PKM1 Confers Metabolic Advantages and Promotes Cell-Autonomous Tumor Cell Growth

Cancer Cell

Volumn 33, Issue 3, 2018, Pages 355-367.e7

  Morita, Mami ^a,c,i   Sato, Taku ^a,d   Nomura, Miyuki ^a   Sakamoto, Yoshimi ^a   Inoue, Yui ^a   Tanaka, Ryota ^a,d   Ito, Shigemi ^a   Kurosawa, Koreyuki ^a   Yamaguchi, Kazunori ^a   Sugiura, Yuki ^b   Takizaki, Hiroshi ^c   Yamashita, Yoji ^a   Katakura, Ryuichi ^a   Sato, Ikuro ^a   Kawai, Masaaki ^a   Okada, Yoshinori ^d   Watanabe, Hitomi ^e   Kondoh, Gen ^e   Matsumoto, Shoko ^f   Kishimoto, Ayako ^f   Obata, Miki ^g   Matsumoto, Masaki ^h   Fukuhara, Tatsuro ⁱ   Motohashi, Hozumi ^d   Suematsu, Makoto ^b   Komatsu, Masaaki ^g   Nakayama, Keiichi I ^h   Watanabe, Toshio ^f   Soga, Tomoyoshi ^j   Shima, Hiroshi ^a,c   Maemondo, Makoto ^c,i   Tanuma, Nobuhiro ^a,c   more..

^a MIYAGI CANCER CENTER RESEARCH INSTITUTE   (Japan)

^b KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d TOHOKU UNIVERSITY   (Japan)

^e KYOTO UNIVERSITY   (Japan)

^f NARA WOMEN'S UNIVERSITY   (Japan)

^g NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

^h KYUSHU UNIVERSITY   (Japan)

ⁱ Miyagi Cancer Center   (Japan)

^j KEIO UNIVERSITY   (Japan)

more..

Author keywords

autophagy; glucose metabolism; lung neuroendocrine tumor; mitophagy; PKM; PKM1; PKM2; small cell lung cancer

Indexed keywords

MESSENGER RNA; ONCOPROTEIN; PYRUVATE KINASE; PYRUVATE KINASE M 1; PYRUVATE KINASE M 2; UNCLASSIFIED DRUG; CARRIER PROTEIN; ISOPROTEIN; MEMBRANE PROTEIN; THYROID HORMONE; THYROID HORMONE-BINDING PROTEINS;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; CANCER GROWTH; CARBON METABOLISM; CARCINOID; CELL AUTONOMOUS; CELL FUNCTION; CELL PROLIFERATION; COMPARATIVE STUDY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; GLYCOLYSIS; HUMAN; HUMAN CELL; HUMAN TISSUE; LARGE CELL NEUROENDOCRINE CARCINOMA; LUNG TUMOR; MALE; METABOLISM; MITOPHAGY; MOUSE; MOUSE MUTANT; MRNA EXPRESSION LEVEL; NEUROENDOCRINE TUMOR; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN EXPRESSION LEVEL; PROTEIN TARGETING; SMALL CELL LUNG CANCER; ANIMAL; CARCINOGENESIS; CELL CYCLE; CELL TRANSFORMATION; GENE EXPRESSION REGULATION; GENETICS; KNOCKOUT MOUSE; TUMOR CELL LINE;

ANIMALS; CARCINOGENESIS; CARRIER PROTEINS; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; GENE EXPRESSION REGULATION, NEOPLASTIC; MEMBRANE PROTEINS; MICE, KNOCKOUT; PROTEIN ISOFORMS; THYROID HORMONES;

EID: 85042821230     PISSN: 15356108     EISSN: 18783686     Source Type: Journal    
DOI: 10.1016/j.ccell.2018.02.004     Document Type: Article

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