Emotional exhaustion and overcommitment to work are differentially associated with hypothalamus-pituitary-adrenal (HPA) axis responses to a low-dose ACTH1-24 (Synacthen) and dexamethasone-CRH test in healthy school teachers

Stress

Volumn 16, Issue 1, 2013, Pages 54-64

  Wolfram, Maren ^a   Bellingrath, Silja ^a,b   Feuerhahn, Nicolas ^a   Kudielka, Brigitte M ^a,c  

^a JACOBS UNIVERSITY BREMEN   (Germany)

^b UNIVERSITY OF MÜNSTER   (Germany)

^c UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

ACTH1 24 (Synacthen) test; Chronic work stress; Dexamethasone CRH test; Emotional exhaustion; HPA axis regulation; Overcommitment

Indexed keywords

CORTICOTROPIN RELEASING FACTOR; DEXAMETHASONE; HYDROCORTISONE; TETRACOSACTIDE;

ADULT; ARTICLE; BURNOUT; CHRONIC STRESS; EMOTIONAL STRESS; FEMALE; HUMAN; HYDROCORTISONE BLOOD LEVEL; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; JOB STRESS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL;

ADRENOCORTICOTROPIC HORMONE; ADULT; BURNOUT, PROFESSIONAL; CHRONIC DISEASE; CORTICOTROPIN-RELEASING HORMONE; DEPRESSION; DEXAMETHASONE; EMOTIONS; FEMALE; GERMANY; HUMANS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; MALE; MENTAL FATIGUE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; PITUITARY-ADRENAL SYSTEM; SCHOOLS; STRESS, PSYCHOLOGICAL; TEACHING;

EID: 84870798704     PISSN: 10253890     EISSN: 16078888     Source Type: Journal    
DOI: 10.3109/10253890.2012.683465     Document Type: Article

References (57)

1. Ahola K, Honkonen T, Isometsa E, Kalimo R, Nykyri E, Aromaa A, Lonnqvist J. 2005. The relationship between job-related burnout and depressive disorders-results from the Finnish Health 2000 Study. J Affect Disord 88:55-62.
2. Aiken LR, West SG. 1991. Multiple regression: Testing and interpreting interactions. Newbury Park, CA: Sage.
3. Babyak MA. 2004. What you see may not be what you get: a brief, nontechnical introduction to overfitting in regression-type models. Psychosom Med 66:411-421.
4. Bakker AB, Van der Zee KI, Lewig KA, Dollard MF. 2006. The relationship between the big five personality factors and burnout: A study among volunteer counselors. J Soc Psychol 146:31-50.
5. Bellingrath S, Kudielka BM. 2008. Effort-reward-imbalance and overcommitment are associated with hypothalamus-pituitary-adrenal (HPA) axis responses to acute psychosocial stress in healthy working schoolteachers. Psychoneuroendocrinology 33: 1335-1343.
6. Bellingrath S, Weigl T, Kudielka BM. 2008. Cortisol dysregulation in school teachers in relation to burnout, vital exhaustion, and effort-reward-imbalance. Biol Psychol 78:104-113.
7. Bellingrath S, Weigl T, Kudielka BM. 2009. Chronic work stress and exhaustion is associated with higher allostastic load in female school teachers. Stress 12:37-48.
8. Bosma H, Peter R, Siegrist J, Marmot M. 1998. Two alternative job stress models and the risk of coronary heart disease. Am J Public Health 88:68-74.
9. Butterworth P, Leach LS, Strazdins L, Olesen SC, Rodgers B, Broom DH. 2011. The psychosocial quality of work determines whether employment has benefits for mental health: Results from a longitudinal national household panel survey. Occup Environ Med 68:806-812.
10. Cano-Garc?́a FJ, Padilla-Muñoz EM, Carrasco-Ortiz MÁ . 2005. Personality and contextual variables in teacher burnout. Pers Ind Diff 38:929-940.
11. Chrousos GP, Gold PW. 1992. The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis. JAMA 267:1244-1252.
12. De Kloet ER. 1997. Why dexamethasone poorly penetrates in brain. Stress 2:13-20.
13. Dragano N, He Y, Moebus S, Jockel KH, Erbel R, Siegrist J. 2008. Two models of job stress and depressive symptoms. Results from a population-based study. Soc Psychiatry Psychiatr Epidemiol 43:72-78.
14. Fries E, Hesse J, Hellhammer J, Hellhammer DH. 2005. A new view on hypocortisolism. Psychoneuroendocrinology 30:1010-1016.
15. Goddard R, PattonW, Creed P. 2004. The importance and place of neuroticism in predicting burnout in employment service case managers. J Appl Soc Psychol 34:282-296.
16. Grzywacz JG, Dooley D. 2003. "Good jobs" to "bad jobs": Replicated evidence of an employment continuum from two large surveys. Soc Sci Med 56:1749-1760.
17. Heim C, Ehlert U, Hellhammer DH. 2000. The potential role of hypocortisolism in the pathophysiology of stress-related bodily disorders. Psychoneuroendocrinology 25:1-35.
18. Hellhammer DH, Wade S. 1993. Endocrine correlates of stress vulnerability. Psychother Psychosom 60:8-17.
19. Hellhammer DH, Wü st S, Kudielka BM. 2009. Salivary cortisol as biomarker in stress research. Psychoneuroendocrinology 34: 163-171.
20. Herrmann C, Buss U, Snaith RP. 1995. HADS-D hospital anxiety and depression scale-Deutsche Version Ein Fragebogen zur Erfassung von Angst und Depressivität in der somatischen Medizin. Bern: Verlag Hans Huber.
21. Heuser I, Yassouridis A, Holsboer F. 1994. The combined dexamethasone/CRH test: A refined laboratory test for psychiatric disorders. J Psychiatr Res 28:341-356.
22. Hinz A, Brähler E. 2011. Normative values for the hospital anxiety and depression scale (HADS) in the general German population. J Psychosom Res 71:74-78.
23. Holsboer F, von Bardeleben U, Wiedemann K, Muller OA, Stalla GK. 1987. Serial assessment of corticotropin-releasing hormone response after dexamethasone in depression. Implications for pathophysiology of DST nonsuppression. Biol Psychiatry 22:228-234.
24. Kirschbaum C, Kudielka BM, Gaab J, Schommer NC, Hellhammer DH. 1999. Impact of gender, menstrual cycle phase, and oral contraceptives on the activity of the hypothalamus-pituitary-adrenal axis. Psychosom Med 61:154-162.
25. Kivimaki M, Leino-Arjas P, Luukkonen R, Riihimaki H, Vahtera J, Kirjonen J. 2002. Work stress and risk of cardiovascular mortality: Prospective cohort study of industrial employees. BMJ 325:857-860.
26. Kudielka BM, Bellingrath S, Hellhammer DH. 2006. Cortisol in burnout and vital exhaustion: An overview. G Ital Med Lav Ergon 28:34-42.
27. Kudielka BM, Kirschbaum C. 2005. Sex differences in HPA axis responses to stress: A review. Biol Psychol 69:113-132.
28. Kudielka BM, von Känel R, Preckel D, Zgraggen L, Mischler K, Fischer JE. 2006. Exhaustion is associated with reduced habituation of free cortisol responses to repeated acute psychosocial stress. Biol Psychol 72:147-153.
29. Kumari M, Head J, Marmot M. 2004. Prospective study of social and other risk factors for incidence of type 2 diabetes in the Whitehall II study. Arch Intern Med 164:1873-1880.
30. Kyriacou C, Pratt J. 1985. Teacher stress and psychoneurotic symptoms. Br J Educ Psychol 55(Pt 1):61-64.
31. Kyriacou C, Sutcliffe J. 1978. Teacher stress: Prevalence, sources, and symptoms. Br J Educ Psychol 48:159-167.
32. Lehr D, Koch S, Hillert A. 2009. Where is (im)balance? Necessity and construction of evaluated cut-off points for effort-reward-imbalance and overcommitment. J Occup Org Psychol 83: 251-261.
33. Maslach C, Jackson SE. 1986. Maslach burnout inventory, Manual. 2nd ed., Palo Alto, CA: Consulting Psychologists Press.
34. Maslach C, Schaufeli WB, Leiter MP. 2001. Job burnout. Annu Rev Psychol 52:397-422.
35. McEwen BS. 1998a. Protective and damaging effects of stress mediators. N Engl J Med 338:171-179.
36. McEwen BS. 1998b. Stress, adaptation, and disease. Allostasis and allostatic load. Ann N Y Acad Sci 840:33-44.
37. Miller GE, Chen E, Zhou ES. 2007. If it goes up, must it come down? Chronic stress and the hypothalamic-pituitary-adrenocortical axis in humans. Psychol Bull 133:25-45.
38. Mommersteeg PM, Heijnen CJ, Verbraak MJ, van Doornen LJ. 2006. Clinical burnout is not reflected in the cortisol awakening response, the day-curve or the response to a low-dose dexamethasone suppression test. Psychoneuroendocrinology 31:216-225.
39. Pruessner JC, Hellhammer DH, Kirschbaum C. 1999. Burnout, perceived stress, and cortisol responses to awakening. Psychosom Med 61:197-204.
40. Royston P, Altman DG, Sauerbrei W. 2006. Dichotomizing continuous predictors in multiple regression: A bad idea. Stat Med 25:127-141.
41. Rydmark I, Wahlberg K, Ghatan PH, Modell S, Nygren A, Ingvar M, Asberg M, Heilig M. 2006. Neuroendocrine, cognitive and structural imaging characteristics of women on longterm sickleave with job stress-induced depression. Biol Psychiatry 60:867-873.
42. Schaufeli WB, Van Dierendonck D. 1995. A cautionary note about the cross-national and clinical validity of cut-off points for the Maslach burnout inventory. Psychol Rep 76:1083-1090.
43. Schlotz W, Hellhammer J, Schulz P, Stone AA. 2004. Perceived work overload and chronic worrying predict weekend-weekday differences in the cortisol awakening response. Psychosom Med 66:207-214.
44. Schwarzer R, Jerusalem M. 2001. Skalen zur Erfassung von Lehrerund Schü lermerkmalen. Dokumentation der psychometrischen Verfahren im Rahmen der wissenschaftlichen Begleitstudie des Modellversuchs selbstwirksame Schulen. Berlin: Online Web Version.
45. Siegrist J. 1996. Adverse health effects of high-effort/low-reward conditions. J Occup Health Psychol 1:27-41.
46. Siegrist J. 2005. Social reciprocity and health: New scientific evidence and policy implications. Psychoneuroendocrinology 30:1033-1038.
47. Siegrist J, StarkeD, Chandola T, Godin I, Marmot M, Niedhammer I, Peter R. 2004. The measurement of effort-reward imbalance at work: European comparisons. Soc Sci Med 58:1483-1499.
48. Sonnenschein M, Mommersteeg PM, Houtveen JH, Sorbi MJ, Schaufeli WB, van Doornen LJ. 2007. Exhaustion and endocrine functioning in clinical burnout: An in-depth study using the experience sampling method. Biol Psychol 75: 176-184.
49. Stansfeld SA, Fuhrer R, Shipley MJ, Marmot MG. 1999. Work characteristics predict psychiatric disorder: Prospective results from the Whitehall II Study. Occup Environ Med 56:302-307.
50. Tsigos C, Chrousos GP. 1994. Physiology of the hypothalamic-pituitary- adrenal axis in health and dysregulation in psychiatric and autoimmune disorders. Endocrinol Metab Clin North Am 23:451-466.
51. Wahlberg K, Ghatan PH, Modell S, Nygren A, IngvarM, Asberg M, Heilig M. 2009. Suppressed neuroendocrine stress response in depressed women on job-stress-related long-term sick leave: A stable marker potentially suggestive of preexisting vulnerability. Biol Psychiatry 65:742-747.
52. Weber A, Weltle D, Lederer P. 2001. "Macht Schule krank?" Zur Problematik krankheitsbedingter Frühpensionierung von Lehrkra ̈ften. Bayrische Schule 6:214-215.
53. Weber A, Weltle D, Lederer P. 2004. Frü hinvalidität im Lehrerberuf: Sozial-und arbeitsmedizinische Aspekte. Deutsches Ä rzteblatt 101:A850-A859.
54. Wirtz PH, Siegrist J, Rimmele U, Ehlert U. 2008. Higher overcommitment to work is associated with lower norepinephrine secretion before and after acute psychosocial stress in men. Psychoneuroendocrinology 33:92-99.
55. Wirtz PH, Siegrist J, Schuhmacher A, Hoefels S, Maier W, Zobel AW. 2010. Higher overcommitment to work is associated with higher plasma cortisol but not ACTH responses in the combined dexamethasone/CRH test in apparently healthy men and women. Psychoneuroendocrinology 35:536-543.
56. Yehuda R, Resnick H, Kahana B, Giller EL. 1993. Long-lasting hormonal alterations to extreme stress in humans: Normative or maladaptive? Psychosom Med 55:287-297.
57. Zigmond AS, Snaith RP. 1983. The hospital anxiety and depression scale. Acta Psychiatr Scand 67:361-370.