메뉴 건너뛰기




Volumn 77, Issue 19, 2003, Pages 10227-10236

Rational design of drugs that induce human immunodeficiency virus replication

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN P24; CD4 ANTIGEN; CELL SURFACE RECEPTOR; CHEMOKINE RECEPTOR CXCR4; DIACYLGLYCEROL DERIVATIVE; IMMUNOTOXIN; LMC 01; LMC 02; LMC 03; LMC 04; LMC 05; LMC 06; LMC 07; LMC 08; LMC 09; LMC 10; PROTEIN KINASE C; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 0141856405     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.77.19.10227-10236.2003     Document Type: Article
Times cited : (46)

References (41)
  • 1
    • 0036952044 scopus 로고    scopus 로고
    • Protein kinase C-theta (PKCθ): A key enzyme in T cell life and death
    • Altman, A., and M. Villalba. 2002. Protein kinase C-theta (PKCθ): a key enzyme in T cell life and death. J. Biochem. (Tokyo) 132:841-846.
    • (2002) J. Biochem. (Tokyo) , vol.132 , pp. 841-846
    • Altman, A.1    Villalba, M.2
  • 2
    • 0036176509 scopus 로고    scopus 로고
    • The challenge of viral reservoirs in HIV-1 infection
    • Blankson, J. N., D. Persaud, and R. F. Siliciano. 2002. The challenge of viral reservoirs in HIV-1 infection. Annu. Rev. Med. 53:557-593.
    • (2002) Annu. Rev. Med. , vol.53 , pp. 557-593
    • Blankson, J.N.1    Persaud, D.2    Siliciano, R.F.3
  • 3
    • 0038271178 scopus 로고    scopus 로고
    • Inhibitors of protein kinase C and related receptors for the lipophilic second messenger sn-1,2-diacylglycerol
    • J. S. Gutkind (ed.). Humana Press, Totowa, N.J.
    • Blumberg, P. M., P. Acs, D. K. Bhattacharyya, and P. S. Lorenzo. 2000. Inhibitors of protein kinase C and related receptors for the lipophilic second messenger sn-1,2-diacylglycerol, p. 347-364. In J. S. Gutkind (ed.), Signal transduction and cell cycle inhibitors. Humana Press, Totowa, N.J.
    • (2000) Signal Transduction and Cell Cycle Inhibitors , pp. 347-364
    • Blumberg, P.M.1    Acs, P.2    Bhattacharyya, D.K.3    Lorenzo, P.S.4
  • 4
    • 0041743235 scopus 로고    scopus 로고
    • Activation of latent HIV-1 expression by the potent anti-tumor promoter 12-deoxyphorbol 13-phenylacetate
    • Bocklandt, S., P. M. Blumberg, and D. H. Hamer. 2003. Activation of latent HIV-1 expression by the potent anti-tumor promoter 12-deoxyphorbol 13-phenylacetate. Antiviral Res. 59:89-98.
    • (2003) Antiviral Res. , vol.59 , pp. 89-98
    • Bocklandt, S.1    Blumberg, P.M.2    Hamer, D.H.3
  • 5
    • 0036905264 scopus 로고    scopus 로고
    • Move over protein kinase C, you've got company: Alternative cellular effectors of diacylglycerol and phorbol esters
    • Brose, N., and C. Rosenmund. 2002. Move over protein kinase C, you've got company: alternative cellular effectors of diacylglycerol and phorbol esters. J. Cell Sci. 115:4399-4411.
    • (2002) J. Cell Sci. , vol.115 , pp. 4399-4411
    • Brose, N.1    Rosenmund, C.2
  • 8
    • 0033613070 scopus 로고    scopus 로고
    • Latent reservoirs of HIV: Obstacles to the eradication of virus
    • Chun, T. W., and A. S. Fauci. 1999. Latent reservoirs of HIV: obstacles to the eradication of virus. Proc. Natl. Acad. Sci. USA 96:10958-10961.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 10958-10961
    • Chun, T.W.1    Fauci, A.S.2
  • 10
    • 0033031437 scopus 로고    scopus 로고
    • DNA arrays for analysis of gene expression
    • Elsen, M. B., and P. O. Brown. 1999. DNA arrays for analysis of gene expression. Methods Enzymol. 303:179-205.
    • (1999) Methods Enzymol. , vol.303 , pp. 179-205
    • Elsen, M.B.1    Brown, P.O.2
  • 11
    • 0018293860 scopus 로고
    • The succulent euphorbias of Nigeria. III. Structure and potency of the aromatic ester diterpenes of Euphorbia poissonii Pax
    • Evans, F. J., and R. J. Schmidt. 1979. The succulent euphorbias of Nigeria. III. Structure and potency of the aromatic ester diterpenes of Euphorbia poissonii Pax. Acta Pharmacol. Toxicol. (Copenhagen) 45:181-191.
    • (1979) Acta Pharmacol. Toxicol. (Copenhagen) , vol.45 , pp. 181-191
    • Evans, F.J.1    Schmidt, R.J.2
  • 12
    • 0010472999 scopus 로고
    • Tumor necrosis factor alpha induces expression of human immunodeficiency virus in a chronically infected T-cell clone
    • Folks, T. M., K. A. Clouse, J. Justement, A. Rabson, E. Duh, J. H. Kehrl, and A. S. Fauci. 1989. Tumor necrosis factor alpha induces expression of human immunodeficiency virus in a chronically infected T-cell clone. Proc. Natl. Acad. Sci. USA 86:2365-2368.
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 2365-2368
    • Folks, T.M.1    Clouse, K.A.2    Justement, J.3    Rabson, A.4    Duh, E.5    Kehrl, J.H.6    Fauci, A.S.7
  • 14
    • 0026752139 scopus 로고
    • Human immunodeficiency virus type 1 Tat-mediated trans-activation correlates with the phosphorylation state of a cellular TAR RNA stem-binding factor
    • Han, X. M., A. Laras, M. P. Rounseville, A. Kumar, and P. R. Shank. 1992. Human immunodeficiency virus type 1 Tat-mediated trans-activation correlates with the phosphorylation state of a cellular TAR RNA stem-binding factor. J. Virol. 66:4065-4072.
    • (1992) J. Virol. , vol.66 , pp. 4065-4072
    • Han, X.M.1    Laras, A.2    Rounseville, M.P.3    Kumar, A.4    Shank, P.R.5
  • 15
    • 0021244509 scopus 로고
    • On the active principles of the spurge family (Euphorbiaceae). V. Extremely skin-irritant and moderately tumor-promoting diterpene esters from Euphorbia resinifera Berg
    • Hergenhahn, M., S. Kusumoto, and E. Hecker. 1984. On the active principles of the spurge family (Euphorbiaceae). V. Extremely skin-irritant and moderately tumor-promoting diterpene esters from Euphorbia resinifera Berg. J. Cancer Res. Clin. Oncol. 108:98-109.
    • (1984) J. Cancer Res. Clin. Oncol. , vol.108 , pp. 98-109
    • Hergenhahn, M.1    Kusumoto, S.2    Hecker, E.3
  • 16
    • 0032546919 scopus 로고    scopus 로고
    • Toward HIV eradication or remission: The tasks ahead
    • Ho, D. D. 1998. Toward HIV eradication or remission: the tasks ahead. Science 280:1866-1867.
    • (1998) Science , vol.280 , pp. 1866-1867
    • Ho, D.D.1
  • 17
    • 0025342317 scopus 로고
    • Trans-activation of HIV-1 LTR-directed gene expression by tat requires protein kinase C
    • Jakobovits, A., A. Rosenthal, and D. J. Capon. 1990. Trans-activation of HIV-1 LTR-directed gene expression by tat requires protein kinase C. EMBO J. 9:1165-1170.
    • (1990) EMBO J. , vol.9 , pp. 1165-1170
    • Jakobovits, A.1    Rosenthal, A.2    Capon, D.J.3
  • 18
    • 0032920068 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 (HIV-1) infection and expression in intestinal epithelial cells: Role of protein kinase A and C pathways in HIV-1 transcription
    • Kagnoff, M. F., and K. A. Roebuck. 1999. Human immunodeficiency virus type 1 (HIV-1) infection and expression in intestinal epithelial cells: role of protein kinase A and C pathways in HIV-1 transcription. J. Infect. Dis. 179(Suppl. 3):S444-S447.
    • (1999) J. Infect. Dis. , vol.179 , Issue.SUPPL. 3
    • Kagnoff, M.F.1    Roebuck, K.A.2
  • 19
    • 0032421728 scopus 로고    scopus 로고
    • Signal transduction by protein kinase C in mammalian cells
    • Kanashiro, C. A., and R. A. Khalil. 1998. Signal transduction by protein kinase C in mammalian cells. Clin. Exp. Pharmacol. Physiol. 25:974-985.
    • (1998) Clin. Exp. Pharmacol. Physiol. , vol.25 , pp. 974-985
    • Kanashiro, C.A.1    Khalil, R.A.2
  • 20
    • 0036209077 scopus 로고    scopus 로고
    • Novel "nonkinase" phorbol ester receptors: The C1 domain connection
    • Kazanietz, M. G. 2002. Novel "nonkinase" phorbol ester receptors: the C1 domain connection. Mol. Pharmacol. 61:759-767.
    • (2002) Mol. Pharmacol. , vol.61 , pp. 759-767
    • Kazanietz, M.G.1
  • 21
    • 0027297104 scopus 로고
    • Characterization of ligand and substrate specificity for the calcium-dependent and calcium-independent protein kinase C isozymes
    • Kazanietz, M. G., L. B. Areces, A. Bahador, H. Mischak, J. Goodnight, J. F. Mushinski, and P. M. Blumberg. 1993. Characterization of ligand and substrate specificity for the calcium-dependent and calcium-independent protein kinase C isozymes. Mol. Pharmacol. 44:298-307.
    • (1993) Mol. Pharmacol. , vol.44 , pp. 298-307
    • Kazanietz, M.G.1    Areces, L.B.2    Bahador, A.3    Mischak, H.4    Goodnight, J.5    Mushinski, J.F.6    Blumberg, P.M.7
  • 22
    • 0034670173 scopus 로고    scopus 로고
    • Pharmacology of the receptors for the phorbol ester tumor promoters: Multiple receptors with different biochemical properties
    • Kazanietz, M. G., M. J. Caloca, P. Eroles, T. Fujii, M. L. Garcia-Bermejo, M. Reilly, and H. Wang. 2000. Pharmacology of the receptors for the phorbol ester tumor promoters: multiple receptors with different biochemical properties. Biochem. Pharmacol. 60:1417-1424.
    • (2000) Biochem. Pharmacol. , vol.60 , pp. 1417-1424
    • Kazanietz, M.G.1    Caloca, M.J.2    Eroles, P.3    Fujii, T.4    Garcia-Bermejo, M.L.5    Reilly, M.6    Wang, H.7
  • 23
    • 0036315848 scopus 로고    scopus 로고
    • Effects of prostratin on T-cell activation and human immunodeficiency virus latency
    • Korin, Y. D., D. G. Brooks, S. Brown, A. Korotzer, and J. A. Zack. 2002. Effects of prostratin on T-cell activation and human immunodeficiency virus latency. J. Virol. 76:8118-8123.
    • (2002) J. Virol. , vol.76 , pp. 8118-8123
    • Korin, Y.D.1    Brooks, D.G.2    Brown, S.3    Korotzer, A.4    Zack, J.A.5
  • 24
    • 0035892120 scopus 로고    scopus 로고
    • Prostratin: Activation of latent HIV-1 expression suggests a potential inductive adjuvant therapy for HAART
    • Kulkosky, J., D. M. Culnan, J. Roman, G. Dornadula, M. Schnell, M. R. Boyd, and R. J. Pomerantz. 2001. Prostratin: activation of latent HIV-1 expression suggests a potential inductive adjuvant therapy for HAART. Blood 98:3006-3015.
    • (2001) Blood , vol.98 , pp. 3006-3015
    • Kulkosky, J.1    Culnan, D.M.2    Roman, J.3    Dornadula, G.4    Schnell, M.5    Boyd, M.R.6    Pomerantz, R.J.7
  • 25
    • 0037115244 scopus 로고    scopus 로고
    • Approaching eradication of highly active antiretroviral therapy-persistent human immunodeficiency virus type 1 reservoirs with immune activation therapy
    • Kulkosky, J., and R. J. Pomerantz. 2002. Approaching eradication of highly active antiretroviral therapy-persistent human immunodeficiency virus type 1 reservoirs with immune activation therapy. Clin. Infect. Dis. 35:1520-1526.
    • (2002) Clin. Infect. Dis. , vol.35 , pp. 1520-1526
    • Kulkosky, J.1    Pomerantz, R.J.2
  • 26
    • 0035818887 scopus 로고    scopus 로고
    • Conformationally constrained analogues of diacylglycerol. 18. The incorporation of a hydroxamate moiety into diacylglycerol-lactones reduces lipophilicity and helps discriminate between sn-1 and sn-2 binding modes to protein kinase C (PK-C). Implications for isozyme specificity
    • Lee, J., K. C. Han, J. H. Kang, L. L. Pearce, N. E. Lewin, S. Yan, S. Benzaria, M. C. Nicklaus, P. M. Blumberg, and V. E. Marquez. 2001. Conformationally constrained analogues of diacylglycerol. 18. The incorporation of a hydroxamate moiety into diacylglycerol-lactones reduces lipophilicity and helps discriminate between sn-1 and sn-2 binding modes to protein kinase C (PK-C). Implications for isozyme specificity. J. Med. Chem. 44:4309-4312.
    • (2001) J. Med. Chem. , vol.44 , pp. 4309-4312
    • Lee, J.1    Han, K.C.2    Kang, J.H.3    Pearce, L.L.4    Lewin, N.E.5    Yan, S.6    Benzaria, S.7    Nicklaus, M.C.8    Blumberg, P.M.9    Marquez, V.E.10
  • 28
    • 0037072948 scopus 로고    scopus 로고
    • Increased affinity and stability of an anti-HIV-1 envelope immunotoxin by structure based mutagenesis
    • McHugh, L., S. Hu, B. K. Lee, K. Santora, P. E. Kennedy, E. A. Berger, I. Pastan, and D. H. Hamer. 2002. Increased affinity and stability of an anti-HIV-1 envelope immunotoxin by structure based mutagenesis. J. Biol. Chem. 277:34383-34390.
    • (2002) J. Biol. Chem. , vol.277 , pp. 34383-34390
    • McHugh, L.1    Hu, S.2    Lee, B.K.3    Santora, K.4    Kennedy, P.E.5    Berger, E.A.6    Pastan, I.7    Hamer, D.H.8
  • 29
    • 0023176085 scopus 로고
    • An inducible transcription factor activates expression of human immunodeficiency virus in T cells
    • Nabel, G., and D. Baltimore. 1987. An inducible transcription factor activates expression of human immunodeficiency virus in T cells. Nature 326:711-713.
    • (1987) Nature , vol.326 , pp. 711-713
    • Nabel, G.1    Baltimore, D.2
  • 30
    • 0034624775 scopus 로고    scopus 로고
    • Conformationally constrained analogues of diacylglycerol (DAG). 16. How much structural complexity is necessary for recognition and high binding affinity to protein kinase C?
    • Nacro, K., B. Bienfait, J. Lee, K. C. Han, J. H. Kang, S. Benzaria, N. E. Lewin, D. K. Bhattacharyya, P. M. Blumberg, and V. E. Marquez. 2000. Conformationally constrained analogues of diacylglycerol (DAG). 16. How much structural complexity is necessary for recognition and high binding affinity to protein kinase C? J. Med. Chem. 43:921-944.
    • (2000) J. Med. Chem. , vol.43 , pp. 921-944
    • Nacro, K.1    Bienfait, B.2    Lee, J.3    Han, K.C.4    Kang, J.H.5    Benzaria, S.6    Lewin, N.E.7    Bhattacharyya, D.K.8    Blumberg, P.M.9    Marquez, V.E.10
  • 31
    • 0034599717 scopus 로고    scopus 로고
    • Diacylglycerols with lipophilically equivalent branched acyl chains display high affinity for protein kinase C (PK-C). A direct measure of the effect of constraining the glycerol backbone in DAG lactones
    • Nacro, K., B. Bienfait, N. E. Lewin, P. M. Blumberg, and V. E. Marquez. 2000. Diacylglycerols with lipophilically equivalent branched acyl chains display high affinity for protein kinase C (PK-C). A direct measure of the effect of constraining the glycerol backbone in DAG lactones. Bioorg. Med. Chem. Lett. 10:653-655.
    • (2000) Bioorg. Med. Chem. Lett. , vol.10 , pp. 653-655
    • Nacro, K.1    Bienfait, B.2    Lewin, N.E.3    Blumberg, P.M.4    Marquez, V.E.5
  • 33
    • 0036133364 scopus 로고    scopus 로고
    • Reservoirs of human immunodeficiency virus type 1: The main obstacles to viral eradication
    • Pomerantz, R. J. 2002. Reservoirs of human immunodeficiency virus type 1: the main obstacles to viral eradication. Clin. Infect. Dis. 34:91-97.
    • (2002) Clin. Infect. Dis. , vol.34 , pp. 91-97
    • Pomerantz, R.J.1
  • 34
    • 0029980243 scopus 로고    scopus 로고
    • Activating protein-1 cooperates with phorbol ester activation signals to increase HIV-1 expression
    • Roebuck, K. A., D. S. Gu, and M. F. Kagnoff. 1996. Activating protein-1 cooperates with phorbol ester activation signals to increase HIV-1 expression. AIDS 10:819-826.
    • (1996) AIDS , vol.10 , pp. 819-826
    • Roebuck, K.A.1    Gu, D.S.2    Kagnoff, M.F.3
  • 35
    • 0035474310 scopus 로고    scopus 로고
    • Adaptor proteins in protein kinase C-mediated signal transduction
    • Schechtman, D., and D. Mochly-Rosen. 2001. Adaptor proteins in protein kinase C-mediated signal transduction. Oncogene 20:6339-6347.
    • (2001) Oncogene , vol.20 , pp. 6339-6347
    • Schechtman, D.1    Mochly-Rosen, D.2
  • 37
    • 0034763958 scopus 로고    scopus 로고
    • Reservoirs for HIV infection and their persistence in the face of undetectable viral load
    • Sonza, S., and S. M. Crowe. 2001. Reservoirs for HIV infection and their persistence in the face of undetectable viral load. AIDS Patient Care STDS 15:511-518.
    • (2001) AIDS Patient Care STDS , vol.15 , pp. 511-518
    • Sonza, S.1    Crowe, S.M.2
  • 38
    • 0027212503 scopus 로고
    • Nonpromoting 12-deoxyphorbol 13-esters inhibit phorbol 12-myristate 13-acetate induced tumor promotion in CD-1 mouse skin
    • Szallasi, Z., L. Krsmanovic, and P. M. Blumberg. 1993. Nonpromoting 12-deoxyphorbol 13-esters inhibit phorbol 12-myristate 13-acetate induced tumor promotion in CD-1 mouse skin. Cancer Res. 53:2507-2512.
    • (1993) Cancer Res. , vol.53 , pp. 2507-2512
    • Szallasi, Z.1    Krsmanovic, L.2    Blumberg, P.M.3
  • 40
    • 0033601367 scopus 로고    scopus 로고
    • Differential localization of protein kinase C delta by phorbol esters and related compounds using a fusion protein with green fluorescent protein
    • Wang, Q. J., D. Bhattacharyya, S. Garfield, K. Nacro, V. E. Marquez, and P. M. Blumberg. 1999. Differential localization of protein kinase C delta by phorbol esters and related compounds using a fusion protein with green fluorescent protein. J. Biol. Chem. 274:37233-37239.
    • (1999) J. Biol. Chem. , vol.274 , pp. 37233-37239
    • Wang, Q.J.1    Bhattacharyya, D.2    Garfield, S.3    Nacro, K.4    Marquez, V.E.5    Blumberg, P.M.6
  • 41
    • 0033600851 scopus 로고    scopus 로고
    • ERK MAP kinase links cytokine signals to activation of latent HIV-1 infection by stimulating a cooperative interaction of AP-1 and NF-κB
    • Yang, X., Y. Chen, and D. Gabuzda. 1999. ERK MAP kinase links cytokine signals to activation of latent HIV-1 infection by stimulating a cooperative interaction of AP-1 and NF-κB. J. Biol. Chem. 274:27981-27988.
    • (1999) J. Biol. Chem. , vol.274 , pp. 27981-27988
    • Yang, X.1    Chen, Y.2    Gabuzda, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.