The neurobiology of burnout: The hypothalamus-pituitary-adrenal gland axis and other findings

Turk Psikiyatri Dergisi

Volumn 19, Issue 3, 2008, Pages

  Sertöz, Özen Önen ^a   Binbay, Ibrahim Tolga ^a   Elbi Mete, Hayriye ^a  

^a NONE

Author keywords

BDNF; Burnout; Cortisol; Hippocampal neurogenesis; HPA axis; Monoaminergic system; Proinflammatory response

Indexed keywords

EID: 63249124776     PISSN: 13002163     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (73)

1. Afari N, Buchwald D (2003) Chronic fatigue syndrome: A review. Am J Psychiatry, 160: 221-236.
2. American Psychiatric Association (1994) DSM-IV-Diagnostic and Statistical Manual of Mental Disorders-4th Ed. American Psychiatric Association, Washington DC.
3. Aslan H, Alpaslan NZ, Aslan O et al. (1996) Burnout, job satisfaction and psychiatric symptoms among nurses [Article in Turkish]. NöroPsikiyatri Arşivi, 33: 192-199.
4. Bargellini A, Barbieri A, Rovesti S et al. (2000) Relation between immune variables and burnout in a sample of physicians. Occup Environ Med, 57: 453-457.
5. Cameron HA, Gould E (1994) Adult neurogenesis is regulated by adrenal steroids in the dentate gyrus. Neuroscience, 61: 203-209.
6. Cleare AJ, Bearn J, Allain T et al. (1995) Contrasting neuroendocrine responses in depression and chronic fatigue syndrome. J Affect Disord, 35: 283-289.
7. Cloninger CR, Svrakic DM, Przybeck TR (1993) A psychobiological model of temperament and character. Arch Gen Psychiatry, 50: 975-990.
8. Cohen S, Janicki-Deverts D, Miller GE (2007) Psychological stress and disease. JAMA, 298: 1685-1687.
9. Cowen PJ, Sargent PA (1997) Changes in plasma prolactin during SSRI treatment: Evidence for a delayed increase in 5-HT neurotransmission. J Psychopharmacol, 11: 345-348.
10. De Vente W, Olff M, van Amsterdam JGC et al. (2003) Physiological differences between burnout patients and healthy controls: Blood pressure, heart rate, and cortisol responses. Occup Environ Med, 60: 54-61.
11. Duman RS, Malberg J, Nakagawa S et al. (2000) Neuronal plasticity and survival in mood disorders. Biol Psychiatry, 48: 732-739.
12. Duman RS, Monteggia LM (2006) A neurotrophic model for stress-related mood disorders. Biol Psychiatry, 59: 1116-11127.
13. Ehlert U, Gaab J, Heinrichs M (2001) Psychoneuroendocrinological contributions to the etiology of depression, posttraumatic stress disorder, and stress-related bodily disorders: The role of the hypothalamus-pituitary-adrenal axis. Biol Psychol, 57: 141-152.
14. Ekstedt M, Akerstedt T, Söderström M (2004) Microarousals during sleep are associated with increased levels of lipids, cortisol, and blood pressure. Psychosom Med, 66: 925-931.
15. Ergin C (1996) Health workers norms of Maslach Burnout Inventory in Turkey. 3P, 4: 28-33.
16. Eriksson PS, Wallin L (2004) Functional consequences of stress-related suppression of adult hippocampal neurogenesis-a novel hypothesis on the neurobiology of burnout. Acta Neurol Scand, 110: 275-280.
17. Freudenberger HJ (1975) The staff burnout syndrome in alternative institutions. Psychother Theory Res Pract, 12: 73-82.
18. First MB, Spitzer RL, Gibbon M et al. (1997) Structured Clinical Interview for DSM-IV Axis I Disorders, Clinical Version. Washington DC, American Psychiatric Press, Inc.
19. Galantino ML, Baime M, Maguire M et al. (2005) Association of psychological and physiological measures of stress in healthcare professionals during an 8-week mindfulness meditation program: Mindfulness in practice. Stress Health, 21: 255-261.
20. Geracioti TD, Loosen PT, Orth DN (1997) Low cerebrospinal fluid corticotropin-releasing hormone concentrations in eucortisolemic depression. Biol Psychiatry, 42: 165-174.
21. Gonul AS, Akdeniz F, Taneli F et al. (2005) Effect of treatment on serum brain-derived neurotrophic factor levels in depressed patients. Eur Arch Psychiatry Clin Neurosci, 255: 381-386.
22. Gould E, Tanapat P, McEwen BS et al. (1998) Proliferation of granule cell precursors in the dentate gyrus of adult monkeys is diminished by stress. Proc Natl Acad Sci USA, 95: 3168-3171.
23. Grossi G, Theorell T, Jürisoo M et al. (1999) Psychophysiological correlates of organizational change and threat of unemployment among police inspectors. Integr Physiol Behav Sci, 34: 30-42.
24. Grossi G, Perski A, Evengård B et al. (2003) Physiological correlates of burnout among women. J Psychosom Res, 55: 309-316.
25. Grossi G, Perski A, Ekstedt M et al. (2005) The morning salivary cortisol response in burnout. J Psychosom Res, 59: 103-111.
26. Honkonen T, Ahola K, Pertovaara M et al. (2006) The association between burnout and physical illness in the general population-results from the Finnish Health 2000 Study. J Psychosom Res, 61: 59-66.
27. Heim C, Ehlert U, Hellhammer DH (2000) The potential role of hypocortisolism in the pathophysiology of stress-related bodily disorders. Psychoneuroendocrinology, 25: 1-35.
28. Huang EJ, Reichardt LF (2001) Neurotrophins: Roles in neuronal development and function. Annu Rev Neurosci, 24: 677-736.
29. Kaçmaz N (2005) Burnout syndrome [Article in Turkish]. Ist Tip Fak Derg, 68: 29-32.
30. Kempermann G, Kronenberg G (2003) Depressed new neurons-adult hippocampal neurogenesis and a cellular plasticity hypothesis of major depression. Biol Psychiatry, 54: 499-503.
31. Kent S, Bluthe RM, Kelley KW et al. (1992) Sickness behavior as a new target for drug development. Trends Pharmacol Sci, 13: 24-28.
32. Kiecolt-Glaser JK, McGuire L, Robles TF et al. (2002) Psychoneuroimmunology and psychosomatic medicine: back to the future. Psychosom Med, 64: 15-28.
33. Kudielka BM, Bellingrath S, Hellhammer DH (2006) Cortisol in burnout and vital exhaustion: an overview. G Ital Med Lav Erg, 28: (Suppl 1) 34-42.
34. Kunz-Ebrecht SR, Kirschbaum C, Steptoe A (2004) Work stress, socioeconomic status and neuroendocrine activation over the working day. Soc Sci Med, 58: 1523-1530.
35. Langelaan S, Bakker AB, Schaufeli WB et al. (2006) Do burned-out and work-engaged employees differ in the functioning of the hypothalamic-pituitary-adrenal axis? Scand J Work Environ Health, 32: 339-348.
36. Lee BH, Kim H, Park SH et al. (2007) Decreased plasma BDNF level in depressive patients. J Affect Disord, 101: 239-244.
37. Malhi GS, Parker GB, Greenwood J (2005) Structural and functional models of depression: From sub-types to substrates. Acta Psychiatr Scand, 111: 94-105.
38. Maslach C (1976) Burned-out. Human Behav, 5: 16-22.
39. Maslach C, Jackson SE (1986) Maslach Burnout Inventory Manual. 2nd ed. Consulting Psychologist Press, Palo Alto.
40. Maslach C, Schaufeli WB, Leiter MP (2001) Job burnout. Annu Rev Psychol, 52: 397-422.
41. McEwen BS (2001) Plasticity of the hippocampus: adaptation to chronic stress and allostatic load. Ann N Y Acad Sci, 933: 265-77.
42. Melamed S, Ugarten U, Shirom A et al. (1999) Chronic burnout, somatic arousal and elevated salivary cortisol levels. J Psychosom Res, 46: 591-598.
43. Moch SL, Panz VR, Joffe BI et al. (2003) Longitudinal changes in pituitary-adrenal hormones in South African women with burnout. Endocrine, 21: 267-272.
44. Mohren DCL, Swaen GMH, Kant I et al. (2003) Common infections and the role of burnout in a Dutch working population. J Psychosom Res, 55: 201-208.
45. Moll J, Zahn R, de Oliveira-Souza R et al. (2005) The neural basis of human moral cognition. Nat Rev Neurosci, 6: 799-809.
46. Mommersteeg PMC, Heijnen CJ, Verbraak MJPM et al. (2006a) Clinical burnout is not reflected in the cortisol awakening response, the day-curve or the response to a low-dose dexamethasone suppression test. Psychoneuroendocrinology, 31: 216-225.
47. Mommersteeg PMC, Heijnen CJ, Verbraak MJPM et al. (2006b) A longitudinal study on cortisol and complaint reduction in burnout. Psychoneuroendocrinology, 31:793-804.
48. Mommersteeg PMC, Keijsers GP, Heijnen CJ et al. (2006c) Cortisol deviations in people with burnout before and after psychotherapy: A pilot study. Health Psychol, 25: 243-248.
49. Mommersteeg PMC, Heijnen CJ, Kavelaars A et al. (2006d) Immune and endocrine function in burnout syndrome. Psychosom Med, 68: 879-886.
50. Morgan CA, Cho T, Hazlet G et al. (2002) The impact of burnout on human physiology and on operational performance: a prospective study of soldiers enrolled in the combat diver qualification course. Yale J Biol Med, 75: 199-205.
51. Nakamura H, Nagase H, Yoshida M et al. (1999) Natural killer (NK) cell activity and NK cell subsets in workers with a tendency of burnout. J Psychosom Res, 46: 569-578.
52. Ockenfels MC, Porter L, Smyth J et al. (1995) Effect of chronic stress associated with unemployment on salivary cortisol levels, diurnal rhythm and acute stress reactivity. Psychosom Med, 57: 460-467.
53. Onen Sertoz O, Binbay IT, Elbi Mete H et al. (2007) Clinical burnout is not related with hypothalamus-pituitary-adrenal axis functioning: Comparison of basal cortisol level and dexametasone suppression test with healthy controls [poster presentation]. American Psychiatric Association 160th Annual Meeting, San Diego, California, USA, May 19-24, 2007.
54. Onen Sertoz O, Binbay IT, Koylu E, Noyan A, Yildirim E, Elbi Mete H (2008) The role of BDNF and HPA axis in the neurobiology of burnout syndrome. Prog Neuro-Psychopharmacol Biol Psychiatry, doi:10.1016/ j.pnpbp.2008.05.001, (article in press).
55. Pruessner JC, Hellhammer DH, Kirschbaum C (1999) Burnout, perceived stress, and cortisol responses to awekening. Psychosom Med, 61: 197-204.
56. Raison CL, Miller AH (2003) When not enough is too much: The role of insufficient glucocorticoid signaling in the pathophysiology of stress-related disorders. Am J Psychiatry, 160: 1554-1565.
57. Sapolsky RM (2000) Glucocorticoids and hippocampal athrophy in neuropsychiatric disorders. Arch Gen Psychiatry, 57: 925-935.
58. Schule C, Baghai T, Laakmann G (2004) Mirtazapine decreases stimulatory effects of reboxetine on cortisol, adrenocorticotropin and prolactin secretion in healthy male subjects. Neuroendocrinology, 79: 54-62.
59. Scott LV, Medbak S, Dinan TG (1998) Blunted adrenocorticotropin and cortisol responses to corticotropin-releasing hormone stimulation in chronic fatigue syndrome. Acta Psychiatr Scand, 97: 450-457.
60. Shimizu E, Hashimoto K, Okamura N et al. (2003) Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants. Biol Psychiatry, 54: 70-75.
61. Sluiter JK, van der Beek AJ, Frings-Dresen MH (2003) Medical staff in emergency situations: severity of patient status predicts stress hormone reactivity and recovery. Occup Environ Med, 60: 373-375.
62. Smith MA, Makino S, Kvetnansky R et al. (1995) Stress alters the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus. J Neurosci, 15: 1768 -1777.
63. Sonnenschein M, Mommersteeg PMC, Houtveen JH et al. (2007) Exhaustion and endocrine functioning in clinical burnout: An in-depth study using the experience sampling method. Biol Psychol, 75: 176-184.
64. Sonnentag S (2006) Burnout and functioning of the hypothalamus-pituitary-axis-there are no simple answers. Scand J Work Environ Health, 32: 333-337.
65. Söderström M, Ekstedt M, Akerstedt T (2006) Weekday and weekend patterns of diurnal cortisol, activation and fatigue among people scoring high for burnout. Scand J Work Environ Health, 2: 35-40.
66. Tops M, Boksem MAS, Wijers AA et al. (2007) The psychobiology of burnout: Are there two different syndromes? Neuropsychobiology, 55: 143-150.
67. Torpy DJ, Papanicolaou DA, Lotsikas AJ et al. (2000) Responses of the sympathetic nervous system and the hypothalamic-pituitary-adrenal axis to interleukin-6: A pilot study in fibromyalgia. Arthritis Rheum, 43: 872-880.
68. Tsankova NM, Berton O, Renthal W et al. (2006) Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action. Nat Neurosci, 9: 519-525.
69. Warner-Schmidt JL, Duman RS (2006) Hippocampal neurogenesis: opposing effects of stress and antidepressant treatment. Hippocampus, 16: 239-249.
70. Weibel L, Gabrion I, Aussedat M et al. (2003) Work-related stress in an emergency medical dispatch center. Ann Emerg Med, 41: 500-506.
71. World Health Organization (1992) ICD-10 International Statistical Classification of Diseases and Related Health Problems. (ed: Öztürk MO, Uluǧ B, translation: Çuhadaroǧlu F, Kaplan I Özgen G, Öztürk MO, Rezaki M, Uluǧ B). Türkiye Sinir ve Ruh Saǧliǧi Dernegi Yayιnι, Ankara, 1993.
72. Wüst S, Federenko I, Hellhammer DH et al. (2000) Genetic factors, perceived chronic stress, and the free cortisol response to awekening. Psychoneuroendocrinology, 25: 707-720.
73. Zanstra YJ, Schellekens JMHS, Schaap C et al. (2006) Vagal and sympathetic activity in burnouts during a mentally demanding workday. Psychosom Med, 68: 583-590.