-
1
-
-
84883138799
-
Nuclear calcium signalling in the regulation of brain function
-
Bading H. Nuclear calcium signalling in the regulation of brain function. Nat. Rev. Neurosci. 2013, 14:593-608.
-
(2013)
Nat. Rev. Neurosci.
, vol.14
, pp. 593-608
-
-
Bading, H.1
-
2
-
-
0035943525
-
Genetic polymorphism in the cathepsin G gene and the risk of Alzheimer's disease
-
Bhojak T.J., DeKosky S.T., Ganguli M., Kamboh M.I. Genetic polymorphism in the cathepsin G gene and the risk of Alzheimer's disease. Neurosci. Lett. 2001, 309:138-140.
-
(2001)
Neurosci. Lett.
, vol.309
, pp. 138-140
-
-
Bhojak, T.J.1
DeKosky, S.T.2
Ganguli, M.3
Kamboh, M.I.4
-
3
-
-
0030836345
-
Increased neuronal endocytosis and protease delivery to early endosomes in sporadic Alzheimer's disease: neuropathologic evidence for a mechanism of increased beta-amyloidogenesis
-
Cataldo A.M., Barnett J.L., Pieroni C., Nixon R.A. Increased neuronal endocytosis and protease delivery to early endosomes in sporadic Alzheimer's disease: neuropathologic evidence for a mechanism of increased beta-amyloidogenesis. J. Neurosci. 1997, 17:6142-6151.
-
(1997)
J. Neurosci.
, vol.17
, pp. 6142-6151
-
-
Cataldo, A.M.1
Barnett, J.L.2
Pieroni, C.3
Nixon, R.A.4
-
4
-
-
62149125434
-
Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling
-
Chambers S.M., Fasano C.A., Papapetrou E.P., Tomishima M., Sadelain M., Studer L. Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling. Nat. Biotechnol. 2009, 27:275-280.
-
(2009)
Nat. Biotechnol.
, vol.27
, pp. 275-280
-
-
Chambers, S.M.1
Fasano, C.A.2
Papapetrou, E.P.3
Tomishima, M.4
Sadelain, M.5
Studer, L.6
-
5
-
-
84907991157
-
The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1
-
Chantranupong L., Wolfson R.L., Orozco J.M., Saxton R.A., Scaria S.M., Bar-Peled L., Spooner E., Isasa M., Gygi S.P., Sabatini D.M. The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1. Cell Rep. 2014, 9:1-8.
-
(2014)
Cell Rep.
, vol.9
, pp. 1-8
-
-
Chantranupong, L.1
Wolfson, R.L.2
Orozco, J.M.3
Saxton, R.A.4
Scaria, S.M.5
Bar-Peled, L.6
Spooner, E.7
Isasa, M.8
Gygi, S.P.9
Sabatini, D.M.10
-
6
-
-
84880427381
-
Ultrasensitive fluorescent proteins for imaging neuronal activity
-
Chen T.-W., Wardill T.J., Sun Y., Pulver S.R., Renninger S.L., Baohan A., Schreiter E.R., Kerr R.A., Orger M.B., Jayaraman V., et al. Ultrasensitive fluorescent proteins for imaging neuronal activity. Nature 2013, 499:295-300.
-
(2013)
Nature
, vol.499
, pp. 295-300
-
-
Chen, T.-W.1
Wardill, T.J.2
Sun, Y.3
Pulver, S.R.4
Renninger, S.L.5
Baohan, A.6
Schreiter, E.R.7
Kerr, R.A.8
Orger, M.B.9
Jayaraman, V.10
-
7
-
-
84865086929
-
Lysosomal calcium homeostasis defects, not proton pump defects, cause endo-lysosomal dysfunction in PSEN-deficient cells
-
Coen K., Flannagan R.S., Baron S., Carraro-Lacroix L.R., Wang D., Vermeire W., Michiels C., Munck S., Baert V., Sugita S., et al. Lysosomal calcium homeostasis defects, not proton pump defects, cause endo-lysosomal dysfunction in PSEN-deficient cells. J. Cell Biol. 2012, 198:23-35.
-
(2012)
J. Cell Biol.
, vol.198
, pp. 23-35
-
-
Coen, K.1
Flannagan, R.S.2
Baron, S.3
Carraro-Lacroix, L.R.4
Wang, D.5
Vermeire, W.6
Michiels, C.7
Munck, S.8
Baert, V.9
Sugita, S.10
-
8
-
-
84894212463
-
Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2
-
Demetriades C., Doumpas N., Teleman A.A. Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2. Cell 2014, 156:786-799.
-
(2014)
Cell
, vol.156
, pp. 786-799
-
-
Demetriades, C.1
Doumpas, N.2
Teleman, A.A.3
-
9
-
-
84355162786
-
Endocytic control of growth factor signalling: multivesicular bodies as signalling organelles
-
Dobrowolski R., De Robertis E.M. Endocytic control of growth factor signalling: multivesicular bodies as signalling organelles. Nat. Rev. Mol. Cell Biol. 2011, 13:53-60.
-
(2011)
Nat. Rev. Mol. Cell Biol.
, vol.13
, pp. 53-60
-
-
Dobrowolski, R.1
De Robertis, E.M.2
-
10
-
-
84870407757
-
Presenilin deficiency or lysosomal inhibition enhances Wnt signaling through relocalization of GSK3 to the late-endosomal compartment
-
Dobrowolski R., Vick P., Ploper D., Gumper I., Snitkin H., Sabatini D.D., De Robertis E.M. Presenilin deficiency or lysosomal inhibition enhances Wnt signaling through relocalization of GSK3 to the late-endosomal compartment. Cell Rep. 2012, 2:1316-1328.
-
(2012)
Cell Rep.
, vol.2
, pp. 1316-1328
-
-
Dobrowolski, R.1
Vick, P.2
Ploper, D.3
Gumper, I.4
Snitkin, H.5
Sabatini, D.D.6
De Robertis, E.M.7
-
11
-
-
84891014899
-
The return of the nucleus: transcriptional and epigenetic control of autophagy
-
Füllgrabe J., Klionsky D.J., Joseph B. The return of the nucleus: transcriptional and epigenetic control of autophagy. Nat. Rev. Mol. Cell Biol. 2014, 15:65-74.
-
(2014)
Nat. Rev. Mol. Cell Biol.
, vol.15
, pp. 65-74
-
-
Füllgrabe, J.1
Klionsky, D.J.2
Joseph, B.3
-
13
-
-
0043127125
-
Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
-
Inoki K., Li Y., Xu T., Guan K.L. Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev. 2003, 17:1829-1834.
-
(2003)
Genes Dev.
, vol.17
, pp. 1829-1834
-
-
Inoki, K.1
Li, Y.2
Xu, T.3
Guan, K.L.4
-
14
-
-
0037145062
-
Presenilin couples the paired phosphorylation of beta-catenin independent of axin: implications for beta-catenin activation in tumorigenesis
-
Kang D.E., Soriano S., Xia X., Eberhart C.G., De Strooper B., Zheng H., Koo E.H. Presenilin couples the paired phosphorylation of beta-catenin independent of axin: implications for beta-catenin activation in tumorigenesis. Cell 2002, 110:751-762.
-
(2002)
Cell
, vol.110
, pp. 751-762
-
-
Kang, D.E.1
Soriano, S.2
Xia, X.3
Eberhart, C.G.4
De Strooper, B.5
Zheng, H.6
Koo, E.H.7
-
15
-
-
34548077575
-
Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3
-
Kimura S., Noda T., Yoshimori T. Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3. Autophagy 2007, 3:452-460.
-
(2007)
Autophagy
, vol.3
, pp. 452-460
-
-
Kimura, S.1
Noda, T.2
Yoshimori, T.3
-
16
-
-
33646800306
-
Loss of autophagy in the central nervous system causes neurodegeneration in mice
-
Komatsu M., Waguri S., Chiba T., Murata S., Iwata J., Tanida I., Ueno T., Koike M., Uchiyama Y., Kominami E., Tanaka K. Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature 2006, 441:880-884.
-
(2006)
Nature
, vol.441
, pp. 880-884
-
-
Komatsu, M.1
Waguri, S.2
Chiba, T.3
Murata, S.4
Iwata, J.5
Tanida, I.6
Ueno, T.7
Koike, M.8
Uchiyama, Y.9
Kominami, E.10
Tanaka, K.11
-
17
-
-
84859778293
-
MTOR signaling in growth control and disease
-
Laplante M., Sabatini D.M. mTOR signaling in growth control and disease. Cell 2012, 149:274-293.
-
(2012)
Cell
, vol.149
, pp. 274-293
-
-
Laplante, M.1
Sabatini, D.M.2
-
18
-
-
77953913051
-
Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations
-
Lee J.H., Yu W.H., Kumar A., Lee S., Mohan P.S., Peterhoff C.M., Wolfe D.M., Martinez-Vicente M., Massey A.C., Sovak G., et al. Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations. Cell 2010, 141:1146-1158.
-
(2010)
Cell
, vol.141
, pp. 1146-1158
-
-
Lee, J.H.1
Yu, W.H.2
Kumar, A.3
Lee, S.4
Mohan, P.S.5
Peterhoff, C.M.6
Wolfe, D.M.7
Martinez-Vicente, M.8
Massey, A.C.9
Sovak, G.10
-
19
-
-
77956274584
-
Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease
-
Lipinski M.M., Zheng B., Lu T., Yan Z., Py B.F., Ng A., Xavier R.J., Li C., Yankner B.A., Scherzer C.R., Yuan J. Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease. Proc. Natl. Acad. Sci. USA 2010, 107:14164-14169.
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 14164-14169
-
-
Lipinski, M.M.1
Zheng, B.2
Lu, T.3
Yan, Z.4
Py, B.F.5
Ng, A.6
Xavier, R.J.7
Li, C.8
Yankner, B.A.9
Scherzer, C.R.10
Yuan, J.11
-
20
-
-
0012510759
-
Amyloid plaque core protein in Alzheimer disease and Down syndrome
-
Masters C.L., Simms G., Weinman N.A., Multhaup G., McDonald B.L., Beyreuther K. Amyloid plaque core protein in Alzheimer disease and Down syndrome. Proc. Natl. Acad. Sci. USA 1985, 82:4245-4249.
-
(1985)
Proc. Natl. Acad. Sci. USA
, vol.82
, pp. 4245-4249
-
-
Masters, C.L.1
Simms, G.2
Weinman, N.A.3
Multhaup, G.4
McDonald, B.L.5
Beyreuther, K.6
-
21
-
-
84887863225
-
Lysosome and calcium dysregulation in Alzheimer's disease: partners in crime
-
McBrayer M., Nixon R.A. Lysosome and calcium dysregulation in Alzheimer's disease: partners in crime. Biochem. Soc. Trans. 2013, 41:1495-1502.
-
(2013)
Biochem. Soc. Trans.
, vol.41
, pp. 1495-1502
-
-
McBrayer, M.1
Nixon, R.A.2
-
22
-
-
84923820926
-
Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB
-
Medina D.L., Di Paola S., Peluso I., Armani A., De Stefani D., Venditti R., Montefusco S., Scotto-Rosato A., Prezioso C., Forrester A., et al. Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB. Nat. Cell Biol. 2015, 17:288-299.
-
(2015)
Nat. Cell Biol.
, vol.17
, pp. 288-299
-
-
Medina, D.L.1
Di Paola, S.2
Peluso, I.3
Armani, A.4
De Stefani, D.5
Venditti, R.6
Montefusco, S.7
Scotto-Rosato, A.8
Prezioso, C.9
Forrester, A.10
-
23
-
-
70349660072
-
The 50th anniversary of the discovery of trisomy 21: the past, present, and future of research and treatment of Down syndrome
-
Mégarbané A., Ravel A., Mircher C., Sturtz F., Grattau Y., Rethoré M.-O., Delabar J.-M., Mobley W.C. The 50th anniversary of the discovery of trisomy 21: the past, present, and future of research and treatment of Down syndrome. Genet. Med. 2009, 11:611-616.
-
(2009)
Genet. Med.
, vol.11
, pp. 611-616
-
-
Mégarbané, A.1
Ravel, A.2
Mircher, C.3
Sturtz, F.4
Grattau, Y.5
Rethoré, M.-O.6
Delabar, J.-M.7
Mobley, W.C.8
-
24
-
-
84894114029
-
Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome
-
Menon S., Dibble C.C., Talbott G., Hoxhaj G., Valvezan A.J., Takahashi H., Cantley L.C., Manning B.D. Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome. Cell 2014, 156:771-785.
-
(2014)
Cell
, vol.156
, pp. 771-785
-
-
Menon, S.1
Dibble, C.C.2
Talbott, G.3
Hoxhaj, G.4
Valvezan, A.J.5
Takahashi, H.6
Cantley, L.C.7
Manning, B.D.8
-
25
-
-
36549043900
-
Cystatin C inhibits amyloid-beta deposition in Alzheimer's disease mouse models
-
Mi W., Pawlik M., Sastre M., Jung S.S., Radvinsky D.S., Klein A.M., Sommer J., Schmidt S.D., Nixon R.A., Mathews P.M., Levy E. Cystatin C inhibits amyloid-beta deposition in Alzheimer's disease mouse models. Nat. Genet. 2007, 39:1440-1442.
-
(2007)
Nat. Genet.
, vol.39
, pp. 1440-1442
-
-
Mi, W.1
Pawlik, M.2
Sastre, M.3
Jung, S.S.4
Radvinsky, D.S.5
Klein, A.M.6
Sommer, J.7
Schmidt, S.D.8
Nixon, R.A.9
Mathews, P.M.10
Levy, E.11
-
26
-
-
79951985639
-
Presenilin is necessary for efficient proteolysis through the autophagy-lysosome system in a γ-secretase-independent manner
-
Neely K.M., Green K.N., LaFerla F.M. Presenilin is necessary for efficient proteolysis through the autophagy-lysosome system in a γ-secretase-independent manner. J. Neurosci. 2011, 31:2781-2791.
-
(2011)
J. Neurosci.
, vol.31
, pp. 2781-2791
-
-
Neely, K.M.1
Green, K.N.2
LaFerla, F.M.3
-
27
-
-
84882254367
-
The role of autophagy in neurodegenerative disease
-
Nixon R.A. The role of autophagy in neurodegenerative disease. Nat. Med. 2013, 19:983-997.
-
(2013)
Nat. Med.
, vol.19
, pp. 983-997
-
-
Nixon, R.A.1
-
28
-
-
79955969705
-
Autophagy failure in Alzheimer's disease--locating the primary defect
-
Nixon R.A., Yang D.S. Autophagy failure in Alzheimer's disease--locating the primary defect. Neurobiol. Dis. 2011, 43:38-45.
-
(2011)
Neurobiol. Dis.
, vol.43
, pp. 38-45
-
-
Nixon, R.A.1
Yang, D.S.2
-
29
-
-
14844303381
-
Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study
-
Nixon R.A., Wegiel J., Kumar A., Yu W.H., Peterhoff C., Cataldo A., Cuervo A.M. Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study. J. Neuropathol. Exp. Neurol. 2005, 64:113-122.
-
(2005)
J. Neuropathol. Exp. Neurol.
, vol.64
, pp. 113-122
-
-
Nixon, R.A.1
Wegiel, J.2
Kumar, A.3
Yu, W.H.4
Peterhoff, C.5
Cataldo, A.6
Cuervo, A.M.7
-
31
-
-
0033548409
-
Genetic polymorphism of cathepsin D is strongly associated with the risk for developing sporadic Alzheimer's disease
-
Papassotiropoulos A., Bagli M., Feder O., Jessen F., Maier W., Rao M.L., Ludwig M., Schwab S.G., Heun R. Genetic polymorphism of cathepsin D is strongly associated with the risk for developing sporadic Alzheimer's disease. Neurosci. Lett. 1999, 262:171-174.
-
(1999)
Neurosci. Lett.
, vol.262
, pp. 171-174
-
-
Papassotiropoulos, A.1
Bagli, M.2
Feder, O.3
Jessen, F.4
Maier, W.5
Rao, M.L.6
Ludwig, M.7
Schwab, S.G.8
Heun, R.9
-
32
-
-
84907525131
-
Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling
-
Peng M., Yin N., Li M.O. Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling. Cell 2014, 159:122-133.
-
(2014)
Cell
, vol.159
, pp. 122-133
-
-
Peng, M.1
Yin, N.2
Li, M.O.3
-
33
-
-
84925511980
-
Early etiology of Alzheimer's disease: tipping the balance toward autophagy or endosomal dysfunction?
-
Peric A., Annaert W. Early etiology of Alzheimer's disease: tipping the balance toward autophagy or endosomal dysfunction?. Acta Neuropathol. 2015, 129:363-381.
-
(2015)
Acta Neuropathol.
, vol.129
, pp. 363-381
-
-
Peric, A.1
Annaert, W.2
-
34
-
-
84916928995
-
Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EB
-
Polito V.A., Li H., Martini-Stoica H., Wang B., Yang L., Xu Y., Swartzlander D.B., Palmieri M., di Ronza A., Lee V.M.-Y., et al. Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EB. EMBO Mol. Med. 2014, 6:1142-1160.
-
(2014)
EMBO Mol. Med.
, vol.6
, pp. 1142-1160
-
-
Polito, V.A.1
Li, H.2
Martini-Stoica, H.3
Wang, B.4
Yang, L.5
Xu, Y.6
Swartzlander, D.B.7
Palmieri, M.8
di Ronza, A.9
Lee, V.M.-Y.10
-
35
-
-
84885072179
-
Role of endoplasmic reticulum Ca2+ signaling in the pathogenesis of Alzheimer disease
-
Popugaeva E., Bezprozvanny I. Role of endoplasmic reticulum Ca2+ signaling in the pathogenesis of Alzheimer disease. Front. Mol. Neurosci. 2013, 6:29.
-
(2013)
Front. Mol. Neurosci.
, vol.6
, pp. 29
-
-
Popugaeva, E.1
Bezprozvanny, I.2
-
36
-
-
0021945545
-
Calcium ionophore A23187 induces expression of glucose-regulated genes and their heterologous fusion genes
-
Resendez E., Attenello J.W., Grafsky A., Chang C.S., Lee A.S. Calcium ionophore A23187 induces expression of glucose-regulated genes and their heterologous fusion genes. Mol. Cell. Biol. 1985, 5:1212-1219.
-
(1985)
Mol. Cell. Biol.
, vol.5
, pp. 1212-1219
-
-
Resendez, E.1
Attenello, J.W.2
Grafsky, A.3
Chang, C.S.4
Lee, A.S.5
-
37
-
-
45849105156
-
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
-
Sancak Y., Peterson T.R., Shaul Y.D., Lindquist R.A., Thoreen C.C., Bar-Peled L., Sabatini D.M. The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science 2008, 320:1496-1501.
-
(2008)
Science
, vol.320
, pp. 1496-1501
-
-
Sancak, Y.1
Peterson, T.R.2
Shaul, Y.D.3
Lindquist, R.A.4
Thoreen, C.C.5
Bar-Peled, L.6
Sabatini, D.M.7
-
38
-
-
77951768486
-
Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
-
Sancak Y., Bar-Peled L., Zoncu R., Markhard A.L., Nada S., Sabatini D.M. Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell 2010, 141:290-303.
-
(2010)
Cell
, vol.141
, pp. 290-303
-
-
Sancak, Y.1
Bar-Peled, L.2
Zoncu, R.3
Markhard, A.L.4
Nada, S.5
Sabatini, D.M.6
-
39
-
-
67749122634
-
A gene network regulating lysosomal biogenesis and function
-
Sardiello M., Palmieri M., di Ronza A., Medina D.L., Valenza M., Gennarino V.A., Di Malta C., Donaudy F., Embrione V., Polishchuk R.S., et al. A gene network regulating lysosomal biogenesis and function. Science 2009, 325:473-477.
-
(2009)
Science
, vol.325
, pp. 473-477
-
-
Sardiello, M.1
Palmieri, M.2
di Ronza, A.3
Medina, D.L.4
Valenza, M.5
Gennarino, V.A.6
Di Malta, C.7
Donaudy, F.8
Embrione, V.9
Polishchuk, R.S.10
-
40
-
-
84857997408
-
A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB
-
Settembre C., Zoncu R., Medina D.L., Vetrini F., Erdin S., Erdin S., Huynh T., Ferron M., Karsenty G., Vellard M.C., et al. A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB. EMBO J. 2012, 31:1095-1108.
-
(2012)
EMBO J.
, vol.31
, pp. 1095-1108
-
-
Settembre, C.1
Zoncu, R.2
Medina, D.L.3
Vetrini, F.4
Erdin, S.5
Erdin, S.6
Huynh, T.7
Ferron, M.8
Karsenty, G.9
Vellard, M.C.10
-
41
-
-
84876812269
-
Signals from the lysosome: a control centre for cellular clearance and energy metabolism
-
Settembre C., Fraldi A., Medina D.L., Ballabio A. Signals from the lysosome: a control centre for cellular clearance and energy metabolism. Nat. Rev. Mol. Cell Biol. 2013, 14:283-296.
-
(2013)
Nat. Rev. Mol. Cell Biol.
, vol.14
, pp. 283-296
-
-
Settembre, C.1
Fraldi, A.2
Medina, D.L.3
Ballabio, A.4
-
42
-
-
69249137477
-
Endocytosis and signalling: intertwining molecular networks
-
Sorkin A., von Zastrow M. Endocytosis and signalling: intertwining molecular networks. Nat. Rev. Mol. Cell Biol. 2009, 10:609-622.
-
(2009)
Nat. Rev. Mol. Cell Biol.
, vol.10
, pp. 609-622
-
-
Sorkin, A.1
von Zastrow, M.2
-
43
-
-
84897136184
-
Characterization and molecular profiling of PSEN1 familial Alzheimer's disease iPSC-derived neural progenitors
-
Sproul A.A., Jacob S., Pre D., Kim S.H., Nestor M.W., Navarro-Sobrino M., Santa-Maria I., Zimmer M., Aubry S., Steele J.W., et al. Characterization and molecular profiling of PSEN1 familial Alzheimer's disease iPSC-derived neural progenitors. PLoS ONE 2014, 9:e84547.
-
(2014)
PLoS ONE
, vol.9
, pp. e84547
-
-
Sproul, A.A.1
Jacob, S.2
Pre, D.3
Kim, S.H.4
Nestor, M.W.5
Navarro-Sobrino, M.6
Santa-Maria, I.7
Zimmer, M.8
Aubry, S.9
Steele, J.W.10
-
44
-
-
78650484935
-
Wnt signaling requires sequestration of glycogen synthase kinase 3 inside multivesicular endosomes
-
Taelman V.F., Dobrowolski R., Plouhinec J.L., Fuentealba L.C., Vorwald P.P., Gumper I., Sabatini D.D., De Robertis E.M. Wnt signaling requires sequestration of glycogen synthase kinase 3 inside multivesicular endosomes. Cell 2010, 143:1136-1148.
-
(2010)
Cell
, vol.143
, pp. 1136-1148
-
-
Taelman, V.F.1
Dobrowolski, R.2
Plouhinec, J.L.3
Fuentealba, L.C.4
Vorwald, P.P.5
Gumper, I.6
Sabatini, D.D.7
De Robertis, E.M.8
-
45
-
-
0036827031
-
Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology
-
Takahashi R.H., Milner T.A., Li F., Nam E.E., Edgar M.A., Yamaguchi H., Beal M.F., Xu H., Greengard P., Gouras G.K. Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology. Am. J. Pathol. 2002, 161:1869-1879.
-
(2002)
Am. J. Pathol.
, vol.161
, pp. 1869-1879
-
-
Takahashi, R.H.1
Milner, T.A.2
Li, F.3
Nam, E.E.4
Edgar, M.A.5
Yamaguchi, H.6
Beal, M.F.7
Xu, H.8
Greengard, P.9
Gouras, G.K.10
-
46
-
-
0042701991
-
Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb
-
Tee A.R., Manning B.D., Roux P.P., Cantley L.C., Blenis J. Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb. Curr. Biol. 2003, 13:1259-1268.
-
(2003)
Curr. Biol.
, vol.13
, pp. 1259-1268
-
-
Tee, A.R.1
Manning, B.D.2
Roux, P.P.3
Cantley, L.C.4
Blenis, J.5
-
47
-
-
33748140720
-
Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations
-
Tu H., Nelson O., Bezprozvanny A., Wang Z., Lee S.F., Hao Y.H., Serneels L., De Strooper B., Yu G., Bezprozvanny I. Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations. Cell 2006, 126:981-993.
-
(2006)
Cell
, vol.126
, pp. 981-993
-
-
Tu, H.1
Nelson, O.2
Bezprozvanny, A.3
Wang, Z.4
Lee, S.F.5
Hao, Y.H.6
Serneels, L.7
De Strooper, B.8
Yu, G.9
Bezprozvanny, I.10
-
48
-
-
70449523262
-
Analysis of the gamma-secretase interactome and validation of its association with tetraspanin-enriched microdomains
-
Wakabayashi T., Craessaerts K., Bammens L., Bentahir M., Borgions F., Herdewijn P., Staes A., Timmerman E., Vandekerckhove J., Rubinstein E., et al. Analysis of the gamma-secretase interactome and validation of its association with tetraspanin-enriched microdomains. Nat. Cell Biol. 2009, 11:1340-1346.
-
(2009)
Nat. Cell Biol.
, vol.11
, pp. 1340-1346
-
-
Wakabayashi, T.1
Craessaerts, K.2
Bammens, L.3
Bentahir, M.4
Borgions, F.5
Herdewijn, P.6
Staes, A.7
Timmerman, E.8
Vandekerckhove, J.9
Rubinstein, E.10
-
49
-
-
84904354536
-
Enhancing astrocytic lysosome biogenesis facilitates Aβ clearance and attenuates amyloid plaque pathogenesis
-
Xiao Q., Yan P., Ma X., Liu H., Perez R., Zhu A., Gonzales E., Burchett J.M., Schuler D.R., Cirrito J.R., et al. Enhancing astrocytic lysosome biogenesis facilitates Aβ clearance and attenuates amyloid plaque pathogenesis. J. Neurosci. 2014, 34:9607-9620.
-
(2014)
J. Neurosci.
, vol.34
, pp. 9607-9620
-
-
Xiao, Q.1
Yan, P.2
Ma, X.3
Liu, H.4
Perez, R.5
Zhu, A.6
Gonzales, E.7
Burchett, J.M.8
Schuler, D.R.9
Cirrito, J.R.10
-
50
-
-
78650716872
-
Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits
-
Yang D.S., Stavrides P., Mohan P.S., Kaushik S., Kumar A., Ohno M., Schmidt S.D., Wesson D., Bandyopadhyay U., Jiang Y., et al. Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits. Brain 2011, 134:258-277.
-
(2011)
Brain
, vol.134
, pp. 258-277
-
-
Yang, D.S.1
Stavrides, P.2
Mohan, P.S.3
Kaushik, S.4
Kumar, A.5
Ohno, M.6
Schmidt, S.D.7
Wesson, D.8
Bandyopadhyay, U.9
Jiang, Y.10
-
51
-
-
84922368172
-
Defective macroautophagic turnover of brain lipids in the TgCRND8 Alzheimer mouse model: prevention by correcting lysosomal proteolytic deficits
-
Yang D.-S., Stavrides P., Saito M., Kumar A., Rodriguez-Navarro J.A., Pawlik M., Huo C., Walkley S.U., Saito M., Cuervo A.M., Nixon R.A. Defective macroautophagic turnover of brain lipids in the TgCRND8 Alzheimer mouse model: prevention by correcting lysosomal proteolytic deficits. Brain 2014, 137:3300-3318.
-
(2014)
Brain
, vol.137
, pp. 3300-3318
-
-
Yang, D.-S.1
Stavrides, P.2
Saito, M.3
Kumar, A.4
Rodriguez-Navarro, J.A.5
Pawlik, M.6
Huo, C.7
Walkley, S.U.8
Saito, M.9
Cuervo, A.M.10
Nixon, R.A.11
-
52
-
-
85005916271
-
Dysfunction of the mTOR pathway is a risk factor for Alzheimer's disease
-
Yates S.C., Zafar A., Hubbard P., Nagy S., Durant S., Bicknell R., Wilcock G., Christie S., Esiri M.M., Smith A.D., Nagy Z. Dysfunction of the mTOR pathway is a risk factor for Alzheimer's disease. Acta Neuropathol. Commun. 2013, 1:3.
-
(2013)
Acta Neuropathol. Commun.
, vol.1
, pp. 3
-
-
Yates, S.C.1
Zafar, A.2
Hubbard, P.3
Nagy, S.4
Durant, S.5
Bicknell, R.6
Wilcock, G.7
Christie, S.8
Esiri, M.M.9
Smith, A.D.10
Nagy, Z.11
-
53
-
-
70149106202
-
Nuclear calcium signaling controls expression of a large gene pool: identification of a gene program for acquired neuroprotection induced by synaptic activity
-
Zhang S.-J., Zou M., Lu L., Lau D., Ditzel D.A.W., Delucinge-Vivier C., Aso Y., Descombes P., Bading H. Nuclear calcium signaling controls expression of a large gene pool: identification of a gene program for acquired neuroprotection induced by synaptic activity. PLoS Genet. 2009, 5:e1000604.
-
(2009)
PLoS Genet.
, vol.5
, pp. e1000604
-
-
Zhang, S.-J.1
Zou, M.2
Lu, L.3
Lau, D.4
Ditzel, D.A.W.5
Delucinge-Vivier, C.6
Aso, Y.7
Descombes, P.8
Bading, H.9
-
54
-
-
84862883617
-
A role for presenilins in autophagy revisited: normal acidification of lysosomes in cells lacking PSEN1 and PSEN2
-
Zhang X., Garbett K., Veeraraghavalu K., Wilburn B., Gilmore R., Mirnics K., Sisodia S.S. A role for presenilins in autophagy revisited: normal acidification of lysosomes in cells lacking PSEN1 and PSEN2. J. Neurosci. 2012, 32:8633-8648.
-
(2012)
J. Neurosci.
, vol.32
, pp. 8633-8648
-
-
Zhang, X.1
Garbett, K.2
Veeraraghavalu, K.3
Wilburn, B.4
Gilmore, R.5
Mirnics, K.6
Sisodia, S.S.7
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