-
1
-
-
0023838532
-
Immunochemical identification of the serine protease inhibitor alpha 1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease
-
3257719
-
Abraham CR, Selkoe DJ, Potter H. Immunochemical identification of the serine protease inhibitor alpha 1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease. Cell 1988, 52:487-501. 10.1016/0092-8674(88)90462-X, 3257719.
-
(1988)
Cell
, vol.52
, pp. 487-501
-
-
Abraham, C.R.1
Selkoe, D.J.2
Potter, H.3
-
2
-
-
0023757471
-
Immune system associated antigens expressed by cells of the human central nervous system
-
3266526
-
Luber-Narod J, Rogers J. Immune system associated antigens expressed by cells of the human central nervous system. Neurosci Lett 1988, 94:17-22. 10.1016/0304-3940(88)90263-7, 3266526.
-
(1988)
Neurosci Lett
, vol.94
, pp. 17-22
-
-
Luber-Narod, J.1
Rogers, J.2
-
3
-
-
0023782375
-
Expression of the histocompatibility glycoprotein HLA-DR in neurological disease
-
2974227
-
McGeer PL, Itagaki S, McGeer EG. Expression of the histocompatibility glycoprotein HLA-DR in neurological disease. Acta Neuropathol 1988, 76:550-557. 10.1007/BF00689592, 2974227.
-
(1988)
Acta Neuropathol
, vol.76
, pp. 550-557
-
-
McGeer, P.L.1
Itagaki, S.2
McGeer, E.G.3
-
4
-
-
0024157709
-
Expression of immune system-associated antigens by cells of the human central nervous system: relationship to the pathology of Alzheimer's disease
-
3263583
-
Rogers J, Luber-Narod J, Styren SD, Civin WH. Expression of immune system-associated antigens by cells of the human central nervous system: relationship to the pathology of Alzheimer's disease. Neurobiol Aging 1988, 9:339-349. 10.1016/S0197-4580(88)80079-4, 3263583.
-
(1988)
Neurobiol Aging
, vol.9
, pp. 339-349
-
-
Rogers, J.1
Luber-Narod, J.2
Styren, S.D.3
Civin, W.H.4
-
5
-
-
60849109489
-
Astroglia in dementia and Alzheimer's disease
-
19057621
-
Rodriguez JJ, Olabarria M, Chvatal A, Verkhratsky A. Astroglia in dementia and Alzheimer's disease. Cell Death Differ 2009, 16:378-385. 10.1038/cdd.2008.172, 19057621.
-
(2009)
Cell Death Differ
, vol.16
, pp. 378-385
-
-
Rodriguez, J.J.1
Olabarria, M.2
Chvatal, A.3
Verkhratsky, A.4
-
6
-
-
77955281765
-
Activated astroglia during chronic inflammation in Alzheimer's disease - do they neglect their neurosupportive roles?
-
19748514
-
Fuller S, Steele M, Munch G. Activated astroglia during chronic inflammation in Alzheimer's disease - do they neglect their neurosupportive roles?. Mutat Res 2010, 690:40-49. 10.1016/j.mrfmmm.2009.08.016, 19748514.
-
(2010)
Mutat Res
, vol.690
, pp. 40-49
-
-
Fuller, S.1
Steele, M.2
Munch, G.3
-
7
-
-
0037394788
-
-
Adult mouse astrocytes degrade amyloid-beta in vitro and in situ. Nat Med
-
Wyss-Coray T, Loike JD, Brionne TC, Lu E, Anankov R, Yan F, Silverstein SC, Husemann J: Adult mouse astrocytes degrade amyloid-beta in vitro and in situ. Nat Med 2003, 9:453-457.
-
(2003)
, vol.9
, pp. 453-457
-
-
Wyss-Coray, T.1
Loike, J.D.2
Brionne, T.C.3
Lu, E.4
Anankov, R.5
Yan, F.6
Silverstein, S.C.7
Husemann, J.8
-
8
-
-
84875655895
-
Inflammation in Alzheimer disease - a brief review of the basic science and clinical literature
-
22315714
-
Wyss-Coray T, Rogers J. Inflammation in Alzheimer disease - a brief review of the basic science and clinical literature. Cold Spring Harb Perspect Med 2012, 2:a006346. 10.1101/cshperspect.a006346, 22315714.
-
(2012)
Cold Spring Harb Perspect Med
, vol.2
, pp. a006346
-
-
Wyss-Coray, T.1
Rogers, J.2
-
9
-
-
74549169836
-
ER stress in Alzheimer's disease: a novel neuronal trigger for inflammation and Alzheimer's pathology
-
20035627
-
Salminen A, Kauppinen A, Suuronen T, Kaarniranta K, Ojala J. ER stress in Alzheimer's disease: a novel neuronal trigger for inflammation and Alzheimer's pathology. J Neuroinflammation 2009, 6:41. 10.1186/1742-2094-6-41, 20035627.
-
(2009)
J Neuroinflammation
, vol.6
, pp. 41
-
-
Salminen, A.1
Kauppinen, A.2
Suuronen, T.3
Kaarniranta, K.4
Ojala, J.5
-
10
-
-
77956961694
-
Neuroinflammatory processes in Alzheimer's disease
-
20632195
-
Heneka MT, O'Banion MK, Terwel D, Kummer MP. Neuroinflammatory processes in Alzheimer's disease. J Neural Transm 2010, 117:919-947. 10.1007/s00702-010-0438-z, 20632195.
-
(2010)
J Neural Transm
, vol.117
, pp. 919-947
-
-
Heneka, M.T.1
O'Banion, M.K.2
Terwel, D.3
Kummer, M.P.4
-
11
-
-
0034612175
-
Inflammation and Alzheimer's disease
-
10858586
-
Akiyama H, Barger S, Barnum S, Bradt B, Bauer J, Cole GM, Cooper NR, Eikelenboom P, Emmerling M, Fiebich BL, Finch CE, Frautschy S, Griffin WS, Hampel H, Hull M, Landreth G, Lue L, Mrak R, Mackenzie IR, McGeer PL, O'Banion MK, Pachter J, Pasinetti G, Plata-Salaman C, Rogers J, Rydel R, Shen Y, Streit W, Strohmeyer R, Tooyoma I, et al. Inflammation and Alzheimer's disease. Neurobiol Aging 2000, 21:383-421. 10.1016/S0197-4580(00)00124-X, 10858586.
-
(2000)
Neurobiol Aging
, vol.21
, pp. 383-421
-
-
Akiyama, H.1
Barger, S.2
Barnum, S.3
Bradt, B.4
Bauer, J.5
Cole, G.M.6
Cooper, N.R.7
Eikelenboom, P.8
Emmerling, M.9
Fiebich, B.L.10
Finch, C.E.11
Frautschy, S.12
Griffin, W.S.13
Hampel, H.14
Hull, M.15
Landreth, G.16
Lue, L.17
Mrak, R.18
Mackenzie, I.R.19
McGeer, P.L.20
O'Banion, M.K.21
Pachter, J.22
Pasinetti, G.23
Plata-Salaman, C.24
Rogers, J.25
Rydel, R.26
Shen, Y.27
Streit, W.28
Strohmeyer, R.29
Tooyoma, I.30
more..
-
12
-
-
84873087532
-
NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice
-
23254930
-
Heneka MT, Kummer MP, Stutz A, Delekate A, Schwartz S, Vieira-Saecker A, Griep A, Axt D, Remus A, Tzeng TC, Gelpi E, Halle A, Korte M, Latz E, Golenbock DT. NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice. Nature 2013, 493:674-678. 10.1038/nature11729, 23254930.
-
(2013)
Nature
, vol.493
, pp. 674-678
-
-
Heneka, M.T.1
Kummer, M.P.2
Stutz, A.3
Delekate, A.4
Schwartz, S.5
Vieira-Saecker, A.6
Griep, A.7
Axt, D.8
Remus, A.9
Tzeng, T.C.10
Gelpi, E.11
Halle, A.12
Korte, M.13
Latz, E.14
Golenbock, D.T.15
-
13
-
-
84877975754
-
The multifunctional anti-inflammatory drugs used in the therapy of Alzheimer's disease
-
23590711
-
Shi S, Wang Z, Qiao Z. The multifunctional anti-inflammatory drugs used in the therapy of Alzheimer's disease. Curr Med Chem 2013, 20:2583-2588. 10.2174/0929867311320200006, 23590711.
-
(2013)
Curr Med Chem
, vol.20
, pp. 2583-2588
-
-
Shi, S.1
Wang, Z.2
Qiao, Z.3
-
14
-
-
84861325911
-
Alzheimer's disease, autoimmunity and inflammation. The good, the bad and the ugly
-
21996556
-
Sardi F, Fassina L, Venturini L, Inguscio M, Guerriero F, Rolfo E, Ricevuti G. Alzheimer's disease, autoimmunity and inflammation. The good, the bad and the ugly. Autoimmun Rev 2011, 11:149-153. 10.1016/j.autrev.2011.09.005, 21996556.
-
(2011)
Autoimmun Rev
, vol.11
, pp. 149-153
-
-
Sardi, F.1
Fassina, L.2
Venturini, L.3
Inguscio, M.4
Guerriero, F.5
Rolfo, E.6
Ricevuti, G.7
-
15
-
-
68049118952
-
An update on the efficacy of non-steroidal anti-inflammatory drugs in Alzheimer's disease
-
19589092
-
Imbimbo BP. An update on the efficacy of non-steroidal anti-inflammatory drugs in Alzheimer's disease. Expert Opin Investig Drugs 2009, 18:1147-1168. 10.1517/13543780903066780, 19589092.
-
(2009)
Expert Opin Investig Drugs
, vol.18
, pp. 1147-1168
-
-
Imbimbo, B.P.1
-
16
-
-
84880921347
-
Autophagy and Crohn's disease
-
23328432
-
Nguyen HT, Lapaquette P, Bringer MA, Darfeuille-Michaud A. Autophagy and Crohn's disease. J Innate Immun 2013, 5:434-443. 10.1159/000345129, 23328432.
-
(2013)
J Innate Immun
, vol.5
, pp. 434-443
-
-
Nguyen, H.T.1
Lapaquette, P.2
Bringer, M.A.3
Darfeuille-Michaud, A.4
-
17
-
-
84855257058
-
A comprehensive analysis of shared loci between systemic lupus erythematosus (SLE) and sixteen autoimmune diseases reveals limited genetic overlap
-
22174698
-
Ramos PS, Criswell LA, Moser KL, Comeau ME, Williams AH, Pajewski NM, Chung SA, Graham RR, Zidovetzki R, Kelly JA, Kaufman KM, Jacob CO, Vyse TJ, Tsao BP, Kimberly RP, Gaffney PM, Alarcon-Riquelme ME, Harley JB, Langefeld CD. A comprehensive analysis of shared loci between systemic lupus erythematosus (SLE) and sixteen autoimmune diseases reveals limited genetic overlap. PLoS Genet 2011, 7:e1002406. 10.1371/journal.pgen.1002406, 22174698.
-
(2011)
PLoS Genet
, vol.7
, pp. e1002406
-
-
Ramos, P.S.1
Criswell, L.A.2
Moser, K.L.3
Comeau, M.E.4
Williams, A.H.5
Pajewski, N.M.6
Chung, S.A.7
Graham, R.R.8
Zidovetzki, R.9
Kelly, J.A.10
Kaufman, K.M.11
Jacob, C.O.12
Vyse, T.J.13
Tsao, B.P.14
Kimberly, R.P.15
Gaffney, P.M.16
Alarcon-Riquelme, M.E.17
Harley, J.B.18
Langefeld, C.D.19
-
18
-
-
84859951546
-
Functional variant in the autophagy-related 5 gene promotor is associated with childhood asthma
-
22536318
-
Martin LJ, Gupta J, Jyothula SS, Butsch Kovacic M, Biagini Myers JM, Patterson TL, Ericksen MB, He H, Gibson AM, Baye TM, Amirisetty S, Tsoras AM, Sha Y, Eissa NT, Hershey GK. Functional variant in the autophagy-related 5 gene promotor is associated with childhood asthma. PLoS One 2012, 7:e33454. 10.1371/journal.pone.0033454, 22536318.
-
(2012)
PLoS One
, vol.7
, pp. e33454
-
-
Martin, L.J.1
Gupta, J.2
Jyothula, S.S.3
Butsch Kovacic, M.4
Biagini Myers, J.M.5
Patterson, T.L.6
Ericksen, M.B.7
He, H.8
Gibson, A.M.9
Baye, T.M.10
Amirisetty, S.11
Tsoras, A.M.12
Sha, Y.13
Eissa, N.T.14
Hershey, G.K.15
-
19
-
-
70649086092
-
Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk
-
19898481
-
Raychaudhuri S, Thomson BP, Remmers EF, Eyre S, Hinks A, Guiducci C, Catanese JJ, Xie G, Stahl EA, Chen R, Alfredsson L, Amos CI, Ardlie KG, Barton A, Bowes J, Burtt NP, Chang M, Coblyn J, Costenbader KH, Criswell LA, Crusius JB, Cui J, De Jager PL, Ding B, Emery P, Flynn E, Harrison P, Hocking LJ, Huizinga TW, Kastner DL, et al. Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk. Nat Genet 2009, 41:1313-1318. 10.1038/ng.479, 19898481.
-
(2009)
Nat Genet
, vol.41
, pp. 1313-1318
-
-
Raychaudhuri, S.1
Thomson, B.P.2
Remmers, E.F.3
Eyre, S.4
Hinks, A.5
Guiducci, C.6
Catanese, J.J.7
Xie, G.8
Stahl, E.A.9
Chen, R.10
Alfredsson, L.11
Amos, C.I.12
Ardlie, K.G.13
Barton, A.14
Bowes, J.15
Burtt, N.P.16
Chang, M.17
Coblyn, J.18
Costenbader, K.H.19
Criswell, L.A.20
Crusius, J.B.21
Cui, J.22
De Jager, P.L.23
Ding, B.24
Emery, P.25
Flynn, E.26
Harrison, P.27
Hocking, L.J.28
Huizinga, T.W.29
Kastner, D.L.30
more..
-
20
-
-
84879604162
-
NF-kappaB-mediated induction of autophagy in cardiac ischemia/reperfusion injury
-
23727575
-
Zeng M, Wei X, Wu Z, Li W, Li B, Zhen Y, Chen J, Wang P, Fei Y. NF-kappaB-mediated induction of autophagy in cardiac ischemia/reperfusion injury. Biochem Biophys Res Commun 2013, 436:180-185. 10.1016/j.bbrc.2013.05.070, 23727575.
-
(2013)
Biochem Biophys Res Commun
, vol.436
, pp. 180-185
-
-
Zeng, M.1
Wei, X.2
Wu, Z.3
Li, W.4
Li, B.5
Zhen, Y.6
Chen, J.7
Wang, P.8
Fei, Y.9
-
21
-
-
34548700401
-
-
T helper 2 cytokines inhibit autophagic control of intracellular Mycobacterium tuberculosis. Immunity
-
Harris J, De Haro SA, Master SS, Keane J, Roberts EA, Delgado M, Deretic V: T helper 2 cytokines inhibit autophagic control of intracellular Mycobacterium tuberculosis. Immunity 2007, 27:505-517
-
(2007)
, vol.27
, pp. 505-517
-
-
Harris, J.1
De Haro, S.A.2
Master, S.S.3
Keane, J.4
Roberts, E.A.5
Delgado, M.6
Deretic, V.7
-
22
-
-
56249090667
-
Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production
-
18849965
-
Saitoh T, Fujita N, Jang MH, Uematsu S, Yang BG, Satoh T, Omori H, Noda T, Yamamoto N, Komatsu M, Tanaka K, Kawai T, Tsujimura T, Takeuchi O, Yoshimori T, Akira S. Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. Nature 2008, 456:264-268. 10.1038/nature07383, 18849965.
-
(2008)
Nature
, vol.456
, pp. 264-268
-
-
Saitoh, T.1
Fujita, N.2
Jang, M.H.3
Uematsu, S.4
Yang, B.G.5
Satoh, T.6
Omori, H.7
Noda, T.8
Yamamoto, N.9
Komatsu, M.10
Tanaka, K.11
Kawai, T.12
Tsujimura, T.13
Takeuchi, O.14
Yoshimori, T.15
Akira, S.16
-
23
-
-
79953176280
-
Autophagy controls IL-1beta secretion by targeting pro-IL-1beta for degradation
-
21228274
-
Harris J, Hartman M, Roche C, Zeng SG, O'Shea A, Sharp FA, Lambe EM, Creagh EM, Golenbock DT, Tschopp J, Kornfeld H, Fitzgerald KA, Lavelle EC. Autophagy controls IL-1beta secretion by targeting pro-IL-1beta for degradation. J Biol Chem 2011, 286:9587-9597. 10.1074/jbc.M110.202911, 21228274.
-
(2011)
J Biol Chem
, vol.286
, pp. 9587-9597
-
-
Harris, J.1
Hartman, M.2
Roche, C.3
Zeng, S.G.4
O'Shea, A.5
Sharp, F.A.6
Lambe, E.M.7
Creagh, E.M.8
Golenbock, D.T.9
Tschopp, J.10
Kornfeld, H.11
Fitzgerald, K.A.12
Lavelle, E.C.13
-
24
-
-
84857195479
-
Activation of autophagy by inflammatory signals limits IL-1beta production by targeting ubiquitinated inflammasomes for destruction
-
22286270
-
Shi CS, Shenderov K, Huang NN, Kabat J, Abu-Asab M, Fitzgerald KA, Sher A, Kehrl JH. Activation of autophagy by inflammatory signals limits IL-1beta production by targeting ubiquitinated inflammasomes for destruction. Nat Immunol 2012, 13:255-263. 10.1038/ni.2215, 22286270.
-
(2012)
Nat Immunol
, vol.13
, pp. 255-263
-
-
Shi, C.S.1
Shenderov, K.2
Huang, N.N.3
Kabat, J.4
Abu-Asab, M.5
Fitzgerald, K.A.6
Sher, A.7
Kehrl, J.H.8
-
25
-
-
84876439466
-
Negative regulation of NLRP3 inflammasome signaling
-
23519777
-
Chen S, Sun B. Negative regulation of NLRP3 inflammasome signaling. Protein Cell 2013, 4:251-258. 10.1007/s13238-013-2128-8, 23519777.
-
(2013)
Protein Cell
, vol.4
, pp. 251-258
-
-
Chen, S.1
Sun, B.2
-
26
-
-
84900420410
-
Crosstalk between autophagy and inflammasomes
-
24213677
-
Yuk JM, Jo EK. Crosstalk between autophagy and inflammasomes. Mol Cells 2013, 36:393-399. 10.1007/s10059-013-0298-0, 24213677.
-
(2013)
Mol Cells
, vol.36
, pp. 393-399
-
-
Yuk, J.M.1
Jo, E.K.2
-
27
-
-
33745192802
-
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
-
16625204
-
Hara T, Nakamura K, Matsui M, Yamamoto A, Nakahara Y, Suzuki-Migishima R, Yokoyama M, Mishima K, Saito I, Okano H, Mizushima N. Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature 2006, 441:885-889. 10.1038/nature04724, 16625204.
-
(2006)
Nature
, vol.441
, pp. 885-889
-
-
Hara, T.1
Nakamura, K.2
Matsui, M.3
Yamamoto, A.4
Nakahara, Y.5
Suzuki-Migishima, R.6
Yokoyama, M.7
Mishima, K.8
Saito, I.9
Okano, H.10
Mizushima, N.11
-
28
-
-
33748414185
-
Autophagy and neurodegeneration
-
16874063
-
Komatsu M, Kominami E, Tanaka K. Autophagy and neurodegeneration. Autophagy 2006, 2:315-317. 10.4161/auto.2974, 16874063.
-
(2006)
Autophagy
, vol.2
, pp. 315-317
-
-
Komatsu, M.1
Kominami, E.2
Tanaka, K.3
-
29
-
-
14844303381
-
Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study
-
15751225
-
Nixon RA, Wegiel J, Kumar A, Yu WH, Peterhoff C, Cataldo A, Cuervo AM. Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study. J Neuropathol Exp Neurol 2005, 64:113-122. 15751225.
-
(2005)
J Neuropathol Exp Neurol
, vol.64
, pp. 113-122
-
-
Nixon, R.A.1
Wegiel, J.2
Kumar, A.3
Yu, W.H.4
Peterhoff, C.5
Cataldo, A.6
Cuervo, A.M.7
-
30
-
-
26444587508
-
Macroautophagy - a novel beta-amyloid peptide-generating pathway activated in Alzheimer's disease
-
16203860
-
Yu WH, Cuervo AM, Kumar A, Peterhoff CM, Schmidt SD, Lee JH, Mohan PS, Mercken M, Farmery MR, Tjernberg LO, Jiang Y, Duff K, Uchiyama Y, Naslund J, Mathews PM, Cataldo AM, Nixon RA. Macroautophagy - a novel beta-amyloid peptide-generating pathway activated in Alzheimer's disease. J Cell Biol 2005, 171:87-98. 10.1083/jcb.200505082, 16203860.
-
(2005)
J Cell Biol
, vol.171
, pp. 87-98
-
-
Yu, W.H.1
Cuervo, A.M.2
Kumar, A.3
Peterhoff, C.M.4
Schmidt, S.D.5
Lee, J.H.6
Mohan, P.S.7
Mercken, M.8
Farmery, M.R.9
Tjernberg, L.O.10
Jiang, Y.11
Duff, K.12
Uchiyama, Y.13
Naslund, J.14
Mathews, P.M.15
Cataldo, A.M.16
Nixon, R.A.17
-
31
-
-
0033869715
-
Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutations
-
10880397
-
Cataldo AM, Peterhoff CM, Troncoso JC, Gomez-Isla T, Hyman BT, Nixon RA. Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutations. Am J Pathol 2000, 157:277-286. 10.1016/S0002-9440(10)64538-5, 10880397.
-
(2000)
Am J Pathol
, vol.157
, pp. 277-286
-
-
Cataldo, A.M.1
Peterhoff, C.M.2
Troncoso, J.C.3
Gomez-Isla, T.4
Hyman, B.T.5
Nixon, R.A.6
-
32
-
-
3843114301
-
Presenilin mutations in familial Alzheimer disease and transgenic mouse models accelerate neuronal lysosomal pathology
-
15330337
-
Cataldo AM, Peterhoff CM, Schmidt SD, Terio NB, Duff K, Beard M, Mathews PM, Nixon RA. Presenilin mutations in familial Alzheimer disease and transgenic mouse models accelerate neuronal lysosomal pathology. J Neuropathol Exp Neurol 2004, 63:821-830. 15330337.
-
(2004)
J Neuropathol Exp Neurol
, vol.63
, pp. 821-830
-
-
Cataldo, A.M.1
Peterhoff, C.M.2
Schmidt, S.D.3
Terio, N.B.4
Duff, K.5
Beard, M.6
Mathews, P.M.7
Nixon, R.A.8
-
33
-
-
38349046973
-
Autophagy, amyloidogenesis and Alzheimer disease
-
18032783
-
Nixon RA. Autophagy, amyloidogenesis and Alzheimer disease. J Cell Sci 2007, 120:4081-4091. 10.1242/jcs.019265, 18032783.
-
(2007)
J Cell Sci
, vol.120
, pp. 4081-4091
-
-
Nixon, R.A.1
-
34
-
-
49049096562
-
Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease
-
18596167
-
Boland B, Kumar A, Lee S, Platt FM, Wegiel J, Yu WH, Nixon RA. Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease. J Neurosci 2008, 28:6926-6937. 10.1523/JNEUROSCI.0800-08.2008, 18596167.
-
(2008)
J Neurosci
, vol.28
, pp. 6926-6937
-
-
Boland, B.1
Kumar, A.2
Lee, S.3
Platt, F.M.4
Wegiel, J.5
Yu, W.H.6
Nixon, R.A.7
-
35
-
-
45749114895
-
The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice
-
18497889
-
Pickford F, Masliah E, Britschgi M, Lucin K, Narasimhan R, Jaeger PA, Small S, Spencer B, Rockenstein E, Levine B, Wyss-Coray T. The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice. J Clin Invest 2008, 118:2190-2199. 18497889.
-
(2008)
J Clin Invest
, vol.118
, pp. 2190-2199
-
-
Pickford, F.1
Masliah, E.2
Britschgi, M.3
Lucin, K.4
Narasimhan, R.5
Jaeger, P.A.6
Small, S.7
Spencer, B.8
Rockenstein, E.9
Levine, B.10
Wyss-Coray, T.11
-
36
-
-
70350550208
-
Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases
-
19864570
-
Spencer B, Potkar R, Trejo M, Rockenstein E, Patrick C, Gindi R, Adame A, Wyss-Coray T, Masliah E. Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases. J Neurosci 2009, 29:13578-13588. 10.1523/JNEUROSCI.4390-09.2009, 19864570.
-
(2009)
J Neurosci
, vol.29
, pp. 13578-13588
-
-
Spencer, B.1
Potkar, R.2
Trejo, M.3
Rockenstein, E.4
Patrick, C.5
Gindi, R.6
Adame, A.7
Wyss-Coray, T.8
Masliah, E.9
-
37
-
-
73949145739
-
Amyloid deposition and inflammation in APPswe/PS1dE9 mouse model of Alzheimer's disease
-
19747158
-
Ruan L, Kang Z, Pei G, Le Y. Amyloid deposition and inflammation in APPswe/PS1dE9 mouse model of Alzheimer's disease. Curr Alzheimer Res 2009, 6:531-540. 10.2174/156720509790147070, 19747158.
-
(2009)
Curr Alzheimer Res
, vol.6
, pp. 531-540
-
-
Ruan, L.1
Kang, Z.2
Pei, G.3
Le, Y.4
-
38
-
-
84860285084
-
Pharmacological inhibition of PKR in APPswePS1dE9 mice transiently prevents inflammation at 12 months of age but increases Abeta42 levels in the late stages of the Alzheimer's disease
-
22272616
-
Couturier J, Paccalin M, Lafay-Chebassier C, Chalon S, Ingrand I, Pinguet J, Pontcharraud R, Guillard O, Fauconneau B, Page G. Pharmacological inhibition of PKR in APPswePS1dE9 mice transiently prevents inflammation at 12 months of age but increases Abeta42 levels in the late stages of the Alzheimer's disease. Curr Alzheimer Res 2012, 9:344-360. 10.2174/156720512800107582, 22272616.
-
(2012)
Curr Alzheimer Res
, vol.9
, pp. 344-360
-
-
Couturier, J.1
Paccalin, M.2
Lafay-Chebassier, C.3
Chalon, S.4
Ingrand, I.5
Pinguet, J.6
Pontcharraud, R.7
Guillard, O.8
Fauconneau, B.9
Page, G.10
-
39
-
-
78650239404
-
Functions and regulation of the 70 kDa ribosomal S6 kinases
-
20932932
-
Fenton TR, Gout IT. Functions and regulation of the 70 kDa ribosomal S6 kinases. Int J Biochem Cell Biol 2011, 43:47-59. 10.1016/j.biocel.2010.09.018, 20932932.
-
(2011)
Int J Biochem Cell Biol
, vol.43
, pp. 47-59
-
-
Fenton, T.R.1
Gout, I.T.2
-
40
-
-
79951529849
-
Mammalian target of rapamycin: hitting the bull's-eye for neurological disorders
-
21307646
-
Chong ZZ, Shang YC, Zhang L, Wang S, Maiese K. Mammalian target of rapamycin: hitting the bull's-eye for neurological disorders. Oxid Med Cell Longev 2010, 3:374-391. 10.4161/oxim.3.6.14787, 21307646.
-
(2010)
Oxid Med Cell Longev
, vol.3
, pp. 374-391
-
-
Chong, Z.Z.1
Shang, Y.C.2
Zhang, L.3
Wang, S.4
Maiese, K.5
-
41
-
-
79952628267
-
The Beclin 1 network regulates autophagy and apoptosis
-
21311563
-
Kang R, Zeh HJ, Lotze MT, Tang D. The Beclin 1 network regulates autophagy and apoptosis. Cell Death Differ 2011, 18:571-580. 10.1038/cdd.2010.191, 21311563.
-
(2011)
Cell Death Differ
, vol.18
, pp. 571-580
-
-
Kang, R.1
Zeh, H.J.2
Lotze, M.T.3
Tang, D.4
-
42
-
-
84862295360
-
Guidelines for the use and interpretation of assays for monitoring autophagy
-
22966490
-
Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, Al-Younes HM, Al-Zeer MA, Albert ML, Albin RL, Alegre-Abarrategui J, Aleo MF, Alirezaei M, Almasan A, Almonte-Becerril M, Amano A, Amaravadi R, Amarnath S, Amer AO, Andrieu-Abadie N, Anantharam V, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 2012, 8:445-544. 10.4161/auto.19496, 22966490.
-
(2012)
Autophagy
, vol.8
, pp. 445-544
-
-
Klionsky, D.J.1
Abdalla, F.C.2
Abeliovich, H.3
Abraham, R.T.4
Acevedo-Arozena, A.5
Adeli, K.6
Agholme, L.7
Agnello, M.8
Agostinis, P.9
Aguirre-Ghiso, J.A.10
Ahn, H.J.11
Ait-Mohamed, O.12
Ait-Si-Ali, S.13
Akematsu, T.14
Akira, S.15
Al-Younes, H.M.16
Al-Zeer, M.A.17
Albert, M.L.18
Albin, R.L.19
Alegre-Abarrategui, J.20
Aleo, M.F.21
Alirezaei, M.22
Almasan, A.23
Almonte-Becerril, M.24
Amano, A.25
Amaravadi, R.26
Amarnath, S.27
Amer, A.O.28
Andrieu-Abadie, N.29
Anantharam, V.30
more..
-
43
-
-
84882254367
-
The role of autophagy in neurodegenerative disease
-
23921753
-
Nixon RA. The role of autophagy in neurodegenerative disease. Nat Med 2013, 19:983-997. 10.1038/nm.3232, 23921753.
-
(2013)
Nat Med
, vol.19
, pp. 983-997
-
-
Nixon, R.A.1
-
44
-
-
77956106755
-
Autophagy, a guardian against neurodegeneration
-
20188203
-
Garcia-Arencibia M, Hochfeld WE, Toh PP, Rubinsztein DC. Autophagy, a guardian against neurodegeneration. Semin Cell Dev Biol 2010, 21:691-698. 10.1016/j.semcdb.2010.02.008, 20188203.
-
(2010)
Semin Cell Dev Biol
, vol.21
, pp. 691-698
-
-
Garcia-Arencibia, M.1
Hochfeld, W.E.2
Toh, P.P.3
Rubinsztein, D.C.4
-
45
-
-
77956305343
-
Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease
-
20376313
-
Spilman P, Podlutskaya N, Hart MJ, Debnath J, Gorostiza O, Bredesen D, Richardson A, Strong R, Galvan V. Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease. PLoS One 2010, 5:e9979. 10.1371/journal.pone.0009979, 20376313.
-
(2010)
PLoS One
, vol.5
, pp. e9979
-
-
Spilman, P.1
Podlutskaya, N.2
Hart, M.J.3
Debnath, J.4
Gorostiza, O.5
Bredesen, D.6
Richardson, A.7
Strong, R.8
Galvan, V.9
-
46
-
-
80053243942
-
Inducing autophagy by rapamycin before, but not after, the formation of plaques and tangles ameliorates cognitive deficits
-
21980451
-
Majumder S, Richardson A, Strong R, Oddo S. Inducing autophagy by rapamycin before, but not after, the formation of plaques and tangles ameliorates cognitive deficits. PLoS One 2011, 6:e25416. 10.1371/journal.pone.0025416, 21980451.
-
(2011)
PLoS One
, vol.6
, pp. e25416
-
-
Majumder, S.1
Richardson, A.2
Strong, R.3
Oddo, S.4
-
47
-
-
79957917512
-
A small-molecule enhancer of autophagy decreases levels of Abeta and APP-CTF via Atg5-dependent autophagy pathway
-
21368103
-
Tian Y, Bustos V, Flajolet M, Greengard P. A small-molecule enhancer of autophagy decreases levels of Abeta and APP-CTF via Atg5-dependent autophagy pathway. FASEB J 2011, 25:1934-1942. 10.1096/fj.10-175158, 21368103.
-
(2011)
FASEB J
, vol.25
, pp. 1934-1942
-
-
Tian, Y.1
Bustos, V.2
Flajolet, M.3
Greengard, P.4
-
48
-
-
79959979604
-
Therapeutic effects of remediating autophagy failure in a mouse model of Alzheimer disease by enhancing lysosomal proteolysis
-
21464620
-
Yang DS, Stavrides P, Mohan PS, Kaushik S, Kumar A, Ohno M, Schmidt SD, Wesson DW, Bandyopadhyay U, Jiang Y, Pawlik M, Peterhoff CM, Yang AJ, Wilson DA, St George-Hyslop P, Westaway D, Mathews PM, Levy E, Cuervo AM, Nixon RA. Therapeutic effects of remediating autophagy failure in a mouse model of Alzheimer disease by enhancing lysosomal proteolysis. Autophagy 2011, 7:788-789. 10.4161/auto.7.7.15596, 21464620.
-
(2011)
Autophagy
, vol.7
, pp. 788-789
-
-
Yang, D.S.1
Stavrides, P.2
Mohan, P.S.3
Kaushik, S.4
Kumar, A.5
Ohno, M.6
Schmidt, S.D.7
Wesson, D.W.8
Bandyopadhyay, U.9
Jiang, Y.10
Pawlik, M.11
Peterhoff, C.M.12
Yang, A.J.13
Wilson, D.A.14
St George-Hyslop, P.15
Westaway, D.16
Mathews, P.M.17
Levy, E.18
Cuervo, A.M.19
Nixon, R.A.20
more..
-
49
-
-
84885998575
-
Intestinal epithelium and autophagy: partners in gut homeostasis
-
24137160
-
Randall-Demllo S, Chieppa M, Eri R. Intestinal epithelium and autophagy: partners in gut homeostasis. Front Immunol 2013, 4:301. 10.3389/fimmu.2013.00301, 24137160.
-
(2013)
Front Immunol
, vol.4
, pp. 301
-
-
Randall-Demllo, S.1
Chieppa, M.2
Eri, R.3
-
50
-
-
84883505832
-
Beta-cell inflammation in human type 2 diabetes and the role of autophagy
-
24003929
-
Marselli L, Bugliani M, Suleiman M, Olimpico F, Masini M, Petrini M, Boggi U, Filipponi F, Syed F, Marchetti P. beta-cell inflammation in human type 2 diabetes and the role of autophagy. Diabetes Obes Metab 2013, 15(Suppl 3):130-136. 10.1111/dom.12152, 24003929.
-
(2013)
Diabetes Obes Metab
, vol.15
, pp. 130-136
-
-
Marselli, L.1
Bugliani, M.2
Suleiman, M.3
Olimpico, F.4
Masini, M.5
Petrini, M.6
Boggi, U.7
Filipponi, F.8
Syed, F.9
Marchetti, P.10
-
51
-
-
84860491083
-
Cathepsin S deficiency results in abnormal accumulation of autophagosomes in macrophages and enhances Ang II-induced cardiac inflammation
-
22558139
-
Pan L, Li Y, Jia L, Qin Y, Qi G, Cheng J, Qi Y, Li H, Du J. Cathepsin S deficiency results in abnormal accumulation of autophagosomes in macrophages and enhances Ang II-induced cardiac inflammation. PLoS One 2012, 7:e35315. 10.1371/journal.pone.0035315, 22558139.
-
(2012)
PLoS One
, vol.7
, pp. e35315
-
-
Pan, L.1
Li, Y.2
Jia, L.3
Qin, Y.4
Qi, G.5
Cheng, J.6
Qi, Y.7
Li, H.8
Du, J.9
-
52
-
-
84896957356
-
The emerging potential of autophagy-based therapies in the treatment of cystic fibrosis lung infections
-
24434788
-
Junkins RD, McCormick C, Lin TJ. The emerging potential of autophagy-based therapies in the treatment of cystic fibrosis lung infections. Autophagy 2014, 10:538-547. 10.4161/auto.27750, 24434788.
-
(2014)
Autophagy
, vol.10
, pp. 538-547
-
-
Junkins, R.D.1
McCormick, C.2
Lin, T.J.3
-
53
-
-
84889985155
-
Involvement of interleukin-1beta in the autophagic process of microglia: relevance to Alzheimer's disease
-
24330807
-
Francois A, Terro F, Janet T, Bilan AR, Paccalin M, Page G. Involvement of interleukin-1beta in the autophagic process of microglia: relevance to Alzheimer's disease. J Neuroinflammation 2013, 10:151. 10.1186/1742-2094-10-151, 24330807.
-
(2013)
J Neuroinflammation
, vol.10
, pp. 151
-
-
Francois, A.1
Terro, F.2
Janet, T.3
Bilan, A.R.4
Paccalin, M.5
Page, G.6
-
54
-
-
77956064235
-
Inflammation in transgenic mouse models of neurodegenerative disorders
-
19883753
-
Schwab C, Klegeris A, McGeer PL. Inflammation in transgenic mouse models of neurodegenerative disorders. Biochim Biophys Acta 2010, 1802:889-902. 10.1016/j.bbadis.2009.10.013, 19883753.
-
(2010)
Biochim Biophys Acta
, vol.1802
, pp. 889-902
-
-
Schwab, C.1
Klegeris, A.2
McGeer, P.L.3
-
55
-
-
84884634690
-
Regulation of autophagy by mTOR-dependent and mTOR-independent pathways: autophagy dysfunction in neurodegenerative diseases and therapeutic application of autophagy enhancers
-
24059496
-
Sarkar S. Regulation of autophagy by mTOR-dependent and mTOR-independent pathways: autophagy dysfunction in neurodegenerative diseases and therapeutic application of autophagy enhancers. Biochem Soc Trans 2013, 41:1103-1130. 10.1042/BST20130134, 24059496.
-
(2013)
Biochem Soc Trans
, vol.41
, pp. 1103-1130
-
-
Sarkar, S.1
-
58
-
-
33645738458
-
Complexity of the TOR signaling network
-
16516475
-
Inoki K, Guan KL. Complexity of the TOR signaling network. Trends Cell Biol 2006, 16:206-212. 10.1016/j.tcb.2006.02.002, 16516475.
-
(2006)
Trends Cell Biol
, vol.16
, pp. 206-212
-
-
Inoki, K.1
Guan, K.L.2
-
59
-
-
42949139481
-
AMPK phosphorylation of raptor mediates a metabolic checkpoint
-
18439900
-
Gwinn DM, Shackelford DB, Egan DF, Mihaylova MM, Mery A, Vasquez DS, Turk BE, Shaw RJ. AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol Cell 2008, 30:214-226. 10.1016/j.molcel.2008.03.003, 18439900.
-
(2008)
Mol Cell
, vol.30
, pp. 214-226
-
-
Gwinn, D.M.1
Shackelford, D.B.2
Egan, D.F.3
Mihaylova, M.M.4
Mery, A.5
Vasquez, D.S.6
Turk, B.E.7
Shaw, R.J.8
-
60
-
-
84872351818
-
-
Inhibition of glycogen synthase kinase-3 ameliorates beta-amyloid pathology and restores lysosomal acidification and mammalian target of rapamycin activity in the Alzheimer disease mouse model: in vivo and in vitro studies.
-
Avrahami L, Farfara D, Shaham-Kol M, Vassar R, Frenkel D, Eldar-Finkelman H: Inhibition of glycogen synthase kinase-3 ameliorates beta-amyloid pathology and= restores lysosomal acidification and mammalian target of rapamycin activity in the Alzheimer disease mouse model: in vivo and in vitro studies. J Biol Chem 2013, 288:1295-1306.
-
(2013)
J Biol Chem
, vol.288
, pp. 1295-1306
-
-
Avrahami, L.1
Farfara, D.2
Shaham-Kol, M.3
Vassar, R.4
Frenkel, D.5
Eldar-Finkelman, H.6
-
61
-
-
84877803859
-
MTOR regulates tau phosphorylation and degradation: implications for Alzheimer's disease and other tauopathies
-
23425014
-
Caccamo A, Magri A, Medina DX, Wisely EV, Lopez-Aranda MF, Silva AJ, Oddo S. mTOR regulates tau phosphorylation and degradation: implications for Alzheimer's disease and other tauopathies. Aging Cell 2013, 12:370-380. 10.1111/acel.12057, 23425014.
-
(2013)
Aging Cell
, vol.12
, pp. 370-380
-
-
Caccamo, A.1
Magri, A.2
Medina, D.X.3
Wisely, E.V.4
Lopez-Aranda, M.F.5
Silva, A.J.6
Oddo, S.7
-
62
-
-
21344459656
-
MTOR/p70S6k signalling alteration by Abeta exposure as well as in APP-PS1 transgenic models and in patients with Alzheimer's disease
-
15953364
-
Lafay-Chebassier C, Paccalin M, Page G, Barc-Pain S, Perault-Pochat MC, Gil R, Pradier L, Hugon J. mTOR/p70S6k signalling alteration by Abeta exposure as well as in APP-PS1 transgenic models and in patients with Alzheimer's disease. J Neurochem 2005, 94:215-225. 10.1111/j.1471-4159.2005.03187.x, 15953364.
-
(2005)
J Neurochem
, vol.94
, pp. 215-225
-
-
Lafay-Chebassier, C.1
Paccalin, M.2
Page, G.3
Barc-Pain, S.4
Perault-Pochat, M.C.5
Gil, R.6
Pradier, L.7
Hugon, J.8
-
63
-
-
77951227122
-
Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments
-
20178983
-
Caccamo A, Majumder S, Richardson A, Strong R, Oddo S. Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments. J Biol Chem 2010, 285:13107-13120. 10.1074/jbc.M110.100420, 20178983.
-
(2010)
J Biol Chem
, vol.285
, pp. 13107-13120
-
-
Caccamo, A.1
Majumder, S.2
Richardson, A.3
Strong, R.4
Oddo, S.5
-
64
-
-
38149055561
-
Dissociation of Akt/PKB and ribosomal S6 kinase signaling markers in a transgenic mouse model of Alzheimer's disease
-
18023354
-
Damjanac M, Rioux Bilan A, Paccalin M, Pontcharraud R, Fauconneau B, Hugon J, Page G. Dissociation of Akt/PKB and ribosomal S6 kinase signaling markers in a transgenic mouse model of Alzheimer's disease. Neurobiol Dis 2008, 29:354-367. 10.1016/j.nbd.2007.09.008, 18023354.
-
(2008)
Neurobiol Dis
, vol.29
, pp. 354-367
-
-
Damjanac, M.1
Rioux Bilan, A.2
Paccalin, M.3
Pontcharraud, R.4
Fauconneau, B.5
Hugon, J.6
Page, G.7
-
65
-
-
84857029592
-
Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer's mice hippocampus
-
22020633
-
Sanchez-Varo R, Trujillo-Estrada L, Sanchez-Mejias E, Torres M, Baglietto-Vargas D, Moreno-Gonzalez I, De Castro V, Jimenez S, Ruano D, Vizuete M, Davila JC, Garcia-Verdugo JM, Jimenez AJ, Vitorica J, Gutierrez A. Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer's mice hippocampus. Acta Neuropathol 2012, 123:53-70. 10.1007/s00401-011-0896-x, 22020633.
-
(2012)
Acta Neuropathol
, vol.123
, pp. 53-70
-
-
Sanchez-Varo, R.1
Trujillo-Estrada, L.2
Sanchez-Mejias, E.3
Torres, M.4
Baglietto-Vargas, D.5
Moreno-Gonzalez, I.6
De Castro, V.7
Jimenez, S.8
Ruano, D.9
Vizuete, M.10
Davila, J.C.11
Garcia-Verdugo, J.M.12
Jimenez, A.J.13
Vitorica, J.14
Gutierrez, A.15
-
66
-
-
79956048660
-
Parkin mediates beclin-dependent autophagic clearance of defective mitochondria and ubiquitinated Abeta in AD models
-
21378096
-
Khandelwal PJ, Herman AM, Hoe HS, Rebeck GW, Moussa CE. Parkin mediates beclin-dependent autophagic clearance of defective mitochondria and ubiquitinated Abeta in AD models. Hum Mol Genet 2011, 20:2091-2102. 10.1093/hmg/ddr091, 21378096.
-
(2011)
Hum Mol Genet
, vol.20
, pp. 2091-2102
-
-
Khandelwal, P.J.1
Herman, A.M.2
Hoe, H.S.3
Rebeck, G.W.4
Moussa, C.E.5
-
67
-
-
0034293631
-
Brain expression of presenilins in sporadic and early-onset, familial Alzheimer's disease
-
11126202
-
Mathews PM, Cataldo AM, Kao BH, Rudnicki AG, Qin X, Yang JL, Jiang Y, Picciano M, Hulette C, Lippa CF, Bird TD, Nochlin D, Walter J, Haass C, Levesque L, Fraser PE, Andreadis A, Nixon RA. Brain expression of presenilins in sporadic and early-onset, familial Alzheimer's disease. Mol Med 2000, 6:878-891. 11126202.
-
(2000)
Mol Med
, vol.6
, pp. 878-891
-
-
Mathews, P.M.1
Cataldo, A.M.2
Kao, B.H.3
Rudnicki, A.G.4
Qin, X.5
Yang, J.L.6
Jiang, Y.7
Picciano, M.8
Hulette, C.9
Lippa, C.F.10
Bird, T.D.11
Nochlin, D.12
Walter, J.13
Haass, C.14
Levesque, L.15
Fraser, P.E.16
Andreadis, A.17
Nixon, R.A.18
-
68
-
-
4644319713
-
Abeta localization in abnormal endosomes: association with earliest Abeta elevations in AD and Down syndrome
-
15465622
-
Cataldo AM, Petanceska S, Terio NB, Peterhoff CM, Durham R, Mercken M, Mehta PD, Buxbaum J, Haroutunian V, Nixon RA. Abeta localization in abnormal endosomes: association with earliest Abeta elevations in AD and Down syndrome. Neurobiol Aging 2004, 25:1263-1272. 10.1016/j.neurobiolaging.2004.02.027, 15465622.
-
(2004)
Neurobiol Aging
, vol.25
, pp. 1263-1272
-
-
Cataldo, A.M.1
Petanceska, S.2
Terio, N.B.3
Peterhoff, C.M.4
Durham, R.5
Mercken, M.6
Mehta, P.D.7
Buxbaum, J.8
Haroutunian, V.9
Nixon, R.A.10
-
69
-
-
0034721509
-
Up-regulation of the lysosomal system in experimental models of neuronal injury: implications for Alzheimer's disease
-
11098128
-
Adamec E, Mohan PS, Cataldo AM, Vonsattel JP, Nixon RA. Up-regulation of the lysosomal system in experimental models of neuronal injury: implications for Alzheimer's disease. Neuroscience 2000, 100:663-675. 10.1016/S0306-4522(00)00281-5, 11098128.
-
(2000)
Neuroscience
, vol.100
, pp. 663-675
-
-
Adamec, E.1
Mohan, P.S.2
Cataldo, A.M.3
Vonsattel, J.P.4
Nixon, R.A.5
-
70
-
-
47849124269
-
Identification of miRNA changes in Alzheimer's disease brain and CSF yields putative biomarkers and insights into disease pathways
-
18525125
-
Cogswell JP, Ward J, Taylor IA, Waters M, Shi Y, Cannon B, Kelnar K, Kemppainen J, Brown D, Chen C, Prinjha RK, Richardson JC, Saunders AM, Roses AD, Richards CA. Identification of miRNA changes in Alzheimer's disease brain and CSF yields putative biomarkers and insights into disease pathways. J Alzheimers Dis 2008, 14:27-41. 18525125.
-
(2008)
J Alzheimers Dis
, vol.14
, pp. 27-41
-
-
Cogswell, J.P.1
Ward, J.2
Taylor, I.A.3
Waters, M.4
Shi, Y.5
Cannon, B.6
Kelnar, K.7
Kemppainen, J.8
Brown, D.9
Chen, C.10
Prinjha, R.K.11
Richardson, J.C.12
Saunders, A.M.13
Roses, A.D.14
Richards, C.A.15
-
71
-
-
77953913051
-
Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations
-
20541250
-
Lee JH, Yu WH, Kumar A, Lee S, Mohan PS, Peterhoff CM, Wolfe DM, Martinez-Vicente M, Massey AC, Sovak G, Uchiyama Y, Westaway D, Cuervo AM, Nixon RA. Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations. Cell 2010, 141:1146-1158. 10.1016/j.cell.2010.05.008, 20541250.
-
(2010)
Cell
, vol.141
, pp. 1146-1158
-
-
Lee, J.H.1
Yu, W.H.2
Kumar, A.3
Lee, S.4
Mohan, P.S.5
Peterhoff, C.M.6
Wolfe, D.M.7
Martinez-Vicente, M.8
Massey, A.C.9
Sovak, G.10
Uchiyama, Y.11
Westaway, D.12
Cuervo, A.M.13
Nixon, R.A.14
-
72
-
-
84879232282
-
Autophagy failure in Alzheimer's disease and the role of defective lysosomal acidification
-
23773064
-
Wolfe DM, Lee JH, Kumar A, Lee S, Orenstein SJ, Nixon RA. Autophagy failure in Alzheimer's disease and the role of defective lysosomal acidification. Eur J Neurosci 2013, 37:1949-1961. 10.1111/ejn.12169, 23773064.
-
(2013)
Eur J Neurosci
, vol.37
, pp. 1949-1961
-
-
Wolfe, D.M.1
Lee, J.H.2
Kumar, A.3
Lee, S.4
Orenstein, S.J.5
Nixon, R.A.6
-
73
-
-
79955964504
-
Depletion of Beclin-1 due to proteolytic cleavage by caspases in the Alzheimer's disease brain
-
21081164
-
Rohn TT, Wirawan E, Brown RJ, Harris JR, Masliah E, Vandenabeele P. Depletion of Beclin-1 due to proteolytic cleavage by caspases in the Alzheimer's disease brain. Neurobiol Dis 2011, 43:68-78. 10.1016/j.nbd.2010.11.003, 21081164.
-
(2011)
Neurobiol Dis
, vol.43
, pp. 68-78
-
-
Rohn, T.T.1
Wirawan, E.2
Brown, R.J.3
Harris, J.R.4
Masliah, E.5
Vandenabeele, P.6
-
74
-
-
74249109983
-
Apoptosis blocks Beclin 1-dependent autophagosome synthesis: an effect rescued by Bcl-xL
-
19713971
-
Luo S, Rubinsztein DC. Apoptosis blocks Beclin 1-dependent autophagosome synthesis: an effect rescued by Bcl-xL. Cell Death Differ 2010, 17:268-277. 10.1038/cdd.2009.121, 19713971.
-
(2010)
Cell Death Differ
, vol.17
, pp. 268-277
-
-
Luo, S.1
Rubinsztein, D.C.2
-
75
-
-
84873267192
-
Beclin 1 interactome controls the crosstalk between apoptosis, autophagy and inflammasome activation: impact on the aging process
-
23220384
-
Salminen A, Kaarniranta K, Kauppinen A. Beclin 1 interactome controls the crosstalk between apoptosis, autophagy and inflammasome activation: impact on the aging process. Ageing Res Rev 2013, 12:520-534. 10.1016/j.arr.2012.11.004, 23220384.
-
(2013)
Ageing Res Rev
, vol.12
, pp. 520-534
-
-
Salminen, A.1
Kaarniranta, K.2
Kauppinen, A.3
-
76
-
-
85046981182
-
MiR-376b controls starvation and mTOR inhibition-related autophagy by targeting ATG4C and BECN1
-
22248718
-
Korkmaz G, le Sage C, Tekirdag KA, Agami R, Gozuacik D. miR-376b controls starvation and mTOR inhibition-related autophagy by targeting ATG4C and BECN1. Autophagy 2012, 8:165-176. 10.4161/auto.8.2.18351, 22248718.
-
(2012)
Autophagy
, vol.8
, pp. 165-176
-
-
Korkmaz, G.1
le Sage, C.2
Tekirdag, K.A.3
Agami, R.4
Gozuacik, D.5
-
77
-
-
84863011747
-
MicroRNA-30a sensitizes tumor cells to cis-platinum via suppressing beclin 1-mediated autophagy
-
22157765
-
Zou Z, Wu L, Ding H, Wang Y, Zhang Y, Chen X, Zhang CY, Zhang Q, Zen K. MicroRNA-30a sensitizes tumor cells to cis-platinum via suppressing beclin 1-mediated autophagy. J Biol Chem 2012, 287:4148-4156. 10.1074/jbc.M111.307405, 22157765.
-
(2012)
J Biol Chem
, vol.287
, pp. 4148-4156
-
-
Zou, Z.1
Wu, L.2
Ding, H.3
Wang, Y.4
Zhang, Y.5
Chen, X.6
Zhang, C.Y.7
Zhang, Q.8
Zen, K.9
-
78
-
-
77956215864
-
Regulation of amyloid precursor protein processing by the Beclin 1 complex
-
20559548
-
Jaeger PA, Pickford F, Sun CH, Lucin KM, Masliah E, Wyss-Coray T. Regulation of amyloid precursor protein processing by the Beclin 1 complex. PLoS One 2010, 5:e11102. 10.1371/journal.pone.0011102, 20559548.
-
(2010)
PLoS One
, vol.5
, pp. e11102
-
-
Jaeger, P.A.1
Pickford, F.2
Sun, C.H.3
Lucin, K.M.4
Masliah, E.5
Wyss-Coray, T.6
-
79
-
-
84869147050
-
Akt-mediated regulation of autophagy and tumorigenesis through Beclin 1 phosphorylation
-
23112296
-
Wang RC, Wei Y, An Z, Zou Z, Xiao G, Bhagat G, White M, Reichelt J, Levine B. Akt-mediated regulation of autophagy and tumorigenesis through Beclin 1 phosphorylation. Science 2012, 338:956-959. 10.1126/science.1225967, 23112296.
-
(2012)
Science
, vol.338
, pp. 956-959
-
-
Wang, R.C.1
Wei, Y.2
An, Z.3
Zou, Z.4
Xiao, G.5
Bhagat, G.6
White, M.7
Reichelt, J.8
Levine, B.9
-
80
-
-
84884185631
-
Microglial beclin 1 regulates retromer trafficking and phagocytosis and is impaired in Alzheimer's disease
-
24012002
-
Lucin KM, O'Brien CE, Bieri G, Czirr E, Mosher KI, Abbey RJ, Mastroeni DF, Rogers J, Spencer B, Masliah E, Wyss-Coray T. Microglial beclin 1 regulates retromer trafficking and phagocytosis and is impaired in Alzheimer's disease. Neuron 2013, 79:873-886. 10.1016/j.neuron.2013.06.046, 24012002.
-
(2013)
Neuron
, vol.79
, pp. 873-886
-
-
Lucin, K.M.1
O'Brien, C.E.2
Bieri, G.3
Czirr, E.4
Mosher, K.I.5
Abbey, R.J.6
Mastroeni, D.F.7
Rogers, J.8
Spencer, B.9
Masliah, E.10
Wyss-Coray, T.11
-
81
-
-
79251588741
-
NLRP4 negatively regulates autophagic processes through an association with beclin1
-
21209283
-
Jounai N, Kobiyama K, Shiina M, Ogata K, Ishii KJ, Takeshita F. NLRP4 negatively regulates autophagic processes through an association with beclin1. J Immunol 2011, 186:1646-1655. 10.4049/jimmunol.1001654, 21209283.
-
(2011)
J Immunol
, vol.186
, pp. 1646-1655
-
-
Jounai, N.1
Kobiyama, K.2
Shiina, M.3
Ogata, K.4
Ishii, K.J.5
Takeshita, F.6
-
82
-
-
69549139978
-
Involvement of mTOR kinase in cytokine-dependent microglial activation and cell proliferation
-
19576187
-
Dello Russo C, Lisi L, Tringali G, Navarra P. Involvement of mTOR kinase in cytokine-dependent microglial activation and cell proliferation. Biochem Pharmacol 2009, 78:1242-1251. 10.1016/j.bcp.2009.06.097, 19576187.
-
(2009)
Biochem Pharmacol
, vol.78
, pp. 1242-1251
-
-
Dello Russo, C.1
Lisi, L.2
Tringali, G.3
Navarra, P.4
-
83
-
-
54949109311
-
The TSC-mTOR signaling pathway regulates the innate inflammatory response
-
18848473
-
Weichhart T, Costantino G, Poglitsch M, Rosner M, Zeyda M, Stuhlmeier KM, Kolbe T, Stulnig TM, Horl WH, Hengstschlager M, Muller M, Saemann MD. The TSC-mTOR signaling pathway regulates the innate inflammatory response. Immunity 2008, 29:565-577. 10.1016/j.immuni.2008.08.012, 18848473.
-
(2008)
Immunity
, vol.29
, pp. 565-577
-
-
Weichhart, T.1
Costantino, G.2
Poglitsch, M.3
Rosner, M.4
Zeyda, M.5
Stuhlmeier, K.M.6
Kolbe, T.7
Stulnig, T.M.8
Horl, W.H.9
Hengstschlager, M.10
Muller, M.11
Saemann, M.D.12
-
84
-
-
0034649707
-
Interstitial pneumonitis associated with sirolimus therapy in renal-transplant recipients
-
11185606
-
Singer SJ, Tiernan R, Sullivan EJ. Interstitial pneumonitis associated with sirolimus therapy in renal-transplant recipients. N Engl J Med 2000, 343:1815-1816. 11185606.
-
(2000)
N Engl J Med
, vol.343
, pp. 1815-1816
-
-
Singer, S.J.1
Tiernan, R.2
Sullivan, E.J.3
-
85
-
-
28544432476
-
Anemia after late introduction of sirolimus may correlate with biochemical evidence of a chronic inflammatory state
-
16314788
-
Thaunat O, Beaumont C, Chatenoud L, Lechaton S, Mamzer-Bruneel MF, Varet B, Kreis H, Morelon E. Anemia after late introduction of sirolimus may correlate with biochemical evidence of a chronic inflammatory state. Transplantation 2005, 80:1212-1219. 10.1097/01.tp.0000179106.07382.6a, 16314788.
-
(2005)
Transplantation
, vol.80
, pp. 1212-1219
-
-
Thaunat, O.1
Beaumont, C.2
Chatenoud, L.3
Lechaton, S.4
Mamzer-Bruneel, M.F.5
Varet, B.6
Kreis, H.7
Morelon, E.8
-
86
-
-
84879236199
-
The effect of mTOR-inhibition on NF-kappaB activity in kidney ischemia-reperfusion injury in mice
-
23769029
-
Kezic A, Becker JU, Thaiss F. The effect of mTOR-inhibition on NF-kappaB activity in kidney ischemia-reperfusion injury in mice. Transplant Proc 2013, 45:1708-1714. 10.1016/j.transproceed.2013.02.110, 23769029.
-
(2013)
Transplant Proc
, vol.45
, pp. 1708-1714
-
-
Kezic, A.1
Becker, J.U.2
Thaiss, F.3
-
87
-
-
74849083093
-
Lysosomal enhancement: a CLEAR answer to cellular degradative needs
-
19949301
-
Sardiello M, Ballabio A. Lysosomal enhancement: a CLEAR answer to cellular degradative needs. Cell Cycle 2009, 8:4021-4022. 10.4161/cc.8.24.10263, 19949301.
-
(2009)
Cell Cycle
, vol.8
, pp. 4021-4022
-
-
Sardiello, M.1
Ballabio, A.2
-
88
-
-
80052716148
-
Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways
-
21752829
-
Palmieri M, Impey S, Kang H, di Ronza A, Pelz C, Sardiello M, Ballabio A. Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways. Hum Mol Genet 2011, 20:3852-3866. 10.1093/hmg/ddr306, 21752829.
-
(2011)
Hum Mol Genet
, vol.20
, pp. 3852-3866
-
-
Palmieri, M.1
Impey, S.2
Kang, H.3
di Ronza, A.4
Pelz, C.5
Sardiello, M.6
Ballabio, A.7
-
89
-
-
84878606239
-
TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop
-
23604321
-
Settembre C, De Cegli R, Mansueto G, Saha PK, Vetrini F, Visvikis O, Huynh T, Carissimo A, Palmer D, Klisch TJ, Wollenberg AC, Di Bernardo D, Chan L, Irazoqui JE, Ballabio A. TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop. Nat Cell Biol 2013, 15:647-658. 10.1038/ncb2718, 23604321.
-
(2013)
Nat Cell Biol
, vol.15
, pp. 647-658
-
-
Settembre, C.1
De Cegli, R.2
Mansueto, G.3
Saha, P.K.4
Vetrini, F.5
Visvikis, O.6
Huynh, T.7
Carissimo, A.8
Palmer, D.9
Klisch, T.J.10
Wollenberg, A.C.11
Di Bernardo, D.12
Chan, L.13
Irazoqui, J.E.14
Ballabio, A.15
-
90
-
-
84857997408
-
A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB
-
22343943
-
Settembre C, Zoncu R, Medina DL, Vetrini F, Erdin S, Huynh T, Ferron M, Karsenty G, Vellard MC, Facchinetti V, Sabatini DM, Ballabio A. A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB. EMBO J 2012, 31:1095-1108. 10.1038/emboj.2012.32, 22343943.
-
(2012)
EMBO J
, vol.31
, pp. 1095-1108
-
-
Settembre, C.1
Zoncu, R.2
Medina, D.L.3
Vetrini, F.4
Erdin, S.5
Huynh, T.6
Ferron, M.7
Karsenty, G.8
Vellard, M.C.9
Facchinetti, V.10
Sabatini, D.M.11
Ballabio, A.12
-
91
-
-
84888001234
-
Autophagy modulation for Alzheimer's disease therapy
-
23625314
-
Zhu XC, Yu JT, Jiang T, Tan L. Autophagy modulation for Alzheimer's disease therapy. Mol Neurobiol 2013, 48:702-714. 10.1007/s12035-013-8457-z, 23625314.
-
(2013)
Mol Neurobiol
, vol.48
, pp. 702-714
-
-
Zhu, X.C.1
Yu, J.T.2
Jiang, T.3
Tan, L.4
-
92
-
-
84869861910
-
Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus
-
23173743
-
Torres M, Jimenez S, Sanchez-Varo R, Navarro V, Trujillo-Estrada L, Sanchez-Mejias E, Carmona I, Davila JC, Vizuete M, Gutierrez A, Vitorica J. Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus. Mol Neurodegener 2012, 7:59. 10.1186/1750-1326-7-59, 23173743.
-
(2012)
Mol Neurodegener
, vol.7
, pp. 59
-
-
Torres, M.1
Jimenez, S.2
Sanchez-Varo, R.3
Navarro, V.4
Trujillo-Estrada, L.5
Sanchez-Mejias, E.6
Carmona, I.7
Davila, J.C.8
Vizuete, M.9
Gutierrez, A.10
Vitorica, J.11
|