How to measure glucocorticoid receptor's sensitivity in patients with stress-related psychiatric disorders

Psychoneuroendocrinology

Volumn 91, Issue , 2018, Pages 235-260

  Leistner, Carolin ^a   Menke, Andreas ^a  

^a UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

Author keywords

Dex CRH test; Dexamethasone; DST; FKBP5; Gene expression; Glucocorticoid receptor; HPA axis; Hypothalamic pituitary adrenal axis; Major depression

Indexed keywords

DEXAMETHASONE; FK 506 BINDING PROTEIN; GLUCOCORTICOID RECEPTOR; CORTICOTROPIN; CORTICOTROPIN RELEASING FACTOR; HYDROCORTISONE; TACROLIMUS BINDING PROTEIN 5;

CLINICAL FEATURE; DEXAMETHASONE SUPPRESSION TEST; EMOTIONAL STRESS; GENE EXPRESSION; GENE FUNCTION; HUMAN; HYPOPHYSIS ADRENAL SYSTEM; JOB STRESS; MAJOR DEPRESSION; MENTAL DISEASE; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; REVIEW; STRESS; FEMALE; HYPOTHALAMUS HYPOPHYSIS SYSTEM; MALE; MENTAL STRESS; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY;

ADRENOCORTICOTROPIC HORMONE; CORTICOTROPIN-RELEASING HORMONE; DEXAMETHASONE; FEMALE; GENE EXPRESSION; HUMANS; HYDROCORTISONE; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; MALE; MENTAL DISORDERS; PITUITARY-ADRENAL SYSTEM; RECEPTORS, GLUCOCORTICOID; STRESS, PSYCHOLOGICAL; TACROLIMUS BINDING PROTEINS;

EID: 85044749908     PISSN: 03064530     EISSN: 18733360     Source Type: Journal    
DOI: 10.1016/j.psyneuen.2018.01.023     Document Type: Review

References (220)

1. Ahola, K., Honkonen, T., Isometsa, E., Kalimo, R., Nykyri, E., Aromaa, A., Lonnqvist, J., The relationship between job-related burnout and depressive disorders–results from the Finnish Health Study. J. Affect. Disord. 88 (2000), 55–62.
2. Aihara, M., Ida, I., Yuuki, N., Oshima, A., Kumano, H., Takahashi, K., Fukuda, M., Oriuchi, N., Endo, K., Matsuda, H., Mikuni, M., HPA axis dysfunction in unmedicated major depressive disorder and its normalization by pharmacotherapy correlates with alteration of neural activity in prefrontal cortex and limbic/paralimbic regions. Psychiatry Res. 155 (2007), 245–256.
3. Anacker, C., Zunszain, P.A., Carvalho, L.A., Pariante, C.M., The glucocorticoid receptor: pivot of depression and of antidepressant treatment?. Psychoneuroendocrinology 36 (2011), 415–425.
4. Appelhof, B.C., Huyser, J., Verweij, M., Brouwer, J.P., van Dyck, R., Fliers, E., Hoogendijk, W.J., Tijssen, J.G., Wiersinga, W.M., Schene, A.H., Glucocorticoids and relapse of major depression (dexamethasone/corticotropin-releasing hormone test in relation to relapse of major depression). Biol. Psychiatry 59 (2006), 696–701.
5. Arana, G.W., Baldessarini, R.J., Ornsteen, M., The dexamethasone suppression test for diagnosis and prognosis in psychiatry. Commentary and review. Arch. Gen. Psychiatry 42 (1985), 1193–1204.
6. Arloth, J., Bogdan, R., Weber, P., Frishman, G., Menke, A., Wagner, K.V., Balsevich, G., Schmidt, M.V., Karbalai, N., Czamara, D., Altmann, A., Trumbach, D., Wurst, W., Mehta, D., Uhr, M., Klengel, T., Erhardt, A., Carey, C.E., Conley, E.D., Major Depressive Disorder Working Group of the Psychiatric Genomics C, Ruepp, A., Muller-Myhsok, B., Hariri, A.R., Binder, E.B., Major depressive disorder working group of the psychiatric genomics consortium PGC, genetic differences in the immediate transcriptome response to stress predict risk-related brain function and psychiatric disorders. Neuron 86 (2015), 1189–1202.
7. Arnsten, A.F., Stress signalling pathways that impair prefrontal cortex structure and function. Nat. Rev. Neurosci. 10 (2009), 410–422.
8. Aschbacher, K., Epel, E., Wolkowitz, O.M., Prather, A.A., Puterman, E., Dhabhar, F.S., Maintenance of a positive outlook during acute stress protects against pro-inflammatory reactivity and future depressive symptoms. Brain Behav. Immun. 26 (2012), 346–352.
9. Aubry, J.M., Gervasoni, N., Osiek, C., Perret, G., Rossier, M.F., Bertschy, G., Bondolfi, G., The DEX/CRH neuroendocrine test and the prediction of depressive relapse in remitted depressed outpatients. J. Psychiatr. Res. 41 (2007), 290–294.
10. Bardeleben, U., Holsboer, F., Cortisol response to a combined dexamethasone-human corticotrophin-releasing hormone challenge in patients with depression. J. Neuroendocrinol. 1 (1989), 485–488.
11. Bauer, M.E., Papadopoulos, A., Poon, L., Perks, P., Lightman, S.L., Checkley, S., Shanks, N., Altered glucocorticoid immunoregulation in treatment resistant depression. Psychoneuroendocrinology 28 (2003), 49–65.
12. Bellingrath, S., Weigl, T., Kudielka, B.M., Cortisol dysregulation in school teachers in relation to burnout, vital exhaustion, and effort-reward-imbalance. Biol. Psychol. 78 (2008), 104–113.
13. Bellingrath, S., Rohleder, N., Kudielka, B.M., Effort-reward-imbalance in healthy teachers is associated with higher LPS-stimulated production and lower glucocorticoid sensitivity of interleukin-6 in vitro. Biol. Psychol. 92:2 (2013), 403–409.
14. Belvederi Murri, M., Pariante, C., Mondelli, V., Masotti, M., Atti, A.R., Mellacqua, Z., Antonioli, M., Ghio, L., Menchetti, M., Zanetidou, S., Innamorati, M., Amore, M., HPA axis and aging in depression: systematic review and meta-analysis. Psychoneuroendocrinology 41 (2014), 46–62.
15. Bevilacqua, L., Carli, V., Sarchiapone, M., George, D.K., Goldman, D., Roy, A., Enoch, M.A., Interaction between FKBP5 and childhood trauma and risk of aggressive behavior. Arch. Gen. Psychiatry 69 (2012), 62–70.
16. Binder, E.B., Salyakina, D., Lichtner, P., Wochnik, G.M., Ising, M., Putz, B., Papiol, S., Seaman, S., Lucae, S., Kohli, M.A., Nickel, T., Kunzel, H.E., Fuchs, B., Majer, M., Pfennig, A., Kern, N., Brunner, J., Modell, S., Baghai, T., Deiml, T., Zill, P., Bondy, B., Rupprecht, R., Messer, T., Kohnlein, O., Dabitz, H., Bruckl, T., Muller, N., Pfister, H., Lieb, R., Mueller, J.C., Lohmussaar, E., Strom, T.M., Bettecken, T., Meitinger, T., Uhr, M., Rein, T., Holsboer, F., Muller-Myhsok, B., Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment. Nat. Genet. 36 (2004), 1319–1325.
17. Binder, E.B., Bradley, R.G., Liu, W., Epstein, M.P., Deveau, T.C., Mercer, K.B., Tang, Y., Gillespie, C.F., Heim, C.M., Nemeroff, C.B., Schwartz, A.C., Cubells, J.F., Ressler, K.J., Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults. JAMA 299 (2008), 1291–1305.
18. Binder, E.B., Kunzel, H.E., Nickel, T., Kern, N., Pfennig, A., Majer, M., Uhr, M., Ising, M., Holsboer, F., HPA-axis regulation at in-patient admission is associated with antidepressant therapy outcome in male but not in female depressed patients. Psychoneuroendocrinology 34 (2009), 99–109.
19. Binder, E.B., The role of FKBP5, a co-chaperone of the glucocorticoid receptor in the pathogenesis and therapy of affective and anxiety disorders. Psychoneuroendocrinology 34:Suppl. 1 (2009), S186–195.
20. Bremner, J.D., Vythilingam, M., Anderson, G., Vermetten, E., McGlashan, T., Heninger, G., Rasmusson, A., Southwick, S.M., Charney, D.S., Assessment of the hypothalamic-pituitary-adrenal axis over a 24-hour diurnal period and in response to neuroendocrine challenges in women with and without childhood sexual abuse and posttraumatic stress disorder. Biol. Psychiatry 54 (2003), 710–718.
21. Bresnick, E.H., Dalman, F.C., Sanchez, E.R., Pratt, W.B., Evidence that the 90-kDa heat shock protein is necessary for the steroid binding conformation of the L cell glucocorticoid receptor. J. Biol. Chem. 264 (1989), 4992–4997.
22. Calfa, G., Kademian, S., Ceschin, D., Vega, G., Rabinovich, G.A., Volosin, M., Characterization and functional significance of glucocorticoid receptors in patients with major depression: modulation by antidepressant treatment. Psychoneuroendocrinology 28 (2003), 687–701.
23. Cannon, W.B., The wisdom of the body. Int. J. Ethics 43 (1933), 234–235.
24. Carpenter, L.L., Ross, N.S., Tyrka, A.R., Anderson, G.M., Kelly, M., Price, L.H., Dex/CRH test cortisol response in outpatients with major depression and matched healthy controls. Psychoneuroendocrinology 34 (2009), 1208–1213.
25. Carroll, B.J., Martin, F.I., Davies, B., Resistance to suppression by dexamethasone of plasma 11-O.H.C.S. levels in severe depressive illness. Br. Med. J. 3 (1968), 285–287.
26. Carroll, B.J., Curtis, G.C., Mendels, J., Neuroendocrine regulation in depression. II. Discrimination of depressed from nondepressed patients. Arch. Gen. Psychiatry 33 (1976), 1051–1058.
27. Carroll, B.J., Feinberg, M., Greden, J.F., Tarika, J., Albala, A.A., Haskett, R.F., James, N.M., Kronfol, Z., Lohr, N., Steiner, M., de Vigne, J.P., Young, E., A specific laboratory test for the diagnosis of melancholia. Standardization, validation, and clinical utility. Arch. Gen. Psychiatry 38 (1981), 15–22.
28. Carroll, B.J., Dexamethasone suppression test for depression. Adv. Biochem. Psychopharmacol. 39 (1984), 179–188.
29. Cattaneo, A., Gennarelli, M., Uher, R., Breen, G., Farmer, A., Aitchison, K.J., Craig, I.W., Anacker, C., Zunsztain, P.A., McGuffin, P., Pariante, C.M., Candidate genes expression profile associated with antidepressants response in the GENDEP study: differentiating between baseline ‘predictors’ and longitudinal ‘targets’. Neuropsychopharmacology 38 (2013), 377–385.
30. Cattaneo, A., Ferrari, C., Uher, R., Bocchio-Chiavetto, L., Riva, M.A., Consortium, M.R.C.I., Pariante, C.M., Absolute measurements of macrophage migration inhibitory factor and interleukin-1-beta mRNA levels accurately predict treatment response in depressed patients. Int. J. Neuropsychopharmacol., 19, 2016.
31. Chan, S., Debono, M., Replication of cortisol circadian rhythm: new advances in hydrocortisone replacement therapy. Ther. Adv.n Endocrinol. Metab. 1 (2010), 129–138.
32. Cohen, S., Janicki-Deverts, D., Miller, G.E., Psychological stress and disease. JAMA 298 (2007), 1685–1687.
33. Cox, T., Griffiths, A.J., Rial-Gonzalez, E., Research on Work-related Stress. Report to the European Agency for Safety and Health at Work. (Communities, O. f. O. P. o. t. E., Ed)., 2000 (Luxembourg).
34. Czock, D., Keller, F., Rasche, F.M., Haussler, U., Pharmacokinetics and pharmacodynamics of systemically administered glucocorticoids. Clin. Pharmacokinet. 44 (2005), 61–98.
35. Danhof-Pont, M.B., van Veen, T., Zitman, F.G., Biomarkers in burnout: a systematic review. J. Psychosom. Res. 70 (2011), 505–524.
36. de Kloet, E.R., Joels, M., Holsboer, F., Stress and the brain: from adaptation to disease. Nat. Rev. Neurosci. 6 (2005), 463–475.
37. de Kloet, C.S., Vermetten, E., Geuze, E., Kavelaars, A., Heijnen, C.J., Westenberg, H.G., Assessment of HPA-axis function in posttraumatic stress disorder: pharmacological and non-pharmacological challenge tests, a review. J. Psychiatr. Res. 40 (2006), 550–567.
38. de Kloet, C.S., Vermetten, E., Bikker, A., Meulman, E., Geuze, E., Kavelaars, A., Westenberg, H.G., Heijnen, C.J., Leukocyte glucocorticoid receptor expression and immunoregulation in veterans with and without post-traumatic stress disorder. Mol. Psychiatry 12 (2007), 443–453.
39. de Kloet, C.S., Vermetten, E., Heijnen, C.J., Geuze, E., Lentjes, E.G., Westenberg, H.G., Enhanced cortisol suppression in response to dexamethasone administration in traumatized veterans with and without posttraumatic stress disorder. Psychoneuroendocrinology 32 (2007), 215–226.
40. de Kloet, C., Vermetten, E., Lentjes, E., Geuze, E., van Pelt, J., Manuel, R., Heijnen, C., Westenberg, H., Differences in the response to the combined DEX-CRH test between PTSD patients with and without co-morbid depressive disorder. Psychoneuroendocrinology 33:3 (2008), 313–320.
41. Ehnvall, A., Sjogren, M., Zachrisson, O.C., Agren, H., HPA axis activation determined by the CRH challenge test in patients with few versus multiple episodes of treatment-refractory depression. Eur. Arch. Psychiatry Clin. Neurosci. 254 (2004), 349–355.
42. Fischer, S., Macare, C., Cleare, A.J., Hypothalamic-pituitary-adrenal (HPA) axis functioning as predictor of antidepressant response-Meta-analysis. Neurosci. Biobehav. Rev. 83 (2017), 200–211.
43. Frank, M.G., Watkins, L.R., Maier, S.F., Stress-induced glucocorticoids as a neuroendocrine alarm signal of danger. Brain Behav. Immun. 33 (2013), 1–6.
44. Gallagher, J.P., Orozco-Cabal, L.F., Liu, J., Shinnick-Gallagher, P., Synaptic physiology of central CRH system. Eur. J. Pharmacol. 583 (2008), 215–225.
45. Gerken, A., Holsboer, F., Cortisol and corticosterone response after syn-corticotropin in relationship to dexamethasone suppressibility of cortisol. Psychoneuroendocrinology 11 (1986), 185–194.
46. Gervasoni, N., Bertschy, G., Osiek, C., Perret, G., Denis, R., Golaz, J., Rossier, M.F., Bondolfi, G., Aubry, J.M., Cortisol responses to combined dexamethasone/CRH test in outpatients with a major depressive episode. J. Psychiatr. Res. 38 (2004), 553–557.
47. Goenjian, A.K., Yehuda, R., Pynoos, R.S., Steinberg, A.M., Tashjian, M., Yang, R.K., Najarian, L.M., Fairbanks, L.A., Basal cortisol, dexamethasone suppression of cortisol, and MHPG in adolescents after the 1988 earthquake in Armenia. Am. J. Psychiatry 153 (1996), 929–934.
48. Gold, P.W., Chrousos, G.P., Organization of the stress system and its dysregulation in melancholic and atypical depression: high vs low CRH/NE states. Mol. Psychiatry 7 (2002), 254–275.
49. Gold, P.W., Chrousos, G., Kellner, C., Post, R., Roy, A., Augerinos, P., Schulte, H., Oldfield, E., Loriaux, D.L., Psychiatric implications of basic and clinical studies with corticotropin-releasing factor. Am. J. Psychiatry 141 (1984), 619–627.
50. Gold, P.W., Loriaux, D.L., Roy, A., Kling, M.A., Calabrese, J.R., Kellner, C.H., Nieman, L.K., Post, R.M., Pickar, D., Gallucci, W., et al. Responses to corticotropin-releasing hormone in the hypercortisolism of depression and Cushing's disease. Pathophysiologic and diagnostic implications. N. Engl. J. Med. 314 (1986), 1329–1335.
51. Gold, P.W., The organization of the stress system and its dysregulation in depressive illness. Mol. Psychiatry 20 (2015), 32–47.
52. Golier, J.A., Schmeidler, J., Legge, J., Yehuda, R., Enhanced cortisol suppression to dexamethasone associated with Gulf War deployment. Psychoneuroendocrinology 31 (2006), 1181–1189.
53. Gormley, G.J., Lowy, M.T., Reder, A.T., Hospelhorn, V.D., Antel, J.P., Meltzer, H.Y., Glucocorticoid receptors in depression: relationship to the dexamethasone suppression test. Am. J. Psychiatry 142 (1985), 1278–1284.
54. Greden, J.F., Gardner, R., King, D., Grunhaus, L., Carroll, B.J., Kronfol, Z., Dexamethasone suppression tests in antidepressant treatment of melancholia. The process of normalization and test-retest reproducibility. Arch. Gen. Psychiatry 40 (1983), 493–500.
55. Griffin, M.G., Resick, P.A., Yehuda, R., Enhanced cortisol suppression following dexamethasone administration in domestic violence survivors. Am. J. Psychiatry 162:6 (2005), 1192–1199.
56. Grossi, G., Perski, A., Ekstedt, M., Johansson, T., Lindstrom, M., Holm, K., The morning salivary cortisol response in burnout. J. Psychosom. Res. 59 (2005), 103–111.
57. Grunhaus, L., Zelnik, T., Albala, A.A., Rabin, D., Haskett, R.F., Zis, A.P., Greden, J.F., Serial dexamethasone suppression tests in depressed patients treated only with electroconvulsive therapy. J. Affect. Disord., 13, 1987.
58. Hatzinger, M., Hemmeter, U.M., Baumann, K., Brand, S., Holsboer-Trachsler, E., The combined DEX-CRH test in treatment course and long-term outcome of major depression. J. Psychiatr. Res. 36 (2002), 287–297.
59. Heim, C., Ehlert, U., Hanker, J.P., Hellhammer, D.H., Abuse-related posttraumatic stress disorder and alterations of the hypothalamic-pituitary-adrenal axis in women with chronic pelvic pain. Psychosom. Med. 60 (1998), 309–318.
60. Heim, C., Ehlert, U., Hellhammer, D.H., The potential role of hypocortisolism in the pathophysiology of stress-related bodily disorders. Psychoneuroendocrinology 25 (2000), 1–35.
61. Heim, C., Newport, D.J., Bonsall, R., Miller, A.H., Nemeroff, C.B., Altered pituitary-adrenal axis responses to provocative challenge tests in adult survivors of childhood abuse. Am. J. Psychiatry 158:4 (2001), 575–581.
62. Heim, C., Mletzko, T., Purselle, D., Musselman, D.L., Nemeroff, C.B., The dexamethasone/corticotropin-releasing factor test in men with major depression: role of childhood trauma. Biol. Psychiatry 63 (2008), 398–405.
63. Hennings, J.M., Owashi, T., Binder, E.B., Horstmann, S., Menke, A., Kloiber, S., Dose, T., Wollweber, B., Spieler, D., Messer, T., Lutz, R., Kunzel, H., Bierner, T., Pollmacher, T., Pfister, H., Nickel, T., Sonntag, A., Uhr, M., Ising, M., Holsboer, F., Lucae, S., Clinical characteristics and treatment outcome in a representative sample of depressed inpatients–findings from the Munich Antidepressant Response Signature (MARS) project. J. Psychiatr. Res. 43 (2009), 215–229.
64. Heuser, I., Yassouridis, A., Holsboer, F., The combined dexamethasone/CRH test: a refined laboratory test for psychiatric disorders. J. Psychiatr. Res. 28 (1994), 341–356.
65. Heuser, I.J., Gotthardt, U., Schweiger, U., Schmider, J., Lammers, C.H., Dettling, M., Holsboer, F., Age-associated changes of pituitary-adrenocortical hormone regulation in humans: importance of gender. Neurobiol. Aging 15 (1994), 227–231.
66. Heuser, I.J., Schweiger, U., Gotthardt, U., Schmider, J., Lammers, C.H., Dettling, M., Yassouridis, A., Holsboer, F., Pituitary-adrenal-system regulation and psychopathology during amitriptyline treatment in elderly depressed patients and normal comparison subjects. Am. J. Psychiatry 153 (1996), 93–99.
67. Hohne, N., Poidinger, M., Merz, F., Pfister, H., Bruckl, T., Zimmermann, P., Uhr, M., Holsboer, F., Ising, M., FKBP5 genotype-dependent DNA methylation and mRNA regulation after psychosocial stress in remitted depression and healthy controls. Int. J. Neuropsychopharmacol., 18, 2015.
68. Holsboer, F., Barden, N., Antidepressants and hypothalamic-pituitary-adrenocortical regulation. Endocr. Rev. 17 (1996), 187–205.
69. Holsboer, F., Ising, M., Stress hormone regulation: biological role and translation into therapy. Annu. Rev. Psychol. 61 (2010), 81–109 C101–111.
70. Holsboer, F., Bender, W., Benkert, O., Klein, H.E., Schmauss, M., Diagnostic value of dexamethasone suppression test in depression. Lancet, 2, 1980, 706.
71. Holsboer, F., Liebl, R., Hofschuster, E., Repeated dexamethasone suppression test during depressive illness. Normalisation of test result compared with clinical improvement. J. Affect. Disord. 4 (1982), 93–101.
72. Holsboer, F., Gerken, A., Steiger, A., Benkert, O., Muller, O.A., Stalla, G.K., Corticotropin-releasing-factor induced pituitary-adrenal response in depression. Lancet, 1, 1984, 55.
73. Holsboer, F., Von Bardeleben, U., Gerken, A., Stalla, G.K., Muller, O.A., Blunted corticotropin and normal cortisol response to human corticotropin-releasing factor in depression. N. Engl. J. Med., 311, 1984, 1127.
74. Holsboer, F., Gerken, A., von Bardeleben, U., Grimm, W., Beyer, H., Muller, O.A., Stalla, G.K., Human corticotropin-releasing hormone in depression-correlation with thyrotropin secretion following thyrotropin-releasing hormone. Biol. Psychiatry 21 (1986), 601–611.
75. Holsboer, F., von Bardeleben, U., Wiedemann, K., Muller, O.A., Stalla, G.K., Serial assessment of corticotropin-releasing hormone response after dexamethasone in depression. Implications for pathophysiology of DST nonsuppression. Biol. Psychiatry 22 (1987), 228–234.
76. Holsboer, F., Lauer, C.J., Schreiber, W., Krieg, J.C., Altered hypothalamic-pituitary-adrenocortical regulation in healthy subjects at high familial risk for affective disorders. Neuroendocrinology 62 (1995), 340–347.
77. Holsboer, F., Corticotropin-releasing hormone–a new tool to investigate hypothalamic-pituitary-adrenocortical physiology in psychiatric patients. Psychopharmacol. Bull. 22 (1986), 907–912.
78. Holsboer, F., The corticosteroid receptor hypothesis of depression. Neuropsychopharmacology 23 (2000), 477–501.
79. Holsboer, F., Stress, hypercortisolism and corticosteroid receptors in depression: implications for therapy. J. Affect. Disord. 62 (2001), 77–91.
80. Holsboer, F., How can we realize the promise of personalized antidepressant medicines?. Nat. Rev. Neurosci. 9 (2008), 638–646.
81. Holsboer-Trachsler, E., Stohler, R., Hatzinger, M., Repeated administration of the combined dexamethasone-human corticotropin releasing hormone stimulation test during treatment of depression. Psychiatry Res. 38 (1991), 163–171.
82. Illumina Technical Note, Illumina Technical Note. 2007 (http://www.expressionanalysis.com/pdf/IlluminaBlood_TechNote_2007.pdf).
83. Ising, M., Kunzel, H.E., Binder, E.B., Nickel, T., Modell, S., Holsboer, F., The combined dexamethasone/CRH test as a potential surrogate marker in depression. Prog. Neuro-Psychopharmacol. Biol. Psychiatry 29 (2005), 1085–1093.
84. Ising, M., Lauer, C.J., Holsboer, F., Modell, S., The Munich vulnerability study on affective disorders: premorbid neuroendocrine profile of affected high-risk probands. J. Psychiatr. Res. 39 (2005), 21–28.
85. Ising, M., Horstmann, S., Kloiber, S., Lucae, S., Binder, E.B., Kern, N., Kunzel, H.E., Pfennig, A., Uhr, M., Holsboer, F., Combined dexamethasone/corticotropin releasing hormone test predicts treatment response in major depression–a potential biomarker?. Biol. Psychiatry 62 (2007), 47–54.
86. Ising, M., Depping, A.M., Siebertz, A., Lucae, S., Unschuld, P.G., Kloiber, S., Horstmann, S., Uhr, M., Muller-Myhsok, B., Holsboer, F., Polymorphisms in the FKBP5 gene region modulate recovery from psychosocial stress in healthy controls. Eur. J. Neurosci. 28 (2008), 389–398.
87. Jaaskelainen, T., Makkonen, H., Palvimo, J.J., Steroid up-regulation of FKBP51 and its role in hormone signaling. Curr. Opin. Pharmacol. 11 (2011), 326–331.
88. Joels, M., Baram, T.Z., The neuro-symphony of stress. Nat. Rev. Neurosci. 10 (2009), 459–466.
89. Kaestner, F., Hettich, M., Peters, M., Sibrowski, W., Hetzel, G., Ponath, G., Arolt, V., Cassens, U., Rothermundt, M., Different activation patterns of proinflammatory cytokines in melancholic and non-melancholic major depression are associated with HPA axis activity. J. Affect. Disord. 87 (2005), 305–311.
90. Kellner, M., Yassouridis, A., Hubner, R., Baker, D.G., Wiedemann, K., Endocrine and cardiovascular responses to corticotropin-releasing hormone in patients with posttraumatic stress disorder: a role for atrial natriuretic peptide?. Neuropsychobiology 47 (2003), 102–108.
91. Klengel, T., Mehta, D., Anacker, C., Rex-Haffner, M., Pruessner, J.C., Pariante, C.M., Pace, T.W., Mercer, K.B., Mayberg, H.S., Bradley, B., Nemeroff, C.B., Holsboer, F., Heim, C.M., Ressler, K.J., Rein, T., Binder, E.B., Allele-specific FKBP5 DNA demethylation mediates gene-childhood trauma interactions. Nat. Neurosci. 16 (2013), 33–41.
92. Kohler, C.A., Freitas, T.H., Maes, M., de Andrade, N.Q., Liu, C.S., Fernandes, B.S., Stubbs, B., Solmi, M., Veronese, N., Herrmann, N., Raison, C.L., Miller, B.J., Lanctot, K.L., Carvalho, A.F., Peripheral cytokine and chemokine alterations in depression: a meta-analysis of 82 studies. Acta Psychiatr. Scand. 135 (2017), 373–387.
93. Kudielka, B.M., von Kanel, R., Preckel, D., Zgraggen, L., Mischler, K., Fischer, J.E., Exhaustion is associated with reduced habituation of free cortisol responses to repeated acute psychosocial stress. Biol. Psychol. 72 (2006), 147–153.
94. Kunugi, H., Ida, I., Owashi, T., Kimura, M., Inoue, Y., Nakagawa, S., Yabana, T., Urushibara, T., Kanai, R., Aihara, M., Yuuki, N., Otsubo, T., Oshima, A., Kudo, K., Inoue, T., Kitaichi, Y., Shirakawa, O., Isogawa, K., Nagayama, H., Kamijima, K., Nanko, S., Kanba, S., Higuchi, T., Mikuni, M., Assessment of the dexamethasone/CRH test as a state-dependent marker for hypothalamic-pituitary-adrenal (HPA) axis abnormalities in major depressive episode: a multicenter study. Neuropsychopharmacology 31 (2006), 212–220.
95. Kunzel, H.E., Binder, E.B., Nickel, T., Ising, M., Fuchs, B., Majer, M., Pfennig, A., Ernst, G., Kern, N., Schmid, D.A., Uhr, M., Holsboer, F., Modell, S., Pharmacological and nonpharmacological factors influencing hypothalamic-pituitary-adrenocortical axis reactivity in acutely depressed psychiatric in-patients, measured by the Dex-CRH test. Neuropsychopharmacology 28 (2003), 2169–2178.
96. Langelaan, S., Bakker, A.B., Schaufeli, W.B., van Rhenen, W., van Doornen, L.J., Do burned-out and work-engaged employees differ in the functioning of the hypothalamic-pituitary-adrenal axis? Scandinavian journal of work. Scand. J. Work, Environ. Health 32 (2006), 339–348.
97. Leonard, B.E., Myint, A., The psychoneuroimmunology of depression. Hum. Psychopharmacol. 24 (2009), 165–175.
98. Lessard, J., Holman, E.A., FKBP5 and CRHR1 polymorphisms moderate the stress-physical health association in a national sample. Health Psychol. 33 (2014), 1046–1056.
99. Lindley, S.E., Carlson, E.B., Benoit, M., Basal and dexamethasone suppressed salivary cortisol concentrations in a community sample of patients with posttraumatic stress disorder. Biol. Psychiatry 55:9 (2004), 940–945.
100. Lindqvist, D., Wolkowitz, O.M., Mellon, S., Yehuda, R., Flory, J.D., Henn-Haase, C., Bierer, L.M., Abu-Amara, D., Coy, M., Neylan, T.C., Makotkine, I., Reus, V.I., Yan, X., Taylor, N.M., Marmar, C.R., Dhabhar, F.S., Proinflammatory milieu in combat-related PTSD is independent of depression and early life stress. Brain Behav. Immun. 42 (2014), 81–88.
101. Lisi, L., Camardese, G., Treglia, M., Tringali, G., Carrozza, C., Janiri, L., Dello Russo, C., Navarra, P., Monocytes from depressed patients display an altered pattern of response to endotoxin challenge. PLoS One, 8(1), 2013, e52585.
102. Lowy, M.T., Reder, A.T., Gormley, G.J., Meltzer, H.Y., Comparison of in vivo and in vitro glucocorticoid sensitivity in depression: relationship to the dexamethasone suppression test. Biol. Psychiatry 24 (1988), 619–630.
103. Lowy, M.T., Quantification of type I and II adrenal steroid receptors in neuronal, lymphoid and pituitary tissues. Brain Res. 503 (1989), 191–197.
104. Matic, G., Milutinovic Nestorov, D.V.J., Elakovic, I., Jovanovic, S.M., Perisic, T., Dunderski, J., Damjanovic, S., Knezevic, G., Spiric, Z., Vermetten, E., Savic, D., Lymphocyte glucocorticoid receptor expression level and hormone-binding properties differ between war trauma-exposed men with and without PTSD. Prog. Neuropsychopharmacol. Biol. Psychiatry 43 (2013), 238–245.
105. McEwen, B.S., Protective and damaging effects of stress mediators: central role of the brain. Dialogues Clin. Neurosci. 8 (2006), 367–381.
106. McEwen, B.S., Allostasis and the epigenetics of brain and body health over the life course: the brain on stress. JAMA Psychiatry 74 (2017), 551–552.
107. Meador-Woodruff, J.H., Gurguis, G., Grunhaus, L., Haskett, R.F., Greden, J.F., Multiple depressive episodes and plasma postdexamethasone cortisol levels. Biol. Psychiatry 22 (1987), 583–592.
108. Mehta, D., Menke, A., Binder, E.B., Gene expression studies in major depression. Curr. Psychiatry Rep. 12 (2010), 135–144.
109. Mehta, D., Gonik, M., Klengel, T., Rex-Haffner, M., Menke, A., Rubel, J., Mercer, K.B., Putz, B., Bradley, B., Holsboer, F., Ressler, K.J., Muller-Myhsok, B., Binder, E.B., Using polymorphisms in FKBP5 to define biologically distinct subtypes of posttraumatic stress disorder: evidence from endocrine and gene expression studies. Arch. Gen. Psychiatry 68 (2011), 901–910.
110. Melamed, S., Shirom, A., Toker, S., Berliner, S., Shapira, I., Burnout and risk of cardiovascular disease: evidence, possible causal paths, and promising research directions. Psychol. Bull. 132 (2006), 327–353.
111. Menke, A., Arloth, J., Putz, B., Weber, P., Klengel, T., Mehta, D., Gonik, M., Rex-Haffner, M., Rubel, J., Uhr, M., Lucae, S., Deussing, J.M., Muller-Myhsok, B., Holsboer, F., Binder, E.B., Dexamethasone stimulated gene expression in peripheral blood is a sensitive marker for glucocorticoid receptor resistance in depressed patients. Neuropsychopharmacology 37 (2012), 1455–1464.
112. Menke, A., Rex-Haffner, M., Klengel, T., Binder, E.B., Mehta, D., Peripheral blood gene expression: it all boils down to the RNA collection tubes. BMC Res. Notes, 5, 2012, 1.
113. Menke, A., Klengel, T., Rubel, J., Bruckl, T., Pfister, H., Lucae, S., Uhr, M., Holsboer, F., Binder, E.B., Genetic variation in FKBP5 associated with the extent of stress hormone dysregulation in major depression. Genes Brain Behav. 12 (2013), 289–296.
114. Menke, A., Arloth, J., Gerber, M., Rex-Haffner, M., Uhr, M., Holsboer, F., Binder, E.B., Holsboer-Trachsler, E., Beck, J., Dexamethasone stimulated gene expression in peripheral blood indicates glucocorticoid-receptor hypersensitivity in job-related exhaustion. Psychoneuroendocrinology 44 (2014), 35–46.
115. Menke, A., Arloth, J., Best, J., Namendorf, C., Gerlach, T., Czamara, D., Lucae, S., Dunlop, B.W., Crowe, T.M., Garlow, S.J., Nemeroff, C.B., Ritchie, J.C., Craighead, W.E., Mayberg, H.S., Rex-Haffner, M., Binder, E.B., Uhr, M., Time-dependent effects of dexamethasone plasma concentrations on glucocorticoid receptor challenge tests. Psychoneuroendocrinology 69 (2016), 161–171.
116. Menke, A., Gene expression: biomarker of antidepressant therapy?. Int. Rev. Psychiatry 25 (2013), 579–591.
117. Metzger, L.J., Carson, M.A., Lasko, N.B., Paulus, L.A., Orr, S.P., Pitman, R.K., Yehuda, R., Basal and suppressed salivary cortisol in female Vietnam nurse veterans with and without PTSD. Psychiatry Res. 161:3 (2008), 330–335.
118. Miller, A.H., Raison, C.L., The role of inflammation in depression: from evolutionary imperative to modern treatment target. Nat. Rev. Immunol. 16 (2016), 22–34.
119. Miller, A.H., Spencer, R.L., Pearce, B.D., Pisell, T.L., Azrieli, Y., Tanapat, P., Moday, H., Rhee, R., McEwen, B.S., Glucocorticoid receptors are differentially expressed in the cells and tissues of the immune system. Cell. Immunol. 186 (1998), 45–54.
120. Modell, S., Yassouridis, A., Huber, J., Holsboer, F., Corticosteroid receptor function is decreased in depressed patients. Neuroendocrinology 65 (1997), 216–222.
121. Mokhtari, M., Arfken, C., Boutros, N., The DEX/CRH test for major depression: a potentially useful diagnostic test. Psychiatry Res. 208 (2013), 131–139.
122. Mommersteeg, P.M., Heijnen, C.J., Kavelaars, A., van Doornen, L.J., Immune and endocrine function in burnout syndrome. Psychosom Med. 68:6 (2006), 879–886.
123. Mommersteeg, P.M., Heijnen, C.J., Verbraak, M.J., van Doornen, L.J., A longitudinal study on cortisol and complaint reduction in burnout. Psychoneuroendocrinology 31:7 (2006), 793–804.
124. Mommersteeg, P.M., Heijnen, C.J., Verbraak, M.J., van Doornen, L.J., Clinical burnout is not reflected in the cortisol awakening response, the day-curve or the response to a low-dose dexamethasone suppression test. Psychoneuroendocrinology 31:2 (2006), 216–225.
125. Mommersteeg, P.M., Heijnen, C.J., Kavelaars, A., van Doornen, L.J., The HPA-axis and immune function in burnout. Prog. Brain Res. 167 (2008), 281–285.
126. Morris, M.C., Compas, B.E., Garber, J., Relations among posttraumatic stress disorder, comorbid major depression, and HPA function: a systematic review and meta-analysis. Clin. Psychol. Rev. 32 (2012), 301–315.
127. Muhtz, C., Wester, M., Yassouridis, A., Wiedemann, K., Kellner, M., A combined dexamethasone/corticotropin-releasing hormone test in patients with chronic PTSD–first preliminary results. J. Psychiatr. Res. 42:8 (2008), 689–693.
128. Nelson, J.C., Davis, J.M., DST studies in psychotic depression: a meta-analysis. Am. J. Psychiatry 154 (1997), 1497–1503.
129. Nemeroff, C.B., The corticotropin-releasing factor (CRF) hypothesis of depression: new findings and new directions. Mol. Psychiatry 1 (1996), 336–342.
130. Newport, D.J., Heim, C., Bonsall, R., Miller, A.H., Nemeroff, C.B., Pituitary-adrenal responses to standard and low-dose dexamethasone suppression tests in adult survivors of child abuse. Biol. Psychiatry 55 (2004), 10–20.
131. Nierenberg, A.A., Feinstein, A.R., How to evaluate a diagnostic marker test. Lessons from the rise and fall of dexamethasone suppression test. JAMA 259 (1988), 1699–1702.
132. Nikkheslat, N., Zunszain, P.A., Horowitz, M.A., Barbosa, I.G., Parker, J.A., Myint, A.M., Schwarz, M.J., Tylee, A.T., Carvalho, L.A., Pariante, C.M., Insufficient glucocorticoid signaling and elevated inflammation in coronary heart disease patients with comorbid depression. Brain Behav. Immun. 48 (2015), 8–18.
133. O'Connor, J.C., Lawson, M.A., Andre, C., Moreau, M., Lestage, J., Castanon, N., Kelley, K.W., Dantzer, R., Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice. Mol. Psychiatry 14 (2009), 511–522.
134. Ohayon, M.M., Schatzberg, A.F., Prevalence of depressive episodes with psychotic features in the general population. Am. J. Psychiatry 159 (2002), 1855–1861.
135. Onen Sertoz, O., Binbay, I.T., Elbi Mete, H., The neurobiology of burnout: the hypothalamus-pituitary-adrenal gland axis and other findings. Turk. Psikiyatri Dergisi=Turk. J. Psychiatry 19 (2008), 318–328.
136. Oshima, A., Yamashita, S., Owashi, T., Murata, T., Tadokoro, C., Miyaoka, H., Kamijima, K., Higuchi, T., The differential ACTH responses to combined dexamethasone/CRH administration in major depressive and dysthymic disorders. J. Psychiatr. Res. 34 (2000), 325–328.
137. Otte, C., Gold, S.M., Penninx, B.W., Pariante, C.M., Etkin, A., Fava, M., Mohr, D.C., Schatzberg, A.F., Major depressive disorder. Nat. Rev. Dis. Prim., 2, 2016, 16065.
138. Owashi, T., Otsubo, T., Oshima, A., Nakagome, K., Higuchi, T., Kamijima, K., Longitudinal neuroendocrine changes assessed by dexamethasone/CRH and growth hormone releasing hormone tests in psychotic depression. Psychoneuroendocrinology 33 (2008), 152–161.
139. Pace, T.W., Wingenfeld, K., Schmidt, I., Meinlschmidt, G., Hellhammer, D.H., Heim, C.M., Increased peripheral NF-kappaB pathway activity in women with childhood abuse-related posttraumatic stress disorder. Brain Behav. Immun. 26:1 (2012), 13–17.
140. Padgett, D.A., Glaser, R., How stress influences the immune response. Trends Immunol. 24 (2003), 444–448.
141. Pagliaccio, D., Luby, J.L., Bogdan, R., Agrawal, A., Gaffrey, M.S., Belden, A.C., Botteron, K.N., Harms, M.P., Barch, D.M., Stress-system genes and life stress predict cortisol levels and amygdala and hippocampal volumes in children. Neuropsychopharmacology 39 (2014), 1245–1253.
142. Pariante, C.M., Lightman, S.L., The HPA axis in major depression: classical theories and new developments. Trends Neurosci. 31 (2008), 464–468.
143. Pariante, C.M., Miller, A.H., Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment. Biol. Psychiatry 49 (2001), 391–404.
144. Pariante, C.M., Glucocorticoid receptor function in vitro in patients with major depression. Stress 7 (2004), 209–219.
145. Paslakis, G., Krumm, B., Gilles, M., Schweiger, U., Heuser, I., Richter, I., Deuschle, M., Discrimination between patients with melancholic depression and healthy controls: comparison between 24-h cortisol profiles, the DST and the Dex/CRH test. Psychoneuroendocrinology 36:5 (2011), 691–698.
146. Pfennig, A., Kunzel, H.E., Kern, N., Ising, M., Majer, M., Fuchs, B., Ernst, G., Holsboer, F., Binder, E.B., Hypothalamus-pituitary-adrenal system regulation and suicidal behavior in depression. Biol. Psychiatry 57:4 (2005), 336–342.
147. Popoli, M., Yan, Z., McEwen, B.S., Sanacora, G., The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission. Nat. Rev. Neurosci. 13 (2011), 22–37.
148. Pratt, W.B., Toft, D.O., Steroid receptor interactions with heat shock protein and immunophilin chaperones. Endocr. Rev. 18 (1997), 306–360.
149. Pratt, W.B., Morishima, Y., Murphy, M., Harrell, M., Chaperoning of glucocorticoid receptors. Handb. Exp. Pharmacol., 2006, 111–138.
150. Pruessner, J.C., Hellhammer, D.H., Kirschbaum, C., Burnout, perceived stress, and cortisol responses to awakening. Psychosom. Med. 61 (1999), 197–204.
151. Quintanar, J.L., Guzman-Soto, I., Hypothalamic neurohormones and immune responses. Front. Integr. Neurosci., 7, 2013, 56.
152. Raison, C.L., Miller, A.H., When not enough is too much: the role of insufficient glucocorticoid signaling in the pathophysiology of stress-related disorders. Am. J. Psychiatry 160 (2003), 1554–1565.
153. Rasmusson, A.M., Lipschitz, D.S., Wang, S., Hu, S., Vojvoda, D., Bremner, J.D., Southwick, S.M., Charney, D.S., Increased pituitary and adrenal reactivity in premenopausal women with posttraumatic stress disorder. Biol. Psychiatry 50 (2001), 965–977.
154. Reichenberg, A., Yirmiya, R., Schuld, A., Kraus, T., Haack, M., Morag, A., Pollmacher, T., Cytokine-associated emotional and cognitive disturbances in humans. Arch. Gen. Psychiatry 58 (2001), 445–452.
155. Reppermund, S., Zihl, J., Lucae, S., Horstmann, S., Kloiber, S., Holsboer, F., Ising, M., Persistent cognitive impairment in depression: the role of psychopathology and altered hypothalamic-pituitary-adrenocortical (HPA) system regulation. Biol. Psychiatry 62:5 (2007), 400–406.
156. Reul, J.M., Holsboer, F., Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression. Curr. Opin. Pharmacol. 2 (2002), 23–33.
157. Reul, J.M., de Kloet, E.R., Two receptor systems for corticosterone in rat brain: microdistribution and differential occupation. Endocrinology 117 (1985), 2505–2511.
158. Ribeiro, S.C., Tandon, R., Grunhaus, L., Greden, J.F., The DST as a predictor of outcome in depression: a meta-analysis. Am. J. Psychiatry 150 (1993), 1618–1629.
159. Rinne, T., de Kloet, E.R., Wouters, L., Goekoop, J.G., DeRijk, R.H., van den Brink, W., Hyperresponsiveness of hypothalamic-pituitary-adrenal axis to combined dexamethasone/corticotropin-releasing hormone challenge in female borderline personality disorder subjects with a history of sustained childhood abuse. Biol. Psychiatry 52 (2002), 1102–1112.
160. Rohleder, N., Joksimovic, L., Wolf, J.M., Kirschbaum, C., Hypocortisolism and increased glucocorticoid sensitivity of pro-Inflammatory cytokine production in Bosnian war refugees with posttraumatic stress disorder. Biol. Psychiatry 55 (2004), 745–751.
161. Rollins, B., Martin, M.V., Morgan, L., Vawter, M.P., Analysis of whole genome biomarker expression in blood and brain. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (2010), 919–936.
162. Roozendaal, B., McEwen, B.S., Chattarji, S., Stress, memory and the amygdala. Nat. Rev. Neurosci. 10 (2009), 423–433.
163. Rosenblat, J.D., Cha, D.S., Mansur, R.B., McIntyre, R.S., Inflamed moods: a review of the interactions between inflammation and mood disorders. Prog. Neuro-Psychopharmacol. Biol. Psychiatry 53 (2014), 23–34.
164. Roy, A., Gorodetsky, E., Yuan, Q., Goldman, D., Enoch, M.A., Interaction of FKBP5, a stress-related gene, with childhood trauma increases the risk for attempting suicide. Neuropsychopharmacology 35 (2010), 1674–1683.
165. Roy, A., Hodgkinson, C.A., Deluca, V., Goldman, D., Enoch, M.A., Two HPA axis genes, CRHBP and FKBP5, interact with childhood trauma to increase the risk for suicidal behavior. J. Psychiatr. Res. 46 (2012), 72–79.
166. Rupprecht, R., Wodarz, N., Kornhuber, J., Wild, K., Schmitz, B., Braner, H.U., Muller, O.A., Riederer, P., Beckmann, H., In vivo and in vitro effects of glucocorticoids on lymphocyte proliferation in depression. Eur. Arch. Psychiatry Clin. Neurosci. 241 (1991), 35–40.
167. Rybakowski, J.K., Twardowska, K., The dexamethasone/corticotropin-releasing hormone test in depression in bipolar and unipolar affective illness. J. Psychiatr. Res. 33 (1999), 363–370.
168. Rydmark, I., Wahlberg, K., Ghatan, P.H., Modell, S., Nygren, A., Ingvar, M., Asberg, M., Heilig, M., Neuroendocrine, cognitive and structural imaging characteristics of women on longterm sickleave with job stress-induced depression. Biol. Psychiatry 60 (2006), 867–873.
169. Söderström, M., Ekstedt, M., Akerstedt, T., Weekday and weekend patterns of diurnal cortisol, activation and fatigue among people scoring high for burnout. Scand. J. Work Environ. Health, 2006, 35–40.
170. Schatzberg, A.F., Anna-Monika Award Lecture, DGPPN Kongress, 2013: the role of the hypothalamic-pituitary-adrenal (HPA) axis in the pathogenesis of psychotic major depression. World J. Biol. Psychiatry 16 (2015), 2–11.
171. Schule, C., Baghai, T.C., Eser, D., Zwanzger, P., Jordan, M., Buechs, R., Rupprecht, R., Time course of hypothalamic-pituitary-adrenocortical axis activity during treatment with reboxetine and mirtazapine in depressed patients. Psychopharmacology (Berl) 186:4 (2006), 601–611.
172. Schule, C., Baghai, T.C., Eser, D., Hafner, S., Born, C., Herrmann, S., Rupprecht, R., The combined dexamethasone/CRH Test (DEX/CRH test) and prediction of acute treatment response in major depression. PLoS One, 4(1), 2009, e4324.
173. Selye, H., Stress and the general adaptation syndrome. Br. Med. J. 1 (1950), 1383–1392.
174. Sher, L., Oquendo, M.A., Burke, A.K., Cooper, T.B., Mann, J.J., Combined dexamethasone suppression-corticotrophin-releasing hormone stimulation test in medication-free major depression and healthy volunteers. J. Affect. Disord. 151:3 (2013), 1108–1112.
175. Simeon, D., Knutelska, M., Yehuda, R., Putnam, F., Schmeidler, J., Smith, L.M., Hypothalamic-pituitary-adrenal axis function in dissociative disorders, post-traumatic stress disorder, and healthy volunteers. Biol. Psychiatry 61:8 (2007), 966–973.
176. Smith, M.A., Davidson, J., Ritchie, J.C., Kudler, H., Lipper, S., Chappell, P., Nemeroff, C.B., The corticotropin-releasing hormone test in patients with posttraumatic stress disorder. Biol. Psychiatry 26 (1989), 349–355.
177. Sonnenschein, M., Mommersteeg, P.M., Houtveen, J.H., Sorbi, M.J., Schaufeli, W.B., van Doornen, L.J., Exhaustion and endocrine functioning in clinical burnout: an in-depth study using the experience sampling method. Biol. Psychol. 75 (2007), 176–184.
178. Spijker, S., Sharp-Baker, H.E., Geraerts, W.P., Van Minnen, J., Smit, A.B., Stimulus-dependent regulation and cellular expression of genes encoding neuropeptides, prohormone convertases, alpha-amidating enzyme and 7B2 in identified Lymnaea neurons. J. Neurochem. 90 (2004), 287–296.
179. Spijker, S., Zanten, J.S., De Jong, S., Penninx, B.W., van Dyck, R., Zitman, F.G., Smit, J.H., Ylstra, B., Smit, A.B., Hoogendijk, W.J., Stimulated gene expression profiles as a blood marker of major depressive disorder. Biol. Psychiatry 68 (2010), 179–186.
180. Stein, M.B., Yehuda, R., Koverola, C., Hanna, C., Enhanced dexamethasone suppression of plasma cortisol in adult women traumatized by childhood sexual abuse. Biol. Psychiatry 42 (1997), 680–686.
181. Steinberg, H., Kirkby, K.C., Himmerich, H., The historical development of immunoendocrine concepts of psychiatric disorders and their therapy. Int. J. Mol. Sci. 16 (2015), 28841–28869.
182. Stetler, C., Miller, G.E., Depression and hypothalamic-pituitary-adrenal activation: a quantitative summary of four decades of research. Psychosom. Med. 73 (2011), 114–126.
183. Strohle, A., Scheel, M., Modell, S., Holsboer, F., Blunted ACTH response to dexamethasone suppression-CRH stimulation in posttraumatic stress disorder. J. Psychiatr. Res. 42 (2008), 1185–1188.
184. Sullivan, P.F., Fan, C., Perou, C.M., Evaluating the comparability of gene expression in blood and brain. Am. J. Med. Genet. B Neuropsychiatr. Genet. 141 (2006), 261–268.
185. Van Den Eede, F., Van den Bossche, B., Hulstijn, W., Sabbe, B.G., Cosyns, P., Claes, S.J., Combined dexamethasone/CRF test in remitted outpatients with recurrent major depressive disorder. J. Affect. Disord. 93:1-3 (2006), 259–263.
186. van Zuiden, M., Heijnen, C.J., Maas, M., Amarouchi, K., Vermetten, E., Geuze, E., Kavelaars, A., Glucocorticoid sensitivity of leukocytes predicts PTSD, depressive and fatigue symptoms after military deployment: a prospective study. Psychoneuroendocrinology 37:11 (2012), 1822–1836.
187. van Zuiden, M., Kavelaars, A., Vermetten, E., Olff, M., Geuze, E., Heijnen, C., Pre-deployment differences in glucocorticoid sensitivity of leukocytes in soldiers developing symptoms of PTSD, depression or fatigue persist after return from military deployment. Psychoneuroendocrinology 51 (2015), 513–524.
188. Vermeer, H., Hendriks-Stegeman, B.I., van der Burg, B., van Buul-Offers, S.C., Jansen, M., Glucocorticoid-induced increase in lymphocytic FKBP51 messenger ribonucleic acid expression: a potential marker for glucocorticoid sensitivity, potency, and bioavailability. J. Clin. Endocrinol. Metab. 88 (2003), 277–284.
189. von Bardeleben, U., Holsboer, F., Effect of age on the cortisol response to human corticotropin-releasing hormone in depressed patients pretreated with dexamethasone. Biol. Psychiatry 29 (1991), 1042–1050.
190. Vythilingam, M., Gill, J.M., Luckenbaugh, D.A., Gold, P.W., Collin, C., Bonne, O., Plumb, K., Polignano, E., West, K., Charney, D., Low early morning plasma cortisol in posttraumatic stress disorder is associated with co-morbid depression but not with enhanced glucocorticoid feedback inhibition. Psychoneuroendocrinology 35:3 (2010), 442–450.
191. Wahlberg, K., Ghatan, P.H., Modell, S., Nygren, A., Ingvar, M., Asberg, M., Heilig, M., Suppressed neuroendocrine stress response in depressed women on job-stress-related long-term sick leave: a stable marker potentially suggestive of preexisting vulnerability. Biol. Psychiatry 65 (2009), 742–747.
192. Wassef, A., Smith, E.M., Rose, R.M., Gardner, R., Nguyen, H., Meyer, W.J., Mononuclear leukocyte glucocorticoid receptor binding characteristics and down-regulation in major depression. Psychoneuroendocrinology 15 (1990), 59–68.
193. Watson, S., Gallagher, P., Del-Estal, D., Hearn, A., Ferrier, I.N., Young, A.H., Hypothalamic-pituitary-adrenal axis function in patients with chronic depression. Psychol. Med. 32 (2002), 1021–1028.
194. Whitney, A.R., Diehn, M., Popper, S.J., Alizadeh, A.A., Boldrick, J.C., Relman, D.A., Brown, P.O., Individuality and variation in gene expression patterns in human blood. Proc. Natl. Acad. Sci. U. S. A. 100 (2003), 1896–1901.
195. Willour, V.L., Chen, H., Toolan, J., Belmonte, P., Cutler, D.J., Goes, F.S., et al. Family-based association of FKBP5 in bipolar disorder. Mol. Psychiatry 14:January (3) (2009), 261–268.
196. Wirtz, P.H., von Kanel, R., Schnorpfeil, P., Ehlert, U., Frey, K., Fischer, J.E., Reduced glucocorticoid sensitivity of monocyte interleukin-6 production in male industrial employees who are vitally exhausted. Psychosom. Med. 65:4 (2003), 672–678.
197. Wolfram, M., Bellingrath, S., Feuerhahn, N., Kudielka, B.M., Emotional exhaustion and overcommitment to work are differentially associated with hypothalamus-pituitary-adrenal (HPA) axis responses to a low-dose ACTH1-24 (Synacthen) and dexamethasone-CRH test in healthy school teachers. Stress 16 (2013), 54–64.
198. Wong, C.M., Post-traumatic stress disorder: advances in psychoneuroimmunology. Psychiatr. Clin. North Am. 25 (2002), 369–383 (vii).
199. Wurm, W., Vogel, K., Holl, A., Ebner, C., Bayer, D., Morkl, S., Szilagyi, I.S., Hotter, E., Kapfhammer, H.P., Hofmann, P., Depression-burnout overlap in physicians. PLoS One, 11, 2016, e0149913.
200. Yehuda, R., Southwick, S.M., Nussbaum, G., Wahby, V., Giller, E.L. Jr., Mason, J.W., Low urinary cortisol excretion in patients with posttraumatic stress disorder. J. Nerv. Ment. Dis. 178 (1990), 366–369.
201. Yehuda, R., Lowy, M.T., Southwick, S.M., Shaffer, D., Giller, E.L. Jr., Lymphocyte glucocorticoid receptor number in posttraumatic stress disorder. Am. J. Psychiatry 148 (1991), 499–504.
202. Yehuda, R., Boisoneau, D., Mason, J.W., Giller, E.L., Glucocorticoid receptor number and cortisol excretion in mood, anxiety, and psychotic disorders. Biol. Psychiatry 34 (1993), 18–25.
203. Yehuda, R., Southwick, S.M., Krystal, J.H., Bremner, D., Charney, D.S., Mason, J.W., Enhanced suppression of cortisol following dexamethasone administration in posttraumatic stress disorder. Am. J. Psychiatry 150:1 (1993), 83–86.
204. Yehuda, R., Teicher, M.H., Levengood, R.A., Trestman, R.L., Siever, L.J., Circadian regulation of basal cortisol levels in posttraumatic stress disorder. Ann. N. Y. Acad. Sci. 746 (1994), 378–380.
205. Yehuda, R., Boisoneau, D., Lowy, M.T., Giller, E.L. Jr., Dose-response changes in plasma cortisol and lymphocyte glucocorticoid receptors following dexamethasone administration in combat veterans with and without posttraumatic stress disorder. Arch. Gen. Psychiatry 52 (1995), 583–593.
206. Yehuda, R., Teicher, M.H., Trestman, R.L., Levengood, R.A., Siever, L.J., Cortisol regulation in posttraumatic stress disorder and major depression: a chronobiological analysis. Biol. Psychiatry 40 (1996), 79–88.
207. Yehuda, R., Halligan, S.L., Grossman, R., Golier, J.A., Wong, C., The cortisol and glucocorticoid receptor response to low dose dexamethasone administration in aging combat veterans and holocaust survivors with and without posttraumatic stress disorder. Biol. Psychiatry 52 (2002), 393–403.
208. Yehuda, R., Golier, J.A., Halligan, S.L., Meaney, M., Bierer, L.M., The ACTH response to dexamethasone in PTSD. Am. J. Psychiatry 161 (2004), 1397–1403.
209. Yehuda, R., Golier, J.A., Yang, R.K., Tischler, L., Enhanced sensitivity to glucocorticoids in peripheral mononuclear leukocytes in posttraumatic stress disorder. Biol. Psychiatry 55 (2004), 1110–1116.
210. Yehuda, R., Halligan, S.L., Golier, J.A., Grossman, R., Bierer, L.M., Effects of trauma exposure on the cortisol response to dexamethasone administration in PTSD and major depressive disorder. Psychoneuroendocrinology 29 (2004), 389–404.
211. Yehuda, R., Golier, J.A., Kaufman, S., Circadian rhythm of salivary cortisol in Holocaust survivors with and without PTSD. Am. J. Psychiatry 162 (2005), 998–1000.
212. Yehuda, R., Hoge, C.W., McFarlane, A.C., Vermetten, E., Lanius, R.A., Nievergelt, C.M., Hobfoll, S.E., Koenen, K.C., Neylan, T.C., Hyman, S.E., Post-traumatic stress disorder. Nat. Rev. Dis. Prim., 1, 2015, 15057.
213. Yehuda, R., Post-traumatic stress disorder. N. Engl. J. Med. 346 (2002), 108–114.
214. Yuuki, N., Ida, I., Oshima, A., Kumano, H., Takahashi, K., Fukuda, M., Oriuchi, N., Endo, K., Matsuda, H., Mikuni, M., HPA axis normalization, estimated by DEX/CRH test, but less alteration on cerebral glucose metabolism in depressed patients receiving ECT after medication treatment failures. Acta Psychiatr. Scand. 112 (2005), 257–265.
215. Zannas, A.S., Wiechmann, T., Gassen, N.C., Binder, E.B., Gene-stress-epigenetic regulation of FKBP5: clinical and translational implications. Neuropsychopharmacology 41 (2016), 261–274.
216. Zhang, X., Clark, A.F., Yorio, T., FK506-binding protein 51 regulates nuclear transport of the glucocorticoid receptor beta and glucocorticoid responsiveness. Invest. Ophthalmol. Vis. Sci. 49 (2008), 1037–1047.
217. Zhou, J., Cidlowski, J.A., The human glucocorticoid receptor: one gene, multiple proteins and diverse responses. Steroids 70 (2005), 407–417.
218. Zimmermann, P., Bruckl, T., Nocon, A., Pfister, H., Binder, E.B., Uhr, M., Lieb, R., Moffitt, T.E., Caspi, A., Holsboer, F., Ising, M., Interaction of FKBP5 gene variants and adverse life events in predicting depression onset: results from a 10-year prospective community study. Am. J. Psychiatry 168 (2011), 1107–1116.
219. Zobel, A.W., Yassouridis, A., Frieboes, R.M., Holsboer, F., Prediction of medium-term outcome by cortisol response to the combined dexamethasone-CRH test in patients with remitted depression. Am. J. Psychiatry 156 (1999), 949–951.
220. Zobel, A.W., Nickel, T., Sonntag, A., Uhr, M., Holsboer, F., Ising, M., Cortisol response in the combined dexamethasone/CRH test as predictor of relapse in patients with remitted depression. a prospective study. J. Psychiatr. Res. 35 (2001), 83–94.