Decay characteristics of HIV-1-infected compartments during combination therapy

Nature

Volumn 387, Issue 6629, 1997, Pages 188-191

  Perelson, Alan S ^a   Essunger, Paulina ^a   Cao, Yunzhen ^b   Vesanen, Mika ^b   Hurley, Arlene ^b   Saksela, Kalle ^c   Markowitz, Martin ^b   Ho, David D ^b  

^a LOS ALAMOS NATIONAL LABORATORY   (United States)

^b ROCKEFELLER UNIVERSITY   (United States)

^c UNIVERSITY OF TAMPERE   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; LAMIVUDINE; NELFINAVIR; PROTEINASE INHIBITOR; RNA DIRECTED DNA POLYMERASE INHIBITOR; ZIDOVUDINE;

ARTICLE; CLINICAL ARTICLE; DOSE RESPONSE; HELPER CELL; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; PRIORITY JOURNAL; VIRUS INFECTIVITY;

ANTI-HIV AGENTS; CD4-POSITIVE T-LYMPHOCYTES; DRUG THERAPY, COMBINATION; HALF-LIFE; HIV INFECTIONS; HIV PROTEASE INHIBITORS; HIV-1; HUMANS; ISOQUINOLINES; LAMIVUDINE; LEUKOCYTES, MONONUCLEAR; MACROPHAGES; MATHEMATICS; MODELS, BIOLOGICAL; NELFINAVIR; PROVIRUSES; REVERSE TRANSCRIPTASE INHIBITORS; RNA, VIRAL; SULFONIC ACIDS; VIRAL LOAD; VIREMIA; VIRUS LATENCY; ZIDOVUDINE;

EID: 0030952479     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/387188a0     Document Type: Article

References (25)

1. Wei, X. et al. Viral dynamics in human immunodeficiency virus type 1 infection. Nature 273, 117-122 (1995).
2. Ho, D. D. et al. Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature 373, 123-126 (1995).
3. Perelson, A. S. et al. HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral generation time. Science 271, 1582-1586 (1996).
4. Patick, A. K. et al. Antiviral and resistance studies of AG1343, an orally bioavailable inhibitor of human immunodeficiency virus protease. Antimicrob. Agents Chemother. 40, 292-297 (1996).
5. Heath, S. L. et al. Follicular dendritic cells and human immunodeficiency virus infectivity. Nature 377, 740-744 (1995).
6. Pope, M. et al. Conjugates of dendritic cells and memory T lymphocytes from skin facilitate productive infection with HIV-1. Cell 78, 389-398 (1994).
7. Haase, A. T. et al. Quantitative image analysis of HIV-1 infection in lymphoid tissue. Science 274, 985-989 (1996).
8. Herz, A. V. et al. Viral dynamics in vivo: limitations on estimates of intracellular delay and virus decay. Proc. Natl Acad. Sci. USA 93, 7247-7251 (1996).
9. Ho, D. D., Moudgil, T. & Alam, M. Quantitation of human immunodeficiency virus type 1 in the blood of infected persons. N. Engl. J. Med. 321, 1621-1625 (1989).
10. Connor, R. I., Mohri, H., Cao, Y. & Ho, D. D. Increased viral burden and cytopathicity correlate temporally with CD4+ T-lymphocyte decline and clinical progression in human immunodeficiency virus type 1-infected individuals. J. Virol. 67, 1772-1777 (1993).
11. Fazekas de St Groth, S. The evaluation of limiting dilution assays. J. Immunol. Meth. 49, R11-R23 (1982).
12. Nowak, M. A., Bonhoeffer, S., Shaw, G. M. & May, R. M. Antiviral drug treatment: dynamics of resistance in free virus and infected cell populations. J. Theor. Biol. 184, 203-217 (1997).
13. Vesanen, M. et al. Stability in controlling viral replication identifies long-term nonprogressors as a distinct subgroup among human immunodeficiency virus type 1-infected persons. J. Virol. 70, 9035-9040 (1996).
14. Mitchie, C. A. et al. Lifespan of human lymphocyte subsets defined by CD45 isoforms. Nature 360, 264-265 (1992).
15. Shaw, G. M. Viral and cellular dynamics in HIV-1 infection. Dixième Colloque des Cent Gardes (eds Girard, M. & Dodet, B.) 9-11 (Elsevier, New York, 1995).
16. Chun, T.-W. et al. In vivo fate of HIV-1-infected T cells: quantitative analysis of the transition to stable latency. Nature Med. 1, 1284-1290 (1995).
17. Moreno, P. et al. Alveolar macrophages are not an important source of viral production in HIV-1 infected patients. AIDS 10, 682-684 (1996).
18. Koenig,. S. et al. Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy. Science 233, 1089-1093 (1986).
19. Cao, Y. et al. Identification and quantitation of HIV-1 in the liver of patients with AIDS. AIDS 6, 65-70 (1992).
20. Ho, D. D., Rota, T. R., Hirsch, M. S. Infection of monocyte-macrophages by human T lymphotropic virus type III. J. Clin. Invest. 77, 1712-1715 (1986).
21. Gartner, S. et al. The role of mononuclear phagocytes in HTLV-II/LAV infection. Science 233, 215-219 (1986).
22. Chun, T.-W. et al. Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection. Nature 387, 183-188 (1997).
23. Trepel, F. Number and distribution of lymphocytes in man. A critical analysis. Klin. Wschr. 52, 511-515 (1974).
24. van Furth, R. Inflammation: Basic Principles and Clinical Correlates (eds Gallin, J. I., Goldstein, I. M. & Snyderman, S.) 325-339 (Raven, New York, 1992).
25. Efron, B. & Tibshirani, R. Bootstrap measures for standard errors, confidence intervals, and other measures of statistical accuracy. Stat. Sci. 1, 54-77 (1986).