Altered pituitary-adrenal axis responses to provocative challenge tests in adult survivors of childhood abuse

American Journal of Psychiatry

Volumn 158, Issue 4, 2001, Pages 575-581

  Heim, C ^a   Newport, D J ^a   Bonsall, R ^a   Miller, A H ^a   Nemeroff, C B ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOTROPIN; CORTICOTROPIN RELEASING FACTOR; HYDROCORTISONE;

ADAPTATION; ADENOHYPOPHYSIS; ADULT; AFFECTIVE NEUROSIS; ANXIETY NEUROSIS; ARTICLE; CHILD ABUSE; CLINICAL ARTICLE; CONTROLLED STUDY; CORTICOTROPIN BLOOD LEVEL; CORTICOTROPIN TEST; DEPRESSION; DISEASE PREDISPOSITION; FEMALE; HUMAN; HYDROCORTISONE BLOOD LEVEL; HYPOPHYSIS ADRENAL SYSTEM; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; LIFE EVENT; MENTAL STRESS; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; PROVOCATION TEST; RECEPTOR DOWN REGULATION; SEXUAL ABUSE;

ADRENOCORTICOTROPIC HORMONE; ADULT; AGE FACTORS; CHILD; CHILD ABUSE; COMORBIDITY; CORTICOTROPIN-RELEASING HORMONE; COSYNTROPIN; DEPRESSIVE DISORDER; DISEASE SUSCEPTIBILITY; DOWN-REGULATION; FEMALE; HUMANS; HYDROCORTISONE; LIFE CHANGE EVENTS; PITUITARY GLAND, ANTERIOR; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; STRESS DISORDERS, POST-TRAUMATIC; SURVIVORS;

EID: 0035072969     PISSN: 0002953X     EISSN: None     Source Type: Journal    
DOI: 10.1176/appi.ajp.158.4.575     Document Type: Article

References (41)

1. The prediction of major depression in women: Toward an integrated etiologic model
2. Clinical characteristics of women with a history of childhood abuse
3. The long-term impact of the physical, emotional, and sexual abuse of children: A community study
4. Environment and vulnerability to major psychiatric illness: A case control study of early parental loss in major depression, bipolar disorder and schizophrenia
5. Childhood physical and sexual abuse in patients with anxiety disorders and in a community sample
6. Childhood physical abuse and combat-related posttraumatic stress disorder in Vietnam veterans
7. Physiology and pharmacology of corticotropin-releasing factor
8. Physiological and behavioral responses to corticotropin-releasing factor administration: Is CRF a mediator of anxiety or stress responses?
9. Elevated concentrations of CSF corticotropin releasing factor like immunoreactivity in depressed patients
10. Elevated CSF corticotropin-releasing factor concentrations in posttraumatic stress disorder
11. Serial CSF corticotropin-releasing hormone levels and adrenocortical activity in combat veterans with posttraumatic stress disorder
12. Early, postnatal experience alters hypothalamic corticotropin-releasing factor (CRF) mRNA, median eminence CRF content and stress-induced release in adult rats
13. Persistent changes in corticotropin-releasing factor neuronal systems induced by maternal deprivation
14. Persistent elevations of cerebrospinal fluid concentrations of corticotropin-releasing factor in adult nonhuman primates exposed to early-life stressors: Implications for the pathophysiology of mood and anxiety disorders
15. The impact of early adverse experiences on brain systems involved in anxiety and affective disorders
16. Pituitary-adrenal and autonomic responses to stress in women after sexual and physical abuse in childhood
17. A rating scale for depression
18. The development of a clinician-administered PTSD scale
19. Development and preliminary psychometric properties of an instrument for the measurement of childhood trauma: The early trauma inventory
20. Assessing the impact of life changes: Development of the Life Experiences Survey
21. Comparison of two modes of stress measurement: Daily hassles and uplifts versus major life events
22. Corticotropin-releasing factor in men and and its measurement: A review
23. Cosyntropin (ACTH alpha 1-24) stimulation test in depressed patients and healthy subjects
24. Age-associated changes of pituitary-adrenocortical hormone regulation in humans: Importance of gender
25. Differences in the hypothalamic-pituitary-adrenal axis of black and white women
26. Psychiatric history and stress: Predictors of severity of unipolar depression
27. Five psychosocial variables related to the existence of posttraumatic stress disorder symptoms
28. Hypothalamic-pituitary-adrenal dysregulation in sexually abused girls
29. The corticotropin-releasing hormone challenge in depressed abused, depressed nonabused, and normal control children
30. Psychiatric implications of basic and clinical studies with corticotropin-releasing factor
31. ACTH, cortisol and corticosterone output after ovine corticotropin-releasing factor challenge during depression and after recovery
32. The corticotropin-releasing hormone test in patients with posttraumatic stress disorder
33. Depressive affect and endocrine function: Blood levels of adrenal cortex and thyroid hormones in patients suffering from depressive reactions
34. Sensitization of the hypothalamic-pituitary-adrenal axis in posttraumatic stress disorder
35. The potential role of hypercortisolism in the pathophysiology of stress-related bodily disorders
36. The effects of neonatal rearing environment on CRF mRNA and CRF receptor levels in adult rat brain
37. The arginine vasopressin and corticotropin-releasing hormone gene transcription responses to varied frequencies of repeated stress in rats
38. Short inescapable stress produces long-lasting changes in the brain-pituitary-adrenal axis of adult male rats