Abuse-related posttraumatic stress disorder and alterations of the hypothalamic-pituitary-adrenal axis in women with chronic pelvic pain

Psychosomatic Medicine

Volumn 60, Issue 3, 1998, Pages 309-318

  Heim, Christine ^a,b   Ehlert, Ulrike ^a   Hanker, Jürgen P ^a   Hellhammer, Dirk H ^a  

^a UNIVERSITY OF TRIER   (Germany)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Abuse; Chronic pelvic pain; Corticotropin releasing factor; Dexamethasone; Hypothalamic pituitary adrenal axis; Posttraumatic stress disorder; Stress

Indexed keywords

CORTICOTROPIN; CORTICOTROPIN RELEASING FACTOR; HYDROCORTISONE;

ADULT; ARTICLE; CHILD ABUSE; CHRONIC PAIN; CLINICAL ARTICLE; CONTROLLED STUDY; CORTICOTROPIN BLOOD LEVEL; FEMALE; HUMAN; HYDROCORTISONE BLOOD LEVEL; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; MENTAL STRESS; PELVIS PAIN SYNDROME; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; SEXUAL ABUSE;

EID: 0031866221     PISSN: 00333174     EISSN: None     Source Type: Journal    
DOI: 10.1097/00006842-199805000-00017     Document Type: Article

References (97)

1. Artner J: Funktionelle Unterleibsbeschwerden der Frau. Med Klin 77:683-685, 1982
2. Jansen B: Pelipathie. In Schulze, C (ed), Gynäkopsychologie. Tübingen, DGVT-Verlag, 1990
3. Reiter RC: A profile of women with chronic pelvic pain. Clin Obstet Gynecol 33:130-136, 1990
4. Howard FM: The role of laparoscopy in chronic pelvic pain: Promise and pitfalls. Obstet Gynecol Surv 48:357-387, 1993
5. Knörr K, Knörr-Gärtner, H, Beller FK, et al: Gynäkologie und Geburtshilfe. Berlin, Springer, 1989
6. Fedele L, Parazzini F, Bianchi S, et al: Stage and localization of pelvic endometriosis and pain. Fertil Steril 53:155-158, 1990
7. Marana R, Muzii L, Caruana P, et al: Evaluation of the correlation between endometriosis extent, age of the patients and associated symptomatology. Acta Eur Fertil 22:209-212, 1991
8. Stout AL, Steege JF, Dodson WC, et al: Relationship of laparoscopic findings to self report of pelvic pain. Am J Obstet Gynecol 164:73-79, 1991
9. Rosenthal RH: Psychology of chronic pelvic pain. Obstet Gynecol Clin North Am 20:627-642, 1993
10. Magni G, Andreoli C, deLeo D, et al: Psychological profile of women with chronic pelvic pain. Arch Gynecol Obstet 237:165-168, 1986
11. Walker EA, Katon WJ, Harrop-Griffiths J, et al: Relationship of chronic pelvic pain to psychiatric diagnoses and childhood sexual abuse. Am J Psychiatry 145:75-80, 1988
12. Slocumb JC, Kellner R, Rosenfeld RC, et al: Anxiety and depression in patients with the abdominal pelvic pain syndrome. Gen Hosp Psychiatry 11:48-53, 1989
13. Reiter RC, Shakerin LR, Gambone JC, et al: Correlation between sexual abuse and somatization in women with somatic and nonsomatic chronic pelvic pain. Am J Obstet Gynecol 165:104-109, 1991
14. Harrop-Griffiths J, Katon W, Walker E, et al: The association between chronic pelvic pain, psychiatric diagnoses, and childhood sexual abuse. Obstet Gynecol 71:589-594, 1988
15. Menges A: Streßkrankheit Pelipathie. Diplomarbeit, Universität Marburg, 1985
16. Rapkin AJ, Kames LD, Darke LL, et al: History of physical and sexual abuse in women with chronic pelvic pain. Obstet Gynecol 76:92-96, 1990
17. Reiter RC, Gambone JC: Demographic and historic variables in women with idiopathic chronic pelvic pain. Obstet Gynecol 75:428-432, 1990
18. Walling MK, Reiter RC, O'Hara MW, et al: Abuse history and chronic pain in women: I. Prevalences of sexual abuse and physical abuse. Obstet Gynecol 84:193-199, 1994
19. Glod CA: Long term consequences of childhood physical and sexual abuse. Arch Psychiatr Nurs 7:163-173, 1993
20. Selye H: A syndrome produced by diverse noxious agents. Nature 138:32-36, 1936
21. Reul JM, deKloet ER: Two receptor systems for corticosterone in rat brain: Microdistribution and differential occupation. Endocrinology 117:2505-2511, 1985
22. Holsboer F, Philipp M, von Bardeleben U, et al: Endocrine methods in affective disorders. In Hingtgen JN, Hellhammer DH, Huppmann G (eds), Advanced Methods in Psychobiology. Toronto, Hogrefe, 1987
23. Lowy MT: Quantification of type I and II adrenal steroid receptors in neuronal, lymphoid and pituitary tissues. Brain Res 503:191-197, 1989
24. Friedman SB, Mason JW, Hanburg DA: Urinary 17-hydroxycorticosteroid levels in parents of children with neoplastic disease: A study of chronic psychological stress. Psychosom Med 25: 364-376, 1963
25. Bourne PG, Rose RM, Mason JW: 17 OHCS levels in combat. Special forces "A" team under threat of attack. Arch Gen Psychiatry 19:135-140, 1968
26. Caplan RD, Cobb S, French JR: White collar work load and cortisol: Disruption of a circadian rhythm by job stress? J Psychosom Res 23:181-192, 1979
27. Mason JW, Giller EL, Kosten TR, et al: Urinary free-cortisol levels in post-traumatic stress disorder patients. J Nerv Ment Dis 174:145-159, 1986
28. Yehuda R, Southwick SM, Nussbaum G, et al: Low urinary cortisol excretion in patients with posttraumatic stress disorder. J Nerv Ment Dis 178:366-369, 1990
29. Yehuda R, Kahana B, Binder-Brynes K, et al: Low urinary cortisol excretion in holocaust survivors with posttraumatic stress disorder. Am J Psychiatry 152:982-986, 1995
30. Yehuda R, Southwick SM, Krystal JH, et al: Enhanced suppression of cortisol following dexamethasone administration in posttraumatic stress disorder. Am J Psychiatry 150:83-86, 1993
31. Yehuda R, Boisenau D, Lowy MT, et al: Dose-response changes in plasma cortisol and glucocorticoid receptors following dexamethasone administration in combat veterans with and without posttraumatic stress disorder. Arch Gen Psychiatry 52:583-593, 1995
32. Yehuda R, Lowy MT, Southwick SM, et al: Increased number of glucocorticoid receptors in posttraumatic stress disorder. Am J Psychiatry 148:499-504, 1991
33. Yehuda R, Boisoneau D, Mason J, et al: Glucocorticoid receptor number and cortisol excretion in mood, anxiety, and psychotic disorders. Biol Psychiatry 34:18-25, 1993
34. Smith MA, Davidson J, Ritchie JC, et al: The corticotropin-releasing hormone test in patients with posttraumatic stress disorder. Biol Psychiatry 26:349-355, 1989
35. Yehuda R, Levengood RA, Schmeidler J, et al: Increased pituitary activation following metyrapone administration in post-traumatic stress disorder. Psychoneuroendocrinology 21:1-16, 1996
36. Yehuda R, Giller EL, Levengood RA, et al: Hypothalamic-pituitary-adrenal functioning in post-traumatic stress disorder: Expanding the concept of the stress response spectrum. In Friedman MJ, Charney DS, Deutch AY (eds), Neurobiological and Clinical Consequences of Stress. From Normal Adaptation to Post-Traumatic Stress Disorder. Philadelphia, Lippincott-Raven, 1995
37. Demitrack MA, Dale JK, Straus SE, et al: Evidence for impaired activation of the hypothalamic-pituitary-adrenal axis in patients with chronic fatigue syndrome. J Clin Endocrinol Metab 73: 1224-1234, 1991
38. Valdés M, Garcia L, Treserra J, et al: Psychogenic pain and depressive disorders: An empirical study. J Affect Disord 16: 21-25, 1989
39. von Knorring L, Almay BGL: Neuroendocrine responses to fenfluramine in patients with idiopathic pain syndromes. Nord Psykiatr Tidsskr 43:61-65, 1989
40. Elwan O, Abdella M, El Bayad AB, et al: Hormonal changes in headache patients. J Neurol Sei 106:75-81, 1991
41. Griep EN, Boersma JW, deKloet ER: Altered reactivity of the hypothalamic-pituitary-adrenal axis in the primary fibromyalgia syndrome. J Rheumatol 20:469-474, 1993
42. Crofford LJ, Pillemer SR, Kalogeras KT, et al: Hypothalamic-pituitary-adrenal axis perturbations in patients with fibromyalgia. Arthritis Rheum 37:1583-1592, 1994
43. Cash JM, Crofford LJ, Galucci WT, et al: Pituitary-adrenal axis responsiveness to ovine corticotropin releasing hormone in patients with rheumatoid arthritis treated with low dose prednisone. J Rheumatol 19:1692-1696, 1992
44. Chikanza IC, Petrou P, Kingsley G, et al: Defective hypothalamic pituitary adrenal response to immune and inflammatory stimuli in patients with rheumatoid arthritis. Arthritis Rheum 35:1281-1288, 1992
45. Hedman M, Nilsson E, de la Torre B: Low blood and synovial fluid levels of sulpho-conjugated steroids in rheumatoid arthritis. Clin Exp Rheumatol 10:25-30, 1992
46. Kruger U, Spiecker H: Die Diagnostik der Nebennierenrinden-insuffizienz bei steroidpflichtigem Asthma bronchiale: Der CRH-Test im Vergleich zu Kortisol Tagesprofil im Serum und Kortisol im 24 h-Urin. Pneumologie 48:793-789, 1994
47. Alfvén G, de la Torre B, Uvnäs-Moberg K: Depressed concentrations of oxytocin and cortisol in children with recurrent abdominal pain of non-organic origin. Acta Paediatr 83:1076-1080, 1994
48. Ehlert U, Rösner A, Kirschbaum C: Stress and infertility: Some endocrinological correlates. In Lehnert H, Murison R, Weiner H, et al (eds), Endocrine and Nutritional Control of Basic Biological Functions. Seattle, Hogrefe & Huber, 1993, 502-510
49. Margraf J, Schneider S, Ehlers A: Diagnostisches Interview bei psychischen Störungen. Berlin, Springer, 1991
50. Russel DEH: The Secret Trauma. New York, Basic Books, 1986
51. Drossman DA, Leserman J, Nachman G, et al: Sexual and physical abuse in women with functional or organic gastrointestinal disorders. Ann Intern Med 113:828-833, 1990
52. Diagnostic and Statistical Manual of Mental Disorders, 3rd Edition-Revised. Washington DC, American Psychiatric Association, 1987
53. Horowitz M, Wilner N, Alvarez W: Impact of Event Scale: A measure of subjective stress. Psychosom Med 41:209-218, 1979
54. Ferring D, Filipp SH: Teststatistische Überprüfung der Impact of Event Skala: Befunde zu Reliabilität und Stabilität. Diagnostica 40:344-362, 1994
55. Ehlert U, Lupke U, Hellhammer DH: Verhaltensmedizin im Allgemeinkrankenhaus: I. Zielgruppe und Rahmenbedingungen. Verhaltensmodifikation und Verhaltensmedizin 13:235-259, 1992
56. Zung WWK: A self-rating depression scale. Arch Gen Psychiatry 12:63-70, 1965
57. Kirschbaum C, Hellhammer DH: Salivary cortisol in psychobiological research: An overview. Neuropsychobiology 22:150-169, 1989
58. Linton EA, Lowry PJ: Corticotropin releasing factor in man and its measurement: A review. Clin Endocrinol 31:225-249, 1989
59. Dressendörfer RA, Kirschbaum C, Rohde W, et al: Synthesis of a cortisol biotin conjugate and evaluation as a tracer in an immunoassay for salivary cortisol measurement. J Steroid Biochem 43:683-692, 1992
60. Wood DP, Wiesner MG, Reiter RC: Psychogenic chronic pelvic pain: Diagnosis and management. Clin Obstet Gynecol 33:179-195, 1990
61. Walker EA, Katon WJ, Neraas K, et al: Dissociation in women with chronic pelvic pain. Am J Psychiatry 149:534-537, 1992
62. Albach F, Everaerd W: Posttraumatic stress symptoms in victims of childhood incest. Psychother Psychosom 57:143-151, 1992
63. Ruch LO, Chandler, SM, Harter RA: Life change and rape impact. J Health Soc Behav 21:248-260, 1980
64. McFarlane AC: Posttraumatic morbidity of a disaster: A study of cases presenting for psychiatric treatment. J Nerv Ment Dis 174:4-14, 1988
65. Yehuda R, Kahana B, Schmeidler J, et al: Impact of cumulative lifetime trauma and recent stress on current posttraumatic stress disorder symptoms in holocaust survivors. Am J Psychiatry 152:1815-1818, 1995
66. Green MA, Berlin MA: Five psychosocial variables related to the existence of posttraumatic stress disorder symptoms. J Clin Psychol 43:643-649, 1987
67. Green BL: Psychosocial research in traumatic stress: An update. J Trauma Stress 7:341-362, 1994
68. Dunner D, Patrick V, Fieve RR: Life events at the onset of bipolar affective illness. Am J Psychiatry 136:508-511, 1979
69. Hammen C, Davila J, Brown G, et al: Psychiatric history and stress: Predictors of severity of unipolar depression. J Abnorm Psychol 101:45-52, 1992
70. Rothschild AJ: The dexamethasone suppression test in psychiatric disorders. Psychiatr Ann 23:662-670, 1993
71. Vining RF, McGinley RA, Symons RG: Hormones in saliva: Mode of entry and consequent implications for clinical interpretation. Clin Chem 29:1752-1756, 1987
72. DeBellis MD, Chrousos GP, Dorn LD, et al: Hypothalamic pituitary adrenal axis dysregulation in sexually abused girls. J Clin Endocrinol Metab 78:249-255, 1994
73. Gold PW, Chrousos G, Kellner C, et al: Psychiatric implications of basic and clinical studies with corticotropin-releasing factor. Am J Psychiatry 141:619-627, 1984
74. Holsboer F, Gerken A, Stalla GK, et al: ACTH, cortisol and corticosterone output after ovine corticotropin-releasing factor challenge during depression and after recovery. Biol Psychiatry 20:276-286, 1985
75. Hudson JI, Pliner LF, Hudson MS, et al: The dexamethasone suppression test in fibrositis. Biol Psychiatry 19:1489-1493, 1984
76. France RD, Krishnan KR: The dexamethasone suppression test as a biological marker of depression in chronic pain. Pain 21:49-55, 1985
77. Lowy MT, Meltzer HY: Dexamethasone bioavailability: Implications for DST research. Biol Psychiatry 22:373-385, 1987
78. Sternberg EM: Hypoimmune fatigue syndromes: Diseases of the stress response? J Rheumatol 20:418-421, 1993
79. Waylonis GW, Heck W: Fibromyalgia syndrome. New associations. Am J Phys Med Rehabil 71:343-348, 1992
80. Bateman A, Singh A, Krai T, et al: The immune hypothalamic pituitary adrenal axis. Endocrine Rev 10:92-112, 1989
81. Flower RJ: Macrocortin and the antiphospholipase proteins. In Weissman G (ed), Advances in Inflammation Research. New York, Raven Press, 1984
82. Handwerker HO: Influences of algogenic substances and prostaglandins on the discharges of unmyelinated cutaneous nerve fibers identified as nociceptors. In Bonica JJ, Albe-Fessard D (eds), Advances in Pain Research and Therapy. New York, Raven Press, 1976
83. 2 increases calcium conductance and stimulates release of substance P in avian sensory neurons. J Neurosci 12:1917-1927, 1992
84. Hingtgen CM, Vasko MR: Prostacyclin enhances the evoked release of substance P and calcitonin gene related peptide from rat sensory neurons. Brain Res 655:51-60, 1994
85. Munck A, Guyre PM, Holbrook NJ: Physiological functions of glucocorticoids in stress and their relation to pharmacological actions. Endocr Rev 5:25-44, 1984
86. Sternberg EM, Hill JM, Chrousos GP, et al: Inflammatory mediator-induced hypothalamic-pituitary-adrenal axis activation is defective in streptococcal cell wall arthritis-susceptible Lewis rats. Proc Natl Acad Sci U S A 86:2374-2378, 1989
87. Sternberg EM, Young WS, Bernardini R, et al: A central nervous system defect in biosynthesis of corticotropin releasing hormone is associated with susceptibility to streptococcal cell wall induced arthritis in Lewis rats. Proc Natl Acad Sci U S A 86:4771-4775, 1989
88. Benedetto C: Eicosanoids in primary dysmenorrhea, endometriosis and menstrual migraine. Gynecol Endocrinol 3:71-94, 1989
89. Dawood MY, Khan-Dawood FS, Wilson L: Peritoneal fluid prostaglandins and prostanoids in women with endometriosis, chronic pelvic inflammatory disease, and pelvic pain. Am J Obstet Gynecol 148:391-395, 1984
90. Rapkin AJ, Bhattacherjee P: Peritoneal fluid eicosanoids in chronic pelvic pain. Prostaglandins 38:447-452, 1989
91. Wang ZH, Wu RF, Ge XL: Relationships between pelvic pain and prostaglandin levels in plasma and peritoneal fluid collected from women after sterilization. Contraception 45: 67-71, 1992
92. Hamaty D, Valentine JL, Howard CW, et al: The plasma endorphin, prostaglandin and catecholamine profile of patients with fibrositis treated with cyclobenzaprine and placebo: A 5 month study. J Rheumatol 19:164-168, 1989
93. Kirschbaum C, Wüst, S, Hellhammer DH: Consistent sex differences in cortisol responses to psychological stress. Psychosom Med 54:648-657, 1992
94. Kirschbaum C, Wüst, S, Faig HG, et al: Heritability of cortisol responses to hCRH, ergometry, and psychological stress in humans. J Clin Endocrinol Metab 75:1526-1530, 1992
95. Henry JP, Haviland MG, Cummings MA, et al: Shared neuroendocrine patterns of post-traumatic stress disorder and alexithymia. Psychosom Med 54:407-415, 1992
96. Henry JP: Psychological and physiological responses to stress: The right hemisphere and the hypothalamo-pituitary-adrenal axis. An inquiry into problems of human bonding. Integr Physiol Behav Sci 28:368-387, 1993
97. Wolff CT, Hofer M, Mason JW: Relationship between psychological defenses and mean urinary 17-hydroxicorticosteroid excretion rates. Methodologic and theoretical considerations. Psychosom Med 26:592-609, 1964