Global metabolic reprogramming of colorectal cancer occurs at adenoma stage and is induced by MYC

Proceedings of the National Academy of Sciences of the United States of America

Volumn 114, Issue 37, 2017, Pages E7697-E7706

  Satoh, Kiyotoshi ^a   Yachida, Shinichi ^b   Sugimoto, Masahiro ^a   Oshima, Minoru ^c   Nakagawa, Toshitaka ^d   Akamoto, Shintaro ^c   Tabata, Sho ^a   Saitoh, Kaori ^a   Kato, Keiko ^a   Sato, Saya ^a   Igarashi, Kaori ^a   Aizawa, Yumi ^a   Kajino Sakamoto, Rie ^e   Kojima, Yasushi ^e   Fujishita, Teruaki ^e   Enomoto, Ayame ^a   Hirayama, Akiyoshi ^a   Ishikawa, Takamasa ^a   Taketo, Makoto Mark ^f   Kushida, Yoshio ^c   Haba, Reiji ^c   Okano, Keiichi ^c   Tomita, Masaru ^a   Suzuki, Yasuyuki ^c   Fukuda, Shinji ^a   Aoki, Masahiro ^e   Soga, Tomoyoshi ^a   more..

^a KEIO UNIVERSITY   (Japan)

^b NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^c KAGAWA UNIVERSITY   (Japan)

^d KAGAWA UNIVERSITY   (Japan)

^e AICHI CANCER CENTER HOSPITAL   (Japan)

^f KYOTO UNIVERSITY   (Japan)

Author keywords

Colorectal cancer; Metabolism; Metabolomics; MYC; Omics

Indexed keywords

APC PROTEIN; CYTIDINE TRIPHOSPHATE; DNA; DNA METHYLTRANSFERASE 1; DNA METHYLTRANSFERASE 3B; FLUOROURACIL; FOLATE TRANSPORTER; HISTONE LYSINE METHYLTRANSFERASE; K RAS PROTEIN; LAT PROTEIN; LAT1 PROTEIN; LAT2 PROTEIN; MITOCHONDRIAL FOLATE TRANSPORTER; MYC PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PROTEIN P53; S ADENOSYLMETHIONINE; TRANSCRIPTION FACTOR EZH2; UNCLASSIFIED DRUG; URIDINE PHOSPHATE; MYC PROTEIN, HUMAN; MYC PROTEIN, MOUSE; PYRIMIDINE; PYRIMIDINE DERIVATIVE; TRANSCRIPTOME;

AMINO ACID METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER STAGING; CANCER TISSUE; CAPILLARY ELECTROPHORESIS; CARBON METABOLISM; CARCINOGENESIS; CELL GROWTH; CELL PROLIFERATION; COLORECTAL ADENOMA; COLORECTAL CANCER; CONTROLLED STUDY; DNA MICROARRAY; DOWN REGULATION; FAMILIAL ADENOMATOUS POLYPOSIS; FATTY ACID OXIDATION; GENE EXPRESSION; GENE SILENCING; GLUCONEOGENESIS; GLUCOSE METABOLISM; HCT 116 CELL LINE; HISTONE METHYLATION; HOMEOSTASIS; HUMAN; HUMAN CELL; HUMAN TISSUE; MAPK SIGNALING; METABOLISM; MICROBIAL COMMUNITY; MITOCHONDRIAL BIOGENESIS; NEXT GENERATION SEQUENCING; NONHUMAN; PENTOSE PHOSPHATE CYCLE; PRIORITY JOURNAL; PROTO ONCOGENE; PURINE SYNTHESIS; PYRIMIDINE METABOLISM; PYRIMIDINE SYNTHESIS; RKO CELL LINE; SANGER SEQUENCING; SOMATIC MUTATION; TIME OF FLIGHT MASS SPECTROMETRY; TRANSCRIPTOMICS; TRANSMISSION ELECTRON MICROSCOPY; TUMOR SUPPRESSOR GENE; TUMOR-RELATED GENE; UPREGULATION; ADENOMA; ANIMAL; BIOSYNTHESIS; COLORECTAL TUMOR; DISEASE MODEL; FEMALE; GENETICS; MALE; METABOLOMICS; MOUSE; ONCOGENE MYC; PHYSIOLOGY; PROCEDURES;

ADENOMA; ANIMALS; CARCINOGENESIS; CELL PROLIFERATION; COLORECTAL NEOPLASMS; DISEASE MODELS, ANIMAL; FEMALE; GENES, MYC; HUMANS; MALE; METABOLOMICS; MICE; PROTO-ONCOGENE PROTEINS C-MYC; PYRIMIDINES; TRANSCRIPTOME;

EID: 85029515651     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1710366114     Document Type: Article

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