Preparation of inclusion complex of apigenin-hydroxypropyl-β-cyclodextrin by using supercritical antisolvent process for dissolution and bioavailability enhancement

International Journal of Pharmaceutics

Volumn 511, Issue 2, 2016, Pages 921-930

  Huang, Yannian ^a   Zu, Yuangang ^a   Zhao, Xiuhua ^a   Wu, Mingfang ^a   Feng, Ziqi ^a   Deng, Yiping ^a   Zu, Chang ^a   Wang, Lingling ^a  

^a NORTHEAST FORESTRY UNIVERSITY   (China)

Author keywords

Apigenin; Bioavailability; Dissolution; Hydroxypropyl cyclodextrin; Inclusion complex; Supercritical antisolvent method

Indexed keywords

2 HYDROXYPROPYL BETA CYCLODEXTRIN; APIGENIN DERIVATIVE; 2-HYDROXYPROPYL-BETA-CYCLODEXTRIN; APIGENIN; BETA CYCLODEXTRIN DERIVATIVE; SOLVENT;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DISSOLUTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG FORMULATION; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; HYDROGEN BOND; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PARTICLE SIZE; PRECIPITATION; PRIORITY JOURNAL; RAT; ANIMAL; BIOAVAILABILITY; BLOOD; MEDICINAL CHEMISTRY; METABOLISM; PROCEDURES; SOLUBILITY; SPRAGUE DAWLEY RAT; SUPERCRITICAL FLUID CHROMATOGRAPHY; SYNTHESIS;

ANIMALS; APIGENIN; BETA-CYCLODEXTRINS; BIOLOGICAL AVAILABILITY; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, SUPERCRITICAL FLUID; FEMALE; RATS; RATS, SPRAGUE-DAWLEY; SOLUBILITY; SOLVENTS;

EID: 84981278142     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2016.08.007     Document Type: Article

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