Steroid up-regulation of FKBP51 and its role in hormone signaling

Current Opinion in Pharmacology

Volumn 11, Issue 4, 2011, Pages 326-331

  Jääskeläinen, Tiina ^a   Makkonen, Harri ^a   Palvimo, Jorma J ^a,b  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b KUOPIO UNIVERSITY HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; ANDROGEN; ANDROGEN RECEPTOR; ANTIDEPRESSANT AGENT; CORTICOSTEROID; FK 506 BINDING PROTEIN; FK 506 BINDING PROTEIN 51; FK 506 BINDING PROTEIN 52; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; HEAT SHOCK PROTEIN 90; MINERALOCORTICOID RECEPTOR; OPIATE; PROGESTERONE RECEPTOR; PROTEIN P23; STEROID; STEROID HORMONE; UNCLASSIFIED DRUG;

ALCOHOLISM; ANDROGEN DEPRIVATION THERAPY; ANXIETY DISORDER; ARTICLE; ASTHMA; DRUG RESPONSE; FKBP51 GENE; GENE; GENE CONTROL; GENE EXPRESSION; GENETIC POLYMORPHISM; HORMONE RESPONSE; HORMONE SENSITIVITY; HUMAN; MOOD DISORDER; NONHUMAN; OPIATE ADDICTION; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; STEROID RELEASE; STRESS; THERAPY RESISTANCE; TRANSCRIPTION REGULATION; UPREGULATION;

EID: 80051671580     PISSN: 14714892     EISSN: 14714973     Source Type: Journal    
DOI: 10.1016/j.coph.2011.04.006     Document Type: Review

References (38)

1. C.B. Kang, Y. Hong, S. Dhe-Paganon, and H.S. Yoon FKBP family proteins: immunophilins with versatile biological functions Neurosignals 16 2008 318 325
2. A. Galat Peptidylprolyl cis/trans isomerases (immunophilins): biological diversity-targets-functions Curr Top Med Chem 3 2003 1315 1347
3. M.D. Heitzer, I.M. Wolf, E.R. Sanchez, S.F. Witchel, and D.B. DeFranco Glucocorticoid receptor physiology Rev Endocr Metab Disord 8 2007 321 330
4. P.C. Echeverria, and D. Picard Molecular chaperones, essential partners of steroid hormone receptors for activity and mobility Biochim Biophys Acta 1803 2010 641 649
5. H. Makkonen, M. Kauhanen, V. Paakinaho, T. Jääskeläinen, and J.J. Palvimo Long-range activation of FKBP51 transcription by the androgen receptor via distal intronic enhancers Nucleic Acids Res 37 2009 4135 4148
6. V. Paakinaho, H. Makkonen, T. Jääskeläinen, and J.J. Palvimo Glucocorticoid receptor activates poised FKBP51 locus through long-distance interactions Mol Endocrinol 24 2010 511 525
7. T.R. Hubler, W.B. Denny, D.L. Valentine, J. Cheung-Flynn, D.F. Smith, and J.G. Scammell The FK506-binding immunophilin FKBP51 is transcriptionally regulated by progestin and attenuates progestin responsiveness Endocrinology 144 2003 2380 2387 (Pubitemid 36629888)
8. H. Vermeer, B.I. Hendriks-Stegeman, B. van der Burg, S.C. van Buul-Offers, and M. Jansen Glucocorticoid-induced increase in lymphocytic FKBP51 messenger ribonucleic acid expression: a potential marker for glucocorticoid sensitivity, potency, and bioavailability J Clin Endocrinol Metab 88 2003 277 284 (Pubitemid 36115178)
9. J.A. Magee, L.W. Chang, G.D. Stormo, and J. Milbrandt Direct, androgen receptor-mediated regulation of the FKBP5 gene via a distal enhancer element Endocrinology 147 2006 590 598 (Pubitemid 43004313)
10. P.G. Woodruff, H.A. Boushey, G.M. Dolganov, C.S. Barker, Y.H. Yang, S. Donnelly, A. Ellwanger, S.S. Sidhu, T.P. Dao-Pick, and C. Pantoja Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids Proc Natl Acad Sci U S A 104 2007 15858 15863 (Pubitemid 350035389)
11. H. Vermeer, B.I. Hendriks-Stegeman, D. van Suylekom, G.T. Rijkers, S.C. van Buul-Offers, and M. Jansen An in vitro bioassay to determine individual sensitivity to glucocorticoids: induction of FKBP51 mRNA in peripheral blood mononuclear cells Mol Cell Endocrinol 218 2004 49 55 (Pubitemid 38578427)
12. E.A. Mostaghel, S.T. Page, D.W. Lin, L. Fazli, I.M. Coleman, L.D. True, B. Knudsen, D.L. Hess, C.C. Nelson, and A.M. Matsumoto Intraprostatic androgens and androgen-regulated gene expression persist after testosterone suppression: therapeutic implications for castration-resistant prostate cancer Cancer Res 67 2007 5033 5041 (Pubitemid 46910214)
13. J. Yu, J. Yu, R.-S. Mani, Q. Cao, C.J. Brenner, X. Cao, X. Wang, L. Wu, J. Li, and M. Hu An integrated network of androgen receptor, polycomb, and TMPRSS2-ERG gene fusions in prostate cancer progression Cancer Cell 17 2010 443 454
14. T.E. Reddy, F. Pauli, R.O. Sprouse, N.F. Neff, K.M. Newberry, M.J. Garabedian, and R.M. Myers Genomic determination of the glucocorticoid response reveals unexpected mechanisms of gene regulation Genome Res 19 2009 2163 2171
15. S.H. Scharf, C. Liebl, E.B. Binder, M.V. Schmidt, and M.B. Müller Expression and regulation of the Fkbp5 gene in the adult mouse brain PLoS ONE 6 2011 e16883 10.1371/journal.pone.0016883
16. R.S. Lee, K.L. Tamashiro, X. Yang, R.H. Purcell, A. Harvey, V.L. Willour, Y. Huo, M. Rongione, G.S. Wand, and J.B. Potash Chronic corticosterone exposure increases expression and decreases deoxyribonucleic acid methylation of Fkbp51 in mice Endocrinology 151 2010 4332 4343
17. X. Zhang, A.F. Clark, and T. Yorio FK506-binding protein 51 regulates nuclear transport of the glucocorticoid receptor b and glucocorticoid responsiveness Invest Ophthalmol Vis Sci 49 2008 1037 1047
18. E.T. Tatro, I.P. Everall, M. Kaul, and C.L. Achim Modulation of glucocorticoid receptor nuclear translocation in neurons by immunophilins FKBP51 and FKBP52: implications for major depressive disorder Brain Res 1286 2009 1 12
19. P.D. Reynolds, Y. Ruan, D.F. Smith, and J.G. Scammell Glucocorticoid resistance in the squirrel monkey is associated with overexpression of the immunophilin FKBP51 J Clin Endocrinol Metab 84 1999 663 669 (Pubitemid 29075703)
20. L.I. Gallo, A.A. Ghini, G.P. Pilipuk, and M.D. Galigniana Differential recruitment of tetratricorpeptide repeat domain immunophilins to the mineralocorticoid receptor influences both heat-shock protein 90-dependent retrotransport and hormone-dependent transcriptional activity Biochemistry 46 2007 14044 14057 (Pubitemid 350250300)
21. S. Periyasamy, T. Hinds Jr., L. Shemshedini, W. Shou, and E.R. Sanchez FKBP51 and Cyp40 are positive regulators of androgen-dependent prostate cancer cell growth and the targets of FK506 and cyclosporin A Oncogene 29 2010 1691 1701
22. L. Ni, C.S. Yang, D. Gioeli, H. Frierson, D.O. Toft, and B.M. Paschal FKBP51 promotes assembly of the Hsp90 chaperone complex and regulates androgen receptor signaling in prostate cancer cells Mol Cell Biol 30 2010 1243 1253
23. M.D. Galigniana, A.G. Erlejman, M. Monte, C. Gomez-Sanchez, and G. Piwien-Pilipuk The hsp90-FKBP52 complex links the mineralocorticoid receptor to motor proteins and persists bound to the receptor in early nuclear events Mol Cell Biol 30 2010 1285 1298
24. G.P. Chrousos, D. Renquist, D. Brandon, C. Eil, M. Pugeat, R. Vigersky, G.B. Cutler Jr., D.L. Loriaux, and M.B. Lipsett Glucocorticoid hormone resistance during primate evolution: receptor-mediated mechanisms Proc Natl Acad Sci U S A 79 1982 2036 2040 (Pubitemid 12088564)
25. W.B. Denny, V. Prapapanich, D.F. Smith, and J.G. Scammell Structure-function analysis of squirrel monkey FK506-binding protein 51, a potent inhibitor of glucocorticoid receptor activity Endocrinology 146 2005 3194 3201 (Pubitemid 41002828)
26. Z. Yang, I.M. Wolf, H. Chen, S. Periyasamy, Z. Chen, W. Yong, S. Shi, W. Zhao, J. Xu, and A. Srivastava FK506-binding protein 52 is essential to uterine reproductive physiology controlled by the progesterone receptor A isoform Mol Endocrinol 20 2006 2682 2694 (Pubitemid 44833530)
27. W. Yong, Z. Yang, S. Periyasamy, H. Chen, S. Yucel, W. Li, L.Y. Lin, I.M. Wolf, M.J. Cohn, and L.S. Baskin Essential role for co-chaperone Fkbp52 but not Fkbp51 in androgen receptor-mediated signaling and physiology J Biol Chem 282 2007 5026 5036 (Pubitemid 47100995)
28. C.M. Pariante, and S.L. Lightman The HPA axis in major depression: classical theories and new developments Trends Neurosci 31 2008 464 468
29. E.B. Binder The role of FKBP5, a co-chaperone of the glucocorticoid receptor in the pathogenesis and therapy of affective and anxiety disorders Psychoneuroendocrinology 34S 2009 S186 S195
30. R. Yehuda, G. Cai, J.A. Golier, C. Sarapas, S. Galea, M. Ising, T. Rein, J. Schmeidler, B. Müller-Myhsok, F. Holsboer, and J.D. Buxbaum Gene expression patterns associated with posttraumatic stress disorder following exposure to the World Trade Center attacks Biol Psychiatry 66 2009 708 711
31. E.B. Binder, R.G. Bradley, W. Liu, M.P. Epstein, T.C. Deveau, K.B. Mercer, Y. Tang, C.F. Gillespie, C.M. Heim, and C.B. Nemeroff Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults JAMA 299 2008 1291 1305 (Pubitemid 351439075)
32. C.F. Gillespie, J. Phifer, B. Bradley, and K.J. Ressler Risk and resilience: genetic and environmental influences on development of the stress response Depress Anxiety 26 2009 984 992
33. E.F. van Rossum, E.B. Binder, M. Majer, J.W. Koper, M. Ising, S. Modell, D. Salvakina, S.W. Lamberts, and F. Holsboer Polymorphisms of the glucocorticoid receptor gene and major depression Biol Psychiatry 59 2006 681 688
34. M. Ising, A.-M. Depping, A. Siebertz, S. Lucae, P.G. Unschuld, S. Kloiber, S. Horstmann, M. Uhr, B. Müller-Myhsok, and F. Holsboer Polymorphisms in the FKBP5 gene region modulate recovery from psychosocial stress in healthy controls Eur J Neurosci 28 2008 389 398
35. N. Shibuya, A. Suzuki, R. Sadahiro, M. Kamata, Y. Matsumoto, K. Goto, Y. Hozumi, and K. Otani Association study between a functional polymorphism of FK506-binding protein51 (FKBP5) gene and personality traits in healthy subjects Neurosci Lett 485 2010 184 187
36. A. Zobel, A. Schuhmacher, F. Jessen, S. Höfels, O. von Widdern, M. Metten, U. Pfeiffer, C. Hanses, T. Becker, and M. Rietschel DNA sequence variants of the FKBP5 gene are associated with unipolar depression Int J Neuropsychopharmacol 13 2010 649 660
37. S. Horstmann, S. Lucae, A. Menke, J.M. Hennings, M. Ising, D. Roeske, B. Müller-Myhsok, F. Holsboer, and E.B. Binder Polymorphism in GRIK4, HTR2A, and FKBP5 show interactive effects in predicting remission to antidepressant treatment Neuropsychopharmacology 35 2010 727 740
38. M. Piechota, M. Korostynski, W. Solecki, A. Gieryk, M. Slezak, W. Bilecki, B. Ziolkowska, E. Kostrzewa, I. Cymerman, and L. Swiech The dissection of transcriptional modules regulated by various drugs of abuse in the mouse striatum Genome Biol 11 2010 R48