메뉴 건너뛰기




Volumn 29, Issue 12, 2015, Pages 1429-1432

The need for treatment interruption studies and biomarker identification in the search for an HIV cure

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; BIOLOGICAL MARKER;

EID: 84941701713     PISSN: 02699370     EISSN: 14735571     Source Type: Journal    
DOI: 10.1097/QAD.0000000000000658     Document Type: Note
Times cited : (55)

References (31)
  • 1
    • 0038025296 scopus 로고    scopus 로고
    • A prospective trial of structured treatment interruptions in human immunodeficiency virus infection
    • Fagard C, Oxenius A, Gunthard H, Garcia F, Le Braz M, Mestre G, et al. A prospective trial of structured treatment interruptions in human immunodeficiency virus infection. Arch Intern Med 2003; 163:1220-1226.
    • (2003) Arch Intern Med , vol.163 , pp. 1220-1226
    • Fagard, C.1    Oxenius, A.2    Gunthard, H.3    Garcia, F.4    Le Braz, M.5    Mestre, G.6
  • 3
    • 84859783970 scopus 로고    scopus 로고
    • Assessing risk of a short-term antiretroviral therapy discontinuation as a read-out of viral control in immune-based therapy
    • Routy JP, Boulassel MR, Nicolette CA, Jacobson JM. Assessing risk of a short-term antiretroviral therapy discontinuation as a read-out of viral control in immune-based therapy. J Med Virol 2012; 84:885-889.
    • (2012) J Med Virol , vol.84 , pp. 885-889
    • Routy, J.P.1    Boulassel, M.R.2    Nicolette, C.A.3    Jacobson, J.M.4
  • 4
    • 84895487305 scopus 로고    scopus 로고
    • Gene editing of ccr5 in autologous cd4 t cells of persons infected with hiv
    • Tebas P, Stein D, Tang WW, Frank I, Wang SQ, Lee G, et al. Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV. N Engl J Med 2014; 370:901-910.
    • (2014) N Engl J Med , vol.370 , pp. 901-910
    • Tebas, P.1    Stein, D.2    Tang, W.W.3    Frank, I.4    Wang, S.Q.5    Lee, G.6
  • 5
    • 77955671541 scopus 로고    scopus 로고
    • Aids clinical trials group 5197: A placebocontrolled trial of immunization of HIV-1-infected persons with a replication-deficient adenovirus type 5 vaccine expressing the HIV-1 core protein
    • Schooley RT, Spritzler J, Wang H, Lederman MM, Havlir D, Kuritzkes DR, et al. AIDS clinical trials group 5197: a placebocontrolled trial of immunization of HIV-1-infected persons with a replication-deficient adenovirus type 5 vaccine expressing the HIV-1 core protein. J Infect Dis 2010; 202:705-716.
    • (2010) J Infect Dis , vol.202 , pp. 705-716
    • Schooley, R.T.1    Spritzler, J.2    Wang, H.3    Lederman, M.M.4    Havlir, D.5    Kuritzkes, D.R.6
  • 6
    • 84872037286 scopus 로고    scopus 로고
    • A dendritic cell-based vaccine elicits t cell responses associated with control of HIV-1 replication
    • Garcia F, Climent N, Guardo AC, Gil C, Leon A, Autran B, et al. A dendritic cell-based vaccine elicits T cell responses associated with control of HIV-1 replication. Sci Transl Med 2013; 5:166ra162.
    • (2013) Sci Transl Med , vol.5 , pp. 166ra162
    • Garcia, F.1    Climent, N.2    Guardo, A.C.3    Gil, C.4    Leon, A.5    Autran, B.6
  • 7
    • 33847036340 scopus 로고    scopus 로고
    • Intermittent antiretroviral therapy in patients with controlled hiv infection
    • Marchou B, Tangre P, Charreau I, Izopet J, Girard PM, May T, et al. Intermittent antiretroviral therapy in patients with controlled HIV infection. AIDS 2007; 21:457-466.
    • (2007) AIDS , vol.21 , pp. 457-466
    • Marchou, B.1    Tangre, P.2    Charreau, I.3    Izopet, J.4    Girard, P.M.5    May, T.6
  • 8
    • 0037012982 scopus 로고    scopus 로고
    • Warning: Antiretroviral treatment interruption could lead to an increased risk of hiv transmission
    • Tubiana R, Ghosn J, De-Sa M, Wirden M, Gautheret-Dejean A, Bricaire F, Katlama C. Warning: antiretroviral treatment interruption could lead to an increased risk of HIV transmission. AIDS 2002; 16:1083-1084.
    • (2002) AIDS , vol.16 , pp. 1083-1084
    • Tubiana, R.1    Ghosn, J.2    De-Sa, M.3    Wirden, M.4    Gautheret-Dejean, A.5    Bricaire, F.6    Katlama, C.7
  • 9
    • 73349123499 scopus 로고    scopus 로고
    • Incidence and risk factors of thrombocytopenia in patients receiving intermittent antiretroviral therapy: A substudy of the anrs 106-window trial
    • Bouldouyre MA, Charreau I, Marchou B, Tangre P, Katlama C, Morlat P, et al. Incidence and risk factors of thrombocytopenia in patients receiving intermittent antiretroviral therapy: a substudy of the ANRS 106-window trial. J Acquir Immune Defic Syndr 2009; 52:531-537.
    • (2009) J Acquir Immune Defic Syndr , vol.52 , pp. 531-537
    • Bouldouyre, M.A.1    Charreau, I.2    Marchou, B.3    Tangre, P.4    Katlama, C.5    Morlat, P.6
  • 10
    • 0034687138 scopus 로고    scopus 로고
    • Retroviral rebound syndrome after cessation of suppressive antiretroviral therapy in three patients with chronic hiv infection
    • Colven R, Harrington RD, Spach DH, Cohen CJ, Hooton TM. Retroviral rebound syndrome after cessation of suppressive antiretroviral therapy in three patients with chronic HIV infection. Ann Intern Med 2000; 133:430-434.
    • (2000) Ann Intern Med , vol.133 , pp. 430-434
    • Colven, R.1    Harrington, R.D.2    Spach, D.H.3    Cohen, C.J.4    Hooton, T.M.5
  • 11
    • 84924365877 scopus 로고    scopus 로고
    • Large number of rebounding/founder hiv variants emerge from multifocal infection in lymphatic tissues after treatment interruption
    • Rothenberger MK, Keele BF, Wietgrefe SW, Fletcher CV, Beilman GJ, Chipman JG, et al. Large number of rebounding/founder HIV variants emerge from multifocal infection in lymphatic tissues after treatment interruption. Proc Natl Acad Sci U S A 2015; 112:E1126-E1134.
    • (2015) Proc Natl Acad Sci U S A , vol.112 , pp. E1126-E1134
    • Rothenberger, M.K.1    Keele, B.F.2    Wietgrefe, S.W.3    Fletcher, C.V.4    Beilman, G.J.5    Chipman, J.G.6
  • 12
    • 84906970468 scopus 로고    scopus 로고
    • Antiretroviral-free HIV-1 remission and viral rebound after allogeneic stem cell transplantation: Report of 2 cases
    • Henrich TJ, Hanhauser E, Marty FM, Sirignano MN, Keating S, Lee TH, et al. Antiretroviral-free HIV-1 remission and viral rebound after allogeneic stem cell transplantation: report of 2 cases. Ann Intern Med 2014; 161:319-327.
    • (2014) Ann Intern Med , vol.161 , pp. 319-327
    • Henrich, T.J.1    Hanhauser, E.2    Marty, F.M.3    Sirignano, M.N.4    Keating, S.5    Lee, T.H.6
  • 13
    • 0034687137 scopus 로고    scopus 로고
    • Recurrence of the acute hiv syndrome after interruption of antiretroviral therapy in a patient with chronic hiv infection: A case report
    • Kilby JM, Goepfert PA, Miller AP, Gnann JW Jr., Sillers M, Saag MS, Bucy RP. Recurrence of the acute HIV syndrome after interruption of antiretroviral therapy in a patient with chronic HIV infection: a case report. Ann Intern Med 2000; 133:435-438.
    • (2000) Ann Intern Med , vol.133 , pp. 435-438
    • Kilby, J.M.1    Goepfert, P.A.2    Miller, A.P.3    Gnann, J.W.4    Sillers, M.5    Saag, M.S.6    Bucy, R.P.7
  • 14
    • 84875985311 scopus 로고    scopus 로고
    • Post-treatment HIV-1 controllers with a long-term virological remission after the interruption of early initiated antiretroviral therapy anrs visconti study
    • Saez-Cirion A, Bacchus C, Hocqueloux L, Avettand-Fenoel V, Girault I, Lecuroux C, et al. Post-treatment HIV-1 controllers with a long-term virological remission after the interruption of early initiated antiretroviral therapy ANRS VISCONTI Study. PLoS Pathog 2013; 9:e1003211.
    • (2013) PLoS Pathog , vol.9 , pp. e1003211
    • Saez-Cirion, A.1    Bacchus, C.2    Hocqueloux, L.3    Avettand-Fenoel, V.4    Girault, I.5    Lecuroux, C.6
  • 16
    • 0005150171 scopus 로고    scopus 로고
    • The relation of virologic and immunologic markers to clinical outcomes after nucleoside therapy in HIV-infected adults with 200 to 500 cd4 cells per cubic millimeter. Aids clinical trials group study 175 virology study team
    • Katzenstein DA, Hammer SM, Hughes MD, Gundacker H, Jackson JB, Fiscus S, et al. The relation of virologic and immunologic markers to clinical outcomes after nucleoside therapy in HIV-infected adults with 200 to 500 CD4 cells per cubic millimeter. AIDS Clinical Trials Group Study 175 Virology Study Team. N Engl J Med 1996; 335:1091-1098.
    • (1996) N Engl J Med , vol.335 , pp. 1091-1098
    • Katzenstein, D.A.1    Hammer, S.M.2    Hughes, M.D.3    Gundacker, H.4    Jackson, J.B.5    Fiscus, S.6
  • 17
    • 0032903843 scopus 로고    scopus 로고
    • The use of plasma hiv rna as a study endpoint in efficacy trials of antiretroviral drugs
    • Murray JS, Elashoff MR, Iacono-Connors LC, Cvetkovich TA, Struble KA. The use of plasma HIV RNA as a study endpoint in efficacy trials of antiretroviral drugs. AIDS 1999; 13:797-804.
    • (1999) AIDS , vol.13 , pp. 797-804
    • Murray, J.S.1    Elashoff, M.R.2    Iacono-Connors, L.C.3    Cvetkovich, T.A.4    Struble, K.A.5
  • 18
    • 84925375640 scopus 로고    scopus 로고
    • HIV-1 dna predicts disease progression and posttreatment virological control
    • Williams JP, Hurst J, Stohr W, Robinson N, Brown H, Fisher M, et al. HIV-1 DNA predicts disease progression and posttreatment virological control. Elife 2014:e03821.
    • (2014) Elife , pp. e03821
    • Williams, J.P.1    Hurst, J.2    Stohr, W.3    Robinson, N.4    Brown, H.5    Fisher, M.6
  • 20
    • 84942569841 scopus 로고    scopus 로고
    • Brief interruption of hiv antiretroviral therapy in patients with preserved cd4 count and virologic suppression is safe and well tolerated [abstract 1355]
    • October 2012; San Diego, CA
    • Rothenberger M, Haase A, Khoruts A, Beilman G, Chipman J, Thorkelson A, et al. Brief interruption of HIV antiretroviral therapy in patients with preserved CD4 count and virologic suppression is safe and well tolerated [Abstract 1355]. Infectious Disease Society of America Annual Meeting; 17-21 October 2012; San Diego, CA.
    • Infectious Disease Society of America Annual Meeting , pp. 17-21
    • Rothenberger, M.1    Haase, A.2    Khoruts, A.3    Beilman, G.4    Chipman, J.5    Thorkelson, A.6
  • 21
    • 84873472629 scopus 로고    scopus 로고
    • Comparative analysis of measures of viral reservoirs in HIV-1 eradication studies
    • Eriksson S, Graf EH, Dahl V, Strain MC, Yukl SA, Lysenko ES, et al. Comparative analysis of measures of viral reservoirs in HIV-1 eradication studies. PLoS Pathog 2013; 9:e1003174.
    • (2013) PLoS Pathog , vol.9 , pp. e1003174
    • Eriksson, S.1    Graf, E.H.2    Dahl, V.3    Strain, M.C.4    Yukl, S.A.5    Lysenko, E.S.6
  • 22
    • 84864203255 scopus 로고    scopus 로고
    • Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy
    • Archin NM, Liberty AL, Kashuba AD, Choudhary SK, Kuruc JD, Crooks AM, et al. Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy. Nature 2012; 487:482-485.
    • (2012) Nature , vol.487 , pp. 482-485
    • Archin, N.M.1    Liberty, A.L.2    Kashuba, A.D.3    Choudhary, S.K.4    Kuruc, J.D.5    Crooks, A.M.6
  • 23
    • 84901309171 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor romidepsin induces hiv expression in cd4 t cells from patients on suppressive antiretroviral therapy at concentrations achieved by clinical dosing
    • Wei DG, Chiang V, Fyne E, Balakrishnan M, Barnes T, Graupe M, et al. Histone deacetylase inhibitor romidepsin induces HIV expression in CD4 T cells from patients on suppressive antiretroviral therapy at concentrations achieved by clinical dosing. PLoS Pathog 2014; 10:e1004071.
    • (2014) PLoS Pathog , vol.10 , pp. e1004071
    • Wei, D.G.1    Chiang, V.2    Fyne, E.3    Balakrishnan, M.4    Barnes, T.5    Graupe, M.6
  • 24
    • 84942638874 scopus 로고    scopus 로고
    • Panobinostat induces hiv transcription and plasma viremia in hiv patients on suppressive cart [abstract 438lb]
    • CLEAR Study Group 3-6 March 2014; Boston, MA
    • Rasmussen T, CLEAR Study Group. Panobinostat induces HIV transcription and plasma viremia in HIV patients on suppressive cART [Abstract 438LB]. Conference on Retroviruses and Opportunistic Infections; 3-6 March 2014; Boston, MA.
    • Conference on Retroviruses and Opportunistic Infections
    • Rasmussen, T.1
  • 25
    • 84898423894 scopus 로고    scopus 로고
    • Newex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivo
    • Bullen CK, Laird GM, Durand CM, Siliciano JD, Siliciano RF. New ex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivo. Nat Med 2014; 20:425-429.
    • (2014) Nat Med , vol.20 , pp. 425-429
    • Bullen, C.K.1    Laird, G.M.2    Durand, C.M.3    Siliciano, J.D.4    Siliciano, R.F.5
  • 26
    • 84877278315 scopus 로고    scopus 로고
    • Long-term reduction in peripheral blood hiv type 1 reservoirs following reduced-intensity conditioning allogeneic stem cell transplantation
    • Henrich TJ, Hu Z, Li JZ, Sciaranghella G, Busch MP, Keating SM, et al. Long-term reduction in peripheral blood HIV type 1 reservoirs following reduced-intensity conditioning allogeneic stem cell transplantation. J Infect Dis 2013; 207:1694-1702.
    • (2013) J Infect Dis , vol.207 , pp. 1694-1702
    • Henrich, T.J.1    Hu, Z.2    Li, J.Z.3    Sciaranghella, G.4    Busch, M.P.5    Keating, S.M.6
  • 27
    • 70249100307 scopus 로고    scopus 로고
    • Expression of latent human immunodeficiency type 1 is induced by novel and selective histone deacetylase inhibitors
    • Archin NM, Keedy KS, Espeseth A, Dang H, Hazuda DJ, Margolis DM. Expression of latent human immunodeficiency type 1 is induced by novel and selective histone deacetylase inhibitors. AIDS 2009; 23:1799-1806.
    • (2009) AIDS , vol.23 , pp. 1799-1806
    • Archin, N.M.1    Keedy, K.S.2    Espeseth, A.3    Dang, H.4    Hazuda, D.J.5    Margolis, D.M.6
  • 28
    • 4744346009 scopus 로고    scopus 로고
    • Proviral HIV-dna predicts viral rebound and viral setpoint after structured treatment interruptions
    • Yerly S, Gunthard HF, Fagard C, Joos B, Perneger TV, Hirschel B, Perrin L. Proviral HIV-DNA predicts viral rebound and viral setpoint after structured treatment interruptions. AIDS 2004; 18:1951-1953.
    • (2004) AIDS , vol.18 , pp. 1951-1953
    • Yerly, S.1    Gunthard, H.F.2    Fagard, C.3    Joos, B.4    Perneger, T.V.5    Hirschel, B.6    Perrin, L.7
  • 29
    • 79952116429 scopus 로고    scopus 로고
    • A high hiv dna level in pbmcs at antiretroviral treatment interruption predicts a shorter time to treatment resumption, independently of the cd4 nadir
    • Piketty C, Weiss L, Assoumou L, Burgard M, Melard A, Ragnaud JM, et al. A high HIV DNA level in PBMCs at antiretroviral treatment interruption predicts a shorter time to treatment resumption, independently of the CD4 nadir. J Med Virol 2010; 82:1819-1828.
    • (2010) J Med Virol , vol.82 , pp. 1819-1828
    • Piketty, C.1    Weiss, L.2    Assoumou, L.3    Burgard, M.4    Melard, A.5    Ragnaud, J.M.6
  • 30
    • 84879614980 scopus 로고    scopus 로고
    • Unravelling the mechanisms of durable control of HIV-1
    • Walker BD, Yu XG. Unravelling the mechanisms of durable control of HIV-1. Nat Rev Immunol 2013; 13:487-498.
    • (2013) Nat Rev Immunol , vol.13 , pp. 487-498
    • Walker, B.D.1    Yu, X.G.2
  • 31
    • 34249852256 scopus 로고    scopus 로고
    • Hiv controllers exhibit potent cd8 t cell capacity to suppress hiv infection ex vivo and peculiar cytotoxic t lymphocyte activation phenotype
    • Saez-Cirion A, Lacabaratz C, Lambotte O, Versmisse P, Urrutia A, Boufassa F, et al. HIV controllers exhibit potent CD8 T cell capacity to suppress HIV infection ex vivo and peculiar cytotoxic T lymphocyte activation phenotype. Proc Natl Acad Sci U S A 2007; 104:6776-6781.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 6776-6781
    • Saez-Cirion, A.1    Lacabaratz, C.2    Lambotte, O.3    Versmisse, P.4    Urrutia, A.5    Boufassa, F.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.