Pituitary-adrenal-system regulation and psychopathology during amitriptyline treatment in elderly depressed patients and normal comparison subjects

American Journal of Psychiatry

Volumn 153, Issue 1, 1996, Pages 93-99

  Heuser, Isabella J E ^a   Schweiger, Ulrich ^a   Gotthardt, Ulrike ^a   Schmider, Jürgen ^a   Lammers, Claas H ^a   Dettling, Michael ^a   Yassouridis, A ^a   Holsboer, Florian ^a  

^a MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMITRIPTYLINE;

AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DEPRESSION; DOSE RESPONSE; ELDERLY CARE; FEEDBACK SYSTEM; HORMONAL REGULATION; HUMAN; HYDROCORTISONE BLOOD LEVEL; HYDROCORTISONE RELEASE; HYPOPHYSIS ADRENAL SYSTEM; HYPOTHESIS; MENTAL DISEASE; PATIENT COMPLIANCE; PRIORITY JOURNAL;

EID: 0030029615     PISSN: 0002953X     EISSN: None     Source Type: Journal    
DOI: 10.1176/ajp.153.1.93     Document Type: Article

References (26)

1. Holsboer F, Spengler D, Heuser I: The role of corticotropin-releasing hormone in the pathogenesis of Cushing's disease, anorexia nervosa, alcoholism, affective disorders and dementia. Prog Brain Res 1992; 93:385-417
2. Nemeroff CB: The role of corticotropin-releasing factor in the pathogenesis of major depression. Pharmacopsychiatry 1988; 21: 76-82
3. Nemeroff CB, Widerlöv E, Bissette G, Wallcus H, Karlsson I, Eklund K, Kilts CS, Loosen PT, Vale W: Elevated concentration of CSF corticotropin-releasing factor-like immunoreactivity in depressed patients. Science 1984; 226:1342-1344
4. Nemeroff CB, Owens MJ, Bissette G, Andorn AC, Stanley M: Reduced corticotropin-releasing factor binding sites in the frontal cortex of suicide victims. Arch Gen Psychiatry 1988; 45:577-579
5. Carroll BJ, Feinberg M, Greden JF, Tarika J, Albala AA, Haskett RF, James NM, Kronfol Z, Lohr N, Steiner M, de Vigne JP, Young E: A specific laboratory test for the diagnosis of melancholia: standardization, validation, and clinical utility. Arch Gen Psychiatry 1981; 38:15-22
6. Holsboer F, von Bardeleben U, Gerken A, Stalla GK, Müller OA: Blunted corticotropin and normal cortisol response to human corticotropin-releasing factor in depression (letter). N Engl J Med 1984; 311:1127
7. Gold PW, Loriaux DL, Roy A, Kling MA, Calabrese JR, Kellner CH, Nieman LK, Post RM, Pickar D, Gallucci W, Augerinos P, Paul S, Oldfield EH, Cutler GB Jr, Chrousos GP: Responses to corticotropin-releasing hormone in the hypercortisolism of depression and Cushing's disease: pathophysiologic and diagnostic implications. N Engl J Med 1986; 314:1329-1335
8. Amsterdam JD, Maislin G, Winokur A, Kling M, Gold P: Pituitary and adrenocortical responses to the ovine corticotropin-releasing hormone in depressed patients and healthy volunteers. Arch Gen Psychiatry 1987; 44:775-781
9. Heuser I, Yassouridis A, Holsboer F: The combined dexamethasone/CRH test: a refined laboratory test for psychiatric disorders. J Psychiatr Res 1994; 28:341-356
10. Ribeiro SC, Tandon R, Grunhaus L, Greden JF: The DST as a predictor of outcome in depression: a meta-analysis. Am J Psychiatry 1993; 150:1618-1629
11. Barden N, Reul JMHM, Holsboer F: Do antidepressants stabilize mood through actions on the hypothalamic-pituitary-adrenocortical system? Trends Neurosci 1995; 18:6-11
12. von Bardeleben U, Holsboer F: Effect of age upon the cortisol response to human CRH in depressed patients pretreated with dexamethasone. Biol Psychiatry 1991; 29:1042-1050
13. Heuser IJ, Gotthardt U, Schweiger U, Schmider J, Lammers C-H, Dettling M, Holsboer F: Age-associated changes of pituitary-adrenocortical hormone regulation in humans: importance of gender. Neurobiol Aging 1994; 15:227-231
14. Hamilton M: Development of a rating scale for primary depressive illness. Br J Soc Clin Psychol 1967; 6:278-296
15. Holsboer-Trachsler E, Stohler R, Hatzinger M: Repeated administration of the combined dexamethasone-human corticotropin releasing hormone stimulation test during treatment of depression. Psychiatry Res 1991; 38:163-171
16. De Kloet ER: Brain corticosteroid receptor balance and homeostatic control. Front Neuroendocrinol 1991; 12:95-165
17. Brady LS, Whitfield HJ Jr, Fox RJ, Gold PW, Herkenham M: Long-term antidepressant administration alters corticotropin-releasing hormone, tyrosine hydroxylase, and mineralocorticoid receptor gene expression in rat brain. J Clin Invest 1991; 87: 831-837
18. Pepin MC, Beaulieu S, Barden N: Antidepressants regulate glucocorticoid receptor messenger RNA concentrations in primary neuronal cultures. Brain Res Mol Brain Res 1989; 6:77-83
19. Reul JMHM, Stec I, Söder M, Holsboer F: Chronic treatment of rats with the antidepressant amitriptyline attenuates the activity of the hypothalamic-pituitary-adrenocortical system. Endocrinology 1993; 133:312-320
20. Wolkowitz OM, Reus VI, Manfredi F, Ingbar J, Brizendine L, Weingartner H: Ketoconazole administration in hypercortisolemic depression. Am J Psychiatry 1993; 150:810-812
21. Thakore JH, Dinan TG: Cortisol synthesis inhibition: a new treatment strategy for the clinical and endocrine manifestations of depression. Biol Psychiatry 1995; 37:364-368
22. Heuser IJE, Wark H-J, Keul J, Holsboer F: Hypothalamic-pituitary-adrenal axis function in elderly endurance athletes. J Clin Endocrinol Metab 1991; 73:485-488
23. Schweiger U, Laessle RG, Tuschl RJ, Broocks A, Krusche T, Pirke K-M: Decreased follicular phase gonadotropin secretion is associated with impaired estradiol and progesterone secretion during the follicular and luteal phases in normally menstruating women. J Clin Endocrinol Metab 1989; 68:888-892
24. Nemeroff CB, Krishnan KRR, Reed D, Leder R, Beam C, Dunnick NR: Adrenal gland enlargement in major depression: a computed tomographic study. Arch Gen Psychiatry 1992; 49:384-387
25. Amsterdam JD, Maislin G, Winokur A, Kling M, Gold P: Pituitary and adrenocortical responses to the ovine corticotropin releasing hormone in depressed patients and healthy volunteers. Arch Gen Psychiatry 1987; 44:775-781
26. Carnes M, Goodman BM, Lent SJ, Vo H, Jaeckels R: Coincident plasma ACTH and corticosterone time series: comparisons between young and old rats. Exp Gerontol 1994; 29:625-643