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Volumn 31, Issue 1, 2015, Pages 4-12

Targeting NF-κB signaling with protein Kinase C agonists as an emerging strategy for combating HIV latency

Author keywords

[No Author keywords available]

Indexed keywords

BRYOSTATIN; DITERPENE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INGENOL; LACTONE DERIVATIVE; PHORBOL ESTER; PROTEIN KINASE C INHIBITOR; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; PROTEIN BINDING; PROTEIN KINASE C; TRANSCRIPTION FACTOR REL; TRANSCRIPTION FACTOR RELA; TRANSCRIPTION FACTOR RELB; VIRUS RECEPTOR;

EID: 84937118026     PISSN: 08892229     EISSN: 19318405     Source Type: Journal    
DOI: 10.1089/aid.2014.0199     Document Type: Review
Times cited : (112)

References (62)
  • 1
    • 0030659177 scopus 로고    scopus 로고
    • Presence of an inducible hiv-1 latent reservoir during highly active antiretroviral therapy
    • Chun TW, Stuyver L, Mizell SB, et al.: Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy. Proc Natl Acad Sci USA 1997;94(24): 13193-13197
    • (1997) Proc Natl Acad Sci USA , vol.94 , Issue.24 , pp. 13193-13197
    • Chun, T.W.1    Stuyver, L.2    Mizell, S.B.3
  • 2
    • 14444273439 scopus 로고    scopus 로고
    • Identification of a reservoir for hiv-1 in patients on highly active antiretroviral therapy
    • Finzi D, Hermankova M, Pierson T, et al.: Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy. Science 1997;278(5341):1295-1300
    • (1997) Science , vol.278 , Issue.5341 , pp. 1295-1300
    • Finzi, D.1    Hermankova, M.2    Pierson, T.3
  • 3
    • 0030712305 scopus 로고    scopus 로고
    • Recovery of replication-competent hiv despite prolonged suppression of plasma viremia
    • Wong JK, Hezareh M, Günthard HF, et al.: Recovery of replication-competent HIV despite prolonged suppression of plasma viremia. Science 1997;278(5341):1291-1295
    • (1997) Science , vol.278 , Issue.5341 , pp. 1291-1295
    • Wong, J.K.1    Hezareh, M.2    Günthard, H.F.3
  • 4
    • 68349139711 scopus 로고    scopus 로고
    • Hiv reservoir size and persistence are driven by t cell survival and homeostatic proliferation
    • Chomont N, El-Far M, Ancuta P, et al.: HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation. Nat Med 2009;15(8):893-900
    • (2009) Nat Med , vol.15 , Issue.8 , pp. 893-900
    • Chomont, N.1    El-Far, M.2    Ancuta, P.3
  • 5
    • 35148858784 scopus 로고    scopus 로고
    • C-myc and sp1 contribute to proviral latency by recruiting histone deacetylase 1 to the human immunodeficiency virus type 1 promoter
    • Jiang G, Espeseth A, Hazuda DJ, and Margolis DM: c-Myc and Sp1 contribute to proviral latency by recruiting histone deacetylase 1 to the human immunodeficiency virus type 1 promoter. J Virol 2007;81(20):10914-10923
    • (2007) J Virol , vol.81 , Issue.20 , pp. 10914-10923
    • Jiang, G.1    Espeseth, A.2    Hazuda, D.J.3    Margolis, D.M.4
  • 6
    • 84864203255 scopus 로고    scopus 로고
    • Administration of vorinostat disrupts hiv-1 latency in patients on antiretroviral therapy
    • Archin NM, Liberty AL, Kashuba AD, et al.: Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy. Nature 2012;487(7408):482-485
    • (2012) Nature , vol.487 , Issue.7408 , pp. 482-485
    • Archin, N.M.1    Liberty, A.L.2    Kashuba, A.D.3
  • 7
    • 84867758122 scopus 로고    scopus 로고
    • Bet bromodomain inhibition as a novel strategy for reactivation of hiv-1
    • Banerjee C, Archin N, Michaels D, et al.: BET bromodomain inhibition as a novel strategy for reactivation of HIV-1. J Leukoc Biol 2012;92(6):1147-1154
    • (2012) J Leukoc Biol , vol.92 , Issue.6 , pp. 1147-1154
    • Banerjee, C.1    Archin, N.2    Michaels, D.3
  • 8
    • 0028973059 scopus 로고
    • Regulation of ikb alpha phosphorylation by pkc- and ca 2 + )-dependent signal transduction pathways
    • Steffan NM, Bren GD, Frantz B, et al.: Regulation of IkB alpha phosphorylation by PKC- and Ca(2 + )-dependent signal transduction pathways. J Immunol 1995;155(10): 4685-4691
    • (1995) J Immunol , vol.155 , Issue.10 , pp. 4685-4691
    • Steffan, N.M.1    Bren, G.D.2    Frantz, B.3
  • 9
    • 0024545370 scopus 로고
    • Signaling through t lymphocyte surface proteins, tcr/cd3 and cd28, activates the hiv-1 long terminal repeat
    • Tong-Starkesen SE, Luciw PA, and Peterlin BM: Signaling through T lymphocyte surface proteins, TCR/CD3 and CD28, activates the HIV-1 long terminal repeat. J Immunol 1989;142(2):702-707
    • (1989) J Immunol , vol.142 , Issue.2 , pp. 702-707
    • Tong-Starkesen, S.E.1    Luciw, P.A.2    Peterlin, B.M.3
  • 10
    • 0025129069 scopus 로고
    • Phorbol ester-mediated induction of hiv-1 from a chronically infected promonocyte clone: Blockade by protein kinase inhibitors and relationship to tat-directed trans-activation
    • Laurence J, Sikder SK, Jhaveri S, and Salmon JE: Phorbol ester-mediated induction of HIV-1 from a chronically infected promonocyte clone: Blockade by protein kinase inhibitors and relationship to tat-directed trans-activation. Biochem Biophys Res Commun 1990;166(1):349-357
    • (1990) Biochem Biophys Res Commun , vol.166 , Issue.1 , pp. 349-357
    • Laurence, J.1    Sikder, S.K.2    Jhaveri, S.3    Salmon, J.E.4
  • 11
    • 0025004457 scopus 로고
    • Direct and cytokinemediated activation of protein kinase c induces human immunodeficiency virus expression in chronically infected promonocytic cells
    • Kinter AL, Poli G, Maury W, et al.: Direct and cytokinemediated activation of protein kinase C induces human immunodeficiency virus expression in chronically infected promonocytic cells. J Virol 1990;64(9):4306-4312
    • (1990) J Virol , vol.64 , Issue.9 , pp. 4306-4312
    • Kinter, A.L.1    Poli, G.2    Maury, W.3
  • 12
    • 0027364898 scopus 로고
    • Novel indolocarbazole protein kinase c inhibitors prevent reactivation of hiv-1 in latently infected cells
    • Pätzold S, Schneider J, Rudolph C, et al.: Novel indolocarbazole protein kinase C inhibitors prevent reactivation of HIV-1 in latently infected cells. Antiviral Res 1993;22(4): 273-283
    • (1993) Antiviral Res , vol.22 , Issue.4 , pp. 273-283
    • Pätzold, S.1    Schneider, J.2    Rudolph, C.3
  • 13
    • 0029813309 scopus 로고    scopus 로고
    • Role of protein kinase c-beta isozyme in activation of latent human immunodeficiency virus type 1 in promonocytic u1 cells by phorbol-12-myristate acetate
    • Kim CH, Gollapudi S, Kim A, et al.: Role of protein kinase C-beta isozyme in activation of latent human immunodeficiency virus type 1 in promonocytic U1 cells by phorbol-12-myristate acetate. AIDS Res Hum Retroviruses 1996; 12(14):1361-1366
    • (1996) AIDS Res Hum Retroviruses , vol.12 , Issue.14 , pp. 1361-1366
    • Kim, C.H.1    Gollapudi, S.2    Kim, A.3
  • 14
    • 0029656248 scopus 로고    scopus 로고
    • Protein kinase c-zeta mediates nf-kappa b activation in human immunodeficiency virus-infected monocytes
    • Folgueira L, McElhinny JA, Bren GD, et al.: Protein kinase C-zeta mediates NF-kappa B activation in human immunodeficiency virus-infected monocytes. J Virol 1996;70(1): 223-231
    • (1996) J Virol , vol.70 , Issue.1 , pp. 223-231
    • Folgueira, L.1    McElhinny, J.A.2    Bren, G.D.3
  • 15
    • 22544466722 scopus 로고    scopus 로고
    • Human immunodeficiency virus reactivation by phorbol esters or t-cell receptor ligation requires both pkcalpha and pkctheta
    • Trushin SA, Bren GD, Asin S, et al.: Human immunodeficiency virus reactivation by phorbol esters or T-cell receptor ligation requires both PKCalpha and PKCtheta. J Virol 2005;79(15):9821-9830
    • (2005) J Virol , vol.79 , Issue.15 , pp. 9821-9830
    • Trushin, S.A.1    Bren, G.D.2    Asin, S.3
  • 16
    • 84860376937 scopus 로고    scopus 로고
    • Protein kinase cdelta regulates hiv-1 replication at an early post-entry step in macrophages
    • Contreras X, Mzoughi O, Gaston F, et al.: Protein kinase Cdelta regulates HIV-1 replication at an early post-entry step in macrophages. Retrovirology 2012;9:37
    • (2012) Retrovirology , vol.9 , pp. 37
    • Contreras, X.1    Mzoughi, O.2    Gaston, F.3
  • 17
    • 4744359117 scopus 로고    scopus 로고
    • Prostratin antagonizes hiv latency by activating nf-kappab
    • Williams SA, Chen LF, Kwon H, et al.: Prostratin antagonizes HIV latency by activating NF-kappaB. J Biol Chem 2004;279(40):42008-42017
    • (2004) J Biol Chem , vol.279 , Issue.40 , pp. 42008-42017
    • Williams, S.A.1    Chen, L.F.2    Kwon, H.3
  • 18
    • 77955287402 scopus 로고    scopus 로고
    • Bryostatin modulates latent hiv-1 infection via pkc and ampk signaling but inhibits acute infection in a receptor independent manner
    • Mehla R, Bivalkar-Mehla S, Zhang R, et al.: Bryostatin modulates latent HIV-1 infection via PKC and AMPK signaling but inhibits acute infection in a receptor independent manner. PLoS One 2010;5(6):e11160
    • (2010) PLoS One , vol.5 , Issue.6 , pp. e11160
    • Mehla, R.1    Bivalkar-Mehla, S.2    Zhang, R.3
  • 19
    • 0031023704 scopus 로고    scopus 로고
    • Antireplicative and anticytopathic activities of prostratin, a non-tumor-promoting phorbol ester, against human immunodeficiency virus (hiv
    • Gulakowski RJ, McMahon JB, Buckheit RW, et al.: Antireplicative and anticytopathic activities of prostratin, a non-tumor-promoting phorbol ester, against human immunodeficiency virus (HIV). Antiviral Res 1997;33(2):87-97
    • (1997) Antiviral Res , vol.33 , Issue.2 , pp. 87-97
    • Gulakowski, R.J.1    McMahon, J.B.2    Buckheit, R.W.3
  • 20
    • 84892845657 scopus 로고    scopus 로고
    • An in-depth comparison of latent hiv-1 reactivation in multiple cell model systems and resting cd4 + t cells from aviremic patients
    • Spina CA, Anderson J, Archin NM, et al.: An in-depth comparison of latent HIV-1 reactivation in multiple cell model systems and resting CD4 + T cells from aviremic patients. PLoS Pathog 2013;9(12):e1003834
    • (2013) PLoS Pathog , vol.9 , Issue.12 , pp. e1003834
    • Spina, C.A.1    Anderson, J.2    Archin, N.M.3
  • 21
    • 84898423894 scopus 로고    scopus 로고
    • New ex vivo approaches distinguish effective and ineffective single agents for reversing hiv-1 latency in vivo
    • Bullen CK, Laird GM, Durand CM, et al.: New ex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivo. Nat Med 2014; 20(4):425-429
    • (2014) Nat Med , vol.20 , Issue.4 , pp. 425-429
    • Bullen, C.K.1    Laird, G.M.2    Durand, C.M.3
  • 22
    • 0035139943 scopus 로고    scopus 로고
    • Hostile takeovers: Viral appropriation of the nf-kappab pathway
    • Hiscott J, Kwon H, and Genin P: Hostile takeovers: Viral appropriation of the NF-kappaB pathway. J Clin Invest 2001;107(2):143-151
    • (2001) J Clin Invest , vol.107 , Issue.2 , pp. 143-151
    • Hiscott, J.1    Kwon, H.2    Genin, P.3
  • 23
    • 70349400891 scopus 로고    scopus 로고
    • Structural basis of hiv-1 activation by nf-kappab-A higher-order complex of p50:rela bound to the hiv-1 ltr
    • Stroud JC, Oltman A, Han A, et al.: Structural basis of HIV-1 activation by NF-kappaB-a higher-order complex of p50:RelA bound to the HIV-1 LTR. J Mol Biol 2009; 393(1):98-112
    • (2009) J Mol Biol , vol.393 , Issue.1 , pp. 98-112
    • Stroud, J.C.1    Oltman, A.2    Han, A.3
  • 24
    • 30444431914 scopus 로고    scopus 로고
    • Nf-kappab p50 promotes hiv latency through hdac recruitment and repression of transcriptional initiation
    • Williams SA, Chen LF, Kwon H, et al.: NF-kappaB p50 promotes HIV latency through HDAC recruitment and repression of transcriptional initiation. EMBO J 2006;25(1): 139-149
    • (2006) EMBO J , vol.25 , Issue.1 , pp. 139-149
    • Williams, S.A.1    Chen, L.F.2    Kwon, H.3
  • 25
    • 84875549556 scopus 로고    scopus 로고
    • Targeting ijb proteins for hiv latency activation: The role of individual ijb and nf-jb proteins
    • Fernandez G, Zaikos TD, Khan SZ, et al.: Targeting IjB proteins for HIV latency activation: The role of individual IjB and NF-jB proteins. J Virol 2013;87(7):3966-3978
    • (2013) J Virol , vol.87 , Issue.7 , pp. 3966-3978
    • Fernandez, G.1    Zaikos, T.D.2    Khan, S.Z.3
  • 26
    • 84866651174 scopus 로고    scopus 로고
    • Sequence insertions in the hiv type 1 subtype c viral promoter predominantly generate an additional nf-kappab binding site
    • Bachu M, Mukthey AB, Murali RV, et al.: Sequence insertions in the HIV type 1 subtype C viral promoter predominantly generate an additional NF-kappaB binding site. AIDS Res Hum Retroviruses 2012;28(10):1362-1368
    • (2012) AIDS Res Hum Retroviruses , vol.28 , Issue.10 , pp. 1362-1368
    • Bachu, M.1    Mukthey, A.B.2    Murali, R.V.3
  • 27
    • 84871772179 scopus 로고    scopus 로고
    • Multiple nf-kappab sites in hiv-1 subtype c long terminal repeat confer superior magnitude of transcription and thereby the enhanced viral predominance
    • Bachu M, Yalla S, Asokan M, et al.: Multiple NF-kappaB sites in HIV-1 subtype C long terminal repeat confer superior magnitude of transcription and thereby the enhanced viral predominance. J Biol Chem 2012;287(53): 44714-44735
    • (2012) J Biol Chem , vol.287 , Issue.53 , pp. 44714-44735
    • Bachu, M.1    Yalla, S.2    Asokan, M.3
  • 28
    • 0033978536 scopus 로고    scopus 로고
    • Elevated tumor necrosis factor-alpha activation of human immunodeficiency virus type 1 subtype c in southern africa is associated with an nf-kappab enhancer gain-of-function
    • Montano MA, Nixon CP, Ndungu T, et al.: Elevated tumor necrosis factor-alpha activation of human immunodeficiency virus type 1 subtype C in Southern Africa is associated with an NF-kappaB enhancer gain-of-function. J Infect Dis 2000; 181(1):76-81.
    • (2000) J Infect Dis , vol.181 , Issue.1 , pp. 76-81
    • Montano, M.A.1    Nixon, C.P.2    Ndungu, T.3
  • 29
    • 1842614352 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 subtypes have a distinct long terminal repeat that determines the replication rate in a host-cell-specific manner
    • van Opijnen T, Jeeninga RE, Boerlijst MC, et al.: Human immunodeficiency virus type 1 subtypes have a distinct long terminal repeat that determines the replication rate in a host-cell-specific manner. J Virol 2004;78(7):3675-3683
    • (2004) J Virol , vol.78 , Issue.7 , pp. 3675-3683
    • Van Opijnen, T.1    Jeeninga, R.E.2    Boerlijst, M.C.3
  • 30
    • 84907288256 scopus 로고    scopus 로고
    • Reactivation of latent hiv-1 by new semi-synthetic ingenol esters
    • 462-463C
    • Pandelo Jose D, Bartholomeeusen K, da Cunha RD, et al.: Reactivation of latent HIV-1 by new semi-synthetic ingenol esters. Virology 2014;462-463C:328-339
    • (2014) Virology , pp. 328-339
    • Pandelo Jose, D.1    Bartholomeeusen, K.2    Da Cunha, R.D.3
  • 31
    • 0036343111 scopus 로고    scopus 로고
    • Differential regulation of hiv-1 clade-specific b c, and e long terminal repeats by nf-kappab and the tat transactivator
    • Roof P, Ricci M, Genin P, et al.: Differential regulation of HIV-1 clade-specific B, C, and E long terminal repeats by NF-kappaB and the Tat transactivator. Virology 2002; 296(1):77-83
    • (2002) Virology , vol.296 , Issue.1 , pp. 77-83
    • Roof, P.1    Ricci, M.2    Genin, P.3
  • 32
    • 0030755311 scopus 로고    scopus 로고
    • Protein kinase c and phospholipase c: Bilayer interactions and regulation
    • Hurley JH and Grobler JA: Protein kinase C and phospholipase C: bilayer interactions and regulation. Curr Opin Struct Biol 1997;7(4):557-565
    • (1997) Curr Opin Struct Biol , vol.7 , Issue.4 , pp. 557-565
    • Hurley, J.H.1    Grobler, J.A.2
  • 33
    • 34547472118 scopus 로고    scopus 로고
    • Phorbol esters: Structure, biological activity, and toxicity in animals
    • Goel G, Makkar HP, Francis G, and Becker K: Phorbol esters: Structure, biological activity, and toxicity in animals. Int J Toxicol 2007;26(4):279-288
    • (2007) Int J Toxicol , vol.26 , Issue.4 , pp. 279-288
    • Goel, G.1    Makkar, H.P.2    Francis, G.3    Becker, K.4
  • 34
    • 84864939469 scopus 로고    scopus 로고
    • Protein kinase c: One pathway towards the eradication of latent hiv-1 reservoirs
    • McKernan LN, Momjian D, and Kulkosky J: Protein kinase C: One pathway towards the eradication of latent HIV-1 reservoirs. Adv Virol 2012;2012:805347
    • (2012) Adv Virol , vol.2012 , pp. 805347
    • McKernan, L.N.1    Momjian, D.2    Kulkosky, J.3
  • 35
    • 77950396049 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of 12-aminoacylphorboids
    • Pagani A, Navarrete C, Fiebich BL, et al.: Synthesis and biological evaluation of 12-aminoacylphorboids. J Nat Prod 2010;73(3):447-451
    • (2010) J Nat Prod , vol.73 , Issue.3 , pp. 447-451
    • Pagani, A.1    Navarrete, C.2    Fiebich, B.L.3
  • 36
    • 0035892120 scopus 로고    scopus 로고
    • Prostratin: Activation of latent hiv-1 expression suggests a potential inductive adjuvant therapy for haart
    • Kulkosky J, Culnan DM, Roman J, et al.: Prostratin: activation of latent HIV-1 expression suggests a potential inductive adjuvant therapy for HAART. Blood 2001;98(10): 3006-3015
    • (2001) Blood , vol.98 , Issue.10 , pp. 3006-3015
    • Kulkosky, J.1    Culnan, D.M.2    Roman, J.3
  • 37
    • 0041348784 scopus 로고
    • Structure of prostratin-toxic tetracyclic diterpene ester from pimeleaprostrata
    • Cashmore AR, Seelye RN, Cain BF, et al.: Structure of prostratin-toxic tetracyclic diterpene ester from Pimeleaprostrata. Tetrahedron Lett 1976(20):1737-1738
    • (1976) Tetrahedron Lett , vol.20 , pp. 1737-1738
    • Cashmore, A.R.1    Seelye, R.N.2    Cain, B.F.3
  • 38
    • 0026734304 scopus 로고
    • A nonpromoting phorbol from the samoan medicinal plant homalanthus nutans inhibits cell killing by hiv-1
    • Gustafson KR, Cardellina JH, McMahon JB, et al.: A nonpromoting phorbol from the Samoan medicinal plant Homalanthus nutans inhibits cell killing by HIV-1. J Med Chem 1992;35(11):1978-1986
    • (1992) J Med Chem , vol.35 , Issue.11 , pp. 1978-1986
    • Gustafson, K.R.1    Cardellina, J.H.2    McMahon, J.B.3
  • 39
    • 46249111900 scopus 로고    scopus 로고
    • Giving samoan healers credit for prostratin
    • Cox PA, Johnson HE, and Tavana G: Giving Samoan healers credit for prostratin. Science 2008;320(5883):1589
    • (2008) Science , vol.320 , Issue.5883 , pp. 1589
    • Cox, P.A.1    Johnson, H.E.2    Tavana, G.3
  • 40
    • 0036315848 scopus 로고    scopus 로고
    • Effects of prostratin on t-cell activation and human immunodeficiency virus latency
    • Korin YD, Brooks DG, Brown S, et al.: Effects of prostratin on T-cell activation and human immunodeficiency virus latency. J Virol 2002;76(16):8118-8123
    • (2002) J Virol , vol.76 , Issue.16 , pp. 8118-8123
    • Korin, Y.D.1    Brooks, D.G.2    Brown, S.3
  • 41
    • 84892922333 scopus 로고    scopus 로고
    • In vivo effects of antiviral protein kinase c modulators on zebrafish development and survival
    • Davis RV, McKernan LN, Rhodes J, and Kulkosky J: In vivo effects of antiviral protein kinase C modulators on zebrafish development and survival. ISRN Toxicol 2011; 2011:248280
    • (2011) ISRN Toxicol , vol.2011 , pp. 248280
    • Davis, R.V.1    McKernan, L.N.2    Rhodes, J.3    Kulkosky, J.4
  • 42
    • 0343692517 scopus 로고    scopus 로고
    • Differential selectivity of ligands for the c1a and c1b phorbol ester binding domains of protein kinase cdelta: Possible correlation with tumorpromoting activity
    • Bögi K, Lorenzo PS, Szállási Z, et al.: Differential selectivity of ligands for the C1a and C1b phorbol ester binding domains of protein kinase Cdelta: Possible correlation with tumorpromoting activity. Cancer Res 1998;58(7):1423-1428
    • (1998) Cancer Res , vol.58 , Issue.7 , pp. 1423-1428
    • Bögi, K.1    Lorenzo, P.S.2    Szállási, Z.3
  • 43
    • 0027212503 scopus 로고
    • Nonpromoting 12-deoxyphorbol 13-esters inhibit phorbol 12-myristate 13-acetate induced tumor promotion in cd-1 mouse skin
    • Szallasi Z, Krsmanovic L, and Blumberg PM: Nonpromoting 12-deoxyphorbol 13-esters inhibit phorbol 12-myristate 13-acetate induced tumor promotion in CD-1 mouse skin. Cancer Res 1993;53(11):2507-2512
    • (1993) Cancer Res , vol.53 , Issue.11 , pp. 2507-2512
    • Szallasi, Z.1    Krsmanovic, L.2    Blumberg, P.M.3
  • 44
    • 0041743235 scopus 로고    scopus 로고
    • Activation of latent hiv-1 expression by the potent anti-tumor promoter 12-deoxyphorbol 13-phenylacetate
    • Bocklandt S, Blumberg PM, and Hamer DH: Activation of latent HIV-1 expression by the potent anti-tumor promoter 12-deoxyphorbol 13-phenylacetate. Antiviral Res 2003; 59(2):89-98
    • (2003) Antiviral Res , vol.59 , Issue.2 , pp. 89-98
    • Bocklandt, S.1    Blumberg, P.M.2    Hamer, D.H.3
  • 46
    • 0020408957 scopus 로고
    • Anti-neoplastic agents 86 isolation and structure of bryostatin-1
    • Pettit GR, Herald CL, Doubek DL, et al.: Anti-neoplastic agents. 86. Isolation and structure of bryostatin-1. J Am Chem Soc 1982;104(24):6846-6848
    • (1982) J Am Chem Soc , vol.104 , Issue.24 , pp. 6846-6848
    • Pettit, G.R.1    Herald, C.L.2    Doubek, D.L.3
  • 47
    • 34147190045 scopus 로고    scopus 로고
    • Asymmetric total synthesis and formal total synthesis of the antitumor sesquiterpenoid ( + )-eremantholide a
    • Li Y and Hale KJ: Asymmetric total synthesis and formal total synthesis of the antitumor sesquiterpenoid ( + )-eremantholide A. Org Lett 2007;9(7):1267-1270
    • (2007) Org Lett , vol.9 , Issue.7 , pp. 1267-1270
    • Li, Y.1    Hale, K.J.2
  • 48
    • 77950789235 scopus 로고    scopus 로고
    • New approaches to the total synthesis of the bryostatin antitumor macrolides
    • Hale KJ and Manaviazar S: New approaches to the total synthesis of the bryostatin antitumor macrolides. Chem Asian J 2010;5(4):704-754
    • (2010) Chem Asian J , vol.5 , Issue.4 , pp. 704-754
    • Hale, K.J.1    Manaviazar, S.2
  • 49
    • 84866842026 scopus 로고    scopus 로고
    • Designed synthetically accessible bryostatin analogues potently induce activation of latent hiv reservoirs in vitro
    • DeChristopher BA, Loy BA, Marsden MD, et al.: Designed, synthetically accessible bryostatin analogues potently induce activation of latent HIV reservoirs in vitro. Nat Chem 2012;4(9):705-710
    • (2012) Nat Chem , vol.4 , Issue.9 , pp. 705-710
    • Dechristopher, B.A.1    Loy, B.A.2    Marsden, M.D.3
  • 50
    • 0032986851 scopus 로고    scopus 로고
    • The transition from a pharmacophore-guided approach to a receptor-guided approach in the design of potent protein kinase c ligands
    • Marquez VE, Nacro K, Benzaria S, et al.: The transition from a pharmacophore-guided approach to a receptor-guided approach in the design of potent protein kinase C ligands. Pharmacol Ther 1999;82(2-3):251-261
    • (1999) Pharmacol Ther , vol.82 , Issue.2-3 , pp. 251-261
    • Marquez, V.E.1    Nacro, K.2    Benzaria, S.3
  • 51
    • 0141856405 scopus 로고    scopus 로고
    • Rational design of drugs that induce human immunodeficiency virus replication
    • Hamer DH, Bocklandt S, McHugh L, et al.: Rational design of drugs that induce human immunodeficiency virus replication. J Virol 2003;77(19):10227-10236
    • (2003) J Virol , vol.77 , Issue.19 , pp. 10227-10236
    • Hamer, D.H.1    Bocklandt, S.2    McHugh, L.3
  • 52
    • 0030044459 scopus 로고    scopus 로고
    • Mechanism of selective inhibition of human immunodeficiency virus by ingenol triacetate
    • Fujiwara M, Ijichi K, Tokuhisa K, et al.: Mechanism of selective inhibition of human immunodeficiency virus by ingenol triacetate. Antimicrob Agents Chemother 1996; 40(1):271-273
    • (1996) Antimicrob Agents Chemother , vol.40 , Issue.1 , pp. 271-273
    • Fujiwara, M.1    Ijichi, K.2    Tokuhisa, K.3
  • 53
    • 15444360575 scopus 로고    scopus 로고
    • Upregulation of hiv-1 replication in chronically infected cells by ingenol derivatives
    • Fujiwara M, Okamoto M, Ijichi K, et al.: Upregulation of HIV-1 replication in chronically infected cells by ingenol derivatives. Arch Virol 1998;143(10):2003-2010
    • (1998) Arch Virol , vol.143 , Issue.10 , pp. 2003-2010
    • Fujiwara, M.1    Okamoto, M.2    Ijichi, K.3
  • 54
    • 84904718063 scopus 로고    scopus 로고
    • Reactivation of hiv latency by a newly modified ingenol derivative via protein kinase cdelta-nf-kappab signaling
    • Jiang G, Mendes EA, Kaiser P, et al.: Reactivation of HIV latency by a newly modified ingenol derivative via protein kinase Cdelta-NF-kappaB signaling. AIDS 2014;28(11): 1555-1566
    • (2014) AIDS , vol.28 , Issue.11 , pp. 1555-1566
    • Jiang, G.1    Mendes, E.A.2    Kaiser, P.3
  • 55
    • 84901354407 scopus 로고    scopus 로고
    • Dual role of novel ingenol derivatives from euphorbia tirucalli in hiv replication: Inhibition of de novo infection and activation of viral ltr
    • Abreu CM, Price SL, Shirk EN, et al.: Dual role of novel ingenol derivatives from Euphorbia tirucalli in HIV replication: Inhibition of de novo infection and activation of viral LTR. PLoS One 2014;9(5):e97257
    • (2014) PLoS One , vol.9 , Issue.5 , pp. e97257
    • Abreu, C.M.1    Price, S.L.2    Shirk, E.N.3
  • 56
    • 80055048496 scopus 로고    scopus 로고
    • Picomolar dichotomous activity of gnidimacrin against hiv-1
    • Huang L, Ho P, Yu J, et al.: Picomolar dichotomous activity of gnidimacrin against HIV-1. PLoS One 2011;6(10): e26677
    • (2011) PLoS One , vol.6 , Issue.10 , pp. e26677
    • Huang, L.1    Ho, P.2    Yu, J.3
  • 57
    • 34249016432 scopus 로고    scopus 로고
    • Isolation of new phenylacetylingol derivatives that reactivate hiv-1 latency and a novel spirotriterpenoid from euphorbia officinarum latex
    • Daoubi M, Marquez N, Mazoir N, et al.: Isolation of new phenylacetylingol derivatives that reactivate HIV-1 latency and a novel spirotriterpenoid from Euphorbia officinarum latex. Bioorg Med Chem 2007;15(13):4577-4584
    • (2007) Bioorg Med Chem , vol.15 , Issue.13 , pp. 4577-4584
    • Daoubi, M.1    Marquez, N.2    Mazoir, N.3
  • 58
    • 60949096639 scopus 로고    scopus 로고
    • Sj23b, a jatrophane diterpene activates classical pkcs and displays strong activity against hiv in vitro
    • Bedoya LM, Marquez N, Martinez N, et al.: SJ23B, a jatrophane diterpene activates classical PKCs and displays strong activity against HIV in vitro. Biochem Pharmacol 2009;77(6):965-978
    • (2009) Biochem Pharmacol , vol.77 , Issue.6 , pp. 965-978
    • Bedoya, L.M.1    Marquez, N.2    Martinez, N.3
  • 59
    • 73649139952 scopus 로고    scopus 로고
    • Effects of diterpenes from latex of euphorbia lactea and euphorbia laurifolia on human immunodeficiency virus type 1 reactivation
    • Avila L, Perez M, Sanchez-Duffhues G, et al.: Effects of diterpenes from latex of Euphorbia lactea and Euphorbia laurifolia on human immunodeficiency virus type 1 reactivation. Phytochemistry 2010;71(2-3):243-248
    • (2010) Phytochemistry , vol.71 , Issue.2-3 , pp. 243-248
    • Avila, L.1    Perez, M.2    Sanchez-Duffhues, G.3
  • 60
    • 77952698531 scopus 로고    scopus 로고
    • Combinatorial latency reactivation for hiv-1 subtypes and variants
    • Burnett JC, Lim KI, Calafi A, et al.: Combinatorial latency reactivation for HIV-1 subtypes and variants. J Virol 2010; 84(12):5958-5974
    • (2010) J Virol , vol.84 , Issue.12 , pp. 5958-5974
    • Burnett, J.C.1    Lim, K.I.2    Calafi, A.3
  • 61
    • 43249122214 scopus 로고    scopus 로고
    • Practical synthesis of prostratin, dpp, and their analogs, adjuvant leads against latent hiv
    • Wender PA, Kee JM, and Warrington JM: Practical synthesis of prostratin, DPP, and their analogs, adjuvant leads against latent HIV. Science 2008;320(5876):649-652
    • (2008) Science , vol.320 , Issue.5876 , pp. 649-652
    • Wender, P.A.1    Kee, J.M.2    Warrington, J.M.3
  • 62
    • 84900473405 scopus 로고    scopus 로고
    • Quantification of hiv-1 latency reversal in resting cd4 + t cells from patients on suppressive antiretroviral therapy
    • Cillo AR, Sobolewski MD, Bosch RJ, et al.: Quantification of HIV-1 latency reversal in resting CD4 + T cells from patients on suppressive antiretroviral therapy. Proc Natl Acad Sci USA 2014;111(19):7078-7083
    • (2014) Proc Natl Acad Sci USA , vol.111 , Issue.19 , pp. 7078-7083
    • Cillo, A.R.1    Sobolewski, M.D.2    Bosch, R.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.