The mTOR Complex Controls HIV Latency

Cell Host and Microbe

Volumn 20, Issue 6, 2016, Pages 785-797

  Besnard, Emilie ^a,b   Hakre, Shweta ^a,b   Kampmann, Martin ^c   Lim, Hyung W ^a,b   Hosmane, Nina N ^d   Martin, Alyssa ^d   Bassik, Michael C ^c,f   Verschueren, Erik ^c   Battivelli, Emilie ^a,b   Chan, Jonathan ^a,b   Svensson, J Peter ^e   Gramatica, Andrea ^a,b   Conrad, Ryan J ^a,b   Ott, Melanie ^a,b   Greene, Warner C ^a,b   Krogan, Nevan J ^a,c   Siliciano, Robert F ^d   Weissman, Jonathan S ^c   Verdin, Eric ^a,b  

^a GLADSTONE INSTITUTE OF VIROLOGY AND IMMUNOLOGY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e KAROLINSKA INSTITUTE   (Sweden)

^f STANFORD UNIVERSITY   (United States)

Author keywords

genome wide shRNA screen; HIV latency; HIV LTR; HIV transcription; latency reversal; mTOR inhibition; reactivation from latency

Indexed keywords

2 (4 AMINO 1 ISOPROPYL 1H PYRAZOLO[3,4 D]PYRIMIDIN 3 YL) 1H INDOL 5 OL; ACTIN; CALPAIN 10; CD28 ANTIBODY; CD3 ANTIBODY; CELL ANTIBODY; COFILIN; CYCLIN DEPENDENT KINASE 9; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; RAPAMYCIN; SHORT HAIRPIN RNA; TORIN1; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; UNCLASSIFIED DRUG; CDK9 PROTEIN, HUMAN; MLST8 PROTEIN, HUMAN; POSITIVE TRANSCRIPTION ELONGATION FACTOR B; SIGNAL TRANSDUCING ADAPTOR PROTEIN; SMALL INTERFERING RNA; TARGET OF RAPAMYCIN KINASE; TRANSACTIVATOR PROTEIN;

ACTIN FILAMENT; ARTICLE; CD4+ T LYMPHOCYTE; CELL VIABILITY; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; GENE ACTIVATION; GENE EXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; K-562 CELL LINE; PHENOTYPE; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; SIGNAL TRANSDUCTION; TRANSACTIVATION; TRANSCRIPTION ELONGATION; VIRUS ACTIVATION; VIRUS LATENCY; VIRUS LOAD; VIRUS REACTIVATION; VIRUS TRANSCRIPTION; WESTERN BLOTTING; CELL LINE; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; HUMAN IMMUNODEFICIENCY VIRUS 1; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; VIROLOGY; VIRUS GENE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; CD4-POSITIVE T-LYMPHOCYTES; CELL LINE; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS; CYCLIN-DEPENDENT KINASE 9; GENE EXPRESSION REGULATION, VIRAL; GENE KNOCKDOWN TECHNIQUES; GENES, VIRAL; HIV INFECTIONS; HIV-1; HUMANS; K562 CELLS; PHOSPHORYLATION; POSITIVE TRANSCRIPTIONAL ELONGATION FACTOR B; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TAT GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; TOR SERINE-THREONINE KINASES; TRANSCRIPTION, GENETIC; VIRUS LATENCY;

EID: 85006141771     PISSN: 19313128     EISSN: 19346069     Source Type: Journal    
DOI: 10.1016/j.chom.2016.11.001     Document Type: Article

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