Enhancing the solubility and bioavailability of poorly water-soluble drugs using supercritical antisolvent (SAS) process

International Journal of Pharmaceutics

Volumn 538, Issue 1-2, 2018, Pages 1-13

  Abuzar, Sharif Md ^a,b   Hyun, Sang Min ^a,b   Kim, Jun Hee ^a,b   Park, Hee Jun ^a,b   Kim, Min Soo ^c   Park, Jeong Sook ^d   Hwang, Sung Joo ^a,b  

^a Yonsei University   (South Korea)

^b Yonsei Institute of Pharmaceutical Sciences   (South Korea)

^c Pusan National University   (South Korea)

^d Chungnam National University   (South Korea)

Author keywords

Bioavailability; Micronization; Poorly water soluble drug; Solid dispersion nanoparticles; Solubility; Supercritical antisolvent

Indexed keywords

10 HYDROXYCAMPTOTHECIN; ACETIC ACID; AMPICILLIN; ATORVASTATIN; CELECOXIB; CILOSTAZOL; DICHLOROMETHANE; FLUOROURACIL; IBUPROFEN; NANOPARTICLE; NAPROXEN; ORGANIC SOLVENT; PACLITAXEL; PARACETAMOL; POLYMER; QUERCETIN; RIFAMPICIN; SIMVASTATIN; SURFACTANT; ZIDOVUDINE; DRUG; SOLVENT; WATER;

ARTICLE; CRYSTALLIZATION; DISPERSION; DISSOLUTION; DRUG BIOAVAILABILITY; DRUG SOLUBILITY; FLOW RATE; GEOMETRY; INVESTIGATIVE PROCEDURES; PRECIPITATION; PRESSURE; PRIORITY JOURNAL; SUPERCRITICAL ANTISOLVENT; SUPERCRITICAL FLUID; TEMPERATURE; BIOAVAILABILITY; CHEMISTRY; DRUG FORMULATION; MEDICINAL CHEMISTRY; METABOLISM; PARTICLE SIZE; PHARMACEUTICS; PROCEDURES; SOLUBILITY;

BIOLOGICAL AVAILABILITY; CHEMISTRY, PHARMACEUTICAL; DRUG COMPOUNDING; NANOPARTICLES; PARTICLE SIZE; PHARMACEUTICAL PREPARATIONS; SOLUBILITY; SOLVENTS; TECHNOLOGY, PHARMACEUTICAL; WATER;

EID: 85040129404     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2017.12.041     Document Type: Article

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