메뉴 건너뛰기




Volumn 69, Issue , 2018, Pages 421-436

Novel Latency Reversal Agents for HIV-1 Cure

Author keywords

Benzotriazole; Disulfiram; HIV 1 reservoir; Ingenol; Latency reversal agents; NF B; Protein kinase C; Shock and kill; SMAC; STAT5; Viral latency

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; BENZOTRIAZOLE DERIVATIVE; CYTOKINE; DISULFIRAM; HISTONE DEACETYLASE INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TOLL LIKE RECEPTOR AGONIST; ALDEHYDE DEHYDROGENASE INHIBITOR; IMMUNOLOGICAL ADJUVANT; PROTEIN KINASE C; TOLL LIKE RECEPTOR;

EID: 85041712062     PISSN: 00664219     EISSN: 1545326X     Source Type: Book Series    
DOI: 10.1146/annurev-med-052716-031710     Document Type: Review
Times cited : (129)

References (110)
  • 1
    • 0030659177 scopus 로고    scopus 로고
    • Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy
    • Chun TW, Stuyver L, Mizell SB, et al. 1997. Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy. PNAS 94:13193-97
    • (1997) PNAS , vol.94 , pp. 13193-13197
    • Chun, T.W.1    Stuyver, L.2    Mizell, S.B.3
  • 2
    • 14444273439 scopus 로고    scopus 로고
    • Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy
    • Finzi D, Hermankova M, Pierson T, et al. 1997. Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy. Science 278:1295-300 www.annualreviews.org Latency Reversal for HIV-1 Cure 431
    • (1997) Science , vol.278 , pp. 1295-1300
    • Finzi, D.1    Hermankova, M.2    Pierson, T.3
  • 3
    • 0030712305 scopus 로고    scopus 로고
    • Recovery of replication-competent HIV despite prolonged suppression of plasma viremia
    • Wong JK, Hezareh M, Gunthard HF, et al. 1997. Recovery of replication-competent HIV despite prolonged suppression of plasma viremia. Science 278:1291-95
    • (1997) Science , vol.278 , pp. 1291-1295
    • Wong, J.K.1    Hezareh, M.2    Gunthard, H.F.3
  • 4
    • 0032953920 scopus 로고    scopus 로고
    • Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy
    • Finzi D, Blankson J, Siliciano JD, et al. 1999. Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy. Nat.Med. 5:512-17
    • (1999) Nat. Med. , vol.5 , pp. 512-517
    • Finzi, D.1    Blankson, J.2    Siliciano, J.D.3
  • 5
    • 0038579210 scopus 로고    scopus 로고
    • Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells
    • Siliciano JD, Kajdas J, Finzi D, et al. 2003. Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells. Nat. Med. 9:727-28
    • (2003) Nat. Med. , vol.9 , pp. 727-728
    • Siliciano, J.D.1    Kajdas, J.2    Finzi, D.3
  • 6
    • 84905565097 scopus 로고    scopus 로고
    • Rapid seeding of the viral reservoir prior to SIV viraemia in rhesus monkeys
    • Whitney JB, Hill AL, Sanisetty S, et al. 2014. Rapid seeding of the viral reservoir prior to SIV viraemia in rhesus monkeys. Nature 512:74-77
    • (2014) Nature , vol.512 , pp. 74-77
    • Whitney, J.B.1    Hill, A.L.2    Sanisetty, S.3
  • 7
    • 20244376915 scopus 로고    scopus 로고
    • Effect of treatment, during primary infection, on establishment and clearance of cellular reservoirs of HIV-1
    • Strain MC, Little SJ, Daar ES, et al. 2005. Effect of treatment, during primary infection, on establishment and clearance of cellular reservoirs of HIV-1. J. Infect. Dis. 191:1410-18
    • (2005) J. Infect. Dis. , vol.191 , pp. 1410-1418
    • Strain, M.C.1    Little, S.J.2    Daar, E.S.3
  • 8
    • 84873472629 scopus 로고    scopus 로고
    • Comparative analysis of measures of viral reservoirs in HIV-1 eradication studies
    • Eriksson S, Graf EH, Dahl V, et al. 2013. Comparative analysis of measures of viral reservoirs in HIV-1 eradication studies. PLOS Pathog. 9:e1003174
    • (2013) PLOS Pathog. , vol.9 , pp. e1003174
    • Eriksson, S.1    Graf, E.H.2    Dahl, V.3
  • 9
    • 84946096080 scopus 로고    scopus 로고
    • Precise quantitation of the latent HIV-1 reservoir: Implications for eradication strategies
    • Crooks AM, Bateson R, Cope AB, et al. 2015. Precise quantitation of the latent HIV-1 reservoir: implications for eradication strategies. J. Infect. Dis. 212:1361-65
    • (2015) J. Infect. Dis. , vol.212 , pp. 1361-1365
    • Crooks, A.M.1    Bateson, R.2    Cope, A.B.3
  • 10
    • 67249121143 scopus 로고    scopus 로고
    • Treatment intensification does not reduce residualHIV-1 viremia in patients on highly active antiretroviral therapy
    • Dinoso JB, Kim SY,Wiegand AM, et al. 2009. Treatment intensification does not reduce residualHIV-1 viremia in patients on highly active antiretroviral therapy. PNAS 106:9403-8
    • (2009) PNAS , vol.106 , pp. 9403-9408
    • Dinoso, J.B.1    Kim, S.Y.2    Wiegand, A.M.3
  • 11
    • 84859752894 scopus 로고    scopus 로고
    • Noeffect of raltegravir intensification on viral replication markers in the blood of HIV-1-infected patients receiving antiretroviral therapy
    • Gandhi RT,CoombsRW,ChanES, et al. 2012.Noeffect of raltegravir intensification on viral replication markers in the blood of HIV-1-infected patients receiving antiretroviral therapy. J. Acquir. Immune Defic. Syndr. 59:229-35
    • (2012) J. Acquir. Immune Defic. Syndr. , vol.59 , pp. 229-235
    • Gandhi, R.T.1    Coombs, R.W.2    Chan, E.S.3
  • 12
    • 77956856393 scopus 로고    scopus 로고
    • The effect of raltegravir intensification on low-level residual viremia in HIV-infected patients on antiretroviral therapy: A randomized controlled trial
    • Gandhi RT, Zheng L, Bosch RJ, et al. 2010. The effect of raltegravir intensification on low-level residual viremia in HIV-infected patients on antiretroviral therapy: a randomized controlled trial. PLOS Med. 7(8):e1000321
    • (2010) PLOS Med. , vol.7 , Issue.8 , pp. e1000321
    • Gandhi, R.T.1    Zheng, L.2    Bosch, R.J.3
  • 13
    • 62249095476 scopus 로고    scopus 로고
    • The challenge of finding a cure for HIV infection
    • Richman DD, Margolis DM, Delaney M, et al. 2009. The challenge of finding a cure for HIV infection. Science 323:1304-7
    • (2009) Science , vol.323 , pp. 1304-1307
    • Richman, D.D.1    Margolis, D.M.2    Delaney, M.3
  • 14
    • 79951990287 scopus 로고    scopus 로고
    • Curing HIV: Pharmacologic approaches to target HIV-1 latency
    • Choudhary SK, Margolis DM. 2011. Curing HIV: pharmacologic approaches to target HIV-1 latency. Annu. Rev. Pharmacol. Toxicol. 51:397-418
    • (2011) Annu. Rev. Pharmacol. Toxicol. , vol.51 , pp. 397-418
    • Choudhary, S.K.1    Margolis, D.M.2
  • 15
    • 84886782112 scopus 로고    scopus 로고
    • An integrated overview of HIV-1 latency
    • Ruelas DS, GreeneWC. 2013. An integrated overview of HIV-1 latency. Cell 155:519-29
    • (2013) Cell , vol.155 , pp. 519-529
    • Ruelas, D.S.1    Greene, W.C.2
  • 16
    • 84878873135 scopus 로고    scopus 로고
    • Targeting HIV latency: Pharmacologic strategies toward eradication
    • Xing S, Siliciano RF. 2013. Targeting HIV latency: pharmacologic strategies toward eradication. Drug Discov. Today 18:541-51
    • (2013) Drug Discov. Today , vol.18 , pp. 541-551
    • Xing, S.1    Siliciano, R.F.2
  • 18
    • 84954551799 scopus 로고    scopus 로고
    • Progress toward HIV eradication: Case reports, current efforts, and the challenges associated with cure
    • Martin AR, Siliciano RF. 2016. Progress toward HIV eradication: case reports, current efforts, and the challenges associated with cure. Annu. Rev. Med. 67:215-28
    • (2016) Annu. Rev. Med. , vol.67 , pp. 215-228
    • Martin, A.R.1    Siliciano, R.F.2
  • 19
    • 84864243685 scopus 로고    scopus 로고
    • HIV: Shock and kill
    • Deeks SG. 2012. HIV: shock and kill. Nature 487:439-40
    • (2012) Nature , vol.487 , pp. 439-440
    • Deeks, S.G.1
  • 20
    • 84996539958 scopus 로고    scopus 로고
    • Ongoing clinical trials of human immunodeficiency virus latency-reversing and immunomodulatory agents
    • Delagreverie HM, Delaugerre C, Lewin SR, et al. 2016. Ongoing clinical trials of human immunodeficiency virus latency-reversing and immunomodulatory agents. Open Forum Infect. Dis. 3:ofw189
    • (2016) Open Forum Infect. Dis. , vol.3 , pp. ofw189
    • Delagreverie, H.M.1    Delaugerre, C.2    Lewin, S.R.3
  • 21
    • 84952864287 scopus 로고    scopus 로고
    • HIV-1 eradication: Early trials (and tribulations)
    • Spivak AM, Planelles V. 2016. HIV-1 eradication: early trials (and tribulations). TrendsMol.Med. 22:10-27
    • (2016) TrendsMol. Med. , vol.22 , pp. 10-27
    • Spivak, A.M.1    Planelles, V.2
  • 22
    • 0025342694 scopus 로고
    • HIV-1 entry into quiescent primary lymphocytes: Molecular analysis reveals a labile, latent viral structure
    • Zack JA, Arrigo SJ,Weitsman SR, et al. 1990. HIV-1 entry into quiescent primary lymphocytes: molecular analysis reveals a labile, latent viral structure. Cell 61:213-22
    • (1990) Cell , vol.61 , pp. 213-222
    • Zack, J.A.1    Arrigo, S.J.2    Weitsman, S.R.3
  • 23
    • 0030952479 scopus 로고    scopus 로고
    • Decay characteristics of HIV-1-infected compartments during combination therapy
    • Perelson AS, Essunger P, Cao Y, et al. 1997. Decay characteristics of HIV-1-infected compartments during combination therapy. Nature 387:188-91
    • (1997) Nature , vol.387 , pp. 188-191
    • Perelson, A.S.1    Essunger, P.2    Cao, Y.3
  • 24
    • 0037111060 scopus 로고    scopus 로고
    • Intensification and stimulation therapy for human immunodeficiency virus type 1 reservoirs in infected persons receiving virally suppressive highly active antiretroviral therapy
    • Kulkosky J, Nunnari G, Otero M, et al. 2002. Intensification and stimulation therapy for human immunodeficiency virus type 1 reservoirs in infected persons receiving virally suppressive highly active antiretroviral therapy. J. Infect. Dis. 186:1403-11
    • (2002) J. Infect. Dis. , vol.186 , pp. 1403-1411
    • Kulkosky, J.1    Nunnari, G.2    Otero, M.3
  • 25
    • 0033520846 scopus 로고    scopus 로고
    • Immuno-activation with anti-CD3 and recombinant human IL-2 in HIV-1-infected patients on potent antiretroviral therapy
    • Prins JM, Jurriaans S, van Praag RM, et al. 1999. Immuno-activation with anti-CD3 and recombinant human IL-2 in HIV-1-infected patients on potent antiretroviral therapy. AIDS 13:2405-10
    • (1999) AIDS , vol.13 , pp. 2405-2410
    • Prins, J.M.1    Jurriaans, S.2    Van Praag, R.M.3
  • 26
    • 84892845657 scopus 로고    scopus 로고
    • An in-depth comparison of latent HIV-1 reactivation in multiple cell model systems and resting CD4+ T cells from aviremic patients
    • Spina CA, Anderson J, Archin NM, et al. 2013. An in-depth comparison of latent HIV-1 reactivation in multiple cell model systems and resting CD4+ T cells from aviremic patients. PLOS Pathog. 9:e1003834
    • (2013) PLOS Pathog. , vol.9 , pp. e1003834
    • Spina, C.A.1    Anderson, J.2    Archin, N.M.3
  • 27
    • 84898423894 scopus 로고    scopus 로고
    • New ex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivo
    • Bullen CK, Laird GM, Durand CM, et al. 2014. New ex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivo. Nat. Med. 20:425-29
    • (2014) Nat. Med. , vol.20 , pp. 425-429
    • Bullen, C.K.1    Laird, G.M.2    Durand, C.M.3
  • 28
    • 84928986546 scopus 로고    scopus 로고
    • Ex vivo analysis identifies effective HIV-1 latencyreversing drug combinations
    • Laird GM, Bullen CK, Rosenbloom DI, et al. 2015. Ex vivo analysis identifies effective HIV-1 latencyreversing drug combinations. J. Clin. Investig. 125:1901-12
    • (2015) J. Clin. Investig. , vol.125 , pp. 1901-1912
    • Laird, G.M.1    Bullen, C.K.2    Rosenbloom, D.I.3
  • 29
    • 84864939469 scopus 로고    scopus 로고
    • Protein kinase C: One pathway towards the eradication of latent HIV-1 reservoirs
    • McKernan LN, Momjian D, Kulkosky J. 2012. Protein kinase C: one pathway towards the eradication of latent HIV-1 reservoirs. Adv. Virol. 2012:805347
    • (2012) Adv. Virol. , vol.2012 , pp. 805347
    • McKernan, L.N.1    Momjian, D.2    Kulkosky, J.3
  • 30
    • 84937118026 scopus 로고    scopus 로고
    • Targeting NF-κB signaling with protein kinase C agonists as an emerging strategy for combating HIV latency
    • Jiang G, Dandekar S. 2015. Targeting NF-κB signaling with protein kinase C agonists as an emerging strategy for combating HIV latency. AIDS Res. Hum. Retrovir. 31(1):4-12
    • (2015) AIDS Res. Hum. Retrovir. , vol.31 , Issue.1 , pp. 4-12
    • Jiang, G.1    Dandekar, S.2
  • 31
    • 0020326790 scopus 로고
    • Direct activation of calcium-activated, phospholipiddependent protein kinase by tumor-promoting phorbol esters
    • Castagna M, Takai Y, Kaibuchi K, et al. 1982. Direct activation of calcium-activated, phospholipiddependent protein kinase by tumor-promoting phorbol esters. J. Biol. Chem. 257:7847-51
    • (1982) J. Biol. Chem. , vol.257 , pp. 7847-7851
    • Castagna, M.1    Takai, Y.2    Kaibuchi, K.3
  • 32
    • 0021227676 scopus 로고
    • The role of protein kinaseCin cell surface signal transduction and tumour promotion
    • Nishizuka Y. 1984. The role of protein kinaseCin cell surface signal transduction and tumour promotion. Nature 308:693-98
    • (1984) Nature , vol.308 , pp. 693-698
    • Nishizuka, Y.1
  • 33
    • 0017655069 scopus 로고
    • New tigliane and daphnane derivatives from Pimelea prostrata and Pimelea simplex
    • Zayed S, Hafez A, Adolf W, Hecker E. 1977. New tigliane and daphnane derivatives from Pimelea prostrata and Pimelea simplex. Experientia 33:1554-55
    • (1977) Experientia , vol.33 , pp. 1554-1555
    • Zayed, S.1    Hafez, A.2    Adolf, W.3    Hecker, E.4
  • 34
    • 0026734304 scopus 로고
    • A nonpromoting phorbol from the Samoan medicinal plant Homalanthus nutans inhibits cell killing by HIV-1
    • Gustafson KR, Cardellina JH2nd,McMahon JB, et al. 1992. A nonpromoting phorbol from the Samoan medicinal plant Homalanthus nutans inhibits cell killing by HIV-1. J. Med. Chem. 35:1978-86
    • (1992) J. Med. Chem. , vol.35 , pp. 1978-1986
    • Gustafson, K.R.1    Cardellina, I.I.J.H.2    McMahon, J.B.3
  • 35
    • 0035892120 scopus 로고    scopus 로고
    • Prostratin: Activation of latentHIV-1 expression suggests a potential inductive adjuvant therapy for HAART
    • Kulkosky J, Culnan DM, Roman J, et al. 2001. Prostratin: activation of latentHIV-1 expression suggests a potential inductive adjuvant therapy for HAART. Blood 98:3006-15
    • (2001) Blood , vol.98 , pp. 3006-3015
    • Kulkosky, J.1    Culnan, D.M.2    Roman, J.3
  • 36
    • 2642546509 scopus 로고    scopus 로고
    • Expression of latent HAART-persistent HIV type 1 induced by novel cellular activating agents
    • Kulkosky J, Sullivan J, Xu Y, et al. 2004. Expression of latent HAART-persistent HIV type 1 induced by novel cellular activating agents. AIDS Res. Hum. Retrovir. 20:497-505
    • (2004) AIDS Res. Hum. Retrovir. , vol.20 , pp. 497-505
    • Kulkosky, J.1    Sullivan, J.2    Xu, Y.3
  • 37
    • 4744359117 scopus 로고    scopus 로고
    • Prostratin antagonizes HIV latency by activating NF-κB
    • Williams SA, Chen LF, Kwon H, et al. 2004. Prostratin antagonizes HIV latency by activating NF-κB. J. Biol. Chem. 279:42008-17
    • (2004) J. Biol. Chem. , vol.279 , pp. 42008-42017
    • Williams, S.A.1    Chen, L.F.2    Kwon, H.3
  • 38
    • 0019846016 scopus 로고
    • Marine animal biosynthetic constituents for cancer chemotherapy
    • PettitGR, Kamano Y, Fujii Y, et al. 1981. Marine animal biosynthetic constituents for cancer chemotherapy. J. Nat. Prod. 44:482-85
    • (1981) J. Nat. Prod. , vol.44 , pp. 482-485
    • Pettit, G.R.1    Kamano, Y.2    Fujii, Y.3
  • 39
    • 0022375243 scopus 로고
    • Bryostatins: Potent, new mitogens that mimic phorbol ester tumor promoters
    • Smith JB, Smith L, Pettit GR. 1985. Bryostatins: potent, new mitogens that mimic phorbol ester tumor promoters. Biochem. Biophys. Res. Commun. 132:939-45
    • (1985) Biochem. Biophys. Res. Commun. , vol.132 , pp. 939-945
    • Smith, J.B.1    Smith, L.2    Pettit, G.R.3
  • 40
    • 84891799728 scopus 로고    scopus 로고
    • Marine natural products: Bryostatins in preclinical and clinical studies
    • Kollar P, Rajchard J, Balounova Z, Pazourek J. 2014. Marine natural products: bryostatins in preclinical and clinical studies. Pharm. Biol. 52:237-42
    • (2014) Pharm. Biol. , vol.52 , pp. 237-242
    • Kollar, P.1    Rajchard, J.2    Balounova, Z.3    Pazourek, J.4
  • 41
    • 0027489606 scopus 로고
    • Phase i study of bryostatin 1: Assessment of interleukin 6 and tumor necrosis factor alpha induction in vivo the Cancer Research Campaign Phase i Committee
    • Philip PA, Rea D, Thavasu P, et al. 1993. Phase I study of bryostatin 1: assessment of interleukin 6 and tumor necrosis factor alpha induction in vivo. The Cancer Research Campaign Phase I Committee. J. Natl. Cancer Inst. 85:1812-18
    • (1993) J. Natl. Cancer Inst. , vol.85 , pp. 1812-1818
    • Philip, P.A.1    Rea, D.2    Thavasu, P.3
  • 42
    • 84958793805 scopus 로고    scopus 로고
    • Bryostatin-1 for latent virus reactivation in HIV-infected patients on antiretroviral therapy
    • Gutierrez C, Serrano-Villar S, Madrid-Elena N, et al. 2016. Bryostatin-1 for latent virus reactivation in HIV-infected patients on antiretroviral therapy. AIDS 30:1385-92
    • (2016) AIDS , vol.30 , pp. 1385-1392
    • Gutierrez, C.1    Serrano-Villar, S.2    Madrid-Elena, N.3
  • 44
    • 0017291041 scopus 로고
    • Antileukemic principles isolated from euphorbiaceae plants
    • Kupchan SM, Uchida I, Branfman AR, et al. 1976. Antileukemic principles isolated from euphorbiaceae plants. Science 191:571-72
    • (1976) Science , vol.191 , pp. 571-572
    • Kupchan, S.M.1    Uchida, I.2    Branfman, A.R.3
  • 45
    • 0030044459 scopus 로고    scopus 로고
    • Mechanism of selective inhibition of human immunodeficiency virus by ingenol triacetate
    • Fujiwara M, Ijichi K, Tokuhisa K, et al. 1996. Mechanism of selective inhibition of human immunodeficiency virus by ingenol triacetate. Antimicrob. Agents Chemother. 40:271-73
    • (1996) Antimicrob. Agents Chemother. , vol.40 , pp. 271-273
    • Fujiwara, M.1    Ijichi, K.2    Tokuhisa, K.3
  • 46
    • 33751068006 scopus 로고    scopus 로고
    • HIV type 1 inhibition by protein kinase C modulatory compounds
    • Warrilow D, Gardner J, Darnell GA, et al. 2006. HIV type 1 inhibition by protein kinase C modulatory compounds. AIDS Res. Hum. Retrovir. 22:854-64
    • (2006) AIDS Res. Hum. Retrovir. , vol.22 , pp. 854-864
    • Warrilow, D.1    Gardner, J.2    Darnell, G.A.3
  • 47
    • 84907288256 scopus 로고    scopus 로고
    • Reactivation of latent HIV-1 by new semi-synthetic ingenol esters
    • Pandelo Jose D, Bartholomeeusen K, da Cunha RD, et al. 2014. Reactivation of latent HIV-1 by new semi-synthetic ingenol esters. Virology 462-463:328-39
    • (2014) Virology , vol.462-463 , pp. 328-339
    • Pandelo, J.D.1    Bartholomeeusen, K.2    Da Cunha, R.D.3
  • 48
    • 84901354407 scopus 로고    scopus 로고
    • Dual role of novel ingenol derivatives from Euphorbia tirucalli in HIV replication: Inhibition of de novo infection and activation of viral LTR
    • AbreuCM, Price SL, Shirk EN, et al. 2014. Dual role of novel ingenol derivatives from Euphorbia tirucalli in HIV replication: inhibition of de novo infection and activation of viral LTR. PLOS ONE 9:e97257
    • (2014) PLOS ONE , vol.9 , pp. e97257
    • Abreu, C.M.1    Price, S.L.2    Shirk, E.N.3
  • 49
    • 84915820021 scopus 로고    scopus 로고
    • Ingenol mebutate: A succinct review of a succinct therapy
    • Alchin DR. 2014. Ingenol mebutate: a succinct review of a succinct therapy. Dermatol. Ther. 4:157-64
    • (2014) Dermatol. Ther. , vol.4 , pp. 157-164
    • Alchin, D.R.1
  • 50
    • 84938767578 scopus 로고    scopus 로고
    • Synergistic reactivation of latent HIV expression by ingenol-3-angelate, PEP005, targeted NF-κB signaling in combination with JQ1 induced p-TEFb activation
    • Jiang G,Mendes EA, Kaiser P, et al. 2015. Synergistic reactivation of latent HIV expression by ingenol-3-angelate, PEP005, targeted NF-κB signaling in combination with JQ1 induced p-TEFb activation. PLOS Pathog. 11:e1005066
    • (2015) PLOS Pathog. , vol.11 , pp. e1005066
    • Jiang, G.1    Mendes, E.A.2    Kaiser, P.3
  • 51
    • 84988603501 scopus 로고    scopus 로고
    • Reactivation of simian immunodeficiency virus reservoirs in the brain of virally suppressed macaques
    • Gama L, Abreu CM, Shirk EN, et al. 2017. Reactivation of simian immunodeficiency virus reservoirs in the brain of virally suppressed macaques. AIDS 31:5-14
    • (2017) AIDS , vol.31 , pp. 5-14
    • Gama, L.1    Abreu, C.M.2    Shirk, E.N.3
  • 52
    • 85014667238 scopus 로고    scopus 로고
    • HIV-1 latency-reversing agents prostratin and bryostatin-1 induce blood-brain barrier disruption/inflammation and modulate leukocyte adhesion/transmigration
    • Dental C, Proust A, Ouellet M, et al. 2017. HIV-1 latency-reversing agents prostratin and bryostatin-1 induce blood-brain barrier disruption/inflammation and modulate leukocyte adhesion/transmigration. J. Immunol. 198:1229-41
    • (2017) J. Immunol. , vol.198 , pp. 1229-1241
    • Dental, C.1    Proust, A.2    Ouellet, M.3
  • 53
    • 54849439280 scopus 로고    scopus 로고
    • Chemical and pharmacological research of the plants in genus Euphorbia
    • Shi QW, Su XH, Kiyota H. 2008. Chemical and pharmacological research of the plants in genus Euphorbia. Chem. Rev. 108:4295-327 www.annualreviews.org Latency Reversal for HIV-1 Cure 433
    • (2008) Chem. Rev. , vol.108 , pp. 4295-4327
    • Shi, Q.W.1    Su, X.H.2    Kiyota, H.3
  • 54
    • 85006341644 scopus 로고    scopus 로고
    • Euphorbia kansui reactivates latent HIV
    • Cary DC, Fujinaga K, Peterlin BM. 2016. Euphorbia kansui reactivates latent HIV. PLOS ONE 11:e0168027
    • (2016) PLOS ONE , vol.11 , pp. e0168027
    • Cary, D.C.1    Fujinaga, K.2    Peterlin, B.M.3
  • 55
    • 0141856405 scopus 로고    scopus 로고
    • Rational design of drugs that induce human immunodeficiency virus replication
    • Hamer DH, Bocklandt S, McHugh L, et al. 2003. Rational design of drugs that induce human immunodeficiency virus replication. J. Virol. 77:10227-36
    • (2003) J. Virol. , vol.77 , pp. 10227-10236
    • Hamer, D.H.1    Bocklandt, S.2    McHugh, L.3
  • 56
    • 39949083208 scopus 로고    scopus 로고
    • Differential effects of phorbol-13-monoesters on human immunodeficiency virus reactivation
    • MarquezN, CalzadoMA, Sanchez-Duffhues G, et al. 2008. Differential effects of phorbol-13-monoesters on human immunodeficiency virus reactivation. Biochem. Pharmacol. 75:1370-80
    • (2008) Biochem. Pharmacol. , vol.75 , pp. 1370-1380
    • Marquez, N.1    Calzado, M.A.2    Sanchez-Duffhues, G.3
  • 57
    • 84904718063 scopus 로고    scopus 로고
    • Reactivation of HIV latency by a newly modified ingenol derivative via protein kinase Cδ-NF-κB signaling
    • Jiang G, Mendes EA, Kaiser P, et al. 2014. Reactivation of HIV latency by a newly modified ingenol derivative via protein kinase Cδ-NF-κB signaling. AIDS 28:1555-66
    • (2014) AIDS , vol.28 , pp. 1555-1566
    • Jiang, G.1    Mendes, E.A.2    Kaiser, P.3
  • 58
    • 85006711804 scopus 로고    scopus 로고
    • Janus kinase inhibition suppresses PKC-induced cytokine release without affecting HIV-1 latency reversal ex vivo
    • Spivak AM, Larragoite ET, Coletti ML, et al. 2016. Janus kinase inhibition suppresses PKC-induced cytokine release without affecting HIV-1 latency reversal ex vivo. Retrovirology 13:88
    • (2016) Retrovirology , vol.13 , pp. 88
    • Spivak, A.M.1    Larragoite, E.T.2    Coletti, M.L.3
  • 59
    • 85014060688 scopus 로고    scopus 로고
    • Rapamycin-mediated mTOR inhibition uncouples HIV-1 latency reversal from cytokine-associated toxicity
    • Martin AR, Pollack RA, Capoferri A, et al. 2017. Rapamycin-mediated mTOR inhibition uncouples HIV-1 latency reversal from cytokine-associated toxicity. J. Clin. Investig. 127:651-56
    • (2017) J. Clin. Investig. , vol.127 , pp. 651-656
    • Martin, A.R.1    Pollack, R.A.2    Capoferri, A.3
  • 61
    • 84900473405 scopus 로고    scopus 로고
    • Quantification of HIV-1 latency reversal in resting CD4+ T cells from patients on suppressive antiretroviral therapy
    • Cillo AR, Sobolewski MD, Bosch RJ, et al. 2014. Quantification of HIV-1 latency reversal in resting CD4+ T cells from patients on suppressive antiretroviral therapy. PNAS 111:7078-83
    • (2014) PNAS , vol.111 , pp. 7078-7083
    • Cillo, A.R.1    Sobolewski, M.D.2    Bosch, R.J.3
  • 62
    • 84864203255 scopus 로고    scopus 로고
    • Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy
    • Archin NM, Liberty AL, Kashuba AD, et al. 2012. Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy. Nature 487:482-85
    • (2012) Nature , vol.487 , pp. 482-485
    • Archin, N.M.1    Liberty, A.L.2    Kashuba, A.D.3
  • 63
    • 84912122037 scopus 로고    scopus 로고
    • Activation of HIV transcription with short-course vorinostat in HIV-infected patients on suppressive antiretroviral therapy
    • Elliott JH, Wightman F, Solomon A, et al. 2014. Activation of HIV transcription with short-course vorinostat in HIV-infected patients on suppressive antiretroviral therapy. PLOS Pathog. 10:e1004473
    • (2014) PLOS Pathog. , vol.10 , pp. e1004473
    • Elliott, J.H.1    Wightman, F.2    Solomon, A.3
  • 64
    • 84911460971 scopus 로고    scopus 로고
    • Panobinostat, a histone deacetylase inhibitor, for latent-virus reactivation in HIV-infected patients on suppressive antiretroviral therapy: A phase 1/2, single group, clinical trial
    • Rasmussen TA, Tolstrup M, Brinkmann CR, et al. 2014. Panobinostat, a histone deacetylase inhibitor, for latent-virus reactivation in HIV-infected patients on suppressive antiretroviral therapy: a phase 1/2, single group, clinical trial. Lancet HIV 1:e13-21
    • (2014) Lancet HIV , vol.1 , pp. e13-21
    • Rasmussen, T.A.1    Tolstrup, M.2    Brinkmann, C.R.3
  • 65
    • 84978328043 scopus 로고    scopus 로고
    • Activation of latent human immunodeficiency virus by the histone deacetylase inhibitor panobinostat: A pilot study to assess effects on the central nervous system
    • Rasmussen TA, Tolstrup M, Moller HJ, et al. 2015. Activation of latent human immunodeficiency virus by the histone deacetylase inhibitor panobinostat: a pilot study to assess effects on the central nervous system. Open Forum Infect. Dis. 2:ofv037
    • (2015) Open Forum Infect. Dis. , vol.2 , pp. ofv037
    • Rasmussen, T.A.1    Tolstrup, M.2    Moller, H.J.3
  • 66
    • 84943557984 scopus 로고    scopus 로고
    • The depsipeptide romidepsin reverses HIV-1 latency in vivo
    • Sogaard OS, Graversen ME, Leth S, et al. 2015. The depsipeptide romidepsin reverses HIV-1 latency in vivo. PLOS Pathog. 11:e1005142
    • (2015) PLOS Pathog. , vol.11 , pp. e1005142
    • Sogaard, O.S.1    Graversen, M.E.2    Leth, S.3
  • 68
    • 79958136377 scopus 로고    scopus 로고
    • Disulfiram reactivates latent HIV-1 in a Bcl-2-transduced primary CD4+ T cell model without inducing global T cell activation
    • Xing S, Bullen CK, Shroff NS, et al. 2011. Disulfiram reactivates latent HIV-1 in a Bcl-2-transduced primary CD4+ T cell model without inducing global T cell activation. J. Virol. 85:6060-64
    • (2011) J. Virol. , vol.85 , pp. 6060-6064
    • Xing, S.1    Bullen, C.K.2    Shroff, N.S.3
  • 69
    • 84872393902 scopus 로고    scopus 로고
    • Disulfiram reactivates latentHIV-1 expression through depletion of the phosphatase and tensin homolog
    • DoyonG, Zerbato J, Mellors JW, Sluis-CremerN. 2013. Disulfiram reactivates latentHIV-1 expression through depletion of the phosphatase and tensin homolog. AIDS 27:F7-F11
    • (2013) AIDS , vol.27 , pp. F7-F11
    • Doyon, G.1    Zerbato, J.2    Mellors, J.W.3    Sluis-Cremer, N.4
  • 70
    • 84895740875 scopus 로고    scopus 로고
    • A pilot study assessing the safety and latency-reversing activity of disulfiram in HIV-1-infected adults on antiretroviral therapy
    • Spivak AM, Andrade A, Eisele E, et al. 2014. A pilot study assessing the safety and latency-reversing activity of disulfiram in HIV-1-infected adults on antiretroviral therapy. Clin. Infect. Dis. 58:883-90
    • (2014) Clin. Infect. Dis. , vol.58 , pp. 883-890
    • Spivak, A.M.1    Andrade, A.2    Eisele, E.3
  • 71
    • 84977937246 scopus 로고    scopus 로고
    • Short-term administration of disulfiram for reversal of latent HIV infection: A phase 2 dose-escalation study
    • Elliott JH, McMahon JH, Chang CC, et al. 2015. Short-term administration of disulfiram for reversal of latent HIV infection: a phase 2 dose-escalation study. Lancet HIV 2:e520-29
    • (2015) Lancet HIV , vol.2 , pp. e520-e529
    • Elliott, J.H.1    McMahon, J.H.2    Chang, C.C.3
  • 72
    • 33947692819 scopus 로고    scopus 로고
    • TLR-mediated innate immune recognition
    • Medzhitov R. 2007. TLR-mediated innate immune recognition. Semin. Immunol. 19:1-2
    • (2007) Semin. Immunol. , vol.19 , pp. 1-2
    • Medzhitov, R.1
  • 73
    • 78751560494 scopus 로고    scopus 로고
    • Pathogen recognition by the innate immune system
    • KumarH, Kawai T, Akira S. 2011. Pathogen recognition by the innate immune system. Int. Rev. Immunol. 30:16-34
    • (2011) Int. Rev. Immunol. , vol.30 , pp. 16-34
    • Kumar, H.1    Kawai, T.2    Akira, S.3
  • 74
    • 67349253004 scopus 로고    scopus 로고
    • TLR5 stimulation is sufficient to trigger reactivation of latent HIV-1 provirus in T lymphoid cells and activate virus gene expression in central memory CD4+ T cells
    • Thibault S, Imbeault M, Tardif MR, Tremblay MJ. 2009. TLR5 stimulation is sufficient to trigger reactivation of latent HIV-1 provirus in T lymphoid cells and activate virus gene expression in central memory CD4+ T cells. Virology 389:20-25
    • (2009) Virology , vol.389 , pp. 20-25
    • Thibault, S.1    Imbeault, M.2    Tardif, M.R.3    Tremblay, M.J.4
  • 75
    • 84886052184 scopus 로고    scopus 로고
    • Reactivation of latent HIV-1 in central memory CD4+ T cells through TLR-1/2 stimulation
    • Novis CL, Archin NM, Buzon MJ, et al. 2013. Reactivation of latent HIV-1 in central memory CD4+ T cells through TLR-1/2 stimulation. Retrovirology 10:119
    • (2013) Retrovirology , vol.10 , pp. 119
    • Novis, C.L.1    Archin, N.M.2    Buzon, M.J.3
  • 76
    • 59449101108 scopus 로고    scopus 로고
    • Induction of HIV-1 latency and reactivation in primary memory CD4+ T cells
    • Bosque A, Planelles V. 2009. Induction of HIV-1 latency and reactivation in primary memory CD4+ T cells. Blood 113:58-65
    • (2009) Blood , vol.113 , pp. 58-65
    • Bosque, A.1    Planelles, V.2
  • 77
    • 85011655854 scopus 로고    scopus 로고
    • Benzotriazoles reactivate latent HIV-1 through inactivation of STAT5 SUMOylation
    • Bosque A, Nilson KA, Macedo AB, et al. 2017. Benzotriazoles reactivate latent HIV-1 through inactivation of STAT5 SUMOylation. Cell Rep. 18:1324-34
    • (2017) Cell Rep. , vol.18 , pp. 1324-1334
    • Bosque, A.1    Nilson, K.A.2    Macedo, A.B.3
  • 78
    • 84863393395 scopus 로고    scopus 로고
    • SUMO-specific protease 1 is critical for early lymphoid development through regulation of STAT5 activation
    • Van Nguyen T, Angkasekwinai P, Dou H, et al. 2012. SUMO-specific protease 1 is critical for early lymphoid development through regulation of STAT5 activation. Mol. Cell 45:210-21
    • (2012) Mol. Cell , vol.45 , pp. 210-221
    • Van Nguyen, T.1    Angkasekwinai, P.2    Dou, H.3
  • 79
    • 30044445017 scopus 로고    scopus 로고
    • The γc-cytokine regulated transcription factor, STAT5, increases HIV-1 production in primary CD4 T cells
    • Selliah N, ZhangM, DeSimone D, et al. 2006. The γc-cytokine regulated transcription factor, STAT5, increases HIV-1 production in primary CD4 T cells. Virology 344:283-91
    • (2006) Virology , vol.344 , pp. 283-291
    • Selliah, N.1    Zhang, M.2    DeSimone, D.3
  • 80
    • 78650920066 scopus 로고    scopus 로고
    • Non-canonical NF-κB signaling pathway
    • Sun SC. 2011. Non-canonical NF-κB signaling pathway. Cell Res. 21:71-85
    • (2011) Cell Res. , vol.21 , pp. 71-85
    • Sun, S.C.1
  • 81
    • 84941275484 scopus 로고    scopus 로고
    • BIRC2/cIAP1 is a negative regulator of HIV-1 transcription and can be targeted by Smac mimetics to promote reversal of viral latency
    • Pache L,Dutra MS, Spivak AM, et al. 2015. BIRC2/cIAP1 is a negative regulator of HIV-1 transcription and can be targeted by Smac mimetics to promote reversal of viral latency. Cell Host Microbe 18:345-53
    • (2015) Cell Host Microbe , vol.18 , pp. 345-353
    • Pache, L.1    Dutra, M.S.2    Spivak, A.M.3
  • 82
    • 84906764768 scopus 로고    scopus 로고
    • HIV-1 expression within resting CD4+ T cells after multiple doses of vorinostat
    • Archin NM, Bateson R, Tripathy MK, et al. 2014. HIV-1 expression within resting CD4+ T cells after multiple doses of vorinostat. J. Infect. Dis. 210:728-35
    • (2014) J. Infect. Dis. , vol.210 , pp. 728-735
    • Archin, N.M.1    Bateson, R.2    Tripathy, M.K.3
  • 83
    • 84946925503 scopus 로고    scopus 로고
    • Synergistic activation of latent HIV-1 expression by novel histone deacetylase inhibitors and bryostatin-1
    • Martinez-Bonet M, Clemente MI, Serramia MJ, et al. 2015. Synergistic activation of latent HIV-1 expression by novel histone deacetylase inhibitors and bryostatin-1. Sci. Rep. 5:16445
    • (2015) Sci. Rep. , vol.5 , pp. 16445
    • Martinez-Bonet, M.1    Clemente, M.I.2    Serramia, M.J.3
  • 84
    • 84938795129 scopus 로고    scopus 로고
    • Anin-depth comparison of latency-reversing agent combinations in various in vitro and ex vivo HIV-1 latency models identified bryostatin-1+JQ1 and ingenol-B+JQ1 to potently reactivate viral gene expression
    • Darcis G, Kula A, Bouchat S, et al. 2015.Anin-depth comparison of latency-reversing agent combinations in various in vitro and ex vivo HIV-1 latency models identified bryostatin-1+JQ1 and ingenol-B+JQ1 to potently reactivate viral gene expression. PLOS Pathog. 11:e1005063
    • (2015) PLOS Pathog. , vol.11 , pp. e1005063
    • Darcis, G.1    Kula, A.2    Bouchat, S.3
  • 85
    • 67650550767 scopus 로고    scopus 로고
    • Synergistic activation of HIV-1 expression by deacetylase inhibitors and prostratin: Implications for treatment of latent infection
    • Reuse S, Calao M, Kabeya K, et al. 2009. Synergistic activation of HIV-1 expression by deacetylase inhibitors and prostratin: implications for treatment of latent infection. PLOS ONE 4:e6093
    • (2009) PLOS ONE , vol.4 , pp. e6093
    • Reuse, S.1    Calao, M.2    Kabeya, K.3
  • 86
    • 85006007491 scopus 로고    scopus 로고
    • In vitro effects of the small-molecule protein kinase C agonists on HIV latency reactivation
    • Brogdon J, ZianiW,Wang X, et al. 2016. In vitro effects of the small-molecule protein kinase C agonists on HIV latency reactivation. Sci. Rep. 6:39032
    • (2016) Sci. Rep. , vol.6 , pp. 39032
    • Brogdon, J.1    Ziani, W.2    Wang, X.3
  • 87
    • 84982182573 scopus 로고    scopus 로고
    • HMBA enhances prostratin-induced activation of latent HIV-1 via suppressing the expression of negative feedback regulator A20/TNFAIP3 in NF-κB signaling
    • Chen D, Wang H, Aweya JJ, et al. 2016. HMBA enhances prostratin-induced activation of latent HIV-1 via suppressing the expression of negative feedback regulator A20/TNFAIP3 in NF-κB signaling. Biomed. Res. Int. 2016:5173205
    • (2016) Biomed. Res. Int. 2016 , pp. 5173205
    • Chen, D.1    Wang, H.2    Aweya, J.J.3
  • 88
    • 85011954105 scopus 로고    scopus 로고
    • Promising role of toll-like receptor 8 agonist in concert with prostratin for activation of silent HIV
    • Rochat MA, Schlaepfer E, Speck RF. 2017. Promising role of toll-like receptor 8 agonist in concert with prostratin for activation of silent HIV. J. Virol. 91(4):e02084-16
    • (2017) J. Virol. , vol.91 , Issue.4 , pp. e02084-e02116
    • Rochat, M.A.1    Schlaepfer, E.2    Speck, R.F.3
  • 89
    • 84897394404 scopus 로고    scopus 로고
    • Activation of HIV-1 from latent infection via synergy of RUNX1 inhibitor Ro5-3335 and SAHA
    • Klase Z, Yedavalli VS, Houzet L, et al. 2014. Activation of HIV-1 from latent infection via synergy of RUNX1 inhibitor Ro5-3335 and SAHA. PLOS Pathog. 10:e1003997
    • (2014) PLOS Pathog. , vol.10 , pp. e1003997
    • Klase, Z.1    Yedavalli, V.S.2    Houzet, L.3
  • 90
    • 84957945298 scopus 로고    scopus 로고
    • Sequential treatment with 5-aza-2-deoxycytidine and deacetylase inhibitors reactivates HIV-1
    • Bouchat S, Delacourt N, Kula A, et al. 2016. Sequential treatment with 5-aza-2-deoxycytidine and deacetylase inhibitors reactivates HIV-1. EMBO. Mol. Med. 8:117-38
    • (2016) EMBO. Mol. Med. , vol.8 , pp. 117-138
    • Bouchat, S.1    Delacourt, N.2    Kula, A.3
  • 91
    • 84978823390 scopus 로고    scopus 로고
    • Human galectin-9 is a potent mediator of HIV transcription and reactivation
    • Abdel-Mohsen M, Chavez L, Tandon R, et al. 2016. Human galectin-9 is a potent mediator of HIV transcription and reactivation. PLOS Pathog. 12:e1005677
    • (2016) PLOS Pathog. , vol.12 , pp. e1005677
    • Abdel-Mohsen, M.1    Chavez, L.2    Tandon, R.3
  • 92
    • 84863337769 scopus 로고    scopus 로고
    • Stimulation ofHIV-1-specific cytolyticTlymphocytes facilitates elimination of latent viral reservoir after virus reactivation
    • Shan L,DengK, ShroffNS, et al. 2012. Stimulation ofHIV-1-specific cytolyticTlymphocytes facilitates elimination of latent viral reservoir after virus reactivation. Immunity 36:491-501
    • (2012) Immunity , vol.36 , pp. 491-501
    • Shan, L.1    Deng, K.2    Shroff, N.S.3
  • 93
    • 84956938667 scopus 로고    scopus 로고
    • HIV-specific CD8+ T cells andHIV eradication
    • Jones RB, Walker BD. 2016. HIV-specific CD8+ T cells andHIV eradication. J. Clin. Investig. 126:455-63
    • (2016) J. Clin. Investig. , vol.126 , pp. 455-463
    • Jones, R.B.1    Walker, B.D.2
  • 94
    • 84912530131 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors impair the elimination of HIV-infected cells by cytotoxic T-lymphocytes
    • Jones RB, O'Connor R, Mueller S, et al. 2014. Histone deacetylase inhibitors impair the elimination of HIV-infected cells by cytotoxic T-lymphocytes. PLOS Pathog. 10:e1004287
    • (2014) PLOS Pathog. , vol.10 , pp. e1004287
    • Jones, R.B.1    O'Connor, R.2    Mueller, S.3
  • 95
    • 84982683043 scopus 로고    scopus 로고
    • The differential short-and long-term effects of HIV-1 latencyreversing agents on T cell function
    • CluttonG, Xu Y, Baldoni PL, et al. 2016. The differential short-and long-term effects of HIV-1 latencyreversing agents on T cell function. Sci. Rep. 6:30749
    • (2016) Sci. Rep. , vol.6 , pp. 30749
    • Clutton, G.1    Xu, Y.2    Baldoni, P.L.3
  • 96
    • 84964301410 scopus 로고    scopus 로고
    • The effect of latency reversal agents on primary CD8+ T cells: Implications for shock and kill strategies for human immunodeficiency virus eradication
    • Walker-Sperling VE, Pohlmeyer CW, Tarwater PM, Blankson JN. 2016. The effect of latency reversal agents on primary CD8+ T cells: implications for shock and kill strategies for human immunodeficiency virus eradication. EBioMedicine 8:217-29
    • (2016) EBioMedicine , vol.8 , pp. 217-229
    • Walker-Sperling, V.E.1    Pohlmeyer, C.W.2    Tarwater, P.M.3    Blankson, J.N.4
  • 97
    • 85018725997 scopus 로고    scopus 로고
    • The effect of ingenol-B on the suppressive capacity of elite suppressor HIV-specific CD8+ T cells
    • Kwaa AK,Goldsborough K,Walker-Sperling VE, et al. 2017. The effect of ingenol-B on the suppressive capacity of elite suppressor HIV-specific CD8+ T cells. PLOS ONE 12:e0174516
    • (2017) PLOS ONE , vol.12 , pp. e0174516
    • Kwaa, A.K.1    Goldsborough, K.2    Walker-Sperling, V.E.3
  • 98
    • 84984799753 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors enhance CD4 T cell susceptibility to NK cell killing but reduce NK cell function
    • Pace M, Williams J, Kurioka A, et al. 2016. Histone deacetylase inhibitors enhance CD4 T cell susceptibility to NK cell killing but reduce NK cell function. PLOS Pathog. 12:e1005782
    • (2016) PLOS Pathog. , vol.12 , pp. e1005782
    • Pace, M.1    Williams, J.2    Kurioka, A.3
  • 99
    • 84992166423 scopus 로고    scopus 로고
    • HIV latency-reversing agents have diverse effects on natural killer cell function
    • Garrido C, Spivak AM, Soriano-SarabiaN, et al. 2016. HIV latency-reversing agents have diverse effects on natural killer cell function. Front. Immunol. 7:356
    • (2016) Front. Immunol. , vol.7 , pp. 356
    • Garrido, C.1    Spivak, A.M.2    Soriano-Sarabia, N.3
  • 100
    • 84991628114 scopus 로고    scopus 로고
    • Combined effect of Vacc-4x, recombinant human granulocyte macrophage colony-stimulating factor vaccination, and romidepsin on the HIV-1 reservoir (REDUC): A single-arm, phase 1B/2A trial
    • Leth S, Schleimann MH, Nissen SK, et al. 2016. Combined effect of Vacc-4x, recombinant human granulocyte macrophage colony-stimulating factor vaccination, and romidepsin on the HIV-1 reservoir (REDUC): a single-arm, phase 1B/2A trial. Lancet HIV 3:e463-72
    • (2016) Lancet HIV , vol.3 , pp. e463-e472
    • Leth, S.1    Schleimann, M.H.2    Nissen, S.K.3
  • 102
    • 84866498069 scopus 로고    scopus 로고
    • Redefining the viral reservoirs that prevent HIV-1 eradication
    • Eisele E, Siliciano RF. 2012. Redefining the viral reservoirs that prevent HIV-1 eradication. Immunity 37:377-88
    • (2012) Immunity , vol.37 , pp. 377-388
    • Eisele, E.1    Siliciano, R.F.2
  • 103
    • 84986551098 scopus 로고    scopus 로고
    • Shutdown of HIV-1 transcription in T cells by Nullbasic, a mutant Tat protein
    • Jin H, Li D, Sivakumaran H, et al. 2016. Shutdown of HIV-1 transcription in T cells by Nullbasic, a mutant Tat protein. MBio 7(4):e00518-16 www.annualreviews.org Latency Reversal for HIV-1 Cure 435
    • (2016) MBio , vol.7 , Issue.4 , pp. e00518-e00616
    • Jin, H.1    Li, D.2    Sivakumaran, H.3
  • 104
    • 0028944744 scopus 로고
    • The human immunodeficiency virus type 1 Tat antagonist, Ro 5-3335, predominantly inhibits transcription initiation from the viral promoter
    • Cupelli LA, Hsu MC. 1995. The human immunodeficiency virus type 1 Tat antagonist, Ro 5-3335, predominantly inhibits transcription initiation from the viral promoter. J. Virol. 69:2640-43
    • (1995) J. Virol. , vol.69 , pp. 2640-2643
    • Cupelli, L.A.1    Hsu, M.C.2
  • 105
    • 84940853263 scopus 로고    scopus 로고
    • The Tat inhibitor didehydro-cortistatin A prevents HIV-1 reactivation from latency
    • Mousseau G, Kessing CF, Fromentin R, et al. 2015. The Tat inhibitor didehydro-cortistatin A prevents HIV-1 reactivation from latency. MBio 6:e00465
    • (2015) MBio , vol.6 , pp. e00465
    • Mousseau, G.1    Kessing, C.F.2    Fromentin, R.3
  • 106
    • 84866295080 scopus 로고    scopus 로고
    • An analog of the natural steroidal alkaloid cortistatin A potently suppresses Tat-dependent HIV transcription
    • Mousseau G, Clementz MA, Bakeman WN, et al. 2012. An analog of the natural steroidal alkaloid cortistatin A potently suppresses Tat-dependent HIV transcription. Cell Host Microbe 12:97-108
    • (2012) Cell Host Microbe , vol.12 , pp. 97-108
    • Mousseau, G.1    Clementz, M.A.2    Bakeman, W.N.3
  • 107
    • 84928822404 scopus 로고    scopus 로고
    • Long lasting control of viral rebound with a new drug ABX464 targeting Rev-mediated viral RNA biogenesis
    • Campos N, Myburgh R, Garcel A, et al. 2015. Long lasting control of viral rebound with a new drug ABX464 targeting Rev-mediated viral RNA biogenesis. Retrovirology 12:30
    • (2015) Retrovirology , vol.12 , pp. 30
    • Campos, N.1    Myburgh, R.2    Garcel, A.3
  • 108
    • 85002899169 scopus 로고    scopus 로고
    • A cure for HIV infection: "not in my lifetime" or "just around the corner"
    • Lederman MM, Cannon PM, Currier JS, et al. 2016. A cure for HIV infection: "not in my lifetime" or "just around the corner"? Pathog. Immun. 1:154-64
    • (2016) Pathog. Immun. , vol.1 , pp. 154-164
    • Lederman, M.M.1    Cannon, P.M.2    Currier, J.S.3
  • 109
    • 85021687880 scopus 로고    scopus 로고
    • HIV persistence in macrophages
    • Stevenson M. 2017. HIV persistence in macrophages. Nat. Med. 23:538-39
    • (2017) Nat. Med. , vol.23 , pp. 538-539
    • Stevenson, M.1
  • 110
    • 84941701713 scopus 로고    scopus 로고
    • The need for treatment interruption studies and biomarker identification in the search for an HIV cure
    • Li JZ, Smith DM, Mellors JW. 2015. The need for treatment interruption studies and biomarker identification in the search for an HIV cure. AIDS 29:1429-32
    • (2015) AIDS , vol.29 , pp. 1429-1432
    • Li, J.Z.1    Smith, D.M.2    Mellors, J.W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.