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Volumn 3, Issue 4, 2016, Pages

Ongoing clinical trials of human immunodeficiency virus latency-reversing and immunomodulatory agents

Author keywords

Anti HIV agents; Clinical trial; HIV 1; Latency reversing agents; Viral reservoir

Indexed keywords

ALPHA INTERFERON; ANTIVIRUS AGENT; BRYOSTATIN 1; BUTYRIC ACID; DISULFIRAM; HYDROXYCHLOROQUINE; IMMUNOMODULATING AGENT; INGENOL; INTERLEUKIN 7; LATENCY REVERSAL AGENT; MARAVIROC; PANOBINOSTAT; PROGRAMMED DEATH 1 RECEPTOR; ROMIDEPSIN; TOLL LIKE RECEPTOR; TUCIDINOSTAT; UNCLASSIFIED DRUG; VALPROIC ACID; VIRUS RNA; VORINOSTAT;

EID: 84996539958     PISSN: None     EISSN: 23288957     Source Type: Journal    
DOI: 10.1093/ofid/ofw189     Document Type: Review
Times cited : (75)

References (97)
  • 1
    • 73249136755 scopus 로고    scopus 로고
    • Molecular control of HIV-1 postintegration latency: implications for the development of new therapeutic strategies
    • Colin L, Van Lint C. Molecular control of HIV-1 postintegration latency: implications for the development of new therapeutic strategies. Retrovirology 2009; 6:111
    • (2009) Retrovirology , vol.6 , pp. 111
    • Colin, L.1    Van Lint, C.2
  • 2
    • 84942162776 scopus 로고    scopus 로고
    • Epigenetic control of HIV-1 post integration latency: implications for therapy
    • Kumar A, Darcis G, Van Lint C, Herbein G. Epigenetic control of HIV-1 post integration latency: implications for therapy. Clin Epigenetics 2015; 7:103
    • (2015) Clin Epigenetics , vol.7 , pp. 103
    • Kumar, A.1    Darcis, G.2    Van Lint, C.3    Herbein, G.4
  • 3
    • 84921819652 scopus 로고    scopus 로고
    • Selective HDAC inhibition for the disruption of latent HIV-1 infection
    • Barton KM, Archin NM, Keedy KS, et al. Selective HDAC inhibition for the disruption of latent HIV-1 infection. PloS One 2014; 9:e102684
    • (2014) PloS One , vol.9
    • Barton, K.M.1    Archin, N.M.2    Keedy, K.S.3
  • 4
    • 84864939469 scopus 로고    scopus 로고
    • Protein kinase C: one pathway towards the eradication of latent HIV-1 reservoirs
    • McKernan LN, Momjian D, Kulkosky J. Protein kinase C: one pathway towards the eradication of latent HIV-1 reservoirs. Adv Virol 2012; 2012:805347
    • (2012) Adv Virol , vol.2012
    • McKernan, L.N.1    Momjian, D.2    Kulkosky, J.3
  • 5
    • 84904718063 scopus 로고    scopus 로고
    • Reactivation of HIV latency by a newly modified Ingenol derivative via protein kinase Cd-NF-κB signaling
    • Jiang G, Mendes EA, Kaiser P, et al. Reactivation of HIV latency by a newly modified Ingenol derivative via protein kinase Cd-NF-κB signaling. AIDS; 28:1555-66
    • AIDS , vol.28 , pp. 1555-1566
    • Jiang, G.1    Mendes, E.A.2    Kaiser, P.3
  • 6
    • 84937118026 scopus 로고    scopus 로고
    • Targeting NF-κB signaling with protein kinase C agonists as an emerging strategy for combating HIV latency
    • Jiang G, Dandekar S. Targeting NF-κB signaling with protein kinase C agonists as an emerging strategy for combating HIV latency. AIDS Res Hum Retroviruses 2015; 31:4-12
    • (2015) AIDS Res Hum Retroviruses , vol.31 , pp. 4-12
    • Jiang, G.1    Dandekar, S.2
  • 7
    • 0034741714 scopus 로고    scopus 로고
    • NF-kappaB binds P-TEFb to stimulate transcriptional elongation by RNA polymerase II
    • Barboric M, Nissen RM, Kanazawa S, et al. NF-kappaB binds P-TEFb to stimulate transcriptional elongation by RNA polymerase II. Mol Cell 2001; 8:327-37
    • (2001) Mol Cell , vol.8 , pp. 327-337
    • Barboric, M.1    Nissen, R.M.2    Kanazawa, S.3
  • 8
    • 84867758122 scopus 로고    scopus 로고
    • BET bromodomain inhibition as a novel strategy for reactivation of HIV-1
    • Banerjee C, Archin N, Michaels D, et al. BET bromodomain inhibition as a novel strategy for reactivation of HIV-1. J Leukoc Biol 2012; 92:1147-54
    • (2012) J Leukoc Biol , vol.92 , pp. 1147-1154
    • Banerjee, C.1    Archin, N.2    Michaels, D.3
  • 9
    • 84880869807 scopus 로고    scopus 로고
    • The complexity of NF-κB signaling in inflammation and cancer
    • Hoesel B, Schmid JA. The complexity of NF-κB signaling in inflammation and cancer. Mol Cancer 2013; 12:86
    • (2013) Mol Cancer , vol.12 , pp. 86
    • Hoesel, B.1    Schmid, J.A.2
  • 10
    • 84873695281 scopus 로고    scopus 로고
    • NF-κB: roles and regulation in different CD4(+) T-cell subsets
    • Oh H, Ghosh S. NF-κB: roles and regulation in different CD4(+) T-cell subsets. Immunol Rev 2013; 252:41-51
    • (2013) Immunol Rev , vol.252 , pp. 41-51
    • Oh, H.1    Ghosh, S.2
  • 11
    • 84864203255 scopus 로고    scopus 로고
    • Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy
    • Archin NM, Liberty AL, Kashuba AD, et al. Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy. Nature 2012; 487:482-5
    • (2012) Nature , vol.487 , pp. 482-485
    • Archin, N.M.1    Liberty, A.L.2    Kashuba, A.D.3
  • 12
    • 84911460971 scopus 로고    scopus 로고
    • Panobinostat, a histone deacetylase inhibitor, for latent-virus reactivation in HIV-infected patients on suppressive antiretroviral therapy: a phase 1/2, single group, clinical trial
    • Rasmussen TA, Tolstrup M, Brinkmann CR, et al. Panobinostat, a histone deacetylase inhibitor, for latent-virus reactivation in HIV-infected patients on suppressive antiretroviral therapy: a phase 1/2, single group, clinical trial. Lancet HIV 2014; 1:e13-21
    • (2014) Lancet HIV , vol.1 , pp. e13-e21
    • Rasmussen, T.A.1    Tolstrup, M.2    Brinkmann, C.R.3
  • 13
    • 84895740875 scopus 로고    scopus 로고
    • A pilot study assessing the safety and latency- reversing activity of disulfiram in HIV-1-infected adults on antiretroviral therapy
    • Spivak AM, Andrade A, Eisele E, et al. A pilot study assessing the safety and latency- reversing activity of disulfiram in HIV-1-infected adults on antiretroviral therapy. Clin Infect Dis 2014; 58:883-90
    • (2014) Clin Infect Dis , vol.58 , pp. 883-890
    • Spivak, A.M.1    Andrade, A.2    Eisele, E.3
  • 14
    • 84977937246 scopus 로고    scopus 로고
    • Short-term administration of disulfiram for reversal of latent HIV infection: a phase 2 dose-escalation study
    • Elliott JH, McMahon JH, Chang CC, et al. Short-term administration of disulfiram for reversal of latent HIV infection: a phase 2 dose-escalation study. Lancet HIV 2015; 2:e520-9
    • (2015) Lancet HIV , vol.2
    • Elliott, J.H.1    McMahon, J.H.2    Chang, C.C.3
  • 15
    • 36148950997 scopus 로고    scopus 로고
    • FDA approval summary: vorinostat for treatment of advanced primary cutaneous T-cell lymphoma
    • Mann BS, Johnson JR, Cohen MH, et al. FDA approval summary: vorinostat for treatment of advanced primary cutaneous T-cell lymphoma. Oncologist 2007; 12:1247-52
    • (2007) Oncologist , vol.12 , pp. 1247-1252
    • Mann, B.S.1    Johnson, J.R.2    Cohen, M.H.3
  • 16
    • 84912122037 scopus 로고    scopus 로고
    • Activation of HIV transcription with short-course vorinostat in HIV-infected patients on suppressive antiretroviral therapy
    • Elliott JH, Wightman F, Solomon A, et al. Activation of HIV transcription with short-course vorinostat in HIV-infected patients on suppressive antiretroviral therapy. PLoS Pathog 2014; 10:e1004473
    • (2014) PLoS Pathog , vol.10
    • Elliott, J.H.1    Wightman, F.2    Solomon, A.3
  • 17
    • 84906764768 scopus 로고    scopus 로고
    • HIV-1 expression within resting CD4+ T cells after multiple doses of vorinostat
    • Archin NM, Bateson R, Tripathy MK, et al. HIV-1 expression within resting CD4+ T cells after multiple doses of vorinostat. J Infect Dis 2014; 210:728-35
    • (2014) J Infect Dis , vol.210 , pp. 728-735
    • Archin, N.M.1    Bateson, R.2    Tripathy, M.K.3
  • 18
    • 84946013715 scopus 로고    scopus 로고
    • Modeling the effects of vorinostat in vivo reveals both transient and delayed HIV transcriptional activation and minimal killing of latently infected cells
    • Ke R, Lewin SR, Elliott JH, Perelson AS. Modeling the effects of vorinostat in vivo reveals both transient and delayed HIV transcriptional activation and minimal killing of latently infected cells. PLoS Pathog 2015; 11:e1005237
    • (2015) PLoS Pathog , vol.11
    • Ke, R.1    Lewin, S.R.2    Elliott, J.H.3    Perelson, A.S.4
  • 19
    • 84903954106 scopus 로고    scopus 로고
    • Safety and tolerability of conserved region vaccines vectored by plasmid DNA, simian adenovirus and modified vaccinia virus ankara administered to human immunodeficiency virus type 1-uninfected adults in a randomized, single-blind phase I trial
    • Hayton EJ, Rose A, Ibrahimsa U, et al. Safety and tolerability of conserved region vaccines vectored by plasmid DNA, simian adenovirus and modified vaccinia virus ankara administered to human immunodeficiency virus type 1-uninfected adults in a randomized, single-blind phase I trial. PLoS One 2014; 9:e101591
    • (2014) PLoS One , vol.9
    • Hayton, E.J.1    Rose, A.2    Ibrahimsa, U.3
  • 20
    • 84895904764 scopus 로고    scopus 로고
    • Vaccine-elicited human T cells recognizing conserved protein regions inhibit HIV-1
    • Borthwick N, Ahmed T, Ondondo B, et al. Vaccine-elicited human T cells recognizing conserved protein regions inhibit HIV-1. Mol Ther 2014; 22:464-75
    • (2014) Mol Ther , vol.22 , pp. 464-475
    • Borthwick, N.1    Ahmed, T.2    Ondondo, B.3
  • 21
    • 84958052645 scopus 로고    scopus 로고
    • Control of HIV-1 replication in vitro by vaccine-induced human CD8(+) T cells through conserved subdominant Pol epitopes
    • Ahmed T, Borthwick NJ, Gilmour J, et al. Control of HIV-1 replication in vitro by vaccine-induced human CD8(+) T cells through conserved subdominant Pol epitopes. Vaccine 2016; 34:1215-24
    • (2016) Vaccine , vol.34 , pp. 1215-1224
    • Ahmed, T.1    Borthwick, N.J.2    Gilmour, J.3
  • 22
    • 84954509568 scopus 로고    scopus 로고
    • Dendritic cell immunotherapy for HIV-1 infection using autologous HIV-1 RNA: a randomized, double-blind, placebocontrolled clinical trial
    • Jacobson JM, Routy JP, Welles S, et al. Dendritic cell immunotherapy for HIV-1 infection using autologous HIV-1 RNA: a randomized, double-blind, placebocontrolled clinical trial. J Acquir Immune Defic Syndr 2016; 72:31-8
    • (2016) J Acquir Immune Defic Syndr , vol.72 , pp. 31-38
    • Jacobson, J.M.1    Routy, J.P.2    Welles, S.3
  • 23
    • 84904062324 scopus 로고    scopus 로고
    • Combined autophagy and HDAC inhibition: a phase I safety, tolerability, pharmacokinetic, and pharmacodynamic analysis of hydroxychloroquine in combination with the HDAC inhibitor vorinostat in patients with advanced solid tumors
    • Mahalingam D, Mita M, Sarantopoulos J, et al. Combined autophagy and HDAC inhibition: a phase I safety, tolerability, pharmacokinetic, and pharmacodynamic analysis of hydroxychloroquine in combination with the HDAC inhibitor vorinostat in patients with advanced solid tumors. Autophagy 2014; 10:1403-14
    • (2014) Autophagy , vol.10 , pp. 1403-1414
    • Mahalingam, D.1    Mita, M.2    Sarantopoulos, J.3
  • 24
    • 84996589131 scopus 로고    scopus 로고
    • Effect of vorinostat, hydroxychloroquine and maraviroc combination therapy on viremia following treatment interruption in individuals initiating ART during acute HIV infection
    • 18-22 July 2016, Durban, South Africa
    • Kroon E, Ananworanich J, Eubanks K, et al. Effect of vorinostat, hydroxychloroquine and maraviroc combination therapy on viremia following treatment interruption in individuals initiating ART during acute HIV infection. In: International AIDS Conference 2016, 18-22 July 2016, Durban, South Africa. Available at: http://programme.aids2016.org/Abstract/Abstract/10535
    • International AIDS Conference 2016
    • Kroon, E.1    Ananworanich, J.2    Eubanks, K.3
  • 25
    • 84871797372 scopus 로고    scopus 로고
    • Pegylated interferon alfa-2a monotherapy results in suppression of HIV type 1 replication and decreased cell-associated HIV DNA integration
    • Azzoni L, Foulkes AS, Papasavvas E, et al. Pegylated interferon alfa-2a monotherapy results in suppression of HIV type 1 replication and decreased cell-associated HIV DNA integration. J Infect Dis 2013; 207:213-22
    • (2013) J Infect Dis , vol.207 , pp. 213-222
    • Azzoni, L.1    Foulkes, A.S.2    Papasavvas, E.3
  • 26
    • 84898894955 scopus 로고    scopus 로고
    • Hepatitis C therapy with interferon-a and ribavirin reduces CD4 T-cell-associated HIV-1 DNA in HIV-1/hepatitis C virus-coinfected patients
    • Sun H, Buzon MJ, Shaw A, et al. Hepatitis C therapy with interferon-a and ribavirin reduces CD4 T-cell-associated HIV-1 DNA in HIV-1/hepatitis C virus-coinfected patients. J Infect Dis 2014; 209:1315-20
    • (2014) J Infect Dis , vol.209 , pp. 1315-1320
    • Sun, H.1    Buzon, M.J.2    Shaw, A.3
  • 27
    • 84888293183 scopus 로고    scopus 로고
    • Entinostat is a histone deacetylase inhibitor selective for class 1 histone deacetylases and activates HIV production from latently infected primary T cells
    • Wightman F, Lu HK, Solomon AE, et al. Entinostat is a histone deacetylase inhibitor selective for class 1 histone deacetylases and activates HIV production from latently infected primary T cells. AIDS 2013; 27:2853-62
    • (2013) AIDS , vol.27 , pp. 2853-2862
    • Wightman, F.1    Lu, H.K.2    Solomon, A.E.3
  • 28
    • 84958073586 scopus 로고    scopus 로고
    • In vitro reactivation of replication competent and infectious HIV-1 by HDAC inhibitors
    • Banga R, Procopio F, Cavassini M, Perreau M. In vitro reactivation of replication competent and infectious HIV-1 by HDAC inhibitors. J Virol 2015; 90:1858-71
    • (2015) J Virol , vol.90 , pp. 1858-1871
    • Banga, R.1    Procopio, F.2    Cavassini, M.3    Perreau, M.4
  • 29
    • 18244383806 scopus 로고    scopus 로고
    • Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells
    • Göttlicher M, Minucci S, Zhu P, et al. Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells. EMBO J 2001; 20:6969-78
    • (2001) EMBO J , vol.20 , pp. 6969-6978
    • Göttlicher, M.1    Minucci, S.2    Zhu, P.3
  • 30
    • 23744500093 scopus 로고    scopus 로고
    • Depletion of latent HIV-1 infection in vivo: a proof-of-concept study
    • Lehrman G, Hogue IB, Palmer S, et al. Depletion of latent HIV-1 infection in vivo: a proof-of-concept study. Lancet 2005; 366:549-55
    • (2005) Lancet , vol.366 , pp. 549-555
    • Lehrman, G.1    Hogue, I.B.2    Palmer, S.3
  • 31
    • 77949592502 scopus 로고    scopus 로고
    • Antiretroviral intensification and valproic acid lack sustained effect on residual HIV-1 viremia or resting CD4+ cell infection
    • Archin NM, Cheema M, Parker D, et al. Antiretroviral intensification and valproic acid lack sustained effect on residual HIV-1 viremia or resting CD4+ cell infection. PLoS One 2010; 5:e9390
    • (2010) PLoS One , vol.5
    • Archin, N.M.1    Cheema, M.2    Parker, D.3
  • 32
    • 84859424538 scopus 로고    scopus 로고
    • Valproic acid in association with highly active antiretroviral therapy for reducing systemic HIV-1 reservoirs: results from a multicentre randomized clinical study
    • Routy JP, Tremblay CL, Angel JB, et al. Valproic acid in association with highly active antiretroviral therapy for reducing systemic HIV-1 reservoirs: results from a multicentre randomized clinical study. HIV Med 2012; 13:291-6
    • (2012) HIV Med , vol.13 , pp. 291-296
    • Routy, J.P.1    Tremblay, C.L.2    Angel, J.B.3
  • 33
    • 0030599390 scopus 로고    scopus 로고
    • Dimethyl sulfoxide and related polar compounds enhance infection of human T cells with HIV-1 in vitro
    • Seki J, Ikeda R, Hoshino H. Dimethyl sulfoxide and related polar compounds enhance infection of human T cells with HIV-1 in vitro. Biochem Biophys Res Commun 1996; 227:724-9
    • (1996) Biochem Biophys Res Commun , vol.227 , pp. 724-729
    • Seki, J.1    Ikeda, R.2    Hoshino, H.3
  • 34
    • 0036839054 scopus 로고    scopus 로고
    • Synergistic activation of human immunodeficiency virus type 1 promoter activity by NF-kappaB and inhibitors of deacetylases: potential perspectives for the development of therapeutic strategies
    • Quivy V, Adam E, Collette Y, et al. Synergistic activation of human immunodeficiency virus type 1 promoter activity by NF-kappaB and inhibitors of deacetylases: potential perspectives for the development of therapeutic strategies. J Virol 2002; 76:11091-103
    • (2002) J Virol , vol.76 , pp. 11091-11103
    • Quivy, V.1    Adam, E.2    Collette, Y.3
  • 35
    • 0025753171 scopus 로고
    • Induction of dormant HIV-1 by sodium butyrate: involvement of the TATA box in the activation of the HIV-1 promoter
    • Golub EI, Li GR, Volsky DJ. Induction of dormant HIV-1 by sodium butyrate: involvement of the TATA box in the activation of the HIV-1 promoter. AIDS 1991; 5:663-8
    • (1991) AIDS , vol.5 , pp. 663-668
    • Golub, E.I.1    Li, G.R.2    Volsky, D.J.3
  • 36
    • 84870415922 scopus 로고    scopus 로고
    • Pharmacologic reactivation of latent feline immunodeficiency virus ex vivo in peripheral CD4+ T-lymphocytes
    • McDonnel SJ, Sparger EE, Luciw PA, Murphy BG. Pharmacologic reactivation of latent feline immunodeficiency virus ex vivo in peripheral CD4+ T-lymphocytes. Virus Res 2012; 170:174-9
    • (2012) Virus Res , vol.170 , pp. 174-179
    • McDonnel, S.J.1    Sparger, E.E.2    Luciw, P.A.3    Murphy, B.G.4
  • 37
    • 84960426869 scopus 로고    scopus 로고
    • Elevated plasma viral loads in romidepsin treated SIV-infected rhesus macaques on suppressive combination antiretroviral therapy
    • Del Prete GQ, Oswald K, Lara A, et al. Elevated plasma viral loads in romidepsin treated SIV-infected rhesus macaques on suppressive combination antiretroviral therapy. Antimicrob Agents Chemother 2015; 60:1560-72
    • (2015) Antimicrob Agents Chemother , vol.60 , pp. 1560-1572
    • Del Prete, G.Q.1    Oswald, K.2    Lara, A.3
  • 38
    • 84943557984 scopus 로고    scopus 로고
    • The depsipeptide romidepsin reverses HIV-1 latency in vivo
    • Søgaard OS, Graversen ME, Leth S, et al. The depsipeptide romidepsin reverses HIV-1 latency in vivo. PLoS Pathog 2015; 11:e1005142
    • (2015) PLoS Pathog , vol.11
    • Søgaard, O.S.1    Graversen, M.E.2    Leth, S.3
  • 39
    • 84971376158 scopus 로고    scopus 로고
    • Effect of sequential Vacc-4x/GM-CSF immunization and romidepsin on the HIV reservoir
    • 22-25 February, Boston, USA
    • Leth S, Højen J, Schleimann M, et al. Effect of sequential Vacc-4x/GM-CSF immunization and romidepsin on the HIV reservoir. Abstract 26LB. In: Conference on Retroviruses and Opportunistic Infections CROI 2016, 22-25 February 2016, Boston, USA. Available at: http://www.croiconference.org/sessions/effect-sequential-vacc-4xgm-csfimmunization- and-romidepsin-hiv-reservoir
    • (2016) Conference on Retroviruses and Opportunistic Infections CROI 2016
    • Leth, S.1    Højen, J.2    Schleimann, M.3
  • 40
    • 84928405730 scopus 로고    scopus 로고
    • Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117
    • Caskey M, Klein F, Lorenzi JC, et al. Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117. Nature 2015; 522:487-91
    • (2015) Nature , vol.522 , pp. 487-491
    • Caskey, M.1    Klein, F.2    Lorenzi, J.C.3
  • 41
    • 84966397893 scopus 로고    scopus 로고
    • Enhanced clearance of HIV-1-infected cells by broadly neutralizing antibodies against HIV-1 in vivo
    • Lu CL, Murakowski DK, Bournazos S, et al. Enhanced clearance of HIV-1-infected cells by broadly neutralizing antibodies against HIV-1 in vivo. Science 2016; 352:1001-4
    • (2016) Science , vol.352 , pp. 1001-1004
    • Lu, C.L.1    Murakowski, D.K.2    Bournazos, S.3
  • 42
    • 84966341056 scopus 로고    scopus 로고
    • HIV-1 therapy with monoclonal antibody 3BNC117 elicits host immune responses against HIV-1
    • Schoofs T, Klein F, Braunschweig M, et al. HIV-1 therapy with monoclonal antibody 3BNC117 elicits host immune responses against HIV-1. Science 2016; 352:997-1001
    • (2016) Science , vol.352 , pp. 997-1001
    • Schoofs, T.1    Klein, F.2    Braunschweig, M.3
  • 43
    • 77955287402 scopus 로고    scopus 로고
    • Bryostatin modulates latent HIV-1 infection via PKC and AMPK signaling but inhibits acute infection in a receptor independent manner
    • Mehla R, Bivalkar-Mehla S, Zhang R, et al. Bryostatin modulates latent HIV-1 infection via PKC and AMPK signaling but inhibits acute infection in a receptor independent manner. PLoS One 2010; 5:e11160
    • (2010) PLoS One , vol.5
    • Mehla, R.1    Bivalkar-Mehla, S.2    Zhang, R.3
  • 44
    • 84946925503 scopus 로고    scopus 로고
    • Synergistic activation of latent HIV-1 expression by novel histone deacetylase inhibitors and bryostatin-1
    • Martínez-Bonet M, Isabel Clemente M, Jesús Serramía M, et al. Synergistic activation of latent HIV-1 expression by novel histone deacetylase inhibitors and bryostatin-1. Sci Rep 2015; 5:16445
    • (2015) Sci Rep , vol.5 , pp. 16445
    • Martínez-Bonet, M.1    Isabel Clemente, M.2    Jesús Serramía, M.3
  • 45
    • 84898423894 scopus 로고    scopus 로고
    • New ex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivo
    • Bullen CK, Laird GM, Durand CM, et al. New ex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivo. Nat Med 2014; 20:425-9
    • (2014) Nat Med , vol.20 , pp. 425-429
    • Bullen, C.K.1    Laird, G.M.2    Durand, C.M.3
  • 46
    • 84938795129 scopus 로고    scopus 로고
    • An in-depth comparison of latency-reversing agent combinations in various in vitro and ex vivo HIV-1 latency models identified bryostatin-1+JQ1 and ingenol-B+JQ1 to potently reactivate viral gene expression
    • Darcis G, Kula A, Bouchat S, et al. An in-depth comparison of latency-reversing agent combinations in various in vitro and ex vivo HIV-1 latency models identified bryostatin-1+JQ1 and ingenol-B+JQ1 to potently reactivate viral gene expression. PLoS Pathog 2015; 11:e1005063
    • (2015) PLoS Pathog , vol.11
    • Darcis, G.1    Kula, A.2    Bouchat, S.3
  • 47
    • 84958793805 scopus 로고    scopus 로고
    • Bryostatin-1 for latent virus reactivation in HIV-infected patients on antiretroviral therapy
    • Gutiérrez C, Serrano-Villar S, Madrid-Elena N, et al. Bryostatin-1 for latent virus reactivation in HIV-infected patients on antiretroviral therapy. AIDS 2016; 30:1385-92
    • (2016) AIDS , vol.30 , pp. 1385-1392
    • Gutiérrez, C.1    Serrano-Villar, S.2    Madrid-Elena, N.3
  • 48
    • 84901354407 scopus 로고    scopus 로고
    • Dual role of novel ingenol derivatives from Euphorbia tirucalli in HIV replication: inhibition of de novo infection and activation of viral LTR
    • Abreu CM, Price SL, Shirk EN, et al. Dual role of novel ingenol derivatives from Euphorbia tirucalli in HIV replication: inhibition of de novo infection and activation of viral LTR. PLoS One 2014; 9:e97257
    • (2014) PLoS One , vol.9
    • Abreu, C.M.1    Price, S.L.2    Shirk, E.N.3
  • 49
    • 33751068006 scopus 로고    scopus 로고
    • HIV type 1 inhibition by protein kinase C modulatory compounds
    • Warrilow D, Gardner J, Darnell GA, et al. HIV type 1 inhibition by protein kinase C modulatory compounds. AIDS Res Hum Retroviruses 2006; 22:854-64
    • (2006) AIDS Res Hum Retroviruses , vol.22 , pp. 854-864
    • Warrilow, D.1    Gardner, J.2    Darnell, G.A.3
  • 50
    • 84941290489 scopus 로고    scopus 로고
    • Ex vivo bioactivity and HIV-1 latency reversal by ingenol dibenzoate and panobinostat in resting CD4(+) T cells from aviremic patients
    • Spivak AM, Bosque A, Balch AH, et al. Ex vivo bioactivity and HIV-1 latency reversal by ingenol dibenzoate and panobinostat in resting CD4(+) T cells from aviremic patients. Antimicrob Agents Chemother 2015; 59:5984-91
    • (2015) Antimicrob Agents Chemother , vol.59 , pp. 5984-5991
    • Spivak, A.M.1    Bosque, A.2    Balch, A.H.3
  • 51
    • 84938767578 scopus 로고    scopus 로고
    • Synergistic reactivation of latent HIV expression by ingenol-3-angelate, PEP005, Targeted NF-kB signaling in combination with JQ1 induced p-TEFb activation
    • Jiang G, Mendes EA, Kaiser P, et al. Synergistic reactivation of latent HIV expression by ingenol-3-angelate, PEP005, Targeted NF-kB signaling in combination with JQ1 induced p-TEFb activation. PLoS Pathog 2015; 11:e1005066
    • (2015) PLoS Pathog , vol.11
    • Jiang, G.1    Mendes, E.A.2    Kaiser, P.3
  • 52
    • 13744259064 scopus 로고    scopus 로고
    • IL-7 is a potent and proviral strain-specific inducer of latent HIV-1 cellular reservoirs of infected individuals on virally suppressive HAART
    • Wang FX, Xu Y, Sullivan J, et al. IL-7 is a potent and proviral strain-specific inducer of latent HIV-1 cellular reservoirs of infected individuals on virally suppressive HAART. J Clin Invest 2005; 115:128-37
    • (2005) J Clin Invest , vol.115 , pp. 128-137
    • Wang, F.X.1    Xu, Y.2    Sullivan, J.3
  • 53
    • 65249105408 scopus 로고    scopus 로고
    • Enhanced T cell recovery in HIV-1-infected adults through IL-7 treatment
    • Levy Y, Lacabaratz C, Weiss L, et al. Enhanced T cell recovery in HIV-1-infected adults through IL-7 treatment. J Clin Invest 2009; 119:997-1007
    • (2009) J Clin Invest , vol.119 , pp. 997-1007
    • Levy, Y.1    Lacabaratz, C.2    Weiss, L.3
  • 54
    • 84879302206 scopus 로고    scopus 로고
    • Interleukin-7 promotes HIV persistence during antiretroviral therapy
    • Vandergeeten C, Fromentin R, DaFonseca S, et al. Interleukin-7 promotes HIV persistence during antiretroviral therapy. Blood 2013; 121:4321-9
    • (2013) Blood , vol.121 , pp. 4321-4329
    • Vandergeeten, C.1    Fromentin, R.2    DaFonseca, S.3
  • 55
    • 84952944336 scopus 로고    scopus 로고
    • Treatment intensification followed by interleukin-7 reactivates HIV without reducing total HIV DNA: a randomized trial
    • Katlama C, Lambert-Niclot S, Assoumou L, et al. Treatment intensification followed by interleukin-7 reactivates HIV without reducing total HIV DNA: a randomized trial. AIDS 2016; 30:221-30
    • (2016) AIDS , vol.30 , pp. 221-230
    • Katlama, C.1    Lambert-Niclot, S.2    Assoumou, L.3
  • 56
    • 84907841767 scopus 로고    scopus 로고
    • Dendritic cell-based therapeutic vaccine elicits polyfunctional HIV-specific T-cell immunity associated with control of viral load
    • Lévy Y, Thiébaut R, Montes M, et al. Dendritic cell-based therapeutic vaccine elicits polyfunctional HIV-specific T-cell immunity associated with control of viral load. Eur J Immunol 2014; 44:2802-10
    • (2014) Eur J Immunol , vol.44 , pp. 2802-2810
    • Lévy, Y.1    Thiébaut, R.2    Montes, M.3
  • 57
    • 84926471944 scopus 로고    scopus 로고
    • Decreased HIV-specific T-regulatory responses are associated with effective DC-vaccine induced immunity
    • Brezar V, Ruffin N, Richert L, et al. Decreased HIV-specific T-regulatory responses are associated with effective DC-vaccine induced immunity. PLoS Pathog 2015; 11:e1004752
    • (2015) PLoS Pathog , vol.11
    • Brezar, V.1    Ruffin, N.2    Richert, L.3
  • 58
    • 33947595439 scopus 로고    scopus 로고
    • Dual activity of phosphorothioate CpG oligodeoxynucleotides on HIV: reactivation of latent provirus and inhibition of productive infection in human T cells
    • Scheller C, Ullrich A, Lamla S, et al. Dual activity of phosphorothioate CpG oligodeoxynucleotides on HIV: reactivation of latent provirus and inhibition of productive infection in human T cells. Ann N Y Acad Sci 2006; 1091:540-7
    • (2006) Ann N Y Acad Sci , vol.1091 , pp. 540-547
    • Scheller, C.1    Ullrich, A.2    Lamla, S.3
  • 59
    • 84886052184 scopus 로고    scopus 로고
    • Reactivation of latent HIV-1 in central memory CD4+ T cells through TLR-1/2 stimulation
    • Novis CL, Archin NM, Buzon MJ, et al. Reactivation of latent HIV-1 in central memory CD4+ T cells through TLR-1/2 stimulation. Retrovirology 2013; 10:119
    • (2013) Retrovirology , vol.10 , pp. 119
    • Novis, C.L.1    Archin, N.M.2    Buzon, M.J.3
  • 60
    • 84992396245 scopus 로고    scopus 로고
    • TLR7 agonist GS-9620 activates HIV-1 in PBMCs from HIV-infected patients on cART. Poster 417
    • 23-26 February 2015, Seattle, USA
    • Sloan D, Irrinki A, Tsai A, et al. TLR7 agonist GS-9620 activates HIV-1 in PBMCs from HIV-infected patients on cART. Poster 417. In: Conference on Retroviruses and Opportunistic Infections CROI 2015, 23-26 February 2015, Seattle, USA. Available at: http://www.croiconference.org/sites/default/files/posters-2015/417. pdf
    • Conference on Retroviruses and Opportunistic Infections CROI 2015
    • Sloan, D.1    Irrinki, A.2    Tsai, A.3
  • 61
    • 84934311252 scopus 로고    scopus 로고
    • Treatment with a TLR7 agonist induces transient viremia in SIV-infected ART-suppressed monkeys
    • February 23-26, Seattle, USA
    • Whitney JB, Lim SY, Christa E, et al. Treatment with a TLR7 agonist induces transient viremia in SIV-infected ART-suppressed monkeys. Abstract 108. In: Conference on Retroviruses and Opportunistic Infections CROI 2015, February 23-26 2015, Seattle, USA. Available at: http://www.croiconference.org/sessions/treatment-tlr7-agonist-induces-transient-viremia-siv-infected-art-suppressedmonkeys
    • (2015) Conference on Retroviruses and Opportunistic Infections CROI 2015
    • Whitney, J.B.1    Lim, S.Y.2    Christa, E.3
  • 62
    • 84876867629 scopus 로고    scopus 로고
    • Administration of a Toll-like receptor 9 agonist decreases the proviral reservoir in virologically suppressed HIV-infected patients
    • Winckelmann AA, Munk-Petersen LV, Rasmussen TA, et al. Administration of a Toll-like receptor 9 agonist decreases the proviral reservoir in virologically suppressed HIV-infected patients. PLoS One 2013; 8:e62074
    • (2013) PLoS One , vol.8
    • Winckelmann, A.A.1    Munk-Petersen, L.V.2    Rasmussen, T.A.3
  • 63
    • 84964938403 scopus 로고    scopus 로고
    • A novel Toll-like receptor 9 agonist, MGN1703, enhances HIV-1 transcription and NK cell-mediated inhibition of HIV-1-infected autologous CD4+ T cells
    • Offersen R, Nissen SK, Rasmussen TA, et al. A novel Toll-like receptor 9 agonist, MGN1703, enhances HIV-1 transcription and NK cell-mediated inhibition of HIV-1-infected autologous CD4+ T cells. J Virol 2016; 90:4441-53
    • (2016) J Virol , vol.90 , pp. 4441-4453
    • Offersen, R.1    Nissen, S.K.2    Rasmussen, T.A.3
  • 64
    • 84947722822 scopus 로고    scopus 로고
    • Toll-like receptor-3 mediates HIV-1 transactivation via NFκB and JNK pathways and histone acetylation, but prolonged activation suppresses Tat and HIV-1 replication
    • Bhargavan B, Woollard SM, Kanmogne GD. Toll-like receptor-3 mediates HIV-1 transactivation via NFκB and JNK pathways and histone acetylation, but prolonged activation suppresses Tat and HIV-1 replication. Cell Signal 2016; 28:7-22
    • (2016) Cell Signal , vol.28 , pp. 7-22
    • Bhargavan, B.1    Woollard, S.M.2    Kanmogne, G.D.3
  • 65
    • 79958136377 scopus 로고    scopus 로고
    • Disulfiram reactivates latent HIV-1 in a Bcl-2- transduced primary CD4+ T cell model without inducing global T cell activation
    • Xing S, Bullen CK, Shroff NS, et al. Disulfiram reactivates latent HIV-1 in a Bcl-2- transduced primary CD4+ T cell model without inducing global T cell activation. J Virol 2011; 85:6060-4
    • (2011) J Virol , vol.85 , pp. 6060-6064
    • Xing, S.1    Bullen, C.K.2    Shroff, N.S.3
  • 66
    • 84872393902 scopus 로고    scopus 로고
    • Disulfiram reactivates latent HIV-1 expression through depletion of the phosphatase and tensin homolog
    • Doyon G, Zerbato J, Mellors JW, Sluis-Cremer N. Disulfiram reactivates latent HIV-1 expression through depletion of the phosphatase and tensin homolog. AIDS 2013; 27:F7-11
    • (2013) AIDS , vol.27 , pp. F7-F11
    • Doyon, G.1    Zerbato, J.2    Mellors, J.W.3    Sluis-Cremer, N.4
  • 67
    • 77950525439 scopus 로고    scopus 로고
    • Programmed death-1-induced interleukin- 10 production by monocytes impairs CD4+ T cell activation during HIV infection
    • Said EA, Dupuy FP, Trautmann L, et al. Programmed death-1-induced interleukin- 10 production by monocytes impairs CD4+ T cell activation during HIV infection. Nat Med 2010; 16:452-9
    • (2010) Nat Med , vol.16 , pp. 452-459
    • Said, E.A.1    Dupuy, F.P.2    Trautmann, L.3
  • 68
    • 84924101732 scopus 로고    scopus 로고
    • Role of PD-1 co-inhibitory pathway in HIV infection and potential therapeutic options
    • Velu V, Shetty RD, Larsson M, Shankar EM. Role of PD-1 co-inhibitory pathway in HIV infection and potential therapeutic options. Retrovirology 2015; 12:14
    • (2015) Retrovirology , vol.12 , pp. 14
    • Velu, V.1    Shetty, R.D.2    Larsson, M.3    Shankar, E.M.4
  • 69
    • 84996494369 scopus 로고    scopus 로고
    • Safety, immunologic and virologic activity of anti-PD-L1 in HIV-1 participants on ART
    • 22-25 February, Boston, USA
    • Eron JJ, Gay C, Bosch RJ, et al. Safety, immunologic and virologic activity of anti-PD-L1 in HIV-1 participants on ART. Abstract 25. In: Conference on Retroviruses and Opportunistic Infections CROI 2016, 22-25 February 2016, Boston, USA. Available at: http://www.croiconference.org/sessions/safety-immunologicand- virologic-activity-anti-pd-l1-hiv-1-participants-art
    • (2016) Conference on Retroviruses and Opportunistic Infections CROI 2016
    • Eron, J.J.1    Gay, C.2    Bosch, R.J.3
  • 70
    • 84888226962 scopus 로고    scopus 로고
    • Endocrine side-effects of anti-cancer drugs: mAbs and pituitary dysfunction: clinical evidence and pathogenic hypotheses
    • Torino F, Barnabei A, Paragliola RM, et al. Endocrine side-effects of anti-cancer drugs: mAbs and pituitary dysfunction: clinical evidence and pathogenic hypotheses. Eur J Endocrinol Eur Fed Endocr Soc 2013; 169:R153-64
    • (2013) Eur J Endocrinol Eur Fed Endocr Soc , vol.169 , pp. R153-R164
    • Torino, F.1    Barnabei, A.2    Paragliola, R.M.3
  • 72
    • 84964870083 scopus 로고    scopus 로고
    • A subset of latency-reversing agents expose HIV-infected resting CD4+ T-cells to recognition by cytotoxic T-lymphocytes
    • Jones RB, Mueller S, O'Connor R, et al. A subset of latency-reversing agents expose HIV-infected resting CD4+ T-cells to recognition by cytotoxic T-lymphocytes. PLoS Pathog 2016; 12:e1005545
    • (2016) PLoS Pathog , vol.12
    • Jones, R.B.1    Mueller, S.2    O'Connor, R.3
  • 73
    • 84255197842 scopus 로고    scopus 로고
    • Cancer immunotherapy comes of age
    • Mellman I, Coukos G, Dranoff G. Cancer immunotherapy comes of age. Nature 2011; 480:480-9
    • (2011) Nature , vol.480 , pp. 480-489
    • Mellman, I.1    Coukos, G.2    Dranoff, G.3
  • 74
    • 84879318140 scopus 로고    scopus 로고
    • Immune activation and HIV persistence: implications for curative approaches to HIV infection
    • Klatt NR, Chomont N, Douek DC, Deeks SG. Immune activation and HIV persistence: implications for curative approaches to HIV infection. Immunol Rev 2013; 254:326-42
    • (2013) Immunol Rev , vol.254 , pp. 326-342
    • Klatt, N.R.1    Chomont, N.2    Douek, D.C.3    Deeks, S.G.4
  • 75
    • 84904128252 scopus 로고    scopus 로고
    • Immunologic strategies for HIV-1 remission and eradication
    • Barouch DH, Deeks SG. Immunologic strategies for HIV-1 remission and eradication. Science 2014; 345:169-74
    • (2014) Science , vol.345 , pp. 169-174
    • Barouch, D.H.1    Deeks, S.G.2
  • 76
    • 0041335573 scopus 로고    scopus 로고
    • Rapamycin causes down-regulation of CCR5 and accumulation of anti-HIV beta-chemokines: an approach to suppress R5 strains of HIV-1
    • Heredia A, Amoroso A, Davis C, et al. Rapamycin causes down-regulation of CCR5 and accumulation of anti-HIV beta-chemokines: an approach to suppress R5 strains of HIV-1. Proc Natl Acad Sci U S A 2003; 100:10411-16
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 10411-10416
    • Heredia, A.1    Amoroso, A.2    Davis, C.3
  • 77
    • 67650074206 scopus 로고    scopus 로고
    • mTOR regulates memory CD8 T-cell differentiation
    • Araki K, Turner AP, Shaffer VO, et al. mTOR regulates memory CD8 T-cell differentiation. Nature 2009; 460:108-12
    • (2009) Nature , vol.460 , pp. 108-112
    • Araki, K.1    Turner, A.P.2    Shaffer, V.O.3
  • 78
    • 84899449343 scopus 로고    scopus 로고
    • Reduction of HIV persistence following transplantation in HIV-infected kidney transplant recipients
    • Stock PG, Barin B, Hatano H, et al. Reduction of HIV persistence following transplantation in HIV-infected kidney transplant recipients. Am J Transplant 2014; 14:1136-41
    • (2014) Am J Transplant , vol.14 , pp. 1136-1141
    • Stock, P.G.1    Barin, B.2    Hatano, H.3
  • 79
    • 79952072932 scopus 로고    scopus 로고
    • Elite suppressors harbor low levels of integrated HIV DNA and high levels of 2-LTR circular HIV DNA compared to HIV+ patients on and off HAART
    • Graf EH, Mexas AM, Yu JJ, et al. Elite suppressors harbor low levels of integrated HIV DNA and high levels of 2-LTR circular HIV DNA compared to HIV+ patients on and off HAART. PLoS Pathog 2011; 7:e1001300
    • (2011) PLoS Pathog , vol.7
    • Graf, E.H.1    Mexas, A.M.2    Yu, J.J.3
  • 80
    • 84887290531 scopus 로고    scopus 로고
    • Prospective antiretroviral treatment of asymptomatic, HIV-1 infected controllers
    • Hatano H, Yukl SA, Ferre AL, et al. Prospective antiretroviral treatment of asymptomatic, HIV-1 infected controllers. PLoS Pathog 2013; 9:e1003691
    • (2013) PLoS Pathog , vol.9
    • Hatano, H.1    Yukl, S.A.2    Ferre, A.L.3
  • 81
    • 84875985311 scopus 로고    scopus 로고
    • Post-treatment HIV-1 controllers with a long-term virological remission after the interruption of early initiated antiretroviral therapy ANRS VISCONTI Study
    • Sáez-Cirión A, Bacchus C, Hocqueloux L, et al. Post-treatment HIV-1 controllers with a long-term virological remission after the interruption of early initiated antiretroviral therapy ANRS VISCONTI Study. PLoS Pathog 2013; 9:e1003211
    • (2013) PLoS Pathog , vol.9
    • Sáez-Cirión, A.1    Bacchus, C.2    Hocqueloux, L.3
  • 82
    • 84860255621 scopus 로고    scopus 로고
    • Immune responses driven by protective human leukocyte antigen alleles from long-term nonprogressors are associated with low HIV reservoir in central memory CD4T cells
    • Descours B, Avettand-Fenoel V, Blanc C, et al. Immune responses driven by protective human leukocyte antigen alleles from long-term nonprogressors are associated with low HIV reservoir in central memory CD4T cells. Clin Infect Dis 2012; 54:1495-503
    • (2012) Clin Infect Dis , vol.54 , pp. 1495-1503
    • Descours, B.1    Avettand-Fenoel, V.2    Blanc, C.3
  • 83
    • 84996494372 scopus 로고    scopus 로고
    • Viral and immune characteristics of HIV post-treatment controllers in ACTG studies
    • 22-25 February, Boston, USA
    • Etemad B, Sun X, Lederman MM, et al. Viral and immune characteristics of HIV post-treatment controllers in ACTG studies. Abstract 347. In: Conference on Retroviruses and Opportunistic Infections CROI 2016, 22-25 February 2016, Boston, USA. Available at: http://www.croiconference.org/sessions/viral-and-immunecharacteristics- hiv-post-treatment-controllers-actg-studies
    • (2016) Conference on Retroviruses and Opportunistic Infections CROI 2016
    • Etemad, B.1    Sun, X.2    Lederman, M.M.3
  • 84
    • 84863337769 scopus 로고    scopus 로고
    • Stimulation of HIV-1-specific cytolytic T lymphocytes facilitates elimination of latent viral reservoir after virus reactivation
    • Shan L, Deng K, Shroff NS, et al. Stimulation of HIV-1-specific cytolytic T lymphocytes facilitates elimination of latent viral reservoir after virus reactivation. Immunity 2012; 36:491-501
    • (2012) Immunity , vol.36 , pp. 491-501
    • Shan, L.1    Deng, K.2    Shroff, N.S.3
  • 85
    • 84881319698 scopus 로고    scopus 로고
    • Gag-positive reservoir cells are susceptible to HIV-specific cytotoxic T lymphocyte mediated clearance in vitro and can be detected in vivo [corrected]
    • Graf EH, Pace MJ, Peterson BA, et al. Gag-positive reservoir cells are susceptible to HIV-specific cytotoxic T lymphocyte mediated clearance in vitro and can be detected in vivo [corrected]. PLoS One 2013; 8:e71879
    • (2013) PLoS One , vol.8
    • Graf, E.H.1    Pace, M.J.2    Peterson, B.A.3
  • 87
    • 84876415088 scopus 로고    scopus 로고
    • How to best measure HIV reservoirs?
    • Rouzioux C, Richman D. How to best measure HIV reservoirs? Curr Opin HIV AIDS 2013; 8:170-5
    • (2013) Curr Opin HIV AIDS , vol.8 , pp. 170-175
    • Rouzioux, C.1    Richman, D.2
  • 88
  • 89
    • 84996476770 scopus 로고    scopus 로고
    • Cyanotriazoles activate latent HIV and strongly synergize with proteasome inhibitors ex vivo in resting CD4T cells from suppressed HIV+ donors
    • 8-11 December, Miami, USA
    • Murry JP, Tsai A, Graupe M, et al. Cyanotriazoles activate latent HIV and strongly synergize with proteasome inhibitors ex vivo in resting CD4T cells from suppressed HIV+ donors. Abstract OP7.3. In: HIV Persistence During Therapy Workshop, 8-11 December 2015, Miami, USA. Available at: http://www.hivpersistence. com/index.php/abstract
    • (2015) HIV Persistence During Therapy Workshop
    • Murry, J.P.1    Tsai, A.2    Graupe, M.3
  • 90
    • 84996476771 scopus 로고    scopus 로고
    • Triazol-1-ol analogues as novel therapeutic leads towards reactivating and eradicating latent HIV-1 by manipulating SUMOylation of STAT5
    • 8-11 December, Miami, USA
    • Bosque A, Macedo A, Spivak A, et al. Triazol-1-ol analogues as novel therapeutic leads towards reactivating and eradicating latent HIV-1 by manipulating SUMOylation of STAT5. Abstract OP7.4. In: HIV Persistence During Therapy Workshop, 8-11 December 2015, Miami, USA. Available at: http://www.hivpersistence. com/index.php/abstract
    • (2015) HIV Persistence During Therapy Workshop
    • Bosque, A.1    Macedo, A.2    Spivak, A.3
  • 91
    • 84957945298 scopus 로고    scopus 로고
    • Sequential treatment with 5-aza-2'-deoxycytidine and deacetylase inhibitors reactivates HIV-1
    • Bouchat S, Delacourt N, Kula A, et al. Sequential treatment with 5-aza-2'-deoxycytidine and deacetylase inhibitors reactivates HIV-1. EMBO Mol Med 2015; 8:117-38
    • (2015) EMBO Mol Med , vol.8 , pp. 117-138
    • Bouchat, S.1    Delacourt, N.2    Kula, A.3
  • 92
    • 67650550767 scopus 로고    scopus 로고
    • Synergistic activation of HIV-1 expression by deacetylase inhibitors and prostratin: implications for treatment of latent infection
    • Reuse S, Calao M, Kabeya K, et al. Synergistic activation of HIV-1 expression by deacetylase inhibitors and prostratin: implications for treatment of latent infection. PLoS One 2009; 4:e6093
    • (2009) PLoS One , vol.4
    • Reuse, S.1    Calao, M.2    Kabeya, K.3
  • 93
    • 84928986546 scopus 로고    scopus 로고
    • Ex vivo analysis identifies effective HIV-1 latency-reversing drug combinations
    • Laird GM, Bullen CK, Rosenbloom DI, et al. Ex vivo analysis identifies effective HIV-1 latency-reversing drug combinations. J Clin Invest 2015; 125:1901-12
    • (2015) J Clin Invest , vol.125 , pp. 1901-1912
    • Laird, G.M.1    Bullen, C.K.2    Rosenbloom, D.I.3
  • 94
    • 84877278315 scopus 로고    scopus 로고
    • Long-term reduction in peripheral blood HIV type 1 reservoirs following reduced-intensity conditioning allogeneic stem cell transplantation
    • Henrich TJ, Hu Z, Li JZ, et al. Long-term reduction in peripheral blood HIV type 1 reservoirs following reduced-intensity conditioning allogeneic stem cell transplantation. J Infect Dis 2013; 207:1694-702
    • (2013) J Infect Dis , vol.207 , pp. 1694-1702
    • Henrich, T.J.1    Hu, Z.2    Li, J.Z.3
  • 95
    • 84906970468 scopus 로고    scopus 로고
    • Antiretroviral-free HIV-1 remission and viral rebound after allogeneic stem cell transplantation: report of 2 cases
    • Henrich TJ, Hanhauser E, Marty FM, et al. Antiretroviral-free HIV-1 remission and viral rebound after allogeneic stem cell transplantation: report of 2 cases. Ann Intern Med 2014; 161:319-27
    • (2014) Ann Intern Med , vol.161 , pp. 319-327
    • Henrich, T.J.1    Hanhauser, E.2    Marty, F.M.3
  • 96
    • 84887028999 scopus 로고    scopus 로고
    • Absence of detectable HIV-1 viremia after treatment cessation in an infant
    • Persaud D, Gay H, Ziemniak C, et al. Absence of detectable HIV-1 viremia after treatment cessation in an infant. N Engl J Med 2013; 369:1828-35
    • (2013) N Engl J Med , vol.369 , pp. 1828-1835
    • Persaud, D.1    Gay, H.2    Ziemniak, C.3
  • 97
    • 84923064466 scopus 로고    scopus 로고
    • Viremic relapse after HIV-1 remission in a perinatally infected child
    • Luzuriaga K, Gay H, Ziemniak C, et al. Viremic relapse after HIV-1 remission in a perinatally infected child. N Engl J Med 2015; 372:786-8
    • (2015) N Engl J Med , vol.372 , pp. 786-788
    • Luzuriaga, K.1    Gay, H.2    Ziemniak, C.3


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