메뉴 건너뛰기




Volumn 67, Issue , 2016, Pages 215-228

Progress toward HIV eradication: Case reports, current efforts, and the challenges associated with cure

Author keywords

Early treatment; Genome editing; HIV 1; Persistence; Shock and kill; Vaccine

Indexed keywords

ANTIRETROVIRUS AGENT; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; HUMAN IMMUNODEFICIENCY VIRUS VACCINE;

EID: 84954551799     PISSN: 00664219     EISSN: 1545326X     Source Type: Book Series    
DOI: 10.1146/annurev-med-011514-023043     Document Type: Article
Times cited : (64)

References (82)
  • 1
    • 47649115323 scopus 로고    scopus 로고
    • Life expectancy of individuals on combination antiretroviral therapy in high-income countries: A collaborative analysis of 14 cohort studies
    • Antiretroviral Therapy Cohort Collaboration
    • Antiretroviral Therapy Cohort Collaboration. (2008). Life expectancy of individuals on combination antiretroviral therapy in high-income countries: a collaborative analysis of 14 cohort studies. Lancet 372(9635): 293-99
    • (2008) Lancet , vol.372 , Issue.9635 , pp. 293-299
  • 2
    • 84875355286 scopus 로고    scopus 로고
    • The impact of specificHIV treatment-related adverse events on adherence to antiretroviral therapy: A systematic review and meta-Analysis
    • Al-Dakkak I, Patel S, McCann E, et al. (2013). The impact of specificHIV treatment-related adverse events on adherence to antiretroviral therapy: a systematic review and meta-Analysis. AIDS Care 25(4): 400-14
    • (2013) AIDS Care , vol.25 , Issue.4 , pp. 400-414
    • Al-Dakkak, I.1    Patel, S.2    McCann, E.3
  • 3
    • 33646034630 scopus 로고    scopus 로고
    • Adherence-resistance relationships for protease and non-nucleoside reverse transcriptase inhibitors explained by virological fitness
    • Bangsberg DR, Acosta EP, Gupta R, et al. (2006). Adherence-resistance relationships for protease and non-nucleoside reverse transcriptase inhibitors explained by virological fitness. AIDS 20(2): 223-31
    • (2006) AIDS , vol.20 , Issue.2 , pp. 223-231
    • Bangsberg, D.R.1    Acosta, E.P.2    Gupta, R.3
  • 4
    • 84885753789 scopus 로고    scopus 로고
    • Systemic effects of inflammation on health during chronic HIV infection
    • Deeks SG, Tracy R, Douek DC. (2013). Systemic effects of inflammation on health during chronic HIV infection. Immunity 39(4): 633-45
    • (2013) Immunity , vol.39 , Issue.4 , pp. 633-645
    • Deeks, S.G.1    Tracy, R.2    Douek, D.C.3
  • 5
    • 0033004630 scopus 로고    scopus 로고
    • Rate of HIV-1 RNA rebound upon stopping antiretroviral therapy
    • Harrigan PR, Whaley M, Montaner JS. (1999). Rate of HIV-1 RNA rebound upon stopping antiretroviral therapy. AIDS 13(8): F59-62
    • (1999) AIDS , vol.13 , Issue.8 , pp. F59-62
    • Harrigan, P.R.1    Whaley, M.2    Montaner, J.S.3
  • 6
    • 0036176509 scopus 로고    scopus 로고
    • The challenge of viral reservoirs in HIV-1 infection
    • Blankson JN, Persaud D, Siliciano RF. (2002). The challenge of viral reservoirs in HIV-1 infection. Annu. Rev. Med. 53: 557-93
    • (2002) Annu. Rev. Med , vol.53 , pp. 557-593
    • Blankson, J.N.1    Persaud, D.2    Siliciano, R.F.3
  • 7
    • 0028792184 scopus 로고
    • In vivo fate of HIV-1-infected T cells: Quantitative analysis of the transition to stable latency
    • Chun TW, Finzi D, Margolick J, et al. (1995). In vivo fate of HIV-1-infected T cells: quantitative analysis of the transition to stable latency. Nat. Med. 1(12): 1284-90
    • (1995) Nat. Med , vol.1 , Issue.12 , pp. 1284-1290
    • Chun, T.W.1    Finzi, D.2    Margolick, J.3
  • 8
    • 14444273439 scopus 로고    scopus 로고
    • Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy
    • Finzi D, Hermankova M, Pierson T, et al. (1997). Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy. Science 278(5341): 1295-300
    • (1997) Science , vol.278 , Issue.5341 , pp. 1295-1300
    • Finzi, D.1    Hermankova, M.2    Pierson, T.3
  • 9
    • 0028811974 scopus 로고
    • Viral dynamics in human immunodeficiency virus type 1 infection
    • Wei X, Ghosh SK, Taylor ME, et al. (1995). Viral dynamics in human immunodeficiency virus type 1 infection. Nature 373(6510): 117-22
    • (1995) Nature , vol.373 , Issue.6510 , pp. 117-122
    • Wei, X.1    Ghosh, S.K.2    Taylor, M.E.3
  • 10
    • 0030952479 scopus 로고    scopus 로고
    • Decay characteristics of HIV-1-infected compartments during combination therapy
    • Perelson AS, Essunger P, Cao Y, et al. (1997). Decay characteristics of HIV-1-infected compartments during combination therapy. Nature 387(6629): 188-91
    • (1997) Nature , vol.387 , Issue.6629 , pp. 188-191
    • Perelson, A.S.1    Essunger, P.2    Cao, Y.3
  • 12
    • 0038579210 scopus 로고    scopus 로고
    • Long-Term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells
    • Siliciano JD, Kajdas J, Finzi D, et al. (2003). Long-Term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells. Nat. Med. 9(6): 727-28
    • (2003) Nat. Med , vol.9 , Issue.6 , pp. 727-728
    • Siliciano, J.D.1    Kajdas, J.2    Finzi, D.3
  • 13
    • 84946096080 scopus 로고    scopus 로고
    • Precise quantitation of the latent HIV-1 reservoir: Implications for eradication strategies
    • Crooks AM, Bateson R, Cope AB, et al. (2015). Precise quantitation of the latent HIV-1 reservoir: implications for eradication strategies. J. Infect. Dis. pii: jiv218
    • (2015) J. Infect. Dis
    • Crooks, A.M.1    Bateson, R.2    Cope, A.B.3
  • 14
    • 67249121143 scopus 로고    scopus 로고
    • Treatment intensification does not reduce residual HIV-1 viremia in patients on highly active antiretroviral therapy
    • Dinoso JB, Kim SY, Wiegand AM, et al. (2009). Treatment intensification does not reduce residual HIV-1 viremia in patients on highly active antiretroviral therapy. PNAS 106(23): 9403-8
    • (2009) PNAS , vol.106 , Issue.23 , pp. 9403-9408
    • Dinoso, J.B.1    Kim, S.Y.2    Wiegand, A.M.3
  • 15
    • 77956856393 scopus 로고    scopus 로고
    • The effect of raltegravir intensification on low-level residual viremia in HIV-infected patients on antiretroviral therapy: A randomized controlled trial
    • Gandhi RT, Zheng L, Bosch RJ, et al. (2010). The effect of raltegravir intensification on low-level residual viremia in HIV-infected patients on antiretroviral therapy: a randomized controlled trial. PLOS Med. 7(8): e1000321
    • (2010) PLOS Med , vol.7 , Issue.8 , pp. e1000321
    • Gandhi, R.T.1    Zheng, L.2    Bosch, R.J.3
  • 16
    • 0142092389 scopus 로고    scopus 로고
    • SevereCD4+T-cell depletion in gut lymphoid tissue during primary human immunodeficiency virus type 1 infection and substantial delay in restoration following highly active antiretroviral therapy
    • Guadalupe M, Reay E, Sankaran S, et al. (2003). SevereCD4+T-cell depletion in gut lymphoid tissue during primary human immunodeficiency virus type 1 infection and substantial delay in restoration following highly active antiretroviral therapy. J. Virol. 77(21): 11708-17
    • (2003) J. Virol , vol.77 , Issue.21 , pp. 11708-11717
    • Guadalupe, M.1    Reay, E.2    Sankaran, S.3
  • 17
    • 40549092339 scopus 로고    scopus 로고
    • Persistence of HIV in gut-Associated lymphoid tissue despite long-Term antiretroviral therapy
    • Chun TW, Nickle DC, Justement JS, et al. (2008). Persistence of HIV in gut-Associated lymphoid tissue despite long-Term antiretroviral therapy. J. Infect. Dis. 197(5): 714-20
    • (2008) J. Infect. Dis , vol.197 , Issue.5 , pp. 714-720
    • Chun, T.W.1    Nickle, D.C.2    Justement, J.S.3
  • 19
    • 16244379228 scopus 로고    scopus 로고
    • Role of low CD4 levels in the influence of human immunodeficiency virus type 1 envelope V1 and V2 regions on entry and spread in macrophages
    • Walter BL, Wehrly K, Swanstrom R, et al. (2005). Role of low CD4 levels in the influence of human immunodeficiency virus type 1 envelope V1 and V2 regions on entry and spread in macrophages. J. Virol. 79(8): 4828-37
    • (2005) J. Virol , vol.79 , Issue.8 , pp. 4828-4837
    • Walter, B.L.1    Wehrly, K.2    Swanstrom, R.3
  • 20
    • 0022480641 scopus 로고
    • The role of mononuclear phagocytes in HTLVIII/LAV infection
    • Gartner S, Markovits P, Markovitz DM, et al. (1986). The role of mononuclear phagocytes in HTLVIII/LAV infection. Science 233(4760): 215-19
    • (1986) Science , vol.233 , Issue.4760 , pp. 215-219
    • Gartner, S.1    Markovits, P.2    Markovitz, D.M.3
  • 21
    • 33750486534 scopus 로고    scopus 로고
    • In vitro modeling of the HIV-macrophage reservoir
    • Brown A, Zhang H, Lopez P, et al. (2006). In vitro modeling of the HIV-macrophage reservoir. J. Leukoc. Biol. 80(5): 1127-35
    • (2006) J. Leukoc. Biol , vol.80 , Issue.5 , pp. 1127-1135
    • Brown, A.1    Zhang, H.2    Lopez, P.3
  • 22
    • 84907996442 scopus 로고    scopus 로고
    • Tissuemyeloid cells in SIV-infected primates acquire viralDNA through phagocytosis of infected T cells
    • Calantone N, Wu F, Klase Z, et al. (2014). Tissuemyeloid cells in SIV-infected primates acquire viralDNA through phagocytosis of infected T cells. Immunity 41(3): 493-502
    • (2014) Immunity , vol.41 , Issue.3 , pp. 493-502
    • Calantone, N.1    Wu, F.2    Klase, Z.3
  • 23
    • 84865108061 scopus 로고    scopus 로고
    • As good as it gets? the problem of HIV persistence despite antiretroviral drugs
    • Sigal A, Baltimore D. (2012). As good as it gets? The problem of HIV persistence despite antiretroviral drugs. Cell Host Microbe 12(2): 132-38
    • (2012) Cell Host Microbe , vol.12 , Issue.2 , pp. 132-138
    • Sigal, A.1    Baltimore, D.2
  • 24
    • 1642540589 scopus 로고    scopus 로고
    • HIV-1 cell to cell transfer across an Env-induced, actin-dependent synapse
    • Jolly C, Kashefi K, Hollinshead M, Sattentau QJ. (2004). HIV-1 cell to cell transfer across an Env-induced, actin-dependent synapse. J. Exp. Med. 199(2): 283-93
    • (2004) J. Exp. Med , vol.199 , Issue.2 , pp. 283-293
    • Jolly, C.1    Kashefi, K.2    Hollinshead, M.3    Sattentau, Q.J.4
  • 25
    • 80052395837 scopus 로고    scopus 로고
    • Cell-To-cell spread of HIV permits ongoing replication despite antiretroviral therapy
    • Sigal A, Kim JT, Balazs AB, et al. (2011). Cell-To-cell spread of HIV permits ongoing replication despite antiretroviral therapy. Nature 477(7362): 95-98
    • (2011) Nature , vol.477 , Issue.7362 , pp. 95-98
    • Sigal, A.1    Kim, J.T.2    Balazs, A.B.3
  • 26
    • 84907240033 scopus 로고    scopus 로고
    • Predicting the outcomes of treatment to eradicate the latent reservoir for HIV-1
    • Hill AL, Rosenbloom DI, Fu F, et al. (2014). Predicting the outcomes of treatment to eradicate the latent reservoir for HIV-1. PNAS 111(37): 13475-80
    • (2014) PNAS , vol.111 , Issue.37 , pp. 13475-13480
    • Hill, A.L.1    Rosenbloom, D.I.2    Fu, F.3
  • 27
    • 79958166239 scopus 로고    scopus 로고
    • Thirty years of HIV and AIDS: Future challenges and opportunities
    • Dieffenbach CW, Fauci AS. (2011). Thirty years of HIV and AIDS: future challenges and opportunities. Ann. Intern. Med. 154(11): 766-71
    • (2011) Ann. Intern. Med , vol.154 , Issue.11 , pp. 766-771
    • Dieffenbach, C.W.1    Fauci, A.S.2
  • 28
    • 84866498069 scopus 로고    scopus 로고
    • Redefining the viral reservoirs that prevent HIV-1 eradication
    • Eisele E, Siliciano RF. (2012). Redefining the viral reservoirs that prevent HIV-1 eradication. Immunity 37(3): 377-88
    • (2012) Immunity , vol.37 , Issue.3 , pp. 377-388
    • Eisele, E.1    Siliciano, R.F.2
  • 29
    • 60549090253 scopus 로고    scopus 로고
    • Long-Term control of HIV by CCR5 delta32/delta32 stem-cell transplantation
    • Hutter G, Nowak D, Mossner M, et al. (2009). Long-Term control of HIV by CCR5 delta32/delta32 stem-cell transplantation. N. Engl. J. Med. 360(7): 692-98
    • (2009) N. Engl. J. Med , vol.360 , Issue.7 , pp. 692-698
    • Hutter, G.1    Nowak, D.2    Mossner, M.3
  • 30
    • 15844388931 scopus 로고    scopus 로고
    • Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection
    • Liu R, Paxton WA, Choe S, et al. (1996). Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. Cell 86(3): 367-77
    • (1996) Cell , vol.86 , Issue.3 , pp. 367-377
    • Liu, R.1    Paxton, W.A.2    Choe, S.3
  • 31
    • 84906970468 scopus 로고    scopus 로고
    • Antiretroviral-free HIV-1 remission and viral rebound after allogeneic stem cell transplantation: Report of 2 cases
    • Henrich TJ, Hanhauser E, Marty FM, et al. (2014). Antiretroviral-free HIV-1 remission and viral rebound after allogeneic stem cell transplantation: report of 2 cases. Ann. Intern. Med. 161(5): 319-27
    • (2014) Ann. Intern. Med , vol.161 , Issue.5 , pp. 319-327
    • Henrich, T.J.1    Hanhauser, E.2    Marty, F.M.3
  • 32
    • 84887028999 scopus 로고    scopus 로고
    • Absence of detectableHIV-1 viremia after treatment cessation in an infant
    • Persaud D, Gay H, Ziemniak C, et al. (2013). Absence of detectableHIV-1 viremia after treatment cessation in an infant. N. Engl. J. Med. 369(19): 1828-35
    • (2013) N. Engl. J. Med , vol.369 , Issue.19 , pp. 1828-1835
    • Persaud, D.1    Gay, H.2    Ziemniak, C.3
  • 33
    • 84923064466 scopus 로고    scopus 로고
    • Viremic relapse after HIV-1 remission in a perinatally infected child
    • Luzuriaga K, Gay H, Ziemniak C, et al. (2015). Viremic relapse after HIV-1 remission in a perinatally infected child. N. Engl. J. Med. 372(8): 786-88
    • (2015) N. Engl. J. Med , vol.372 , Issue.8 , pp. 786-788
    • Luzuriaga, K.1    Gay, H.2    Ziemniak, C.3
  • 34
    • 84942134668 scopus 로고    scopus 로고
    • Establishment and replenishment of the viral reservoir in perinatally HIV-1-infected children initiating very early antiretroviral therapy
    • Martinez-Bonet M, Puertas MC, Fortuny C, et al. (2015). Establishment and replenishment of the viral reservoir in perinatally HIV-1-infected children initiating very early antiretroviral therapy. Clin. Infect. Dis. 61(7): 1169-78
    • (2015) Clin. Infect. Dis , vol.61 , Issue.7 , pp. 1169-1178
    • Martinez-Bonet, M.1    Puertas, M.C.2    Fortuny, C.3
  • 35
    • 0030659177 scopus 로고    scopus 로고
    • Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy
    • Chun TW, Stuyver L, Mizell SB, et al. (1997). Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy. PNAS 94(24): 13193-97
    • (1997) PNAS , vol.94 , Issue.24 , pp. 13193-13197
    • Chun, T.W.1    Stuyver, L.2    Mizell, S.B.3
  • 36
    • 84859167158 scopus 로고    scopus 로고
    • Host factors dictate control of viral replication in two HIV-1 controller-chronic progressor transmission pairs
    • Buckheit RW 3rd, Allen TG, Alme A, et al. (2012). Host factors dictate control of viral replication in two HIV-1 controller-chronic progressor transmission pairs. Nat. Commun. 3: 716
    • (2012) Nat. Commun , vol.3 , pp. 716
    • Buckheit, R.W.1    Allen, T.G.2    Alme, A.3
  • 37
    • 33847176917 scopus 로고    scopus 로고
    • Isolation and characterization of replication-competent human immunodeficiency virus type 1 from a subset of elite suppressors
    • Blankson JN, Bailey JR, Thayil S, et al. (2007). Isolation and characterization of replication-competent human immunodeficiency virus type 1 from a subset of elite suppressors. J. Virol. 81(5): 2508-18
    • (2007) J. Virol , vol.81 , Issue.5 , pp. 2508-2518
    • Blankson, J.N.1    Bailey, J.R.2    Thayil, S.3
  • 38
    • 84946147894 scopus 로고    scopus 로고
    • A murine viral outgrowth assay to detect residual HIV type 1 in patients with undetectable viral loads
    • Metcalf Pate KA, Pohlmeyer CW, Walker-Sperling VE, et al. (2015). A murine viral outgrowth assay to detect residual HIV type 1 in patients with undetectable viral loads. J. Infect. Dis. 212(9): 1387-96
    • (2015) J. Infect. Dis , vol.212 , Issue.9 , pp. 1387-1396
    • Metcalf Pate, K.A.1    Pohlmeyer, C.W.2    Walker-Sperling, V.E.3
  • 39
    • 34249852256 scopus 로고    scopus 로고
    • HIV controllers exhibit potentCD8Tcell capacity to suppress HIV infection ex vivo and peculiar cytotoxic T lymphocyte activation phenotype
    • Saez-Cirion A, Lacabaratz C, Lambotte O, et al. (2007). HIV controllers exhibit potentCD8Tcell capacity to suppress HIV infection ex vivo and peculiar cytotoxic T lymphocyte activation phenotype. PNAS 104(16): 6776-81
    • (2007) PNAS , vol.104 , Issue.16 , pp. 6776-6781
    • Saez-Cirion, A.1    Lacabaratz, C.2    Lambotte, O.3
  • 40
    • 43949124825 scopus 로고    scopus 로고
    • HLA class I-restricted T-cell responses may contribute to the control of human immunodeficiency virus infection, but such responses are not always necessary for long-Term virus control
    • Emu B, Sinclair E, Hatano H, et al. (2008). HLA class I-restricted T-cell responses may contribute to the control of human immunodeficiency virus infection, but such responses are not always necessary for long-Term virus control. J. Virol. 82(11): 5398-407
    • (2008) J. Virol , vol.82 , Issue.11 , pp. 5398-5407
    • Emu, B.1    Sinclair, E.2    Hatano, H.3
  • 41
    • 84875985311 scopus 로고    scopus 로고
    • Post-Treatment HIV-1 controllers with a long-Term virological remission after the interruption of early initiated antiretroviral therapy ANRS VISCONTI study
    • Saez-Cirion A, Bacchus C, Hocqueloux L, et al. (2013). Post-Treatment HIV-1 controllers with a long-Term virological remission after the interruption of early initiated antiretroviral therapy ANRS VISCONTI study. PLOS Pathog. 9(3): e1003211
    • (2013) PLOS Pathog , vol.9 , Issue.3 , pp. e1003211
    • Saez-Cirion, A.1    Bacchus, C.2    Hocqueloux, L.3
  • 42
    • 78650440267 scopus 로고    scopus 로고
    • Bcells in early and chronicHIV infection: Evidence for preservation of immune function associated with early initiation of antiretroviral therapy
    • Moir S, Buckner CM, Ho J, et al. 2010.Bcells in early and chronicHIV infection: evidence for preservation of immune function associated with early initiation of antiretroviral therapy. Blood 116(25): 5571-79
    • (2010) Blood , vol.116 , Issue.25 , pp. 5571-5579
    • Moir, S.1    Buckner, C.M.2    Ho, J.3
  • 43
    • 39349088126 scopus 로고    scopus 로고
    • Relationship between T cell activation and CD4+ T cell count inHIV-seropositive individuals with undetectable plasmaHIVRNAlevels in the absence of therapy
    • Hunt PW, Brenchley J, Sinclair E, et al. (2008). Relationship between T cell activation and CD4+ T cell count inHIV-seropositive individuals with undetectable plasmaHIVRNAlevels in the absence of therapy. J. Infect. Dis. 197(1): 126-33
    • (2008) J. Infect. Dis , vol.197 , Issue.1 , pp. 126-133
    • Hunt, P.W.1    Brenchley, J.2    Sinclair, E.3
  • 44
    • 84930466480 scopus 로고    scopus 로고
    • Hospitalization rates and reasons among HIV elite controllers and persons with medically controlled HIV infection
    • Crowell TA, Gebo KA, Blankson JN, et al. (2015). Hospitalization rates and reasons among HIV elite controllers and persons with medically controlled HIV infection. J. Infect. Dis. 211(11): 1692-702
    • (2015) J. Infect. Dis , vol.211 , Issue.11 , pp. 1692-1702
    • Crowell, T.A.1    Gebo, K.A.2    Blankson, J.N.3
  • 45
    • 20244376915 scopus 로고    scopus 로고
    • Effect of treatment, during primary infection, on establishment and clearance of cellular reservoirs of HIV-1
    • Strain MC, Little SJ, Daar ES, et al. (2005). Effect of treatment, during primary infection, on establishment and clearance of cellular reservoirs of HIV-1. J. Infect. Dis. 191(9): 1410-18
    • (2005) J. Infect. Dis , vol.191 , Issue.9 , pp. 1410-1418
    • Strain, M.C.1    Little, S.J.2    Daar, E.S.3
  • 46
    • 84885058930 scopus 로고    scopus 로고
    • Antiretroviral therapy initiated within 6 months of HIV infection is associated with lower T-cell activation and smaller HIV reservoir size
    • Jain V, Hartogensis W, Bacchetti P, et al. (2013). Antiretroviral therapy initiated within 6 months of HIV infection is associated with lower T-cell activation and smaller HIV reservoir size. J. Infect. Dis. 208(8): 1202-11
    • (2013) J. Infect. Dis , vol.208 , Issue.8 , pp. 1202-1211
    • Jain, V.1    Hartogensis, W.2    Bacchetti, P.3
  • 47
    • 34249883292 scopus 로고    scopus 로고
    • Decay of theHIV reservoir in patients receiving antiretroviral therapy for extended periods: Implications for eradication of virus
    • Chun TW, Justement JS, Moir S, et al. (2007). Decay of theHIV reservoir in patients receiving antiretroviral therapy for extended periods: implications for eradication of virus. J. Infect. Dis. 195(12): 1762-64
    • (2007) J. Infect. Dis , vol.195 , Issue.12 , pp. 1762-1764
    • Chun, T.W.1    Justement, J.S.2    Moir, S.3
  • 48
    • 84905565097 scopus 로고    scopus 로고
    • Rapid seeding of the viral reservoir prior to SIV viraemia in rhesus monkeys
    • Whitney JB, Hill AL, Sanisetty S, et al. (2014). Rapid seeding of the viral reservoir prior to SIV viraemia in rhesus monkeys. Nature 512(7512): 74-77
    • (2014) Nature , vol.512 , Issue.7512 , pp. 74-77
    • Whitney, J.B.1    Hill, A.L.2    Sanisetty, S.3
  • 49
    • 77949562114 scopus 로고    scopus 로고
    • Prolonged viral suppression without therapy in an HIV-1 seroconverter following early antiretroviral therapy and daily interleukin-2
    • Margolick JB, Imteyaz H, Gallant JE, et al. (2010). Prolonged viral suppression without therapy in an HIV-1 seroconverter following early antiretroviral therapy and daily interleukin-2. AIDS 24(6): 932-35
    • (2010) AIDS , vol.24 , Issue.6 , pp. 932-935
    • Margolick, J.B.1    Imteyaz, H.2    Gallant, J.E.3
  • 50
    • 84864243685 scopus 로고    scopus 로고
    • HIV: Shock and kill
    • Deeks SG. (2012). HIV: shock and kill. Nature 487(7408): 439-40
    • (2012) Nature , vol.487 , Issue.7408 , pp. 439-440
    • Deeks, S.G.1
  • 51
    • 84878873135 scopus 로고    scopus 로고
    • Targeting HIV latency: Pharmacologic strategies toward eradication
    • Xing S, Siliciano RF. (2013). Targeting HIV latency: pharmacologic strategies toward eradication. Drug Discov. Today 18(11-12): 541-51
    • (2013) Drug Discov. Today , vol.18 , Issue.11-12 , pp. 541-551
    • Xing, S.1    Siliciano, R.F.2
  • 53
    • 84877895204 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors (HDACis) that release the positive transcription elongation factor b (P-TEFb) from its inhibitory complex also activate HIV transcription
    • Bartholomeeusen K, Fujinaga K, Xiang Y, Peterlin BM. (2013). Histone deacetylase inhibitors (HDACis) that release the positive transcription elongation factor b (P-TEFb) from its inhibitory complex also activate HIV transcription. J. Biol. Chem. 288(20): 14400-7
    • (2013) J. Biol. Chem , vol.288 , Issue.20 , pp. 14400-14407
    • Bartholomeeusen, K.1    Fujinaga, K.2    Xiang, Y.3    Peterlin, B.M.4
  • 54
    • 84901309171 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor romidepsin induces HIV expression in CD4 T cells from patients on suppressive antiretroviral therapy at concentrations achieved by clinical dosing
    • Wei DG, Chiang V, Fyne E, et al. (2014). Histone deacetylase inhibitor romidepsin induces HIV expression in CD4 T cells from patients on suppressive antiretroviral therapy at concentrations achieved by clinical dosing. PLOS Pathog. 10(4): e1004071
    • (2014) PLOS Pathog , vol.10 , Issue.4 , pp. e1004071
    • Wei, D.G.1    Chiang, V.2    Fyne, E.3
  • 55
    • 84864203255 scopus 로고    scopus 로고
    • Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy
    • Archin NM, Liberty AL, Kashuba AD, et al. (2012). Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy. Nature 487(7408): 482-85
    • (2012) Nature , vol.487 , Issue.7408 , pp. 482-485
    • Archin, N.M.1    Liberty, A.L.2    Kashuba, A.D.3
  • 56
    • 84900473405 scopus 로고    scopus 로고
    • Quantification of HIV-1 latency reversal in resting CD4+ T cells from patients on suppressive antiretroviral therapy
    • Cillo AR, Sobolewski MD, Bosch RJ, et al. (2014). Quantification of HIV-1 latency reversal in resting CD4+ T cells from patients on suppressive antiretroviral therapy. PNAS 111(19): 7078-83
    • (2014) PNAS , vol.111 , Issue.19 , pp. 7078-7083
    • Cillo, A.R.1    Sobolewski, M.D.2    Bosch, R.J.3
  • 57
    • 84863337769 scopus 로고    scopus 로고
    • Stimulation ofHIV-1-specific cytolytic T lymphocytes facilitates elimination of latent viral reservoir after virus reactivation
    • Shan L, Deng K, Shroff NS, et al. (2012). Stimulation ofHIV-1-specific cytolytic T lymphocytes facilitates elimination of latent viral reservoir after virus reactivation. Immunity 36(3): 491-501
    • (2012) Immunity , vol.36 , Issue.3 , pp. 491-501
    • Shan, L.1    Deng, K.2    Shroff, N.S.3
  • 58
    • 84880714310 scopus 로고    scopus 로고
    • A brief history of the global effort to develop a preventive HIV vaccine
    • Esparza J. (2013). A brief history of the global effort to develop a preventive HIV vaccine. Vaccine 31(35): 3502-18
    • (2013) Vaccine , vol.31 , Issue.35 , pp. 3502-3518
    • Esparza, J.1
  • 59
    • 84894173514 scopus 로고    scopus 로고
    • Structural insights on the role of antibodies in HIV-1 vaccine and therapy
    • West AP Jr, Scharf L, Scheid JF, et al. (2014). Structural insights on the role of antibodies in HIV-1 vaccine and therapy. Cell 156(4): 633-48
    • (2014) Cell , vol.156 , Issue.4 , pp. 633-648
    • West, A.P.1    Scharf, L.2    Scheid, J.F.3
  • 60
    • 84906968862 scopus 로고    scopus 로고
    • Broadly neutralizing antibodies suppress HIV in the persistent viral reservoir
    • Chun TW, Murray D, Justement JS, et al. (2014). Broadly neutralizing antibodies suppress HIV in the persistent viral reservoir. PNAS 111(36): 13151-56
    • (2014) PNAS , vol.111 , Issue.36 , pp. 13151-13156
    • Chun, T.W.1    Murray, D.2    Justement, J.S.3
  • 61
    • 84928405730 scopus 로고    scopus 로고
    • Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC 117
    • Caskey M, Klein F, Lorenzi JC, et al. (2015). Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117. Nature 522(7557): 487-91
    • (2015) Nature , vol.522 , Issue.7557 , pp. 487-491
    • Caskey, M.1    Klein, F.2    Lorenzi, J.C.3
  • 62
    • 84907379431 scopus 로고    scopus 로고
    • Broadly neutralizing antibodies and viral inducers decrease rebound from HIV-1 latent reservoirs in humanized mice
    • Halper-Stromberg A, Lu CL, Klein F, et al. (2014). Broadly neutralizing antibodies and viral inducers decrease rebound from HIV-1 latent reservoirs in humanized mice. Cell 158(5): 989-99
    • (2014) Cell , vol.158 , Issue.5 , pp. 989-999
    • Halper-Stromberg, A.1    Lu, C.L.2    Klein, F.3
  • 63
    • 77956481715 scopus 로고    scopus 로고
    • Phase III HIV vaccine trial in Thailand: A step toward a protective vaccine for HIV
    • Vaccari M, Poonam P, Franchini G. (2010). Phase III HIV vaccine trial in Thailand: a step toward a protective vaccine for HIV. Expert Rev. Vaccines 9(9): 997-1005
    • (2010) Expert Rev. Vaccines , vol.9 , Issue.9 , pp. 997-1005
    • Vaccari, M.1    Poonam, P.2    Franchini, G.3
  • 64
    • 84921350295 scopus 로고    scopus 로고
    • Lessons from the RV144 Thai phase III HIV-1 vaccine trial and the search for correlates of protection
    • Kim JH, Excler JL, Michael NL. (2015). Lessons from the RV144 Thai phase III HIV-1 vaccine trial and the search for correlates of protection. Annu. Rev. Med. 66: 423-37
    • (2015) Annu. Rev. Med , vol.66 , pp. 423-437
    • Kim, J.H.1    Excler, J.L.2    Michael, N.L.3
  • 65
    • 79957618772 scopus 로고    scopus 로고
    • Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine
    • Hansen SG, Ford JC, Lewis MS, et al. (2011). Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine. Nature 473(7348): 523-27
    • (2011) Nature , vol.473 , Issue.7348 , pp. 523-527
    • Hansen, S.G.1    Ford, J.C.2    Lewis, M.S.3
  • 66
    • 84885669019 scopus 로고    scopus 로고
    • Immune clearance of highly pathogenic SIV infection
    • Hansen SG, Piatak M Jr, Ventura AB, et al. (2013). Immune clearance of highly pathogenic SIV infection. Nature 502(7469): 100-4
    • (2013) Nature , vol.502 , Issue.7469 , pp. 100-104
    • Hansen, S.G.1    Piatak, M.2    Ventura, A.B.3
  • 67
    • 84887772816 scopus 로고    scopus 로고
    • Newer gene editing technologies towardHIVgene therapy
    • Manjunath N, Yi G, Dang Y, Shankar P. (2013). Newer gene editing technologies towardHIVgene therapy. Viruses 5(11): 2748-66
    • (2013) Viruses 5 , vol.11 , pp. 2748-2766
    • Manjunath, N.1    Yi, G.2    Dang, Y.3    Shankar, P.4
  • 68
    • 84895487305 scopus 로고    scopus 로고
    • Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV
    • Tebas P, Stein D, Tang WW, et al. (2014). Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV. N. Engl. J. Med. 370(10): 901-10
    • (2014) N. Engl. J. Med , vol.370 , Issue.10 , pp. 901-910
    • Tebas, P.1    Stein, D.2    Tang, W.W.3
  • 69
    • 84928739868 scopus 로고    scopus 로고
    • The CRISPR/Cas9 system inactivates latent HIV-1 proviral DNA
    • Zhu W, Lei R, Le Duff Y, et al. (2015). The CRISPR/Cas9 system inactivates latent HIV-1 proviral DNA. Retrovirology 12: 22
    • (2015) Retrovirology , vol.12 , pp. 22
    • Zhu, W.1    Lei, R.2    Le Duff, Y.3
  • 70
    • 84905643812 scopus 로고    scopus 로고
    • RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection
    • Hu W, Kaminski R, Yang F, et al. (2014). RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection. PNAS 111(31): 11461-66
    • (2014) PNAS , vol.111 , Issue.31 , pp. 11461-11466
    • Hu, W.1    Kaminski, R.2    Yang, F.3
  • 71
    • 40149106131 scopus 로고    scopus 로고
    • Lentiviral vectors encoding human immunodeficiency virus type 1 (HIV-1)-specific T-cell receptor genes efficiently convert peripheral blood CD8 T lymphocytes into cytotoxic T lymphocytes with potent in vitro and in vivo HIV-1-specific inhibitory activity
    • Joseph A, Zheng JH, Follenzi A, et al. (2008). Lentiviral vectors encoding human immunodeficiency virus type 1 (HIV-1)-specific T-cell receptor genes efficiently convert peripheral blood CD8 T lymphocytes into cytotoxic T lymphocytes with potent in vitro and in vivo HIV-1-specific inhibitory activity. J. Virol. 82(6): 3078-89
    • (2008) J. Virol , vol.82 , Issue.6 , pp. 3078-3089
    • Joseph, A.1    Zheng, J.H.2    Follenzi, A.3
  • 72
    • 24944518559 scopus 로고    scopus 로고
    • Enhanced culture assay for detection and quantitation of latently infected, resting CD4+ T-cells carrying replication-competent virus in HIV-1-infected individuals
    • Siliciano JD, Siliciano RF. (2005). Enhanced culture assay for detection and quantitation of latently infected, resting CD4+ T-cells carrying replication-competent virus in HIV-1-infected individuals. Methods Mol. Biol. 304: 3-15
    • (2005) Methods Mol. Biol , vol.304 , pp. 3-15
    • Siliciano, J.D.1    Siliciano, R.F.2
  • 73
    • 84886769508 scopus 로고    scopus 로고
    • Replication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure
    • Ho YC, Shan L, Hosmane NN, et al. (2013). Replication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure. Cell 155(3): 540-51
    • (2013) Cell , vol.155 , Issue.3 , pp. 540-551
    • Ho, Y.C.1    Shan, L.2    Hosmane, N.N.3
  • 74
    • 84934435248 scopus 로고    scopus 로고
    • Quantification of total HIV1-DNA in peripheral blood mononuclear cells
    • Rouzioux C, Melard A, Avettand-Fenoel V. (2014). Quantification of total HIV1-DNA in peripheral blood mononuclear cells. Methods Mol. Biol. 1087: 261-70
    • (2014) Methods Mol. Biol , vol.1087 , pp. 261-270
    • Rouzioux, C.1    Melard, A.2    Avettand-Fenoel, V.3
  • 75
    • 84875712178 scopus 로고    scopus 로고
    • Highly precise measurement of HIV DNA by droplet digital PCR
    • Strain MC, Lada SM, Luong T, et al. (2013). Highly precise measurement of HIV DNA by droplet digital PCR. PLOS ONE 8(4): e55943
    • (2013) PLOS ONE , vol.8 , Issue.4 , pp. e55943
    • Strain, M.C.1    Lada, S.M.2    Luong, T.3
  • 76
    • 84873472629 scopus 로고    scopus 로고
    • Comparative analysis of measures of viral reservoirs in HIV-1 eradication studies
    • Eriksson S, Graf EH, Dahl V, et al. (2013). Comparative analysis of measures of viral reservoirs in HIV-1 eradication studies. PLOS Pathog. 9(2): e1003174
    • (2013) PLOS Pathog , vol.9 , Issue.2 , pp. e1003174
    • Eriksson, S.1    Graf, E.H.2    Dahl, V.3
  • 77
    • 84878482232 scopus 로고    scopus 로고
    • Rapid quantification of the latent reservoir for HIV-1 using a viral outgrowth assay
    • Laird GM, Eisele EE, Rabi SA, et al. (2013). Rapid quantification of the latent reservoir for HIV-1 using a viral outgrowth assay. PLOS Pathog. 9(5): e1003398
    • (2013) PLOS Pathog , vol.9 , Issue.5 , pp. e1003398
    • Laird, G.M.1    Eisele, E.E.2    Rabi, S.A.3
  • 78
    • 84878201859 scopus 로고    scopus 로고
    • A novel PCR assay for quantification of HIV-1 RNA
    • Shan L, Rabi SA, Laird GM, et al. (2013). A novel PCR assay for quantification of HIV-1 RNA. J. Virol. 87(11): 6521-25
    • (2013) J. Virol , vol.87 , Issue.11 , pp. 6521-6525
    • Shan, L.1    Rabi, S.A.2    Laird, G.M.3
  • 79
    • 84898423894 scopus 로고    scopus 로고
    • New ex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivo
    • Bullen CK, Laird GM, Durand CM, et al. (2014). New ex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivo. Nat. Med. 20(4): 425-29
    • (2014) Nat. Med , vol.20 , Issue.4 , pp. 425-429
    • Bullen, C.K.1    Laird, G.M.2    Durand, C.M.3
  • 80
    • 33751515147 scopus 로고    scopus 로고
    • CD4+count-guided interruption of antiretroviral treatment
    • Strategies forManagement of Antiretroviral Therapy (SMART) Study Group
    • Strategies forManagement of Antiretroviral Therapy (SMART) Study Group, El-Sadr WM, Lundgren J, et al. 2006.CD4+count-guided interruption of antiretroviral treatment. N. Engl. J.Med. 355(22): 2283-96
    • (2006) N. Engl. J.Med , vol.355 , Issue.22 , pp. 2283-2296
    • El-Sadr, W.M.1    Lundgren, J.2
  • 81
    • 56549110656 scopus 로고    scopus 로고
    • Viral resuppression and detection of drug resistance following interruption of a suppressive non-nucleoside reverse transcriptase inhibitor-based regimen
    • Fox Z, Phillips A, Cohen C, et al. (2008). Viral resuppression and detection of drug resistance following interruption of a suppressive non-nucleoside reverse transcriptase inhibitor-based regimen. AIDS 22(17): 2279-89
    • (2008) AIDS , vol.22 , Issue.17 , pp. 2279-2289
    • Fox, Z.1    Phillips, A.2    Cohen, C.3
  • 82
    • 84924365877 scopus 로고    scopus 로고
    • Large number of rebounding/founder HIV variants emerge from multifocal infection in lymphatic tissues after treatment interruption
    • Rothenberger MK, Keele BF, Wietgrefe SW, et al. (2015). Large number of rebounding/founder HIV variants emerge from multifocal infection in lymphatic tissues after treatment interruption. PNAS 112(10): E1126-34
    • (2015) PNAS , vol.112 , Issue.10 , pp. E1126-E1134
    • Rothenberger, M.K.1    Keele, B.F.2    Wietgrefe, S.W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.