Benzotriazoles Reactivate Latent HIV-1 through Inactivation of STAT5 SUMOylation

Cell Reports

Volumn 18, Issue 5, 2017, Pages 1324-1334

  Bosque, Alberto ^a   Nilson, Kyle A ^b,c   Macedo, Amanda B ^a   Spivak, Adam M ^a   Archin, Nancie M ^d   Van Wagoner, Ryan M ^e   Martins, Laura J ^a   Novis, Camille L ^a   Szaniawski, Matthew A ^a   Ireland, Chris M ^e   Margolis, David M ^d   Price, David H ^b,c   Planelles, Vicente ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c UNIVERSITY OF IOWA   (United States)

^d UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF UTAH   (United States)

Author keywords

benzotriazoles; HIV 1 latency; HIV 1 reservoir; latency reversing agent; shock and kill; STAT5; SUMOylation

Indexed keywords

1 HYDROXY 7 AMINOBENZOTRIAZOLE; 1 HYDROXYBENZOTRIAZOL; 3 HYDROXY 1,2,3 BENZOTRIAZIN 4(3H)ONE; BENZOTRIAZOLE DERIVATIVE; INTERLEUKIN 2; STAT5 PROTEIN; SUMO 2 PROTEIN; SUMO 3 PROTEIN; UNCLASSIFIED DRUG; BENZOTRIAZOLE; TRIAZOLE DERIVATIVE;

ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE RELEASE; EX VIVO STUDY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IN VITRO STUDY; LONG TERMINAL REPEAT; LYMPHOCYTE PROLIFERATION; NEGATIVE FEEDBACK; NONHUMAN; PROTEIN PHOSPHORYLATION; RNA SEQUENCE; SUMOYLATION; T LYMPHOCYTE ACTIVATION; VIRUS LATENCY; VIRUS REACTIVATION; ADOLESCENT; CELL PROLIFERATION; DRUG EFFECTS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOCYTE ACTIVATION; METABOLISM; MOLECULAR LIBRARY; PHARMACOLOGY; T LYMPHOCYTE; VIROLOGY; VIRUS ACTIVATION;

ADOLESCENT; CELL PROLIFERATION; HIV INFECTIONS; HIV-1; HUMANS; INTERLEUKIN-2; LYMPHOCYTE ACTIVATION; SMALL MOLECULE LIBRARIES; STAT5 TRANSCRIPTION FACTOR; SUMOYLATION; T-LYMPHOCYTES; TRIAZOLES; VIRUS ACTIVATION; VIRUS LATENCY;

EID: 85011655854     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2017.01.022     Document Type: Article

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