Cortisol dysregulation in school teachers in relation to burnout, vital exhaustion, and effort-reward-imbalance

Biological Psychology

Volumn 78, Issue 1, 2008, Pages 104-113

  Bellingrath, Silja ^a   Weigl, Tobias ^a   Kudielka, Brigitte M ^a  

^a UNIVERSITY OF TRIER   (Germany)

Author keywords

Burnout; Dexamethasone suppression test (DST); Effort reward imbalance; HPA axis; Salivary cortisol; Teacher stress; Vital exhaustion

Indexed keywords

DEXAMETHASONE; HYDROCORTISONE;

ADULT; APPELS VITAL EXHAUSTION QUESTIONNAIRE; ARTICLE; BURNOUT; EXHAUSTION; FEMALE; HEALTH STATUS; HORMONAL REGULATION; HUMAN; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; JOB STRESS; LEISURE; MAJOR CLINICAL STUDY; MALE; MASLACH BURNOUT INVENTORY; NEGATIVE FEEDBACK; PRIORITY JOURNAL; QUESTIONNAIRE; RATING SCALE; REWARD; SALIVA; TEACHER; TEACHER BURNOUT SCALE;

ADULT; ANALYSIS OF VARIANCE; BURNOUT, PROFESSIONAL; CIRCADIAN RHYTHM; DEXAMETHASONE; FACULTY; FEMALE; HUMANS; HYDROCORTISONE; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; MALE; MIDDLE AGED; PITUITARY-ADRENAL SYSTEM; PSYCHIATRIC STATUS RATING SCALES; PSYCHOMETRICS; QUESTIONNAIRES; REGRESSION ANALYSIS; REWARD; SALIVA; WAKEFULNESS;

EID: 41149094932     PISSN: 03010511     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsycho.2008.01.006     Document Type: Article

References (66)

1. Ahola K., Honkonen T., Isometsä E., Kalimo R., Nykyri E., Aromaa A., and Lönnqvist J. The relationship between job-related burnout and depressive disorders-results from the Finnish Health 2000 Study. Journal of Affective Disorders 88 1 (2005) 55-62
2. Aiken L.R., and West S.G. Multiple Regression: Testing and Interpreting Interactions (1991), Sage, Newbury Park, CA
3. Appels A. Exhaustion and coronary heart disease: the history of a scientific quest. Patient Education and Counseling 55 2 (2004) 223-229
4. Appels A., Höppener P., and Mulder P. A questionnaire to assess premonitory symptoms of myocardial infarction. International Journal of Cardiology 17 1 (1987) 15-24
5. Bellingrath, S., Weigl, T., Kudielka, B.M., submitted for publication. Chronic work stress and exhaustion is associated with higher allostatic load in female school teachers.
6. Clow A., Thorn L., Evans P., and Hucklebridge F. The awakening cortisol response: methodological issues and significance. Stress 7 1 (2004) 29-37
7. Cole M.A., Kim P.J., Kalman B.A., and Spencer R.L. Dexamethasone suppression of corticosteroid secretion: evaluation of the site of action by receptor measures and functional studies. Psychoneuroendocrinology 25 2 (2000) 151-167
8. de Kloet E.R., Vreugdenhil E., Oitzl M.S., and Joels M. Brain corticosteroid receptor balance in health and disease. Endocrine Reviews 19 3 (1998) 269-301
9. De Vente W., Olff M., Van Amsterdam J.G., Kamphuis J.H., and Emmelkamp P.M. Physiological differences between burnout patients and healthy controls: blood pressure, heart rate, and cortisol responses. Occupational and Environmental Medicine 60 Suppl. 1 (2003) i54-i61
10. Demitrack M.A. Neuroendocrine correlates of chronic fatigue syndrome: a brief review. Journal of Psychiatric Research 31 1 (1997) 69-82
11. Demitrack M.A., and Crofford L.J. Evidence for and pathophysiologic implications of hypothalamic-pituitary-adrenal axis dysregulation in fibromyalgia and chronic fatigue syndrome. Annals of the New York Academy of Sciences 840 (1998) 684-697
12. Edwards S., Evans P., Hucklebridge F., and Clow A. Association between time of awakening and diurnal cortisol secretory activity. Psychoneuroendocrinology 26 6 (2001) 613-622
13. Eller N.H., Netterstrom B., and Hansen A.M. Psychosocial factors at home and at work and levels of salivary cortisol. Biological Psychology 73 3 (2006) 280-287
14. Gaab J., Huster D., Peisen R., Engert V., Schad T., Schürmeyer T.H., and Ehlert U. Low-dose dexamethasone suppression test in chronic fatigue syndrome and health. Psychosomatic Medicine 64 2 (2002) 311-318
15. Gröschl M., and Rauh M. Influence of commercial collection devices for saliva on the reliability of salivary steroids analysis. Steroids 71 13/14 (2006) 1097-1100
16. Grossi G., Perski A., Ekstedt M., Johansson T., Lindstrom M., and Holm K. The morning salivary cortisol response in burnout. Journal of Psychosomatic Research 59 2 (2005) 103-111
17. Hanson E.K., Maas C.J., Meijman T.F., and Godaert G.L. Cortisol secretion throughout the day, perceptions of the work environment, and negative affect. Annals of Behavioral Medicine 22 4 (2000) 316-324
18. Heim C., Ehlert U., and Hellhammer D.H. The potential role of hypocortisolism in the pathophysiology of stress-related bodily disorders. Psychoneuroendocrinology 25 1 (2000) 1-35
19. Hellhammer J., Fries E., Schweisthal O.W., Schlotz W., Stone A.A., and Hagemann D. Several daily measurements are necessary to reliably assess the cortisol rise after awakening: state- and trait components. Psychoneuroendocrinology 32 1 (2007) 80-86
20. Herrmann C., Buss U., and Snaith R.P. HADS-D Hospital Anxiety and Depression Scale-Deutsche Version. Ein Fragebogen zur Erfassung von Angst und Depressivität in der somatischen Medizin (1995), Verlag Hans Huber, Bern
21. Holsboer F. Stress, hypercortisolism and corticosteroid receptors in depression: implications for therapy. Journal of Affective Disorders 62 1/2 (2001) 77-91
22. Huizenga N.A., Koper J.W., De Lange P., Pols H.A., Stolk R.P., Burger H., Grobbee D.E., Brinkmann A.O., De Jong F.H., and Lamberts S.W. A polymorphism in the glucocorticoid receptor gene may be associated with and increased sensitivity to glucocorticoids in vivo. The Journal of Clinical Endocrinology and Metabolism 83 1 (1998) 144-151
23. Iacovides A., Fountoulakis K.N., Kaprinis S., and Kaprinis G. The relationship between job stress, burnout and clinical depression. Journal of Affective Disorders 75 3 (2003) 209-221
24. Kop W.J. Chronic and acute psychological risk factors for clinical manifestations of coronary artery disease. Psychosomatic Medicine 61 4 (1999) 476-487
25. Kopp M.S., Falger P.R., Appels A., and Szedmak S. Depressive symptomatology and vital exhaustion are differentially related to behavioral risk factors for coronary artery disease. Psychosomatic Medicine 60 6 (1998) 752-758
26. Kristenson M., Orth-Gomer K., Kucinskiene Z., Bergdahl B., Calkauskas H., Balinkyniene I., and Olsson A.G. Attenuated cortisol response to a standardized stress test in Lithuanian versus Swedish men: the LiVicordia study. International Journal of Behavioral Medicine 5 1 (1998) 17-30
27. Kudielka B.M., and Wüst S. The cortisol awakening response (CAR): a useful tool for ambulant assessment of hypothalamus-pituitary-adrenal (HPA) axis activity. In: Columbus F. (Ed). Circadian Rhythms and Health Research Trends (2008), NOVA Science Publishers Inc., New York
28. Kudielka B.M., Broderick J.E., and Kirschbaum C. Compliance with saliva sampling protocols: electronic monitoring reveals invalid cortisol daytime profiles in noncompliant subjects. Psychosomatic Medicine 65 2 (2003) 313-319
29. Kudielka B.M., von Känel R., Gander M.-L., Frey K., and Fischer J.E. Effort-reward imbalance, overcommitment and sleep in a working population. Work and Stress 18 (2004) 167-178
30. Kudielka B.M., von Känel R., Gander M.L., and Fischer J.E. The interrelationship of psychosocial risk factors for coronary artery disease in a working population: do we measure distinct or overlapping psychological concepts?. Behavioral Medicine 30 1 (2004) 35-43
31. Kudielka B.M., Hanebuth D., von Känel R., Gander M.L., Grande G., and Fischer J.E. Health-related quality of life measured by the SF12 in working populations: associations with psychosocial work characteristics. Journal of Occupational Health Psychology 10 4 (2005) 429-440
32. Kudielka B.M., Bellingrath S., and Hellhammer D.H. Cortisol in burnout and vital exhaustion: an overview. Applied Psychology to Work and Rehabilitation Medicine 28 Suppl. 1 (2006) 34-42 (Giornale Italiano di Medicina del Lavoro ed Ergonomia)
33. Kudielka B.M., von Känel R., Preckel D., Zgraggen L., Mischler K., and Fischer J.E. Exhaustion is associated with reduced habituation of free cortisol responses to repeated acute psychosocial stress. Biological Psychology 72 2 (2006) 147-153
34. Kunz-Ebrecht S.R., Kirschbaum C., Marmot M., and Steptoe A. Differences in cortisol awakening response on work days and weekends in women and men from the Whitehall II cohort. Psychoneuroendocrinology 29 4 (2004) 516-528
35. Langelaan S., Bakker A.B., Schaufeli W.B., van Rhenen W., and van Doornen L.J. Do burned-out and work-engaged employees differ in the functioning of the hypothalamic-pituitary-adrenal axis?. Scandinavian Journal of Work, Environment and Health 32 5 (2006) 339-348
36. Maslach C., and Jackson S.E. Maslach Burnout Inventory, Manual. 2nd ed. (1986), Consulting Psychologists Press, Palo Alto, CA
37. Maslach C., Schaufeli W.B., and Leiter M.P. Job burnout. Annual Review of Psychology 52 (2001) 397-422
38. Melamed S., Shirom A., Toker S., Berliner S., and Shapira I. Burnout and risk of cardiovascular disease: evidence, possible causal paths, and promising research directions. Psychological Bulletin 132 3 (2006) 327-353
39. Mommersteeg P.M., Heijnen C.J., Verbraak M.J., and van Doornen L.J. Clinical burnout is not reflected in the cortisol awakening response, the day-curve or the response to a low-dose dexamethasone suppression test. Psychoneuroendocrinology 31 2 (2006) 216-225
40. Mommersteeg P.M., Keijsers G.P., Heijnen C.J., Verbraak M.J., and van Doornen L.J. Cortisol deviations in people with burnout before and after psychotherapy: a pilot study. Health Psychology 25 2 (2006) 243-248
41. Nicolson N.A., and van Diest R. Salivary cortisol patterns in vital exhaustion. Journal of Psychosomatic Research 49 5 (2000) 335-342
42. Parker K.J., Schatzberg A.F., and Lyons D.M. Neuroendocrine aspects of hypercortisolism in major depression. Hormones and Behavior 43 1 (2003) 60-66
43. Preckel D., Känel R., Kudielka B.M., and Fischer J.E. Overcommitment to work is associated with vital exhaustion. International Archives of Occupational and Environmental Health 78 2 (2005) 117-122
44. Pruessner J.C., Hellhammer D.H., and Kirschbaum C. Burnout, perceived stress, and cortisol responses to awakening. Psychosomatic Medicine 61 2 (1999) 197-204
45. Raison C.L., and Miller A.H. When not enough is too much: the role of insufficient glucocorticoid signaling in the pathophysiology of stress-related disorders. The American Journal of Psychiatry 160 9 (2003) 1554-1565
46. Rödel A., Siegrist J., Hessel A., and Brähler E. Fragebogen zur Messung beruflicher Gratifikationskrisen. Zeitschrift für Differentielle und Diagnostische Psychologie 25 4 (2004) 227-238
47. Rohleder N., Joksimovic L., Wolf J.M., and Kirschbaum C. Hypocortisolism and increased glucocorticoid sensitivity of pro-inflammatory cytokine production in Bosnian war refugees with posttraumatic stress disorder. Biological Psychiatry 55 7 (2004) 745-751
48. Royston P., Altman D.G., and Sauerbrei W. Dichotomizing continuous predictors in multiple regression: a bad idea. Statistics in Medicine 25 1 (2006) 127-141
49. Schaufeli W.B., and Van Dierendonck D. A cautionary note about the cross-national and clinical validity of cut-off points for the Maslach Burnout Inventory. Psychological Reports 76 3 Pt 2 (1995) 1083-1090
50. Schlotz W., Hellhammer J., Schulz P., and Stone A.A. Perceived work overload and chronic worrying predict weekend-weekday differences in the cortisol awakening response. Psychosomatic Medicine 66 2 (2004) 207-214
51. Schwarzer, R., Jerusalem, M., 2001. Skalen zur Erfassung von Lehrer- und Schülermerkmalen Dokumentation der psychometrischen Verfahren im Rahmen der Wissenschaftlichen Begleitung des Modellversuchs selbstwirksame Schulen. Berlin: online web version.
52. Seidman S.A., and Zager J. The teacher burnout scale. Educational Research Quarterly 11 1 (1986/1987) 26-33
53. Siegrist J., Starke D., Chandola T., Godin I., Marmot M., Niedhammer I., and Peter R. The measurement of effort-reward imbalance at work: European comparisons. Social Science and Medicine 58 8 (2004) 1483-1499
54. Söderström M., Ekstedt M., and Akerstedt T. Weekday and weekend patterns of diurnal cortisol, activation and fatigue among people scoring high for burnout. Scandinavian Journal of Work, Environment and Health Supplement 2 (2006) 35-40
55. Sonnenschein M., Mommersteeg P.M., Houtveen J.H., Sorbi M.J., Schaufeli W.B., and van Doornen L.J. Exhaustion and endocrine functioning in clinical burnout: an in-depth study using the experience sampling method. Biological Psychology 75 2 (2007) 176-184
56. Soo-Quee Koh D., and Choon-Huat Koh G. The use of salivary biomarkers in occupational and environmental medicine. Occupational and Environmental Medicine 64 3 (2007) 202-210
57. Steptoe A., Kunz-Ebrecht S.R., Brydon L., and Wardle J. Central adiposity and cortisol responses to waking in middle-aged men and women. International Journal of Obesity and Related Metabolic Disorders 28 9 (2004) 1168-1173
58. Steptoe A., Siegrist J., Kirschbaum C., and Marmot M. Effort-reward imbalance, overcommitment, and measures of cortisol and blood pressure over the working day. Psychosomatic Medicine 66 3 (2004) 323-329
59. Suls J., and Bunde J. Anger, anxiety, and depression as risk factors for cardiovascular disease: the problems and implications of overlapping affective dispositions. Psychological Bulletin 131 2 (2005) 260-300
60. Therrien F., Drapeau V., Lalonde J., Lupien S.J., Beaulieu S., Tremblay A., and Richard D. Awakening cortisol response in lean, obese, and reduced obese individuals: effect of gender and fat distribution. Obesity 15 2 (2007) 377-385
61. Unterbrink T., Hack A., Pfeifer R., Buhl-Griesshaber V., Müller U., Wesche H., Frommhold M., Scheuch K., Seibt R., Wirsching M., and Bauer J. Burnout and effort-reward-imbalance in a sample of 949 German teachers. International Archives of Occupational and Environmental Health 80 5 (2007) 433-441
62. van Diest R., and Appels A. Vital exhaustion and depression: a conceptual study. Journal of Psychosomatic Research 35 4/5 (1991) 535-544
63. van Vegchel N., de Jonge J., Bosma H., and Schaufeli W. Reviewing the effort-reward imbalance model: drawing up the balance of 45 empirical studies. Social Science and Medicine 60 5 (2005) 1117-1131
64. Weber A., Weltle D., and Lederer P. Zur Problematik krankheitsbedingter Frühpensionierungen von Gymnasiallehrkräften. Versicherungsmedizin 54 2 (2002) 75-83
65. Yehuda R., Southwick S.M., Krystal J.H., Bremner D., Charney D.S., and Mason J.W. Enhanced suppression of cortisol following dexamethasone administration in posttraumatic stress disorder. The American Journal of Psychiatry 150 1 (1993) 83-86
66. Zigmond A.S., and Snaith R.P. The hospital anxiety and depression scale. Acta Psychiatrica Scandinavica 67 6 (1983) 361-370