, mesenchymal dysplasia (mes), is caused by a deletion of the most C-terminal cytoplasmic domain of patched (ptc)
    • Makino S., Masuya H., Ishijima J., Yada Y., Shiroishi T. A spontaneous mouse mutation, mesenchymal dysplasia (mes), is caused by a deletion of the most C-terminal cytoplasmic domain of patched (ptc). Dev Biol 2001, 239:95-106.
    • (2001) Dev Biol , vol.239 , pp. 95-106
    • Makino, S.1    Masuya, H.2    Ishijima, J.3    Yada, Y.4    Shiroishi, T.5
  • 20
    • 0031837454 scopus 로고    scopus 로고
    • Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndrome
    • Hahn H., Wojnowski L., Zimmer A.M., Hall J., Miller G., Zimmer A: Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndrome. Nat Med 1998, 4:619-622.
    • (1998) Nat Med , vol.4 , pp. 619-622
    • Hahn, H.1    Wojnowski, L.2    Zimmer, A.M.3    Hall, J.4    Miller, G.5    Zimmer, A.6
  • 21
    • 0013920756 scopus 로고
    • Teratogenic compounds of Veratrum californicum (Durand). I. Preparation and characterization of fractions and alkaloids for biologic testing
    • Keeler R.F., Binns W. Teratogenic compounds of Veratrum californicum (Durand). I. Preparation and characterization of fractions and alkaloids for biologic testing. Can J Biochem 1966, 44:819-828.
    • (1966) Can J Biochem , vol.44 , pp. 819-828
    • Keeler, R.F.1    Binns, W.2
  • 22
    • 0029777408 scopus 로고    scopus 로고
    • Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function
    • Chiang C., Litingtung Y., Lee E., Young K.E., Corden J.L., Westphal H., et al. Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature 1996, 383:407-413.
    • (1996) Nature , vol.383 , pp. 407-413
    • Chiang, C.1    Litingtung, Y.2    Lee, E.3    Young, K.E.4    Corden, J.L.5    Westphal, H.6
  • 24
    • 84908031043 scopus 로고    scopus 로고
    • Vertical inhibition of PI3K/Akt/mTOR signaling demonstrates in vitro and in vivo anti-fibrotic activity
    • Liang M., Lv J., Chu H., Wang J., Chen X., Zhu X., et al. Vertical inhibition of PI3K/Akt/mTOR signaling demonstrates in vitro and in vivo anti-fibrotic activity. J Dermatol Sci 2014, 76:104-111.
    • (2014) J Dermatol Sci , vol.76 , pp. 104-111
    • Liang, M.1    Lv, J.2    Chu, H.3    Wang, J.4    Chen, X.5    Zhu, X.6
  • 26
    • 84897111970 scopus 로고    scopus 로고
    • Metastatic melanoma cell lines do not secrete IL-1beta but promote IL-1beta production from macrophages
    • Gehrke S., Otsuka A., Huber R., Meier B., Kistowska M., Fenini G., et al. Metastatic melanoma cell lines do not secrete IL-1beta but promote IL-1beta production from macrophages. J Dermatol Sci 2014, 74:167-169.
    • (2014) J Dermatol Sci , vol.74 , pp. 167-169
    • Gehrke, S.1    Otsuka, A.2    Huber, R.3    Meier, B.4    Kistowska, M.5    Fenini, G.6
  • 27
    • 77954743454 scopus 로고    scopus 로고
    • Cancer-testis antigens and immunosurveillance in human cutaneous squamous cell and basal cell carcinomas
    • Walter A., Barysch M.J., Behnke S., Dziunycz P., Schmid B., Ritter E., et al. Cancer-testis antigens and immunosurveillance in human cutaneous squamous cell and basal cell carcinomas. Clin Cancer Res 2010, 16:3562-3570.
    • (2010) Clin Cancer Res , vol.16 , pp. 3562-3570
    • Walter, A.1    Barysch, M.J.2    Behnke, S.3    Dziunycz, P.4    Schmid, B.5    Ritter, E.6
  • 28
    • 84901667309 scopus 로고    scopus 로고
    • Induction of cytotoxic T cells as a novel independent survival factor in malignant melanoma with percutaneous peptide immunization
    • Fujiyama T., Oze I., Yagi H., Hashizume H., Matsuo K., Hino R., et al. Induction of cytotoxic T cells as a novel independent survival factor in malignant melanoma with percutaneous peptide immunization. J Dermatol Sci 2014, 75:43-48.
    • (2014) J Dermatol Sci , vol.75 , pp. 43-48
    • Fujiyama, T.1    Oze, I.2    Yagi, H.3    Hashizume, H.4    Matsuo, K.5    Hino, R.6
  • 29
    • 84903600086 scopus 로고    scopus 로고
    • Combination of HDAC inhibitor MS-275 and IL-2 increased anti-tumor effect in a melanoma model via activated cytotoxic T cells
    • Kato Y., Yoshino I., Egusa C., Maeda T., Pili R., Tsuboi R. Combination of HDAC inhibitor MS-275 and IL-2 increased anti-tumor effect in a melanoma model via activated cytotoxic T cells. J Dermatol Sci 2014, 75:140-147.
    • (2014) J Dermatol Sci , vol.75 , pp. 140-147
    • Kato, Y.1    Yoshino, I.2    Egusa, C.3    Maeda, T.4    Pili, R.5    Tsuboi, R.6
  • 30
    • 84927030619 scopus 로고    scopus 로고
    • Hedgehog pathway inhibitors promote adaptive immune responses in Basal Cell Carcinoma
    • PMID: 25593302
    • Otsuka A., Dreier J., Cheng P.F., Nageli M., Lehmann H., Felderer L., et al. Hedgehog pathway inhibitors promote adaptive immune responses in Basal Cell Carcinoma. Clin Cancer Res 2015, PMID: 25593302.
    • (2015) Clin Cancer Res
    • Otsuka, A.1    Dreier, J.2    Cheng, P.F.3    Nageli, M.4    Lehmann, H.5    Felderer, L.6
  • 31
  • 33
    • 34247332974 scopus 로고    scopus 로고
    • Activation of the Hedgehog signaling pathway in T-lineage cells inhibits TCR repertoire selection in the thymus and peripheral T-cell activation
    • Rowbotham N.J., Hager-Theodorides A.L., Cebecauer M., Shah D.K., Drakopoulou E., Dyson J., et al. Activation of the Hedgehog signaling pathway in T-lineage cells inhibits TCR repertoire selection in the thymus and peripheral T-cell activation. Blood 2007, 109:3757-3766.
    • (2007) Blood , vol.109 , pp. 3757-3766
    • Rowbotham, N.J.1    Hager-Theodorides, A.L.2    Cebecauer, M.3    Shah, D.K.4    Drakopoulou, E.5    Dyson, J.6
  • 34
    • 34548818128 scopus 로고    scopus 로고
    • A novel role for Hedgehog in T-cell receptor signaling: implications for development and immunity
    • Rowbotham N.J., Hager-Theodorides A.L., Furmanski A.L., Crompton T. A novel role for Hedgehog in T-cell receptor signaling: implications for development and immunity. Cell Cycle 2007, 6:2138-2142.
    • (2007) Cell Cycle , vol.6 , pp. 2138-2142
    • Rowbotham, N.J.1    Hager-Theodorides, A.L.2    Furmanski, A.L.3    Crompton, T.4
  • 35
    • 42449087714 scopus 로고    scopus 로고
    • Repression of hedgehog signal transduction in T-lineage cells increases TCR-induced activation and proliferation
    • Rowbotham N.J., Furmanski A.L., Hager-Theodorides A.L., Ross S.E., Drakopoulou E., Koufaris C., et al. Repression of hedgehog signal transduction in T-lineage cells increases TCR-induced activation and proliferation. Cell Cycle 2008, 7:904-908.
    • (2008) Cell Cycle , vol.7 , pp. 904-908
    • Rowbotham, N.J.1    Furmanski, A.L.2    Hager-Theodorides, A.L.3    Ross, S.E.4    Drakopoulou, E.5    Koufaris, C.6
  • 36
    • 71049192398 scopus 로고    scopus 로고
    • Molecular mechanisms of IFN-γ to up-regulate MHC class I antigen processing and presentation
    • Zhou F. Molecular mechanisms of IFN-γ to up-regulate MHC class I antigen processing and presentation. Int Rev Immunol 2009, 28:239-260.
    • (2009) Int Rev Immunol , vol.28 , pp. 239-260
    • Zhou, F.1
  • 38
    • 84922403550 scopus 로고    scopus 로고
    • Recruitment of plasmacytoid dendritic cells to skin regulates treatment responsiveness of actinic keratosis to imiquimod
    • Ogawa Y., Kawamura T., Matsuzawa T., Aoki R., Shimada S. Recruitment of plasmacytoid dendritic cells to skin regulates treatment responsiveness of actinic keratosis to imiquimod. J Dermatol Sci 2014, 76:67-69.
    • (2014) J Dermatol Sci , vol.76 , pp. 67-69
    • Ogawa, Y.1    Kawamura, T.2    Matsuzawa, T.3    Aoki, R.4    Shimada, S.5
  • 39
    • 84898721363 scopus 로고    scopus 로고
    • A phase I, multicenter, open-label, first-in-human, dose-escalation study of the oral smoothened inhibitor Sonidegib (LDE225) in patients with advanced solid tumors
    • Rodon J., Tawbi H.A., Thomas A.L., Stoller R.G., Turtschi C.P., Baselga J., et al. A phase I, multicenter, open-label, first-in-human, dose-escalation study of the oral smoothened inhibitor Sonidegib (LDE225) in patients with advanced solid tumors. Clin Cancer Res 2014, 20:1900-1909.
    • (2014) Clin Cancer Res , vol.20 , pp. 1900-1909
    • Rodon, J.1    Tawbi, H.A.2    Thomas, A.L.3    Stoller, R.G.4    Turtschi, C.P.5    Baselga, J.6
  • 41
    • 79960340656 scopus 로고    scopus 로고
    • Topical treatment of basal cell carcinomas in nevoid basal cell carcinoma syndrome with a smoothened inhibitor
    • Skvara H., Kalthoff F., Meingassner J.G., Wolff-Winiski B., Aschauer H., Kelleher J.F., et al. Topical treatment of basal cell carcinomas in nevoid basal cell carcinoma syndrome with a smoothened inhibitor. J Invest Dermatol 2011, 131:1735-1744.
    • (2011) J Invest Dermatol , vol.131 , pp. 1735-1744
    • Skvara, H.1    Kalthoff, F.2    Meingassner, J.G.3    Wolff-Winiski, B.4    Aschauer, H.5    Kelleher, J.F.6
  • 42
    • 78650845707 scopus 로고    scopus 로고
    • G protein-coupled receptors: novel targets for drug discovery in cancer
    • Lappano R., Maggiolini M. G protein-coupled receptors: novel targets for drug discovery in cancer. Nat Rev Drug Discov 2011, 10:47-60.
    • (2011) Nat Rev Drug Discov , vol.10 , pp. 47-60
    • Lappano, R.1    Maggiolini, M.2
  • 43
    • 67650723106 scopus 로고    scopus 로고
    • Discovery of a potent and orally active hedgehog pathway antagonist (IPI-926)
    • Tremblay M.R., Lescarbeau A., Grogan M.J., Tan E., Lin G., Austad B.C., et al. Discovery of a potent and orally active hedgehog pathway antagonist (IPI-926). J Med Chem 2009, 52:4400-4418.
    • (2009) J Med Chem , vol.52 , pp. 4400-4418
    • Tremblay, M.R.1    Lescarbeau, A.2    Grogan, M.J.3    Tan, E.4    Lin, G.5    Austad, B.C.6
  • 44
    • 84872417679 scopus 로고    scopus 로고
    • Itraconazole and arsenic trioxide inhibit hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists
    • Kim J., Aftab B.T., Tang J.Y., Kim D., Lee A.H., Rezaee M., et al. Itraconazole and arsenic trioxide inhibit hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists. Cancer Cell 2013, 23:23-34.
    • (2013) Cancer Cell , vol.23 , pp. 23-34
    • Kim, J.1    Aftab, B.T.2    Tang, J.Y.3    Kim, D.4    Lee, A.H.5    Rezaee, M.6
  • 45
    • 84860471709 scopus 로고    scopus 로고
    • Randomized controlled trial of sirolimus for renal transplant recipients at high risk for nonmelanoma skin cancer
    • Campbell S.B., Walker R., Tai S.S., Jiang Q., Russ G.R. Randomized controlled trial of sirolimus for renal transplant recipients at high risk for nonmelanoma skin cancer. Am J Transplant 2012, 12:1146-1156.
    • (2012) Am J Transplant , vol.12 , pp. 1146-1156
    • Campbell, S.B.1    Walker, R.2    Tai, S.S.3    Jiang, Q.4    Russ, G.R.5


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