-
1
-
-
79959886270
-
Amyloid precursor protein processing and Alzheimer's disease
-
O'Brien RJ, Wong PC. Amyloid precursor protein processing and Alzheimer's disease. Ann Rev Neurosci. 2011;34:185. doi:10.1146/annurev-neuro-061010-113613.
-
(2011)
Ann Rev Neurosci
, vol.34
, pp. 185
-
-
O'Brien, R.J.1
Wong, P.C.2
-
2
-
-
84871922036
-
Deciphering the mechanism underlying late-onset Alzheimer disease
-
Krstic D, Knuesel I. Deciphering the mechanism underlying late-onset Alzheimer disease. Nat Rev Neurol. 2013;9:25–34. doi:10.1038/nrneurol.2012.236.
-
(2013)
Nat Rev Neurol
, vol.9
, pp. 25-34
-
-
Krstic, D.1
Knuesel, I.2
-
3
-
-
34250819839
-
Intracellular amyloid-β in Alzheimer's disease
-
LaFerla FM, Green KN, Oddo S. Intracellular amyloid-β in Alzheimer's disease. Nat Rev Neurosci. 2007;8:499–509. doi:10.1038/nrn2168.
-
(2007)
Nat Rev Neurosci
, vol.8
, pp. 499-509
-
-
LaFerla, F.M.1
Green, K.N.2
Oddo, S.3
-
5
-
-
0344672942
-
APP processing and synaptic function
-
Kamenetz F, Tomita T, Hsieh H, Seabrook G, Borchelt D, Iwatsubo T, Sisodia S, Malinow R. APP processing and synaptic function. Neuron. 2003;37:925–37. doi:10.1016/S0896-6273(03)00124-7.
-
(2003)
Neuron
, vol.37
, pp. 925-937
-
-
Kamenetz, F.1
Tomita, T.2
Hsieh, H.3
Seabrook, G.4
Borchelt, D.5
Iwatsubo, T.6
Sisodia, S.7
Malinow, R.8
-
6
-
-
0037135111
-
The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
-
Hardy J, DJ S. The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics. Science. 2002;297:353–6. doi:10.1126/science.1072994.
-
(2002)
Science
, vol.297
, pp. 353-356
-
-
Hardy, J.1
Dj, S.2
-
7
-
-
84923250107
-
Cellular functions of the amyloid precursor protein from development to dementia
-
van der Kant R, Goldstein LS. Cellular functions of the amyloid precursor protein from development to dementia. Dev Cell. 2015;32:502–15. doi:10.1016/j.devcel.2015.01.022.
-
(2015)
Dev Cell
, vol.32
, pp. 502-515
-
-
van der Kant, R.1
Goldstein, L.S.2
-
8
-
-
84881481931
-
Neuronal autophagy: Self-eating or self-cannibalism in Alzheimer's disease
-
Ułamek-Kozioł M, Furmaga-Jabłońska W, Januszewski S, Brzozowska J, Ściślewska M, Jabłoński M, Pluta R. Neuronal autophagy: Self-eating or self-cannibalism in Alzheimer's disease. Neurochem Res. 2013;38:1769–73. doi:10.1007/s11064-013-1082-4.
-
(2013)
Neurochem Res
, vol.38
, pp. 1769-1773
-
-
Ułamek-Kozioł, M.1
Furmaga-Jabłońska, W.2
Januszewski, S.3
Brzozowska, J.4
Ściślewska, M.5
Jabłoński, M.6
Pluta, R.7
-
9
-
-
84882254367
-
The role of autophagy in neurodegenerative disease
-
Nixon RA. The role of autophagy in neurodegenerative disease. Nat Med. 2013;19:983–97. doi:10.1038/nm.3232.
-
(2013)
Nat Med
, vol.19
, pp. 983-997
-
-
Nixon, R.A.1
-
10
-
-
84929903016
-
Compromised autophagy and neurodegenerative diseases
-
Menzies FM, Fleming A, Rubinsztein DC. Compromised autophagy and neurodegenerative diseases. Nat Rev Neurosci. 2015;16:345–57. doi:10.1038/nrn3961.
-
(2015)
Nat Rev Neurosci
, vol.16
, pp. 345-357
-
-
Menzies, F.M.1
Fleming, A.2
Rubinsztein, D.C.3
-
11
-
-
84973633815
-
Mammalian Autophagy: How Does It Work?
-
Bento CF, Renna M, Ghislat G, Puri C, Ashkenazi A, Vicinanza M, Menzies FM, Rubinsztein DC. Mammalian Autophagy: How Does It Work? Ann Rev Biochem. 2016;85:685–713. doi:10.1146/annurev-biochem-060815-014556.
-
(2016)
Ann Rev Biochem
, vol.85
, pp. 685-713
-
-
Bento, C.F.1
Renna, M.2
Ghislat, G.3
Puri, C.4
Ashkenazi, A.5
Vicinanza, M.6
Menzies, F.M.7
Rubinsztein, D.C.8
-
12
-
-
77951227122
-
Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-β, and tau effects on cognitive impairments
-
Caccamo A, Majumder S, Richardson A, Strong R, Oddo S. Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-β, and tau effects on cognitive impairments. J Biol Chem. 2010;285:13107–20. doi:10.1074/jbc.M110.100420.
-
(2010)
J Biol Chem
, vol.285
, pp. 13107-13120
-
-
Caccamo, A.1
Majumder, S.2
Richardson, A.3
Strong, R.4
Oddo, S.5
-
13
-
-
79955969705
-
Autophagy failure in Alzheimer's disease—locating the primary defect
-
Nixon RA, Yang D-S. Autophagy failure in Alzheimer's disease—locating the primary defect. Neurobiol Dis. 2011;43:38–45. doi:10.1016/j.nbd.2011.01.021.
-
(2011)
Neurobiol Dis
, vol.43
, pp. 38-45
-
-
Nixon, R.A.1
Yang, D.-S.2
-
14
-
-
49049096562
-
Autophagy induction and autophagosome clearance in neurons: Relationship to autophagic pathology in Alzheimer's disease
-
Boland B, Kumar A, Lee S, Platt FM, Wegiel J, Yu WH, Nixon RA. Autophagy induction and autophagosome clearance in neurons: Relationship to autophagic pathology in Alzheimer's disease. J Neurosci. 2008;28:6926–37. doi:10.1523/JNEUROSCI.0800-08.2008.
-
(2008)
J Neurosci
, vol.28
, pp. 6926-6937
-
-
Boland, B.1
Kumar, A.2
Lee, S.3
Platt, F.M.4
Wegiel, J.5
Yu, W.H.6
Nixon, R.A.7
-
15
-
-
45749114895
-
The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid β accumulation in mice
-
et al
-
Pickford F, Masliah E, Britschgi M, Lucin K, Narasimhan R, Jaeger PA, Small S, Spencer B, Rockenstein E, Levine B, et al. The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid β accumulation in mice. J Clin Invest. 2008;118:2190–9.
-
(2008)
J Clin Invest
, vol.118
, pp. 2190-2199
-
-
Pickford, F.1
Masliah, E.2
Britschgi, M.3
Lucin, K.4
Narasimhan, R.5
Jaeger, P.A.6
Small, S.7
Spencer, B.8
Rockenstein, E.9
Levine, B.10
-
16
-
-
77956215864
-
Regulation of amyloid precursor protein processing by the Beclin 1 complex
-
Jaeger PA, Pickford F, Sun C-H, Lucin KM, Masliah E, Wyss-Coray T. Regulation of amyloid precursor protein processing by the Beclin 1 complex. PloS One. 2010;5:e11102. doi:10.1371/journal.pone.0011102.
-
(2010)
PloS One
, vol.5
-
-
Jaeger, P.A.1
Pickford, F.2
Sun, C.-H.3
Lucin, K.M.4
Masliah, E.5
Wyss-Coray, T.6
-
17
-
-
84992489295
-
BECN1/Beclin 1 sorts cell-surface APP/amyloid β precursor protein for lysosomal degradation
-
Swaminathan G, Zhu W, Plowey ED. BECN1/Beclin 1 sorts cell-surface APP/amyloid β precursor protein for lysosomal degradation. Autophagy. 2016;12:2404–19. doi:10.1080/15548627.2016.1234561.
-
(2016)
Autophagy
, vol.12
, pp. 2404-2419
-
-
Swaminathan, G.1
Zhu, W.2
Plowey, E.D.3
-
18
-
-
84885864424
-
Aβ secretion and plaque formation depend on autophagy
-
Nilsson P, Loganathan K, Sekiguchi M, Matsuba Y, Hui K, Tsubuki S, Tanaka M, Iwata N, Saito T, Saido TC. Aβ secretion and plaque formation depend on autophagy. Cell Rep. 2013;5:61–9. doi:10.1016/j.celrep.2013.08.042.
-
(2013)
Cell Rep
, vol.5
, pp. 61-69
-
-
Nilsson, P.1
Loganathan, K.2
Sekiguchi, M.3
Matsuba, Y.4
Hui, K.5
Tsubuki, S.6
Tanaka, M.7
Iwata, N.8
Saito, T.9
Saido, T.C.10
-
19
-
-
84922276427
-
Autophagy-related protein 7 deficiency in amyloid β (aβ) precursor protein transgenic mice decreases aβ in the multivesicular bodies and induces aβ accumulation in the golgi
-
et al
-
Nilsson P, Sekiguchi M, Akagi T, Izumi S, Komori T, Hui K, Sörgjerd K, Tanaka M, Saito T, Iwata N, et al. Autophagy-related protein 7 deficiency in amyloid β (aβ) precursor protein transgenic mice decreases aβ in the multivesicular bodies and induces aβ accumulation in the golgi. Am J Pathol. 2015;185:305–13. doi:10.1016/j.ajpath.2014.10.011.
-
(2015)
Am J Pathol
, vol.185
, pp. 305-313
-
-
Nilsson, P.1
Sekiguchi, M.2
Akagi, T.3
Izumi, S.4
Komori, T.5
Hui, K.6
Sörgjerd, K.7
Tanaka, M.8
Saito, T.9
Iwata, N.10
-
20
-
-
84940937112
-
Neuronal-targeted TFEB accelerates lysosomal degradation of APP, reducing Aβ generation and amyloid plaque pathogenesis
-
et al
-
Xiao Q, Yan P, Ma X, Liu H, Perez R, Zhu A, Gonzales E, Tripoli DL, Czerniewski L, Ballabio A, et al. Neuronal-targeted TFEB accelerates lysosomal degradation of APP, reducing Aβ generation and amyloid plaque pathogenesis. J Neurosci. 2015;35:12137–51. doi:10.1523/JNEUROSCI.0705-15.2015.
-
(2015)
J Neurosci
, vol.35
, pp. 12137-12151
-
-
Xiao, Q.1
Yan, P.2
Ma, X.3
Liu, H.4
Perez, R.5
Zhu, A.6
Gonzales, E.7
Tripoli, D.L.8
Czerniewski, L.9
Ballabio, A.10
-
21
-
-
77956305343
-
Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-β levels in a mouse model of Alzheimer's disease
-
Spilman P, Podlutskaya N, Hart MJ, Debnath J, Gorostiza O, Bredesen D, Richardson A, Strong R, Galvan V. Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-β levels in a mouse model of Alzheimer's disease. PloS One. 2010;5:e9979. doi:10.1371/journal.pone.0009979.
-
(2010)
PloS One
, vol.5
-
-
Spilman, P.1
Podlutskaya, N.2
Hart, M.J.3
Debnath, J.4
Gorostiza, O.5
Bredesen, D.6
Richardson, A.7
Strong, R.8
Galvan, V.9
-
22
-
-
84862023791
-
Imperfect interface of Beclin1 coiled-coil domain regulates homodimer and heterodimer formation with Atg14L and UVRAG
-
Li X, He L, Che KH, Funderburk SF, Pan L, Pan N, Zhang M, Yue Z, Zhao Y. Imperfect interface of Beclin1 coiled-coil domain regulates homodimer and heterodimer formation with Atg14L and UVRAG. Nat Commun. 2012;3:662. doi:10.1038/ncomms1648.
-
(2012)
Nat Commun
, vol.3
, pp. 662
-
-
Li, X.1
He, L.2
Che, K.H.3
Funderburk, S.F.4
Pan, L.5
Pan, N.6
Zhang, M.7
Yue, Z.8
Zhao, Y.9
-
23
-
-
84943665694
-
Architecture and dynamics of the autophagic phosphatidylinositol 3-kinase complex
-
Baskaran S, Carlson L-A, Stjepanovic G, Young LN, Grob P, Kim DJ, Stanley RE, Nogales E, Hurley JH. Architecture and dynamics of the autophagic phosphatidylinositol 3-kinase complex. Elife. 2014;3:e05115. doi:10.7554/eLife.05115.
-
(2014)
Elife
, vol.3
, pp. e05115
-
-
Baskaran, S.1
Carlson, L.-A.2
Stjepanovic, G.3
Young, L.N.4
Grob, P.5
Kim, D.J.6
Stanley, R.E.7
Nogales, E.8
Hurley, J.H.9
-
24
-
-
77953543377
-
The Beclin 1–VPS34 complex–at the crossroads of autophagy and beyond
-
Funderburk SF, Wang QJ, Yue Z. The Beclin 1–VPS34 complex–at the crossroads of autophagy and beyond. Trends Cell Biol. 2010;20:355–62. doi:10.1016/j.tcb.2010.03.002.
-
(2010)
Trends Cell Biol
, vol.20
, pp. 355-362
-
-
Funderburk, S.F.1
Wang, Q.J.2
Yue, Z.3
-
25
-
-
84903309911
-
NRBF2 regulates macroautophagy as a component of Vps34 Complex I
-
Cao Y, Wang Y, Saab WFA, Yang F, Pessin JE, Backer JM. NRBF2 regulates macroautophagy as a component of Vps34 Complex I. Biochem J. 2014;461:315–22. doi:10.1042/BJ20140515.
-
(2014)
Biochem J
, vol.461
, pp. 315-322
-
-
Cao, Y.1
Wang, Y.2
Saab, W.F.A.3
Yang, F.4
Pessin, J.E.5
Backer, J.M.6
-
26
-
-
84907215529
-
Nrbf2 protein suppresses autophagy by modulating Atg14L protein-containing Beclin 1-Vps34 complex architecture and reducing intracellular phosphatidylinositol-3 phosphate levels
-
Zhong Y, Morris DH, Jin L, Patel MS, Karunakaran SK, Fu Y-J, Matuszak EA, Weiss HL, Chait BT, Wang QJ. Nrbf2 protein suppresses autophagy by modulating Atg14L protein-containing Beclin 1-Vps34 complex architecture and reducing intracellular phosphatidylinositol-3 phosphate levels. J Biol Chem. 2014;289:26021–37. doi:10.1074/jbc.M114.561134.
-
(2014)
J Biol Chem
, vol.289
, pp. 26021-26037
-
-
Zhong, Y.1
Morris, D.H.2
Jin, L.3
Patel, M.S.4
Karunakaran, S.K.5
Fu, Y.-J.6
Matuszak, E.A.7
Weiss, H.L.8
Chait, B.T.9
Wang, Q.J.10
-
27
-
-
84978886102
-
Dynamics and architecture of the NRBF2-containing phosphatidylinositol 3-kinase complex I of autophagy
-
Young LN, Cho K, Lawrence R, Zoncu R, Hurley JH. Dynamics and architecture of the NRBF2-containing phosphatidylinositol 3-kinase complex I of autophagy. Proc Natl Acad Sci U S A. 2016;113(29):8224–9. doi:10.1073/pnas.1603650113.
-
(2016)
Proc Natl Acad Sci U S A
, vol.113
, Issue.29
, pp. 8224-8229
-
-
Young, L.N.1
Cho, K.2
Lawrence, R.3
Zoncu, R.4
Hurley, J.H.5
-
28
-
-
84901304111
-
NRBF2 regulates autophagy and prevents liver injury by modulating Atg14L-linked phosphatidylinositol-3 kinase III activity
-
et al
-
Lu J, He L, Behrends C, Araki M, Araki K, Wang QJ, Catanzaro JM, Friedman SL, Zong WX, Fiel MI, et al. NRBF2 regulates autophagy and prevents liver injury by modulating Atg14L-linked phosphatidylinositol-3 kinase III activity. Nat Commun. 2014;5:3920. doi:10.1038/ncomms4920.
-
(2014)
Nat Commun
, vol.5
, pp. 3920
-
-
Lu, J.1
He, L.2
Behrends, C.3
Araki, M.4
Araki, K.5
Wang, Q.J.6
Catanzaro, J.M.7
Friedman, S.L.8
Zong, W.X.9
Fiel, M.I.10
-
29
-
-
84887543464
-
Atg38 is required for autophagy-specific phosphatidylinositol 3-kinase complex integrity
-
Araki Y, Ku W-C, Akioka M, May AI, Hayashi Y, Arisaka F, Ishihama Y, Ohsumi Y. Atg38 is required for autophagy-specific phosphatidylinositol 3-kinase complex integrity. J Cell Biol. 2013;203:299–313. doi:10.1083/jcb.201304123.
-
(2013)
J Cell Biol
, vol.203
, pp. 299-313
-
-
Araki, Y.1
Ku, W.-C.2
Akioka, M.3
May, A.I.4
Hayashi, Y.5
Arisaka, F.6
Ishihama, Y.7
Ohsumi, Y.8
-
30
-
-
85011292038
-
MTORC1-mediated NRBF2 phosphorylation functions as a switch for the class III PtdIns3K and autophagy
-
et al
-
Ma X, Zhang S, He L, Rong Y, Brier LW, Sun Q, Liu R, Fan W, Chen S, Yue Z, et al. MTORC1-mediated NRBF2 phosphorylation functions as a switch for the class III PtdIns3K and autophagy. Autophagy. 2017;13:592–607. doi:10.1080/15548627.2016.1269988.
-
(2017)
Autophagy
, vol.13
, pp. 592-607
-
-
Ma, X.1
Zhang, S.2
He, L.3
Rong, Y.4
Brier, L.W.5
Sun, Q.6
Liu, R.7
Fan, W.8
Chen, S.9
Yue, Z.10
-
31
-
-
81355124089
-
Motor deficits, neuron loss, and reduced anxiety coinciding with axonal degeneration and intraneuronal Aβ aggregation in the 5XFAD mouse model of Alzheimer's disease
-
e29-. e40
-
Jawhar S, Trawicka A, Jenneckens C, Bayer TA, Wirths O. Motor deficits, neuron loss, and reduced anxiety coinciding with axonal degeneration and intraneuronal Aβ aggregation in the 5XFAD mouse model of Alzheimer's disease. Neurobiol Aging. 2012;33:196. e29-. e40. doi:10.1016/j.neurobiolaging.2010.05.027.
-
(2012)
Neurobiol Aging
, vol.33
, pp. 196
-
-
Jawhar, S.1
Trawicka, A.2
Jenneckens, C.3
Bayer, T.A.4
Wirths, O.5
-
32
-
-
84906830281
-
Longitudinal follow-up of autophagy and inflammation in brain of APPswePS1dE9 transgenic mice
-
François A, Bilan AR, Quellard N, Fernandez B, Janet T, Chassaing D, Paccalin M, Terro F, Page G. Longitudinal follow-up of autophagy and inflammation in brain of APPswePS1dE9 transgenic mice. J Neuroinflammation. 2014;11:139. doi:10.1186/s12974-014-0139-x.
-
(2014)
J Neuroinflammation
, vol.11
, pp. 139
-
-
François, A.1
Bilan, A.R.2
Quellard, N.3
Fernandez, B.4
Janet, T.5
Chassaing, D.6
Paccalin, M.7
Terro, F.8
Page, G.9
-
33
-
-
49049096562
-
Autophagy induction and autophagosome clearance in neurons: Relationship to autophagic pathology in Alzheimer's disease
-
Boland B, Kumar A, Lee S, Platt FM, Wegiel J, Yu WH, Nixon RA. Autophagy induction and autophagosome clearance in neurons: Relationship to autophagic pathology in Alzheimer's disease. J Neurosci. 2008;28:6926–37. doi:10.1523/JNEUROSCI.0800-08.2008.
-
(2008)
J Neurosci
, vol.28
, pp. 6926-6937
-
-
Boland, B.1
Kumar, A.2
Lee, S.3
Platt, F.M.4
Wegiel, J.5
Yu, W.H.6
Nixon, R.A.7
-
34
-
-
84908386761
-
Targeting autophagy in neurodegenerative diseases
-
Vidal RL, Matus S, Bargsted L, Hetz C. Targeting autophagy in neurodegenerative diseases. Trends Pharmacol Sci. 2014;35:583–91. doi:10.1016/j.tips.2014.09.002.
-
(2014)
Trends Pharmacol Sci
, vol.35
, pp. 583-591
-
-
Vidal, R.L.1
Matus, S.2
Bargsted, L.3
Hetz, C.4
-
35
-
-
0029942495
-
Metabolism of the Swedish Amyloid Precursor Protein Variant in Neuro2a (N2a) Cells Evidence That Cleavage at the “β-secretase” site occurs in the golgi apparatus
-
Thinakaran G, Teplow DB, Siman R, Greenberg B, Sisodia SS. Metabolism of the Swedish Amyloid Precursor Protein Variant in Neuro2a (N2a) Cells Evidence That Cleavage at the “β-secretase” site occurs in the golgi apparatus. J Biol Chem. 1996;271:9390–7. doi:10.1074/jbc.271.16.9390.
-
(1996)
J Biol Chem
, vol.271
, pp. 9390-9397
-
-
Thinakaran, G.1
Teplow, D.B.2
Siman, R.3
Greenberg, B.4
Sisodia, S.S.5
-
36
-
-
0036548070
-
γ-Secretase, Notch, Aβ and Alzheimer's disease: Where do the presenilins fit in?
-
Sisodia SS, St George-Hyslop PH. γ-Secretase, Notch, Aβ and Alzheimer's disease: Where do the presenilins fit in? Nat Rev Neurosci. 2002;3:281–90. doi:10.1038/nrn785.
-
(2002)
Nat Rev Neurosci
, vol.3
, pp. 281-290
-
-
Sisodia, S.S.1
St George-Hyslop, P.H.2
-
37
-
-
0036510603
-
A sensitive and quantitative assay for measuring cleavage of presenilin substrates
-
Karlström H, Bergman A, Lendahl U, Näslund J, Lundkvist J. A sensitive and quantitative assay for measuring cleavage of presenilin substrates. J Biol Chem. 2002;277:6763–6. doi:10.1074/jbc.C100649200.
-
(2002)
J Biol Chem
, vol.277
, pp. 6763-6766
-
-
Karlström, H.1
Bergman, A.2
Lendahl, U.3
Näslund, J.4
Lundkvist, J.5
-
38
-
-
0033972940
-
Nuclear receptor binding factor-2 (NRBF-2), a possible gene activator protein interacting with nuclear hormone receptors
-
Yasumo H, Masuda N, Furusawa T, Tsukamoto T, Sadano H, Osumi T. Nuclear receptor binding factor-2 (NRBF-2), a possible gene activator protein interacting with nuclear hormone receptors. Biochim Biophys Acta. 2000;1490:189–97. doi:10.1016/S0167-4781(99)00244-4.
-
(2000)
Biochim Biophys Acta
, vol.1490
, pp. 189-197
-
-
Yasumo, H.1
Masuda, N.2
Furusawa, T.3
Tsukamoto, T.4
Sadano, H.5
Osumi, T.6
-
39
-
-
9744273192
-
Isolation and functional analysis of a keratinocyte-derived, ligand-regulated nuclear receptor comodulator
-
Flores AM, Li L, Aneskievich BJ. Isolation and functional analysis of a keratinocyte-derived, ligand-regulated nuclear receptor comodulator. J Invest Dermatol. 2004;123:1092–101. doi:10.1111/j.0022-202X.2004.23424.x.
-
(2004)
J Invest Dermatol
, vol.123
, pp. 1092-1101
-
-
Flores, A.M.1
Li, L.2
Aneskievich, B.J.3
-
40
-
-
84868687820
-
Glycogen synthase kinase 3 inhibition promotes lysosomal biogenesis and autophagic degradation of the amyloid-β precursor protein
-
Parr C, Carzaniga R, Gentleman SM, Van Leuven F, Walter J, Sastre M. Glycogen synthase kinase 3 inhibition promotes lysosomal biogenesis and autophagic degradation of the amyloid-β precursor protein. Mol Cell Biol. 2012;32:4410–8. doi:10.1128/MCB.00930-12.
-
(2012)
Mol Cell Biol
, vol.32
, pp. 4410-4418
-
-
Parr, C.1
Carzaniga, R.2
Gentleman, S.M.3
Van Leuven, F.4
Walter, J.5
Sastre, M.6
-
41
-
-
0015496390
-
Lysosomes, pH and the anti-malarial action of chloroquine
-
Homewood C, Warhurst D, Peters W, Baggaley V. Lysosomes, pH and the anti-malarial action of chloroquine. Nature. 1972;23:50–2. doi:10.1038/235050a0.
-
(1972)
Nature
, vol.23
, pp. 50-52
-
-
Homewood, C.1
Warhurst, D.2
Peters, W.3
Baggaley, V.4
-
42
-
-
79957917512
-
A small-molecule enhancer of autophagy decreases levels of Aβ and APP-CTF via Atg5-dependent autophagy pathway
-
Tian Y, Bustos V, Flajolet M, Greengard P. A small-molecule enhancer of autophagy decreases levels of Aβ and APP-CTF via Atg5-dependent autophagy pathway. FASEB J. 2011;25:1934–42. doi:10.1096/fj.10-175158.
-
(2011)
FASEB J
, vol.25
, pp. 1934-1942
-
-
Tian, Y.1
Bustos, V.2
Flajolet, M.3
Greengard, P.4
-
43
-
-
57649221135
-
Amyloid precursor protein trafficking, processing, and function
-
Thinakaran G, Koo EH. Amyloid precursor protein trafficking, processing, and function. J Biol Chem. 2008;283:29615–9. doi:10.1074/jbc.R800019200.
-
(2008)
J Biol Chem
, vol.283
, pp. 29615-29619
-
-
Thinakaran, G.1
Koo, E.H.2
-
44
-
-
84881324927
-
Phosphatidylinositol-3-phosphate regulates sorting and processing of amyloid precursor protein through the endosomal system
-
et al
-
Morel E, Chamoun Z, Lasiecka ZM, Chan RB, Williamson RL, Vetanovetz C, Dall'Armi C, Simoes S, Point Du Jour KS, McCabe BD, et al. Phosphatidylinositol-3-phosphate regulates sorting and processing of amyloid precursor protein through the endosomal system. Nat Commun. 2013;4:2250. doi:10.1038/ncomms3250.
-
(2013)
Nat Commun
, vol.4
, pp. 2250
-
-
Morel, E.1
Chamoun, Z.2
Lasiecka, Z.M.3
Chan, R.B.4
Williamson, R.L.5
Vetanovetz, C.6
Dall'Armi, C.7
Simoes, S.8
Point Du Jour, K.S.9
McCabe, B.D.10
-
45
-
-
0037041023
-
Sequential roles for phosphatidylinositol 3-phosphate and Rab5 in tethering and fusion of early endosomes via their interaction with EEA1
-
Lawe DC, Chawla A, Merithew E, Dumas J, Carrington W, Fogarty K, Lifshitz L, Tuft R, Lambright D, Corvera S. Sequential roles for phosphatidylinositol 3-phosphate and Rab5 in tethering and fusion of early endosomes via their interaction with EEA1. J Biol Chem. 2002;277:8611–7. doi:10.1074/jbc.M109239200.
-
(2002)
J Biol Chem
, vol.277
, pp. 8611-8617
-
-
Lawe, D.C.1
Chawla, A.2
Merithew, E.3
Dumas, J.4
Carrington, W.5
Fogarty, K.6
Lifshitz, L.7
Tuft, R.8
Lambright, D.9
Corvera, S.10
-
46
-
-
0028261425
-
Inhibition of rab5 GTPase activity stimulates membrane fusion in endocytosis
-
Stenmark H, Parton RG, Steele-Mortimer O, Lütcke A, Gruenberg J, Zerial M. Inhibition of rab5 GTPase activity stimulates membrane fusion in endocytosis. EMBO J. 1994;13:1287.
-
(1994)
EMBO J
, vol.13
, pp. 1287
-
-
Stenmark, H.1
Parton, R.G.2
Steele-Mortimer, O.3
Lütcke, A.4
Gruenberg, J.5
Zerial, M.6
-
47
-
-
84920400982
-
Autophagy: A druggable process that is deregulated in aging and human disease
-
Kroemer G. Autophagy: A druggable process that is deregulated in aging and human disease. J Clin Invest. 2015;125:1–4. doi:10.1172/JCI78652.
-
(2015)
J Clin Invest
, vol.125
, pp. 1-4
-
-
Kroemer, G.1
-
48
-
-
26444587508
-
Macroautophagy—a novel β-amyloid peptide-generating pathway activated in Alzheimer's disease
-
et al
-
Yu WH, Cuervo AM, Kumar A, Peterhoff CM, Schmidt SD, Lee J-H, Mohan PS, Mercken M, Farmery MR, Tjernberg LO, et al. Macroautophagy—a novel β-amyloid peptide-generating pathway activated in Alzheimer's disease. J Cell Biol. 2005;171:87–98. doi:10.1083/jcb.200505082.
-
(2005)
J Cell Biol
, vol.171
, pp. 87-98
-
-
Yu, W.H.1
Cuervo, A.M.2
Kumar, A.3
Peterhoff, C.M.4
Schmidt, S.D.5
Lee, J.-H.6
Mohan, P.S.7
Mercken, M.8
Farmery, M.R.9
Tjernberg, L.O.10
-
49
-
-
84892875805
-
At the end of the autophagic road: An emerging understanding of lysosomal functions in autophagy
-
Shen H-M, Mizushima N. At the end of the autophagic road: An emerging understanding of lysosomal functions in autophagy. Trends Biochem Sci. 2014;39:61–71. doi:10.1016/j.tibs.2013.12.001.
-
(2014)
Trends Biochem Sci
, vol.39
, pp. 61-71
-
-
Shen, H.-M.1
Mizushima, N.2
-
50
-
-
84862883617
-
A role for presenilins in autophagy revisited: Normal acidification of lysosomes in cells lacking PSEN1 and PSEN2
-
Zhang X, Garbett K, Veeraraghavalu K, Wilburn B, Gilmore R, Mirnics K, Sisodia SS. A role for presenilins in autophagy revisited: Normal acidification of lysosomes in cells lacking PSEN1 and PSEN2. J Neurosci. 2012;32:8633–48. doi:10.1523/JNEUROSCI.0556-12.2012.
-
(2012)
J Neurosci
, vol.32
, pp. 8633-8648
-
-
Zhang, X.1
Garbett, K.2
Veeraraghavalu, K.3
Wilburn, B.4
Gilmore, R.5
Mirnics, K.6
Sisodia, S.S.7
-
51
-
-
84960337720
-
Dysregulation of nutrient sensing and CLEARance in presenilin deficiency
-
Reddy K, Cusack CL, Nnah IC, Khayati K, Saqcena C, Huynh TB, Noggle SA, Ballabio A, Dobrowolski R. Dysregulation of nutrient sensing and CLEARance in presenilin deficiency. Cell Rep. 2016;14:2166–79. doi:10.1016/j.celrep.2016.02.006.
-
(2016)
Cell Rep
, vol.14
, pp. 2166-2179
-
-
Reddy, K.1
Cusack, C.L.2
Nnah, I.C.3
Khayati, K.4
Saqcena, C.5
Huynh, T.B.6
Noggle, S.A.7
Ballabio, A.8
Dobrowolski, R.9
-
52
-
-
84881025556
-
Impaired autophagy and APP processing in Alzheimer's disease: The potential role of Beclin 1 interactome
-
Salminen A, Kaarniranta K, Kauppinen A, Ojala J, Haapasalo A, Soininen H, Hiltunen M. Impaired autophagy and APP processing in Alzheimer's disease: The potential role of Beclin 1 interactome. Prog Neurobiol. 2013;106:33–54. doi:10.1016/j.pneurobio.2013.06.002.
-
(2013)
Prog Neurobiol
, vol.106
, pp. 33-54
-
-
Salminen, A.1
Kaarniranta, K.2
Kauppinen, A.3
Ojala, J.4
Haapasalo, A.5
Soininen, H.6
Hiltunen, M.7
-
53
-
-
57649195400
-
Autophagy and multivesicular bodies: Two closely related partners
-
Fader C, Colombo M. Autophagy and multivesicular bodies: Two closely related partners. Cell Death Differ. 2009;16:70–8. doi:10.1038/cdd.2008.168.
-
(2009)
Cell Death Differ
, vol.16
, pp. 70-78
-
-
Fader, C.1
Colombo, M.2
-
54
-
-
84908321680
-
Beclin 1 is required for neuron viability and regulates endosome pathways via the UVRAG-VPS34 complex
-
McKnight NC, Zhong Y, Wold MS, Gong S, Phillips GR, Dou Z, Zhao Y, Heintz N, Zong WX, Yue Z. Beclin 1 is required for neuron viability and regulates endosome pathways via the UVRAG-VPS34 complex. PLoS Genet. 2014;10:e1004626. doi:10.1371/journal.pgen.1004626.
-
(2014)
PLoS Genet
, vol.10
, pp. e1004626
-
-
McKnight, N.C.1
Zhong, Y.2
Wold, M.S.3
Gong, S.4
Phillips, G.R.5
Dou, Z.6
Zhao, Y.7
Heintz, N.8
Zong, W.X.9
Yue, Z.10
-
55
-
-
79960706730
-
Stimulation of non-amyloidogenic processing of amyloid-β protein precursor by cryptotanshinone involves activation and translocation of ADAM10 and PKC-α
-
Durairajan SSK, Liu L-F, Lu J-H, Koo I, Maruyama K, Chung SK, Huang JD, Li M. Stimulation of non-amyloidogenic processing of amyloid-β protein precursor by cryptotanshinone involves activation and translocation of ADAM10 and PKC-α. J Alzheimer's Dis. 2011;25:245–62.
-
(2011)
J Alzheimer's Dis
, vol.25
, pp. 245-262
-
-
Durairajan, S.S.K.1
Liu, L.-F.2
Lu, J.-H.3
Koo, I.4
Maruyama, K.5
Chung, S.K.6
Huang, J.D.7
Li, M.8
-
56
-
-
0028952749
-
Aggregation of secreted amyloid-protein into sodium dodecyl sulfate-stable oligomers in cell culture
-
Podlisny MB, Ostaszewski BL, Squazzo SL, Koo EH, Rydell RE, Teplow DB, Selkoe DJ. Aggregation of secreted amyloid-protein into sodium dodecyl sulfate-stable oligomers in cell culture. J Biol Chem. 1995;270:9564–70. doi:10.1074/jbc.270.16.9564.
-
(1995)
J Biol Chem
, vol.270
, pp. 9564-9570
-
-
Podlisny, M.B.1
Ostaszewski, B.L.2
Squazzo, S.L.3
Koo, E.H.4
Rydell, R.E.5
Teplow, D.B.6
Selkoe, D.J.7
-
57
-
-
84910004657
-
LRRK2 delays degradative receptor trafficking by impeding late endosomal budding through decreasing Rab7 activity
-
Gómez-Suaga P, Rivero-Ríos P, Fdez E, Ramírez MB, Ferrer I, Aiastui A, López De Munain A, Hilfiker S. LRRK2 delays degradative receptor trafficking by impeding late endosomal budding through decreasing Rab7 activity. Hum Mol Genet. 2014;23:6779–96. doi:10.1093/hmg/ddu395.
-
(2014)
Hum Mol Genet
, vol.23
, pp. 6779-6796
-
-
Gómez-Suaga, P.1
Rivero-Ríos, P.2
Fdez, E.3
Ramírez, M.B.4
Ferrer, I.5
Aiastui, A.6
López De Munain, A.7
Hilfiker, S.8
|