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Volumn 186, Issue 10, 2002, Pages 1403-1411

Intensification and stimulation therapy for human immunodeficiency virus type 1 reservoirs in infected persons receiving virally suppressive highly active antiretroviral therapy

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; DIDANOSINE; HYDROXYUREA; INTERLEUKIN 2; OKT 3; VIRUS RNA;

EID: 0037111060     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/344357     Document Type: Article
Times cited : (125)

References (44)
  • 1
    • 0030869269 scopus 로고    scopus 로고
    • Treatment with indinavir, zidovudine, and lamivudine in adults with human immunodeficiency virus infection and prior antiretroviral therapy
    • Gulick RM, Mellors JW, Havlir D, et al. Treatment with indinavir, zidovudine, and lamivudine in adults with human immunodeficiency virus infection and prior antiretroviral therapy. N Engl J Med 1997;337:734-9.
    • (1997) N Engl J Med , vol.337 , pp. 734-739
    • Gulick, R.M.1    Mellors, J.W.2    Havlir, D.3
  • 2
    • 2642709177 scopus 로고    scopus 로고
    • Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV outpatient study investigators
    • Palella FJ Jr, Delaney KM, Moorman AC, et al. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators. N Engl J Med 1998;338:853-60.
    • (1998) N Engl J Med , vol.338 , pp. 853-860
    • Palella F.J., Jr.1    Delaney, K.M.2    Moorman, A.C.3
  • 3
    • 0030712305 scopus 로고    scopus 로고
    • Recovery of replication-competent HIV despite prolonged suppression of plasma viremia
    • Wong JK, Hezareh M, Gunthard HF, et al. Recovery of replication-competent HIV despite prolonged suppression of plasma viremia. Science 1997;278:1291-5.
    • (1997) Science , vol.278 , pp. 1291-1295
    • Wong, J.K.1    Hezareh, M.2    Gunthard, H.F.3
  • 4
    • 14444273439 scopus 로고    scopus 로고
    • Identification of a reservoir for HIV-1 in patients on highly active anti-retroviral therapy
    • Finzi D, Hermankova M, Pierson T, et al. Identification of a reservoir for HIV-1 in patients on highly active anti-retroviral therapy. Science 1997;278:1295-300.
    • (1997) Science , vol.278 , pp. 1295-1300
    • Finzi, D.1    Hermankova, M.2    Pierson, T.3
  • 5
    • 0030659177 scopus 로고    scopus 로고
    • Presence of an inducible HIV- 1 latent reservoir during highly active anti-retroviral therapy
    • Chun T-W, Stuyver L, Mizell SB, et al. Presence of an inducible HIV- 1 latent reservoir during highly active anti-retroviral therapy. Proc Natl Acad Sci USA 1997;94:13193-7.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 13193-13197
    • Chun, T.-W.1    Stuyver, L.2    Mizell, S.B.3
  • 6
    • 0032542314 scopus 로고    scopus 로고
    • HIV-1 in the semen of men receiving highly active anti-retroviral therapy
    • Zhang H, Dornadula G, Beumont M, et al. HIV-1 in the semen of men receiving highly active anti-retroviral therapy. N Engl J Med 1998;339:1803-9.
    • (1998) N Engl J Med , vol.339 , pp. 1803-1809
    • Zhang, H.1    Dornadula, G.2    Beumont, M.3
  • 7
    • 0035816370 scopus 로고    scopus 로고
    • Residual HIV-1 infection during antiretroviral therapy: The challenge of viral persistence
    • Pomerantz RJ. Residual HIV-1 infection during antiretroviral therapy: The challenge of viral persistence. AIDS 2001;15:1201-11.
    • (2001) AIDS , vol.15 , pp. 1201-1211
    • Pomerantz, R.J.1
  • 8
    • 0031048979 scopus 로고    scopus 로고
    • Accumulation of defective viral genomes in peripheral blood mononuclear cells of human immunodeficiency virus type 1-infected individuals
    • Sanchez G, Xu X, Chermann JC, Hirsch I. Accumulation of defective viral genomes in peripheral blood mononuclear cells of human immunodeficiency virus type 1-infected individuals. J Virol 1997;71:2233-40.
    • (1997) J Virol , vol.71 , pp. 2233-2240
    • Sanchez, G.1    Xu, X.2    Chermann, J.C.3    Hirsch, I.4
  • 9
    • 0035808518 scopus 로고    scopus 로고
    • Monocytes harbour replicationcompetent, non-latent HIV in patients on highly active antiretroviral therapy
    • Sonza S, Mutimer HP, Oelrichs R, et al. Monocytes harbour replicationcompetent, non-latent HIV in patients on highly active antiretroviral therapy. AIDS 2001;15:17-22.
    • (2001) AIDS , vol.15 , pp. 17-22
    • Sonza, S.1    Mutimer, H.P.2    Oelrichs, R.3
  • 10
    • 0036138852 scopus 로고    scopus 로고
    • + monocytes and its potential role as a source of virus in patients on highly active antiretroviral therapy
    • + monocytes and its potential role as a source of virus in patients on highly active antiretroviral therapy. J Virol 2002;76:707-16.
    • (2002) J Virol , vol.76 , pp. 707-716
    • Zhu, T.1    Muthui, D.2    Holte, S.3
  • 11
    • 0033609373 scopus 로고    scopus 로고
    • Quantifying residual HIV-1 replication in patients receiving combination antiretroviral therapy
    • Zhang L, Ramratnam B, Tenner-Racz K, et al. Quantifying residual HIV-1 replication in patients receiving combination antiretroviral therapy. N Engl J Med 1999;340:1605-13.
    • (1999) N Engl J Med , vol.340 , pp. 1605-1613
    • Zhang, L.1    Ramratnam, B.2    Tenner-Racz, K.3
  • 12
    • 2542510364 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 genetic evolution in patients with prolonged depression of plasma viremia
    • Martinez MA, Cababa M, Ibanez A, Clotet B, Arno A, Ruiz L. Human immunodeficiency virus type 1 genetic evolution in patients with prolonged depression of plasma viremia. Virology 1999;256:180-7.
    • (1999) Virology , vol.256 , pp. 180-187
    • Martinez, M.A.1    Cababa, M.2    Ibanez, A.3    Clotet, B.4    Arno, A.5    Ruiz, L.6
  • 13
    • 0033609374 scopus 로고    scopus 로고
    • Persistence of HIV-1 transcription in peripheral blood mononuclear cells in patients receiving potent antiretroviral therapy
    • Furtado MR, Callaway DS, Phair JP, et al. Persistence of HIV-1 transcription in peripheral blood mononuclear cells in patients receiving potent antiretroviral therapy. N Engl J Med 1999;340:1614-22.
    • (1999) N Engl J Med , vol.340 , pp. 1614-1622
    • Furtado, M.R.1    Callaway, D.S.2    Phair, J.P.3
  • 14
    • 0033966504 scopus 로고    scopus 로고
    • Persistence of episomal HIV-1 infection intermediates in patients on highly active antiretroviral therapy
    • Sharkey ME, Teo L, Greenough T, et al. Persistence of episomal HIV-1 infection intermediates in patients on highly active antiretroviral therapy. Nat Med 2000;6:76-81.
    • (2000) Nat Med , vol.6 , pp. 76-81
    • Sharkey, M.E.1    Teo, L.2    Greenough, T.3
  • 15
    • 0033738855 scopus 로고    scopus 로고
    • Determination of HIV-1 circular DNA as a surrogate marker for residual virus replication in patients with undetectable virus loads
    • Hauber I, Harrer T, Low P, et al. Determination of HIV-1 circular DNA as a surrogate marker for residual virus replication in patients with undetectable virus loads. AIDS 2000;14:2619-21.
    • (2000) AIDS , vol.14 , pp. 2619-2621
    • Hauber, I.1    Harrer, T.2    Low, P.3
  • 16
    • 0035822946 scopus 로고    scopus 로고
    • Persistence of intracellular HIV-1 mRNA correlates with HIV-1-specific immune responses in infected subjects on stable HAART
    • Patterson BK, McCalistera S, Schutz M, et al. Persistence of intracellular HIV-1 mRNA correlates with HIV-1-specific immune responses in infected subjects on stable HAART. AIDS 2001;15:1635-41.
    • (2001) AIDS , vol.15 , pp. 1635-1641
    • Patterson, B.K.1    McCalistera, S.2    Schutz, M.3
  • 17
    • 0035890046 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 RNA in peripheral blood mononuclear cells of patients receiving prolonged highly active antiretroviral therapy
    • Zhang J, Crumpacker CS. Human immunodeficiency virus type 1 RNA in peripheral blood mononuclear cells of patients receiving prolonged highly active antiretroviral therapy. J Infect Dis 2001;184:1341-4.
    • (2001) J Infect Dis , vol.184 , pp. 1341-1344
    • Zhang, J.1    Crumpacker, C.S.2
  • 18
    • 0035370773 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1-infected persons with residual disease and viral reservoirs on suppressive highly active antiretroviral therapy can be stratified into relevant virologic and immunologic subgroups
    • Dornadula G, Nunnari G, Vanella M, et al. Human immunodeficiency virus type 1-infected persons with residual disease and viral reservoirs on suppressive highly active antiretroviral therapy can be stratified into relevant virologic and immunologic subgroups. J Infect Dis 2001;183:1682-7.
    • (2001) J Infect Dis , vol.183 , pp. 1682-1687
    • Dornadula, G.1    Nunnari, G.2    Vanella, M.3
  • 19
    • 0036200163 scopus 로고    scopus 로고
    • Intrinsic stability of episomal circles formed during human immunodeficiency virus type 1 replication
    • Pierson TC, Kieffer TL, Ruff CT, Buck C, Gange SJ, Siliciano RF. Intrinsic stability of episomal circles formed during human immunodeficiency virus type 1 replication. J Virol 2002;76:4138-44.
    • (2002) J Virol , vol.76 , pp. 4138-4144
    • Pierson, T.C.1    Kieffer, T.L.2    Ruff, C.T.3    Buck, C.4    Gange, S.J.5    Siliciano, R.F.6
  • 20
    • 0036195928 scopus 로고    scopus 로고
    • Human immunodeficiency virus cDNA metabolism: Notable stability of two-long terminal repeat circles
    • Butler SL, Johnson EP, Bushman FD. Human immunodeficiency virus cDNA metabolism: Notable stability of two-long terminal repeat circles, J Virol 2002;76:3739-47.
    • (2002) J Virol , vol.76 , pp. 3739-3747
    • Butler, S.L.1    Johnson, E.P.2    Bushman, F.D.3
  • 21
    • 0033520673 scopus 로고    scopus 로고
    • Residual HIV-1 RNA in the blood plasma of patients on suppressive highly active anti-retroviral therapy (HAART)
    • Dornadula G, Zhang H, Van Uitert B, et al. Residual HIV-1 RNA in the blood plasma of patients on suppressive highly active anti-retroviral therapy (HAART). JAMA 1999;282:1627-32.
    • (1999) JAMA , vol.282 , pp. 1627-1632
    • Dornadula, G.1    Zhang, H.2    Van Uitert, B.3
  • 22
    • 0034526101 scopus 로고    scopus 로고
    • Decay of cell-associated HIV-1 DNA correlates with residual replication in patients treated during acute HIV-1 infection
    • Yerly S, Perneger TV, Vora S, et al. Decay of cell-associated HIV-1 DNA correlates with residual replication in patients treated during acute HIV-1 infection. AIDS 2000;14:2805-12.
    • (2000) AIDS , vol.14 , pp. 2805-2812
    • Yerly, S.1    Perneger, T.V.2    Vora, S.3
  • 23
    • 0033031218 scopus 로고    scopus 로고
    • + T-cells in HIV-1-infected patients receiving highly active antiretroviral therapy
    • + T-cells in HIV-1-infected patients receiving highly active antiretroviral therapy. Nat Med 1999;5:651-5
    • (1999) Nat Med , vol.5 , pp. 651-655
    • Chun, T.W.1    Engel, D.2    Mizell, S.B.3
  • 24
    • 0033592967 scopus 로고    scopus 로고
    • HIV-1 and T cell dynamics after interruption of highly active antiretroviral therapy (HAART) in patients with a history of sustained viral suppression
    • Davey RT Jr, Bhat N, Yoder C, et al. HIV-1 and T cell dynamics after interruption of highly active antiretroviral therapy (HAART) in patients with a history of sustained viral suppression. Proc Natl Acad Sci USA 1999;96:15109-14.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 15109-15114
    • Davey R.T., Jr.1    Bhat, N.2    Yoder, C.3
  • 25
    • 0033520846 scopus 로고    scopus 로고
    • Immunoactivation with anti-CD3 and recombinant human IL-2 in HIV-1-infected patients on potent antiretroviral therapy
    • Prins JM, Jurriaans S, van Praaga RME, et al. Immunoactivation with anti-CD3 and recombinant human IL-2 in HIV-1-infected patients on potent antiretroviral therapy. AIDS 1999;13:2405-10.
    • (1999) AIDS , vol.13 , pp. 2405-2410
    • Prins, J.M.1    Jurriaans, S.2    Van Praaga, R.M.E.3
  • 26
    • 0034052614 scopus 로고    scopus 로고
    • Reduction of the HIV-1-infected T-cell reservoir by immune activation treatment is dose-dependent and restricted by the potency of antiretroviral drugs
    • Fraser C, Ferguson NM, Ghani AC, et al. Reduction of the HIV-1-infected T-cell reservoir by immune activation treatment is dose-dependent and restricted by the potency of antiretroviral drugs. AIDS 2000;14:659-69.
    • (2000) AIDS , vol.14 , pp. 659-669
    • Fraser, C.1    Ferguson, N.M.2    Ghani, A.C.3
  • 27
    • 0035225147 scopus 로고    scopus 로고
    • Residual HIV-1 persistence during suppressive HAART
    • Remington J, Swartz M, eds. Malden, MA: Blackwell Science
    • Pomerantz RJ, Zhang H. Residual HIV-1 persistence during suppressive HAART. In: Remington J, Swartz M, eds. Current Clinical Topics in Infectious Diseases. Malden, MA: Blackwell Science, 2001:1-30.
    • (2001) Current Clinical Topics in Infectious Diseases , pp. 1-30
    • Pomerantz, R.J.1    Zhang, H.2
  • 28
    • 0027948936 scopus 로고
    • Hydroxyurea as an inhibitor of human immunodeficiency virus type 1 replication
    • Lori F, Malykh A, Cara A, et al. Hydroxyurea as an inhibitor of human immunodeficiency virus type 1 replication. Science 1994;266:801-4.
    • (1994) Science , vol.266 , pp. 801-804
    • Lori, F.1    Malykh, A.2    Cara, A.3
  • 29
    • 0027197842 scopus 로고
    • Phase IB clinical trial of anti-CD3 followed by high-dose bolus interleukin-2 in patients with metastatic melanoma and advanced renal cell carcinoma: Clinical and immunologic effects
    • Sosman JA, Weiss GR, Margolin KA, et al. Phase IB clinical trial of anti-CD3 followed by high-dose bolus interleukin-2 in patients with metastatic melanoma and advanced renal cell carcinoma: Clinical and immunologic effects. J Clin Oncol 1993;11:1496-505.
    • (1993) J Clin Oncol , vol.11 , pp. 1496-1505
    • Sosman, J.A.1    Weiss, G.R.2    Margolin, K.A.3
  • 30
    • 0029057202 scopus 로고
    • A phase IA/IB trial of anti-CD3 murine monoclonal antibody plus low-dose continuous-infusion interleukin-2 in advanced cancer patients
    • Sosman JA, Kefer C, Fisher RI, Jacobs CD, Pumfery P, Ellis TM. A phase IA/IB trial of anti-CD3 murine monoclonal antibody plus low-dose continuous-infusion interleukin-2 in advanced cancer patients. J Immunother Emphasis Tumor Immunol 1995;17:171-80.
    • (1995) J Immunother Emphasis Tumor Immunol , vol.17 , pp. 171-180
    • Sosman, J.A.1    Kefer, C.2    Fisher, R.I.3    Jacobs, C.D.4    Pumfery, P.5    Ellis, T.M.6
  • 31
    • 0035958764 scopus 로고    scopus 로고
    • Effects of treatment intensification with hydroxyurea in HIV-infected patients with virologic suppression
    • Havli DV, Gilbert PB, Bennett K, et al. Effects of treatment intensification with hydroxyurea in HIV-infected patients with virologic suppression. AIDS 2001;15:1379-88.
    • (2001) AIDS , vol.15 , pp. 1379-1388
    • Havli, D.V.1    Gilbert, P.B.2    Bennett, K.3
  • 32
    • 0026663524 scopus 로고
    • Anti-CD3 monoclonal antibody treatment of patients with CD3-negative tumors: A phase IA/B study
    • Urba WJ, Ewel C, Kopp W, et al. Anti-CD3 monoclonal antibody treatment of patients with CD3-negative tumors: A phase IA/B study. Cancer Res 1992;52:2394-401.
    • (1992) Cancer Res , vol.52 , pp. 2394-2401
    • Urba, W.J.1    Ewel, C.2    Kopp, W.3
  • 33
    • 0033135023 scopus 로고    scopus 로고
    • Phase I evaluation of humanized OKT3: Toxicity and immunomodulatory effects of hOKT3g4
    • Richards J, Auger J, Peace D, et al. Phase I evaluation of humanized OKT3: Toxicity and immunomodulatory effects of hOKT3g4. Cancer Res 1999;59:2096-01.
    • (1999) Cancer Res , vol.59 , pp. 2096-3001
    • Richards, J.1    Auger, J.2    Peace, D.3
  • 34
    • 0025228924 scopus 로고
    • In vivo cell activation following P-2 OKT3 administration: Systemic cytokine release and modulation by corticosteroids
    • Chatenoud L, Ferran C, Legendre C, et al. In vivo cell activation following P-2 OKT3 administration: Systemic cytokine release and modulation by corticosteroids. Transplantation 1990;49:697-702.
    • (1990) Transplantation , vol.49 , pp. 697-702
    • Chatenoud, L.1    Ferran, C.2    Legendre, C.3
  • 35
    • 15144342918 scopus 로고    scopus 로고
    • Kinetics of response in lymphoid tissues to antiretroviral therapy of HIV-1 infection
    • Cavert W, Notermans DW, Staskus K, et al. Kinetics of response in lymphoid tissues to antiretroviral therapy of HIV-1 infection. Science 1997;276:960-4.
    • (1997) Science , vol.276 , pp. 960-964
    • Cavert, W.1    Notermans, D.W.2    Staskus, K.3
  • 36
    • 0034727073 scopus 로고    scopus 로고
    • Immune control of HIV-1 after early treatment of acute infection
    • Rosenberg ES, Altfeld M, Poon SH, et al. Immune control of HIV-1 after early treatment of acute infection. Nature 2000;407:523-6.
    • (2000) Nature , vol.407 , pp. 523-526
    • Rosenberg, E.S.1    Altfeld, M.2    Poon, S.H.3
  • 37
    • 0035144503 scopus 로고    scopus 로고
    • Pilot study of a combination of highly active antiretroviral therapy and cytokines to induce HIV-1 remission
    • Lafeuillade A, Poggi C, Chadapaud S, et al. Pilot study of a combination of highly active antiretroviral therapy and cytokines to induce HIV-1 remission. J Acquir Immune Defic Syndr 2001;26:44-55.
    • (2001) J Acquir Immune Defic Syndr , vol.26 , pp. 44-55
    • Lafeuillade, A.1    Poggi, C.2    Chadapaud, S.3
  • 38
    • 0032819454 scopus 로고    scopus 로고
    • Dynamics of viral load rebound and immunological changes after stopping effective antiretroviral therapy
    • Garcia F, Plana M, Vidal C, et al. Dynamics of viral load rebound and immunological changes after stopping effective antiretroviral therapy. AIDS 1999;13:F79-86.
    • (1999) AIDS , vol.13 , pp. F79-F86
    • Garcia, F.1    Plana, M.2    Vidal, C.3
  • 39
    • 0033797161 scopus 로고    scopus 로고
    • Genetic characterization of rebounding of HIV-1 after cessation of highly active antiretroviral therapy
    • Zhang L, Chung C, Hu BS, et al. Genetic characterization of rebounding of HIV-1 after cessation of highly active antiretroviral therapy. J Clin Invest 2000;106:839-45.
    • (2000) J Clin Invest , vol.106 , pp. 839-845
    • Zhang, L.1    Chung, C.2    Hu, B.S.3
  • 40
    • 0033914367 scopus 로고    scopus 로고
    • Relationship between pre-existing viral reservoirs and the re-emergence of plasma viremia after discontinuation of highly active antiretroviral therapy
    • Chun TW, Davey RT, Ostrowski M, et al. Relationship between pre-existing viral reservoirs and the re-emergence of plasma viremia after discontinuation of highly active antiretroviral therapy. Nat Med 2000;6:757-61.
    • (2000) Nat Med , vol.6 , pp. 757-761
    • Chun, T.W.1    Davey, R.T.2    Ostrowski, M.3
  • 41
    • 0035173896 scopus 로고    scopus 로고
    • Human immunodeficiency virus type I quasi species that rebound after discontinuation of highly active antiretroviral therapy are similar to the viral quasi species present before initiation of therapy
    • Imamichi H, Crandel KA, Nataranjan V, et al. Human immunodeficiency virus type I quasi species that rebound after discontinuation of highly active antiretroviral therapy are similar to the viral quasi species present before initiation of therapy. J Infect Dis 2001;183:36-50.
    • (2001) J Infect Dis , vol.183 , pp. 36-50
    • Imamichi, H.1    Crandel, K.A.2    Nataranjan, V.3
  • 42
    • 0035963518 scopus 로고    scopus 로고
    • Nephropathy and establishment of a renal reservoir of HIV type 1 during primary infection
    • Winston JA, Bruggeman LA, Ross MD, et al. Nephropathy and establishment of a renal reservoir of HIV type 1 during primary infection. N Engl J Med 2001;344:1979-84.
    • (2001) N Engl J Med , vol.344 , pp. 1979-1984
    • Winston, J.A.1    Bruggeman, L.A.2    Ross, M.D.3
  • 43
    • 0036147830 scopus 로고    scopus 로고
    • Effect of latent HIV infection on cell surface phenotype
    • Brooks DG, Zack JA. Effect of latent HIV infection on cell surface phenotype. J Virol 2002;76:1673-81.
    • (2002) J Virol , vol.76 , pp. 1673-1681
    • Brooks, D.G.1    Zack, J.A.2
  • 44
    • 0037016479 scopus 로고    scopus 로고
    • Residual HIV-1 disease in seminal cells of HIV-1-infected men on suppressive HAART: Latency without ongoing cellular infections
    • Nunnari G, Otero M, Dornadula G, et al. Residual HIV-1 disease in seminal cells of HIV-1-infected men on suppressive HAART: Latency without ongoing cellular infections. AIDS 2002;16:39-45.
    • (2002) AIDS , vol.16 , pp. 39-45
    • Nunnari, G.1    Otero, M.2    Dornadula, G.3


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