Entrapment of 5-fluorouracil into PLGA matrices using supercritical antisolvent processes

Journal of Pharmacy and Pharmacology

Volumn 63, Issue 4, 2011, Pages 500-506

  Kalantarian, Pardis ^a   Haririan, Ismaeil ^a   Najafabadi, Abdolhossein Rouholamini ^a   Shokrgozar, Mohammad Ali ^b   Vatanara, Alireza ^a  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b PASTEUR INSTITUTE OF IRAN   (Iran)

Author keywords

5 Fluorouracil; Antitumor; Cytotoxicity assay; GAS; SAS; Supercritical antisolvent

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; CARBON DIOXIDE; FLUOROURACIL; POLYGLACTIN;

ARTICLE; CANCER CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DETERMINATION; DRUG STABILITY; HUMAN; HUMAN CELL; HYDROPHILICITY; IC 50; IN VITRO STUDY; LOAD CARRYING CAPACITY; LUNG CARCINOMA; MICROENCAPSULATION; MOLECULAR WEIGHT; PHYSICAL CHEMISTRY; SUSTAINED RELEASE FORMULATION; THERMAL ANALYSIS;

CELL LINE, TUMOR; CHEMICAL PRECIPITATION; CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; DRUG SCREENING ASSAYS, ANTITUMOR; DRUG STABILITY; FLUOROURACIL; HUMANS; POLYGLACTIN 910; SOLUBILITY;

EID: 79952726161     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.2042-7158.2010.01249.x     Document Type: Article

References (23)

1. Nagata M et al. Effect of acute hepatic failure on the hepatic first-pass effect of 5- fluorouracil in rats. J Pharm Pharmacol 2010; 62: 598-603.
2. Yoshisue K et al. Effect of dimethylnitrosamine-induced liver dysfunction on the pharmacokinetics of 5-fluorouracil after administration of S-1, an antitumour drug, to rats. J Pharm Pharmacol 2009; 61: 1643-1651.
3. Wong HL et al. Chemotherapy with anticancer drugs encapsulated in solid lipid nanoparticles. Adv Drug Deliv Rev 2007; 59: 491-504. (Pubitemid 47259227)
4. Hitzman CJ et al. Pharmacokinetics of 5-fluorouracil in the hamster following inhalation delivery of lipid-coated nanoparticles. J Pharm Sci 2006; 95: 1196-1211. (Pubitemid 43874436)
5. Zhang H et al. Preparation and drug release behaviors of 5-fluorouracil loaded poly(glycolide-co-lactide-co-caprolactone) nanoparticles. J Appl Poly Sci 2007; 106: 3757-3767. (Pubitemid 350149335)
6. Guney O, Akgerman A. Synthesis of controlled-release products in supercritical medium. AIChE J 2002; 48: 856-866. (Pubitemid 36173074)
7. Dorta MJ et al. Potential applications of PLGA film-implants in modulating in vitro drugs release. Int J Pharm 2002; 248: 149-156. (Pubitemid 35341419)
8. Mishima K. Biodegradable particle formation for drug and gene delivery using supercritical fluid and dense gas. Adv Drug Deliv Rev 2008; 60: 411-432. (Pubitemid 351222677)
9. Reverchon E. Supercritical antisolvent precipitation of microand nanoparticles. J Supercrit Fluids 1999; 15: 1-21. (Pubitemid 129671809)
10. 2 and highly selective aromatase inhibitors: experimental solubility and empirical data correlation. J Supercrit Fluids 2009; 50: 203-209.
11. Rouholamini Najafabadi A et al. Formation of salbutamol sulphate microparticles using solution enhanced dispersion by supercritical carbon dioxide. DARU 2005; 13: 1-6.
12. Vatanara A et al. A Plackett-Burman design for screening of the operation variables in the formation of salbutamol sulphate particles by supercritical anti-solvent. J Supercrit Fluids 2007; 40: 111-116. (Pubitemid 44909732)
13. Hojjati M et al. Solubility of some statin drugs in supercritical carbon dioxide and representing the solute solubility data with several density-based correlations. J Supercrit Fluids 2007; 41: 187-194. (Pubitemid 46551666)
14. Guney O, Akgerman A. Solubilities of 5-fluorouracil and betaestradiol in supercritical carbon dioxide. J Chem Eng Data 2000; 45: 1049-1052. (Pubitemid 32022987)
15. Yeo SD, Kiran E. Formation of polymer particles with supercritical fluids: a review. J Supercrit Fluids 2005; 34: 287-305.
16. Wang Y et al. Polymer coating/encapsulation of nanoparticles using a supercritical anti-solvent process. J Supercrit Fluids 2004; 28: 85-99.
17. Bakhbakhi Y et al. Experimental study of the GAS process for producing microparticles of beclomethasone-17,21-dipropionate suitable for pulmonary delivery. Int J Pharm 2006; 309: 71-80. (Pubitemid 43129467)
18. Sacha GA et al. Identification of critical process variables affecting particle size following precipitation using a supercritical fluid. Pharm Dev Technol 2006; 11: 187-194.
19. P'erez de Diego Y et al. Operating regimes and mechanism of particle formation during the precipitation of polymers using the PCA process. J Supercrit Fluids 2005; 35: 147-156.
20. Pe'rez Y et al. Improved PCA process for the production of nano- and microparticles of polymers. AIChE J 2004; 50: 2408-2417.
21. Ghaderi R et al. A new method for preparing biodegradable microparticles and entrapment of hydrocortisone in DL-PLG microparticles using supercritical fluids. Eur J Pharm Sci 2000; 10: 1-9. (Pubitemid 30123139)
22. Einmahl S et al. Therapeutic applications of viscous and injectable poly(ortho esters). Adv Drug Deliv Rev 2001; 53: 45-73. (Pubitemid 33152833)
23. Gao H et al. The implantable 5-fluorouracil-loaded poly(L-lactic acid) fibers prepared by wet-spinning from suspension. J Control Release 2007; 118: 325-332. (Pubitemid 46441552)