Mechanism of selective inhibition of human immunodefieieney virus by ingenol triacetate

Antimicrobial Agents and Chemotherapy

Volumn 40, Issue 1, 1996, Pages 271-273

  Fujiwara, Masatoshi ^a   Ijichi, Katsushi ^a   Tokuhisa, Kenji ^b   Katsuura, Kimio ^b   Shigeta, Shiro ^c   Konno, Kenji ^a   Wang, Gui Yang Sheng ^d   Uemura, Daisuke ^d,e   Yokota, Tomoyuki ^a   Baba, Masanori ^f  

^a Rational Drug Design Laboratories   (Japan)

^b TOSOH CORPORATION   (Japan)

^c FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

^d SHIZUOKA UNIVERSITY   (Japan)

^e SAGAMI CHEMICAL RESEARCH CENTER   (Japan)

^f KAGOSHIMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

HERBACEOUS AGENT; INGENOL; INGENOL 3,5,20 TRIACETATE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; DRUG MECHANISM; HUMAN IMMUNODEFICIENCY VIRUS; NONHUMAN; PRIORITY JOURNAL; VIRUS CELL INTERACTION; VIRUS REPLICATION;

ANTIVIRAL AGENTS; CELL LINE; DITERPENES; HIV-1; HIV-2; HUMANS; VIRUS REPLICATION;

EID: 0030044459     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.40.1.271     Document Type: Article

References (22)

1. Baba, M., E, De Clereq, H. Tanaka, M. Ubasawa, H. Takashima, K, Sekiya, I. Nitta, K. Umezu, H. Nakashima, S. Mon, S. Shigeta, R. T. Walker, and T. Miyasaka. 1991. Potent and selective inhibitor of human immunodeficiency virus type 1 (HIV-1) by 5-ethyl-6-phenylthiouracil derivatives through their interaction with the HIV-1 reverse transcriptase. Proc. Natl. Acad. Sci. USA 88:2356-2360.
2. Baba, M., R. Pauwels, J. Balzarini, J. Arnout, J. Desmyter, and E. De Clercq. 1988. Meehanism of inhibitory effect of dextran sulfate and heparin on replication of human immunodeficiency virus in vitro Proc. Natl. Acad Sci. USA 85:6132-6136.
3. Baba, M., D. Schols, R. Pauwels, H. Nakashima, and E. De Clereq. 1990 Sulfated polysaccharides as potent inhibitors of HIV-induced syneytium formation: a new stiategy towards AIDS chemotherapy J. Acquired Immune Defic Syndr. 3:493-499.
4. Baba, M., S. Shigeta, S. Yuasa, H. Takashima, K. Sekiya. M. Ubasawa, H. Tanaka, T. Miyasaka, R. T. Walker, and E. De Clereq. 1994. Preclinical evaluation of MKC-442, a highly potent and specific inhibitor of human immunodeficiency virus type 1 in vitro. Antimicrob. Agents Chemother. 38:688-692
5. Callebaut, C., B. Krust, K. Jacotot, and A. G. Hovanessian. 1993. T cell activation antigen, CD26, as a cofactor for entry of HIV in CD4 cells. Science 262:2045-2049.
6. Chowdhury, M. I. H., Y. Koyanagi, S. Kobayashi, Y. Hamamoto, H. Yoshiyama, T. Yoshida, and N. Yamamoto. 1990 The phorbol ester TPA strongly inhibits HIV-1-induced syncytia formation but enhances virus production: possible involvement of protein kinase C pathway. Virology 176: 126-132.
7. Feorino, P. M., S. T. Butera, T. M. Folks, and R. F. Schinazi, 1993. Prevention of activation of HIV-1 by antiviral agents in OM-10.1 cells. Antiviral Chem. Chemother. 4:55-63.
8. Golding, H., J. Manischewitz, L. Vujcic, R. Blumenthal, and D. S. Dimitrov, 1994. The phorbol ester phorbol myristate acetate inhibits human immunodeficiency virus type 1 envelope-mediated fusion by modulating an accessory component(s) in CD4-expressing cells J. Virol. 68:1962-1969.
9. Gustafson, K. R., J. H. Cardellina II, J. B. McMahon, R. J. Gulakowaski, J. Ishitoya, Z. Szallasi, N. E. Lewin, P. M. Blumberg, O. S. Weislow, J. A. Beutler, R. W. Buckheit, Jr., G. M. Cragg, P. A. Cox, J. P. Bader, and M. R. Boyd. 1992 A nonpromoting phorbol from the Samoan medical plant Homalanthus nutans inhibits cell killing by HIV-1. J. Med Chem. 35:1978-1986.
10. Haslar, C. M., G. Acs, and M. Blumberg. 1992. Specific binding to protein kinase C by ingenol and its induction of biological responses. Cancer Res. 52:202-208.
11. Larder, B. A., G. Darby, and D. D. Rhichman. 1989. HIV with reduced sensitivity to zidovudme (AZT) isolated during prolonged therapy. Science 243:1731-1734.
12. Matsumoto, T., J.-C. Cyong, and H. Yamada. 1992. Stimulatory effects of ingenoi from Euhorbia kansia on the expression of macrophage Fc receptor. Planta Med 58:255-258.
13. Opferkuch, H. J., W. Adolf, B. Sorg, S. Kusumoto, and E. Hecker. 1981. On the chemistry of ingenol. I Ingenoi and some ot its derivatives. Z. Naturheim. 86b:878-887.
14. Pauwels, R., K. Andries, Z. Debyser, P. V. Daele, D. Schols, P. Stoffels, K. D. Vreese, R. Woestenborghs, A.-M. Vandamme, C. G. M. Janssen, E. De Clercq, and P. A. J. Janssen. 1993 Potent and highly selective human immunodeficiency virus type 1 (HIV-I) inhibition by a series of alphaanilinophenylacetamide derivatives targeted it HIV-1 reverse transcriptasc. Proc. Natl. Acad. Sci USA 90:1711-1715.
15. Pauwels, R., K. Andries, J. Desmyter, D. Schols, M. J. Kukla, H. J. Breslin, A. Raeymaeckers, M. A. C. Janssenm, E. De Clercq, and P. A. J. Janssen, 1990. Potent and selective inhibition of HIV-1 replication m vitro by a novel series of TIBO derivatives. Nature (London) 343:470-474.
16. Pauwels, R., J. Balzarini, M. Baba, R. Snoeck, D. Schols, P. Herdwijn, J. Desmyer, and E. De Clercq. 1988 Rapids and automated tetrazolium-based calorimetrie assay for the detection of anti-HIV compounds. J Virol. Methods 20:309-321
17. Schols, D., M. Baba, R. Pauwels, J. Desmyter, and E. De Clercq. 1989. Specific interaction of aurintricarbuxylie acid with human immunodeficiency virus/CD4 cell receptor. Proc. Natl. Acad. Sci. USA 86:3322-3326.
18. Seki, M., Y. Sadakata, S. Yuasa, and M. Baba. 1995. Isolation and characterization of human immunodeficiency virus type-1 mutants resistant to the non-nucleoside reverse transcriptase inhibitor MKC-442. Antiviral Chem. Chemother 6:73-79.
19. 7,8-isoingenol. Z. Naturforsch. 87b:748-756.
20. 7,8 isoingenol-3-tetra-decanoate. Caremogenesis 8:1-4
21. Witvrouw, M., J. A. Este, M. Q. Mateu, D. Reymen, G. Andrei, R. Snoeck, S. Ikeda, R. Pauwels, N. V. Bianehini, J. Desmyter, and E. De Clarcq. 1994. Activity of a sulfate polysaccharide extracted from the red seaweed Aghardhiella tenera against human immunodeficiency virus and other enveloped viruses Antiviral Chem. Chemother. 5:297-303.
22. 1. Kansuiporins A and B, two novel antileukemic diterpene esters from Euphorbia kansui. J. Nat. Prod. 54:823-829.